Clinical trials: Lumbar Puncture
Lumbar Puncture
Hemorrhage Elimination During Lumbar Puncture Using Ultrasound Measurements (HELPUS)
This is a clinical trial to determine the extent to which ultrasound-assisted lumbar puncture using a standardized procedure, including use of ultrasound to ascertain the presence of cerebrospinal fluid (CSF) at L3 - L5 and the…
- Trial name
- HELP (NCT07612644)
- Testing
- ultrasound contrast
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Vanderbilt University Medical Center
Spinal Muscular Atrophy, Spine Deformity
Study of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy
The primary objective of the clinical investigation is to demonstrate successful clinical use of the ThecaFlex DRx™ System in delivering nusinersen in subjects with spinal muscular atrophy (SMA).
- Conditions
- Spinal Muscular Atrophy, Spine Deformity, Scoliosis
- Trial name
- PIERRE (NCT05866419)
- Testing
- ThecaFlex DRx System
- Where
- 21 sites in United States, Germany and 3 more
- Volunteers
- 90 people
- Sponsor
- Alcyone Therapeutics, Inc
Hunter Syndrome
Collection and Study of Cerebrospinal Fluid in Patients With Hunter Syndrome
The purpose of the study is to collect data on CSF biomarkers in patients with Hunter Syndrome that would serve as reference data for comparison with cognitively impaired patients with Hunter syndrome, patients with other…
- Trial name
- NCT01449240
- Testing
- No treatment
- Where
- 7 sites in United States, United Kingdom
- Volunteers
- 10 people
- Sponsor
- Shire
Spinal Puncture, Anesthesia
Anesthesia Lumbar Puncture In Children
The study is carried out in a prospectively randomly controlled way. In the context of acknowledgement and understanding from parents, by comparing with traditional process(no anesthesia), lidocaine surface anesthesia is randomly…
- Trial name
- ALPIC (NCT02590705)
- Testing
- Lidocaine
- Volunteers
- 200 people
- Sponsor
- Beijing Children's Hospital
Spinal Puncture
Co-administration of Propofol and Remifentanil for Lumbar Puncture in Children
The objective of this study is to compare intraoperative and recovery parameters in patients who receive two different dose combinations of propofol and remifentanil in patients undergoing a lumbar puncture.
- Trial name
- NCT00405522
- Testing
- Propofol 2.0 mg/kg + Remifentanil 1.5 ug/kg, Propofol 4.0 mg/kg + Remifentanil 0.5 ug/kg
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- The Hospital for Sick Children
Meningoencephalitis, Other Syndromes Requiring Lumbar Puncture in Emergency Department
Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients
Of all emergency room patients, persons presenting with encephalitis/meningitis syndrome of a potentially infectious nature are among those of greatest concern.
- Trial name
- NCT02207647
- Testing
- no intervention
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Olive View-UCLA Education & Research Institute
Spinal Puncture Complications
Optimization Lumbar Puncture In Children
The study is carried out in a prospective randomized controlled way. In the context of informed understanding from parents, compared with traditional process(no anesthesia; lying without the pillow and fasting water and food for…
- Trial name
- OLPIC (NCT02454894)
- Testing
- lidocaine, postoperative management
- Sponsor
- Beijing Children's Hospital
Lumbar Puncture
Ultrasound Assisted Lumbar Puncture in the Neonate
Clinicians are often unable to successfully do a spinal tap. Ultrasound has been proposed as a method to improve success but it is not known if it helps. This study is designed to see if ultrasound improves the success rate.
- Trial name
- NCT02918149
- Testing
- Palpation Landmark Technique, Ultrasound-Assisted Technique LP
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Children's Hospital of Philadelphia
Meningitis/Encephalitis
QIAstat-Dx® Meningitis/Encephalitis Panel Performance Evaluation Study 001
Study for performance evaluation of the QIAstat-Dx® Meningitis/Encephalitis Panel in comparison with other chosen comparator methods.
- Trial name
- NCT05092438
- Where
- United Kingdom
- Volunteers
- 595 people
- Sponsor
- QIAGEN Gaithersburg, Inc
Traumatic Lumbar Puncture
Variability of Infant LP Insertion Site Based On Procedural Experience
The reported rate of unsuccessful traditional LP in children (defined as the inability to obtain cerebrospinal fluid or obtaining a traumatic puncture) is as high as 50%.
