Clinical trials: Lumbar Puncture
Infant/ Neonate Lumbar Puncture
Bedside Ultrasound Assisted Pediatric Lumbar Puncture
This is a prospective, randomized study evaluating the efficacy of bedside ultrasound assisted lumbar puncture in pediatric patients
- Trial name
- NCT02193763
- Testing
- Ultrasound assisted lumbar puncture
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Pediatric Lumbar Puncture
Identification of Cerebrospinal Fluid With Injeq IQ-Needle During Paediatric Lumbar Puncture
This is clinical feasibility study on the device performance with paediatric patients. The main objective is to validate the performance of investigational device in distinguishing and identifying the cerebrospinal fluid (CSF)…
- Trial name
- NCT02792660
- Testing
- Injeq IQ-Needle
- Where
- 2 sites in Finland
- Volunteers
- 40 people
- Sponsor
- Injeq Ltd
Spontaneous Intracranial Hypotension, Intracranial Hypotension
Pathophysiology and Treatment of Cerebrospinal Hypotension Exploration Study
The goal of this observational study is to learn about the effects of a low-pressure environment on the brain in patients with intracranial hypotension and to potentially improve diagnostics and treatment of this condition.
- Conditions
- Spontaneous Intracranial Hypotension, Intracranial Hypotension, Post-Lumbar Puncture Headache
- Trial name
- PATCHES (NCT06805591)
- Where
- Denmark
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Spinal Muscular Atrophy, Spine Deformity
Study of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy
The primary objective of the clinical investigation is to demonstrate successful clinical use of the ThecaFlex DRx™ System in delivering nusinersen in subjects with spinal muscular atrophy (SMA).
- Conditions
- Spinal Muscular Atrophy, Spine Deformity, Scoliosis
- Trial name
- PIERRE (NCT05866419)
- Testing
- ThecaFlex DRx System
- Where
- 21 sites in United States, Germany and 3 more
- Volunteers
- 90 people
- Sponsor
- Alcyone Therapeutics, Inc
HIV Infection
The Efavirenz (EFV) Central Nervous System Exposure Sub-study of Encore1
Persistent HIV infection in the central nervous system (CNS) compartment may put subjects at risk of developing HIV-related brain disease.
- Trial name
- ENCORE1-CNS (NCT01451333)
- Testing
- Efavirenz
- Where
- 5 sites in Germany, Thailand and 1 more
- Volunteers
- 32 people
- Sponsor
- Kirby Institute
Spinal; Puncture, Complications
Ultrasound vs Palpation for Infant Lumbar Puncture
The purpose of this study is to determine if performing an ultrasound to identify the space to insert the needle before performing a lumbar puncture will improve success of the procedure and patient safety.
- Trial name
- NCT02373774
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Columbia University
Intracranial Pressure
Intracranial Pressure vs Percentage Body Fat
Background: It has already been established that there is a weak positive relationship between increased intracranial pressure (ICP), as measured by lumbar puncture manometry, and increased Body Mass Index (BMI).
- Trial name
- NCT03144297
- Testing
- Lumbar puncture, BOD POD (air-displacement plethysmography)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Gloucestershire Hospitals NHS Foundation Trust
Infectious Encephalitis
Management of Tick-borne Encephalitis
In this retrospective cohort study of patients with tick-borne encephalitis (TBE), potential differences in the clinical presentation at admission and diagnostic and therapeutic management of patients with TBE initially referred…
- Trial name
- NCT06593249
- Testing
- No Intervention: Observational Cohort
- Where
- Slovenia
- Volunteers
- 318 people
- Sponsor
- University Medical Centre Ljubljana
Anesthesia
Needle-Free Lidocaine Injection vs Traditional Local Anesthesia in Infant Lumbar Puncture
We hypothesize that the J-Tip needle-free jet-injection system offers comparable pain control and greater provider satisfaction due to its less invasive nature compared to traditional needle infiltration of 1% lidocaine in…
- Trial name
- NCT06552351
- Testing
- Needle-Free Jet Injection of 1 % lidocaine, traditional needle infiltration of 1% lidocaine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Late Infantile Neuronal Ceroid Lipofuscinosis, Batten Disease
Collection of Cerebrospinal Fluid in Healthy Children
The purpose of this study is to obtain cerebrospinal fluid from healthy children already undergoing a lumbar puncture procedure at New York Presbyterian Hospital, to act as healthy controls when compared to children with late…
- Trial name
- NCT01698229
- Testing
- Group 1
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Syphilis
Lumbar Puncture and Syphilis Outcome
Treponema pallidum, the bacterium that causes syphilis, invades the central nervous system in about 40% of patients with syphilis. This happens early after infection.
- Trial name
- NCT02031146
- Testing
- Lumbar puncture
- Where
- United States
- Volunteers
- 231 people
- Sponsor
- University of Washington
Lumbar Puncture, Virtual Reality
Effect of Virtual Reality Distraction on Pain, Anxiety, Vital Signs in Patients Undergoing Lumbar Puncture
Lumbar puncture (LP) is one of the most frequently applied interventional procedures in the clinical field. It is still used as the gold standard diagnostic tool in some infectious and non-infectious diseases.
- Conditions
- Lumbar Puncture, Virtual Reality, Distraction
- Trial name
- NCT07044856
- Testing
- distraction with virtual reality
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Inonu University
Attention Deficit and Disruptive Behavior Disorder, Attention Deficit Disorder With Hyperactivity
Biological Markers in Attention Deficit/Hyperactivity Disorder (ADHD)
The purpose of this study is to evaluate individuals with Attention Deficit/Hyperactivity Disorder (ADHD) to learn more about the genetics of the disease. This study is part of other ongoing studies of individuals with ADHD.
- Trial name
- NCT00001206
- Where
- United States
- Volunteers
- 347 people
- Sponsor
- National Institute of Mental Health (NIMH)
Post-Dural Puncture Headache, Headache After Spinal Puncture
Comparison of Post-Dural Puncture Headache After Spinal Anesthesia Using Median Versus Paramedian Approach
This randomized controlled trial will compare two commonly used techniques for performing spinal anesthesia, the median (midline) approach and the paramedian (lateral) approach, in adult patients undergoing elective orthopedic or…
- Trial name
- NCT07436403
- Testing
- Spinal anesthesia using median approach (midline), Spinal anesthesia using paramedian approach
- Where
- Pakistan
- Volunteers
- 142 people
- Sponsor
- Mayo Hospital Lahore
Indication for Lumbar Puncture
The Effectiveness of a Pediatric Lumbar Puncture Restraint Device
This is a pilot study to evaluate a restraint device for lumbar punctures. Designed to help improve the restraint techniques for lumbar puncture, the restraint device will be compared to the current standard of manual physical…
- Trial name
- SNOWBOARD (NCT00980070)
- Testing
- Pediatric Restraint for Lumbar Puncture, Lumbar Puncture Device, Standard of Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Nebraska
Normal Pressure Hydrocephalus
Effect of Depletive Lumbar Puncture on Lower Urinary Tract Dysfunction in iNPH
Lower urinary tract dysfunction in normal pressure hydrocephalus has received little attention from the scientific community. Urinary symptoms in normal pressure hydrocephalus are mainly represented by overactive bladder, which…
- Trial name
- PLHPN (NCT03877107)
- Testing
- Urinary symptoms profile questionnaire, Micturition calendar
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- EssaiClinique_PL-HPN
Lumbar Puncture
AI-Assisted Instruction Versus Peer Learning for Sustained Lumbar Puncture Competency
This study compared three teaching methods for training resident physicians in lumbar puncture, a critical medical procedure used to collect spinal fluid for diagnosing conditions like meningitis.
- Trial name
- AI-Assisted (NCT07873073)
- Testing
- Peer Learning
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Labor Pain, Labor Analgesia
Impact of Dural Puncture Epidural Versus Traditional Lumbar Epidural on Onset of Labor Analgesia
This study is to examine the onset of pain relief with two different methods of labor epidural. The traditional labor epidural involves the placement of numbing and anti-pain medicine in the epidural space which surrounds the…
- Trial name
- NCT02412969
- Testing
- Lumbar Epidural, Dural Puncture Epidural
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Fever
Ultrasound-Assisted Lumbar Puncture in Children
The aim of this study is to determine if emergency physician performed ultrasound-assisted lumbar puncture improves first-time success rates in a pediatric population.
- Trial name
- NCT03099642
- Testing
- ultrasound-assisted lumbar puncture
- Where
- Canada
- Volunteers
- 166 people
- Sponsor
- St. Justine's Hospital
Pain, Anxiety
The Effect of ShotBlocker on Symptoms of Pain, Anxiety, and Cortisol Hormone Levels
The aim of this study is to evaluate the effect of Shotblocker, administered during lumbar puncture, on patients' pain levels, anxiety levels, and cortisol levels (a physiological stress indicator).
- Trial name
- NCT07880496
- Testing
- Intervention Group, Control
- Volunteers
- 68 people
- Sponsor
- Ataturk University