Clinical trials: Local Anaesthesia
Anaesthesia, Toxicity
Sensitivity of ECG on Detection of Three Different Intravascular Applied Test Doses of Bupivacaine and Epinephrine
The purpose of this prospective randomised study is to investigate electrocardiographic alterations after intravascular injection of three different test solutions of bupivacaine and epinephrine in anaesthetised children up to 16…
- Trial name
- NCT01091766
- Testing
- intravenous injection of test solution
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Anxiety
Respiratory Biofeedback Device and Reduction of Dental Anxiety Associated With Local Anesthesia in Children
The aim of the study was to investigate the effect of a respiratory biofeedback device (RESPeRATE TM) in reduction of preoperative anxiety in children undergoing dental procedures under local anesthesia.
- Trial name
- NCT04238312
- Testing
- RESPeRATE™, Tell, Show and Do technique
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Nourhan M.Aly
Post Operative Pain, Appendicitis
Evaluation of Local Anesthetic at Incision Site
Patient will have usual appendectomy surgery with an injection of local or saline at incision site either before or after the incision at random.
- Trial name
- NCT02483689
- Testing
- Pre Incisional Local Anesthetic, Pre-Incisional Saline, Post-Closure Local Anesthetic
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Valley Anesthesiology Consultants
Pregnancy, Anesthesia
Continuous Noninvasive Method for Estimating and Predicting Maternal and Fetal Hemodynamic Changes During Regional Anesthesia
Machine learning techniques and algorithms originally developed for use in the field of robotics can be applied to continuous, noninvasive physiological waveform data to discover hidden, hemodynamic relationships.
- Trial name
- NCT01699243
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- University of Colorado, Denver
Infertility
Experience of Pain During Oocyte Retrieval- a Comparison Between Two Aspiration Needles
The purpose of the study is to compare the pain experience between the patients that have had their transvaginal oocytes retrieval with ultrasound guidance performed with reduced single lumen needle (Vitrolife Sweden AB…
- Trial name
- NCT00924885
- Testing
- Swemed Follicle Aspiration Set Reduced Single Lumen, Swemed Follicle Aspiration Set Single Lumen (1.4 mm)
- Where
- 4 sites in Sweden
- Volunteers
- 257 people
- Sponsor
- Vitrolife
Anesthesia, Local, Postoperative Pain
Comparison of Supraclavicular and Costoclavicular Brachial Plexus Blocks in Pediatrics
In upper extremity surgeries, the brachial plexus block can be performed with different techniques at various levels depending on the proximal and distal level of the surgery.
- Trial name
- NCT04782778
- Testing
- Bupivacaine 0.25% Injectable Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Sacral Erector Spinae Plane Block, Pediatric Regional Anesthesia
Sacral Erector Spinae Plane Block Versus Penile Block For Analgesia In Pediatric Circumcision
Circumcision is one of the most frequently performed surgical procedures in childhood and is associated with significant postoperative pain.
- Conditions
- Sacral Erector Spinae Plane Block, Pediatric Regional Anesthesia, Regional Anaesthesia
- Trial name
- NCT07321717
- Testing
- Sacral Erector Spinae Plane Block, Penile Nerve Block (PNB)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University - Cerrahpasa
Dental Caries, Reversible Pulpitis
Assessment of Pain and Anxiety During Infiltration Anesthesia Using Dental Anesthesia Injector Versus Conventional Syringe in Pediatric Patients
This randomized controlled trial is conducted on pediatric dental patients to compare the effectiveness of local anesthesia administered using a dental anesthesia injector device versus the traditional syringe method.
- Trial name
- NCT07101068
- Testing
- Dental Anesthesia Injector, conventional syringe
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pediatric Dentistry, Local Anesthesia
Pain and Anxiety Evaluation in Children Using Different Techniques of Local Anesthesia for Dental Treatment
Fear and dental anxiety are often associated with the use of needles and syringes for local anesthesia, and painful perception during the administration of local anesthetics is often the main reason for anxiety behaviors and…
- Conditions
- Pediatric Dentistry, Local Anesthesia, Pain Management
- Trial name
- NCT03176446
- Testing
- Local anesthesia with traditional technique, Local anesthesia with computerized technique, Local anesthesia with DentalVibe technique
- Where
- Brazil
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Ponta Grossa
Pain, Local Infiltration
Pain Perception With a Comfort-ın Jet Injection and Conventional Dental Injection
The investigators aimed to compare the effectiveness of the Comfort-in system, which is a jet injection type, and infiltrative anesthesia with a traditional injector, and to measure the effect of children's anxiety on the…
- Conditions
- Pain, Local Infiltration, Anesthesia, Fear
- Trial name
- NCT04682080
- Testing
- Needle-free injection
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Local Anesthesia, Tooth Extraction
Pre-emptive Analgesic Administration in Primary Tooth Extraction
Brief Summary: Aims: The objective of the current study will be to compare the effectiveness of Ibuprofen, Acetaminophen, and Placebo on reducing injection pain and post-operative pain in primary tooth extraction, and to compare…
- Trial name
- NCT03786029
- Testing
- Acetaminophen, Ibuprofen
- Where
- Syria
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Latakia University
Circumcision Adult, Circumcision, Male
Technological Devices in Circumcision
It aims to investigate the effect of circumcision on the pain and anxiety level of children who are circumcised by watching videos/playing games during the procedure.