- Trial name
- NCT02949869
- Testing
- Spinal Sonography
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Leukemia, Lymphoma
Propofol Versus Propofol-Fentanyl as Sedation For Lumbar Puncture in Children With Acute Leukemia/Lymphoma
The hypothesis of the study is that propofol-fentanyl sedation for lumbar punctures in children with acute leukemia/lymphoma results in fewer adverse events than propofol sedation alone.
- Trial name
- NCT00214370
- Testing
- Propofol-Fentanyl, Propofol alone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Wisconsin, Madison
Sepsis, Meningitis
Neonatal Comfort Seat Allowing Safe Lumbar Puncture and Minimizing Failure: a Randomized Controlled Trial
A research trial which compares standard of care against employing a novel device for immobilization of babies undergoing upright LP, the present working name for the device is LP Comfort Seat (LPCS).
- Trial name
- NeoCALM (NCT06811428)
- Testing
- A novel device for immobilization of babies undergoing upright LP, the present working name (non-proprietary) for the device is LP Comfort Seat (LPCS), Standard of Care (SOC)
- Volunteers
- 68 people
- Sponsor
- Joel Cox
Febrile Convulsions
The Relevance of Performing Lumbar Puncture in Infants Aged 3 to 12 Months With First Episode of Febrile Convulsion
The actual recommendations for infants aged 3 to 12 months presented with first episode of Febrile Convulsions highly recommend performing lumbar puncture in order to rule out Bacterial Meningitis.
- Trial name
- NCT01443611
- Where
- Israel
- Volunteers
- 122 people
- Sponsor
- HaEmek Medical Center, Israel
Anxiety and Fear
The Effect of Therapeutic Play on Children's Anxiety and Fear Before Lumbar Puncture
The study will be conducted with the randomized controlled experimental method. The children who attended the pediatric department will divide into two groups via randomization in the computer environment.
- Trial name
- NCT06199206
- Testing
- Theraputic Play
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Maltepe University
Nervous System Diseases
Cerebrospinal Fluid Collection and Repository Storage
Background: Cerebrospinal fluid (CSF) is the liquid around the brain and spinal cord. Many diseases can only be diagnosed by examining the CSF. A lumbar puncture is used to collect and test CSF.
- Trial name
- NCT01862107
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Pediatric Lumbar Puncture
Identification of Cerebrospinal Fluid With Injeq IQ-Needle During Paediatric Lumbar Puncture
This is clinical feasibility study on the device performance with paediatric patients. The main objective is to validate the performance of investigational device in distinguishing and identifying the cerebrospinal fluid (CSF)…
- Trial name
- NCT02792660
- Testing
- Injeq IQ-Needle
- Where
- 2 sites in Finland
- Volunteers
- 40 people
- Sponsor
- Injeq Ltd
Hematologic Diseases, Neoplasms
A Dose Finding Study of Remifentanil and Propofol for Lumbar Punctures in Children
This study will examine whether the combination of two anaesthetic medications, propofol and remifentanil, is suitable for short duration surgical procedures, providing a shorter recovery time and fewer side effects than either…
- Trial name
- NCT00213239
- Testing
- Remifentanil
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- The Hospital for Sick Children
Pediatric Lumbar Puncture
Intravenous Fluid Administration's Effect on Pediatric Lumbar Puncture
The purpose of this project is to determine if administration of normal saline intravenous fluids prior to a lumbar puncture improves first time success of lumbar puncture in infants less than 3 months of age.
- Trial name
- NCT05302765
- Testing
- Normal Saline Intravenous Fluids
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of Alabama at Birmingham
Pain, Anxiety
Midazolam Sedation for Neonatal Lumbar Puncture
Lumbar puncture is one of the most common painful procedures performed on neonates in the Emergency Department (ED). The investigators will study in a randomized controlled trial, the efficacy of intravenous administration of a…
- Trial name
- NCT00942539
- Testing
- Midazolam
- Where
- Israel
- Volunteers
- 12 people
- Sponsor
- Rambam Health Care Campus
Spinal Puncture Complications, Simulation-based Training
The Effect of Simulation-Based Training on Performance and Stress in the Clinical Setting
This study will investigate the effect of simulation-based training with mastery learning (SBML) on novice performers' lumbar puncture (LP) performance in a clinical setting.
- Conditions
- Spinal Puncture Complications, Simulation-based Training, Stress, Emotional
- Trial name
- NCT03163927
- Testing
- Simulation-based training
- Where
- 3 sites in Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet