Clinical trials: Lung Function
Cystic Fibrosis
Do Musculoskeletal Techniques Improve Forced Expiratory Volume in One Second in Adults With Cystic Fibrosis?
The pilot study aims to evaluate the effects of a treatment series of gentle joint and muscle movements (in addition to normal optimal care)on lung function, exercise capacity and posture in stable adults with cystic fibrosis.
- Trial name
- NCT00716664
- Testing
- A treatment series of gentle joint and muscle movements, Control group measurements
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Cystic Fibrosis
Use of Formula Fortified With DHA in Infants With Cystic Fibrosis
The hypothesis of this study is that feeding infants diagnosed with CF via newborn screening a formula enhanced with a specific fish-oil fatty acid known as DHA will improve growth and decrease pancreatic dysfunction (as measured…
- Trial name
- DHA (NCT00530244)
- Testing
- Docosahexaenoic acid (DHA), Standard formula (Enfamil)
- Where
- 24 sites in United States
- Volunteers
- 76 people
- Sponsor
- University of Massachusetts, Worcester
Funnel Chest
Functional Capacity of Exercise and Lung Function in Patients Submitted Early Rehabilitation
The aim of this study was to compare the functional capacity of exercise by six-minute walk test and lung function by spirometry, before and after Nuss procedure in subjects who have undergone the early rehabiliation program with…
- Trial name
- NCT02441452
- Testing
- Early rehabilitation
- Volunteers
- 40 people
- Sponsor
- Instituto do Coracao
Exercise Induced Asthma, Exercise Induced Bronchospasm
Evaluation of Exercise Induced Bronchoconstriction Using a Novel Automated Digital Clinical Decision System
The primary objective of this study is to assess if the unstandardized field exercise challenge test (ECT) using AsthmaTuner can be performed independently by youths that have been investigated for asthma.
- Conditions
- Exercise Induced Asthma, Exercise Induced Bronchospasm, Pediatric Respiratory Diseases
- Trial name
- NCT05162703
- Testing
- AsthmaTuner
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
COPD, Interstitial Lung Disease
An Observational Outcomes Study for Autologous Cell Therapy Among Patients With COPD and Interstitial Lung Disease
The purpose of the Lung Institute is to collect and isolate a patient's own cells and platelet rich plasma (PRP) and deliver the product back to the patient same-day.
- Trial name
- NCT03040674
- Testing
- Cell therapy
- Where
- United States
- Volunteers
- 489 people
- Sponsor
- Lung Institute
Preterm, Premature
Effects of Kinesiotaping on Respiratory Muscles in Very Preterm Infants
This study aimed to evaluate the effects of kinesio taping on blood gas parameters, respiratory rate, heart rate, oxygen saturation, and pressure limits in preterm infants with RDS who are on NIV.
- Conditions
- Preterm, Premature, Infant, Newborn, Diseases, Respiratory Distress Syndrome
- Trial name
- NCT06285669
- Testing
- kinesiotaping application
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Ondokuz Mayıs University
Staphylococcus Aureus Pneumonia, Lung Diseases
Mucoid Staphylococcus Aureus in Cystic Fibrosis Airways
Recently, the investigators described a new mucoid phenotype of Staphylococcus aureus cultured from the airways of cystic fibrosis (CF) patients.In this observational study, the investigators plan to determine the prevalence of…
- Conditions
- Staphylococcus Aureus Pneumonia, Lung Diseases, Cystic Fibrosis, Lung Function Decreased
- Trial name
- mucostaph (NCT04171583)
- Where
- 13 sites in Austria, Germany
- Volunteers
- 628 people
- Sponsor
- University Hospital Muenster
Organ Preservation
Ex Vivo Lung Perfusion : Effect of Cellular Perfusate on Mechanical Properties and Gas Exchange Function of Donor Lungs
The lungs retrieved from the brain dead multi organ donor will be placed in a lab . They will be connected to a ventilator and preservative solution will be circulated through it .
- Trial name
- NCT02953483
- Testing
- Red blood cells
- Where
- India
- Volunteers
- 6 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Langerhans Cell Histiocytoses
Characterization of Pulmonary Langerhans Cell Histiocytosis
Very recent studies indicate that a high percentage of HCL, about 50%, have mutations in the B-RAF oncogene. The development of ultrasensitive methodologies capable of identifying these mutations in bronchoalveolar lavage will…
- Trial name
- NCT03093727
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Asthma Control, Asthma
A Community-Based Swimming and Inspiratory Muscle Training Intervention to Promote Physical Activity and Asthma Control in Children With Mild Asthma
This randomized controlled trial investigated the effects of adding inspiratory muscle training (IMT) to a structured swimming program on pulmonary function, respiratory muscle strength, ventilatory capacity, perceived exertion…
- Conditions
- Asthma Control, Asthma, Asthma Chronic
- Trial name
- IMT-SWIM-ASTHM (NCT07394127)
- Testing
- Swimming Training Only (Control Group), Swimming + Inspiratory Muscle Training (Experimental Group)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gümüşhane Universıty
Panic Disorder
CO2 Inhalation and Risk for Panic Disorder
Objective: To examine respiratory/physiological and subjective responding as well as genetic transmission among offspring of parents with a history of or current panic disorder (PD) diagnosis to determine whether…
- Trial name
- NCT00930657
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Institute of Mental Health (NIMH)
Intellectual Disability, Rubinstein-Taybi Syndrome
Functional Tests to Resolve Unsolved Rare Diseases. Rares.