- Conditions
- Circumcision Adult, Circumcision, Male, Circumcision
- Trial name
- NCT06793722
- Testing
- Technological device in circumcision
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Adiyaman University
Pain, Postoperative
Transversus Abdominis Plane Block Versus Quadratus Lumborum Block in The Pediatric Population Undergoing Orchiopexy
Transversus abdominis plane (TAP) and Quadratus lumborum (QL) blocks are used for the management of acute pain treatment, especially after the lower and upper abdominal surgeries.
- Trial name
- NCT03969316
- Testing
- Transversus abdominis plane block, Quadratus lumborum block
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Istanbul University - Cerrahpasa
Local Anesthesia
Effectiveness of Sodium Bicarbonate Buffered Anaesthetic Solution on Pain During Injection
This study will test the effectiveness of addition of Sodium Bicarbonate as a buffering agent to the anaesthetic solution on minimizing the pain of injection and increasing the onset time and potency of the anaesthetic solution…
- Trial name
- NCT05473819
- Testing
- Buffered Local Anesthesia, Conventional Unbuffered Local Anesthesia
- Where
- Egypt
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Hydrocephalus in Children, Regional Block
Scalp Blocks for Pediatric External Ventricular Drainage Placement
External ventricular drainage (EVD) provides cerebrospinal fluid drainage in hydrocephalus. In adults, the neurosurgeon can place EVD at the bedside.
- Conditions
- Hydrocephalus in Children, Regional Block, Pediatric Anesthesia
- Trial name
- NCT06903598
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Hande Gurbuz
Hypospadias, Penile Torsion
Caudal vs. Pudendal Block in Peds GU
This study will compare two techniques to minimize pain during and after penile surgery in children undergoing certain urologic surgeries. These two approaches include the caudal nerve block and the pudendal nerve block.
- Conditions
- Hypospadias, Penile Torsion, Chordee, Phimosis
- Trial name
- NCT05708989
- Testing
- Caudal Block, Ultrasound-guided Pudendal Block, Injectable 1 ml/kg of 0.25% ropivacaine with 1mcg/kg dexmedetomidine
- Where
- United States
- Sponsor
- University Hospitals Cleveland Medical Center
Hypothalamic Neoplasms, Pituitary Diseases
The Cardiovascular Changes Associated With Septal Local Anaesthesia
The purpose of this study is to determine the effects on the heart of injecting local anaesthetic into the nose prior to surgery on the pituitary gland?
- Conditions
- Hypothalamic Neoplasms, Pituitary Diseases, Anesthesia, Local
- Trial name
- NCT03137615
- Testing
- Pituitary surgery, local anaesthetic injection
- Volunteers
- 15 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Labor Pain, Delivery Complication
Effect of Epidural Analgesia on Labour, Neonatal and Maternal Outcomes.
Lumbar epidural analgesia is the most used method for reducing labour pain, but its impact on the duration of the second stage of labour and on neonatal and maternal outcomes remains debated.
- Conditions
- Labor Pain, Delivery Complication, Regional Anesthesia Morbidity
- Trial name
- NCT05579808
- Testing
- Epidural Analgesia
- Where
- Italy
- Volunteers
- 21,808 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Osteoarthritis, Hip
Effect of Local Infiltration Anesthesia With Ropivacaine on Pain After Primary Total Hip Arthroplasty
Background: The Local infiltration analgesic (LIA) technique has been widely used to reduce opioid requirements and improve the patient's mobilization after total hip arthroplasty (THA).
- Trial name
- NCT02359136
- Testing
- local infiltration anesthesia using Ropivacaine and Epinephrine, local infiltration anesthesia using saline, Multimodal analgesic regimen
- Where
- Norway
- Volunteers
- 116 people
- Sponsor
- St. Olavs Hospital
Clubfoot
Clubfoot Tenotomy Trial
Infants undergoing Ponseti treatment for idiopathic clubfoot often require percutaneous tendoachilles lengthening (TAL) after serial casting.
- Trial name
- ClubTT (NCT04766684)
- Testing
- Jet injection of 1% lidocaine, 4% liposomal lidocaine cream
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Vanderbilt University Medical Center