Rares diseases are a heterogeneous group of conditions which need important tools for diagnosis. The use of high-throughput sequencing is able to diagnose half of the patients.
- Conditions
- Intellectual Disability, Rubinstein-Taybi Syndrome, Cystic Fibrosis, Congenital Heart Defect
- Trial name
- RID (NCT05696912)
- Testing
- Ex-vivo approach concerning 25 patients, In-vitro approach concerning 25 patients
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Asthma, Pulmonary Disease
Examining the Role of Vitamin D in Asthma and Chronic Obstructive Pulmonary Disease (COPD)
Asthma and chronic obstructive pulmonary disease (COPD) are diseases that affect a person's ability to breathe normally. People who do not receive enough vitamin D may have a higher risk of developing asthma or COPD.
- Conditions
- Asthma, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT00851695
- Volunteers
- 2,266 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Diastolic Dysfunction, Neonatal Encephalopathy
Assessment of Diastolic Function During the Transitional Period and Infancy Using Serial Echocardiography
The goal of this single-centre longitudinal observational study is to create reference values for diastolic function parameters in neonates born at 35 weeks' gestation or above, and to assess the influence of pre-defined…
- Conditions
- Diastolic Dysfunction, Neonatal Encephalopathy, Small for Gestational Age at Delivery, Transient Tachypnea of the Newborn
- Trial name
- DiFuSE (NCT06200519)
- Where
- Ireland
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University College Cork
Cystic Fibrosis
A Prospective Study to Evaluate Biological and Clinical Effects of Significantly Corrected CFTR Function
This is a prospective, multi-center observational study. The study is designed to measure the clinical effectiveness of elexacaftor, tezacaftor and ivacaftor (ETI) triple combination therapy in people with one or more copies of…
- Trial name
- PROMISE (NCT04038047)
- Where
- 56 sites in United States
- Volunteers
- 490 people
- Sponsor
- Nicole Hamblett
Cystic Fibrosis, Telerehabilitation
The Effect of Telerehabilitation on Functional Capacity, Oxidative Stress and Respiratory Parameters in Cystic Fibrosis
The aim of this study is to examine the effects of different exercise modalities applied with tele-rehabilitation on functional capacity, oxidative stress and respiratory parameters in children with cystic fibrosis
- Trial name
- NCT05147285
- Testing
- stabilization exercises, combined exercises, Physical activity recommendations
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Hacettepe University
Bronchopulmonary Dysplasia, Right Ventricular Dysfunction
Right vEntricular Function Prediction mOdel to Identify pReterm infanTs With Early BronchoPulmonary Dysplasia.
Short title REPORT-BPD feasibility study Design A mixed methods observational cohort feasibility study Study Setting Neonatal Intensive Care Unit at University Hospitals Plymouth NHS Trust Aim To explore the feasibility of…
- Conditions
- Bronchopulmonary Dysplasia, Right Ventricular Dysfunction, In the Perinatal Period
- Trial name
- REPORT-BPD (NCT05235399)
- Testing
- Echo scans
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University Hospital Plymouth NHS Trust
Pulmonary Regurgitation, Congenital Heart Disease
Right Ventricular Diastolic Function in Chronic Adverse RV Loading And Congenital Heart Disease
The aim of the study is to assess the characteristics, incidence and predictors of load-independent right ventricle (RV) diastolic dysfunction in patients with congenital heart disease (CHD) and adverse RV loading conditions by…
- Trial name
- RaDICAL-CHD (NCT03471936)
- Testing
- Acquisition of pressure-volume-loops
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Heart Center Leipzig - University Hospital
Cystic Fibrosis, Bronchiectasis
Comparison of the Efficacy of Comprehensive Respiratory Physiotherapy in Children With Cystic Fibrosis and Non-Cystic Fibrosis Bronchiectasis
The effect of comprehensive respiratory physiotherapy applications on respiratory function, functional capacity and peripheral muscle strength in children with cystic fibrosis and non-cystic fibrosis will be compared.
- Trial name
- NCT04170114
- Testing
- Comprehensive Respiratory Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bezmialem Vakif University
Cystic Fibrosis
Early Assessment of Respiratory Function, Inflammation and Bronchial Reshuffle Among Newborns Screened for Cystic Fibrosis
The main objective of this study is to show that there is a concordance between lung disease at 13 months and the existing 9 weeks in newborn babies with cystic fibrosis asymptomatically.
- Trial name
- NCT02883816
- Testing
- assessment of lung function
- Where
- France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Montpellier