Clinical trials: Lung Function
Respiratory Disease
Does NIV-NAVA Improve Diaphragmatic Function in Preterm Infants
Non-Invasive Positive Pressure Ventilation (NIPPV) provides un-synchronized positive pressure and considered to be superior to nCPAP in preventing extubation failure.
- Trial name
- NCT05079412
- Testing
- Chest ultrasound
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Mount Sinai Hospital, Canada
Spinal Muscular Atrophy
Pulmonary Function Test Changes and Respiratory Muscle Strength Trends in Spinal Muscular Atrophy Patients Receiving Nusinersen Treatments
It is well known that patients with spinal muscular atrophy (SMA) have progressive decline of respiratory muscle function. Therapy traditionally involved supportive means to ensure optimal nutrition and airway clearance.
- Trial name
- NCT04050852
- Testing
- Nusinersen Treatments
- Where
- United States
- Sponsor
- NYU Langone Health
Esophageal Atresia, Healthy Children
Symptoms, Pulmonary Function, Muscle Strength, Exercise Capacity, and Frailty in Esophageal Atresia vs. Healthy Peers
Esophageal atresia is the most common congenital anomaly of the esophagus and is caused by abnormal development of the esophagus during intrauterine life.
- Trial name
- NCT06975982
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Cystic Fibrosis
VX-445/TEZ/IVA Expanded Access Program for Cystic Fibrosis (CF) Patients Heterozygous for F508del Mutation and a Minimal Function Mutation (F/MF Genotypes)
The purpose of this program is to provide elexacaftor(ELX, VX-445)/tezacaftor(TEZ)/ivacaftor(IVA) combination therapy to CF patients in critical need who are 12 years of age and older, heterozygous for F508del and a minimal…
- Trial name
- NCT04058210
- Testing
- ELX/TEZ/IVA, IVA
- Sponsor
- Vertex Pharmaceuticals Incorporated
Inspiratory Muscle Training
The Effect of Inspiratory Muscle Training on Respiratory Function, Balance and Functional Capacity in Trainable Mentally Handicapped Children
Background: The aim of this study was to examine the effect of inspiratory muscle training on respiratory functions, balance and functional capacity in trainable mentally disabled individuals.
- Trial name
- Inspiratory (NCT06635343)
- Testing
- CPRP, Experimental Inspiratuar Muscle Training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kayseri University
Interstitial Lung Diseases
The Effects of Whole-Body Vibration Training on Clinical and Functional Outcomes in Individuals Diagnosed With Interstitial Lung Disease
This randomized controlled trial aims to investigate the clinical and functional effects of Whole Body Vibration (WBV) training when added to a standard pulmonary rehabilitation (PR) program in patients with fibrotic interstitial…
- Trial name
- NCT07709260
- Testing
- Inspiratory Muscle Training, Peripheral Muscle Strengthening Exercises, Aerobic Exercise Training (Cycle Ergometer)
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Istinye University
Immune System Diseases, Eosinophilia
Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia
This study will investigate how, why and under what conditions eosinophils (a type of white blood cell) become activated and will examine their function in immune reactions.
- Conditions
- Immune System Diseases, Eosinophilia, Helminthiasis, Hypersensitivity
- Trial name
- NCT00001406
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Right Ventricular Dysfunction
Role of Echocardiography in the Assessment of Right Ventricular Function in the Pediatric Population With Valvular Pulmonary Stenosis.
Correct assessment of right ventricular function by transthoracic echocardiographic examination in pediatric patients with congenital valvular pulmonary stenosis after Percutaneous Balloon Pulmonary Valvuloplasty
- Trial name
- NCT04960085
- Testing
- echocardiography
- Volunteers
- 50 people
- Sponsor
- Assiut University
Chronic Kidney Diseases, Chronic Renal Disease
Evaluation of Respiratory Function and Functional Capacity in Pediatric Patients With Chronic Kidney Disease (CKD)
Chronic kidney disease (CKD) is defined as a permanent abnormality in kidney structure or function that persists for more than 3 months (for example, glomerular filtration rate [GFR] <60 mL/min/1.73 m2 or albuminuria ≥30 mg/24…
- Conditions
- Chronic Kidney Diseases, Chronic Renal Disease, Chronic Renal Failure
- Trial name
- NCT05339997
- Testing
- 6 minute walk test,
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Acibadem University
Core Stabilization, Trunk Muscle Endurance
Core Stabilization Training in Child and Adolescent Underwater Rugby Athletes
Demographic information of children aged 9-17 who volunteer to participate in the study and who play underwater rugby will be recorded, and all participants; respiratory function will be assessed with a portable spirometer…
- Conditions
- Core Stabilization, Trunk Muscle Endurance, Respiratory Function, Quality of Life
- Trial name
- NCT06728267
- Testing
- Core stabilization training, Training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ozden Gokcek
Asthma, Respiratory Sounds
Treatment of Persistent Wheezing in Infants and Children
Wheezing is a high-pitched whistling sound that is produced when air flows through narrowed lung airways. It is a common symptom of asthma.
- Trial name
- NCT00301171
- Testing
- Inhaled Fluticasone
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cystic Fibrosis
Continuous Azithromycin in Cystic Fibrosis Patients Beyond Two Years
Azithromycin is an antibiotic currently prescribed continuously in cystic fibrosis patients. It was shown that this treatment taken every day or every week for 12 months, can improve the respiratory state of patients.
- Trial name
- AZITHRO (NCT02803944)
- Testing
- Azithromycin
- Where
- France
- Volunteers
- 2,055 people
- Sponsor
- Hospices Civils de Lyon
Gastroparesis
Gastroparesis in Cystic Fibrosis
The purpose of this research is to determine if an investigational device called the 13C-Spirulina Gastric Emptying Breath Test (GEBT), can accurately diagnose gastroparesis (delayed emptying of the stomach) in patients with…
- Trial name
- NCT05223881
- Testing
- 13^C Spirulina Platensis Gastric Emptying Breath Test (GEBT)
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Miami
Febrile Illness Acute, Seizures, Febrile
Respiratory Physiology in Children With Febrile Seizures.
Febrile seizures occur in 2-5% of the population and are typically limited to children between 3 months and 5 years-of-age. The pathophysiological link between increased body temperature and increased seizure susceptibility is…
- Trial name
- NCT01906619
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Embolism, Femoral Fractures
Effect of a Novel Reamer-Irrigator-Aspirator on the Incidence of Fat Embolism
The purpose of this study is to determine the effect on the incidence of fat emboli when using a Reamer-Irrigator Aspirator during reamed IM nail fixation of femoral shaft fractures
- Trial name
- RIA (NCT00509171)
- Testing
- Reamer Irrigator Aspirator
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Pulmonary Hypertension
Study of Remodulin® in Pediatric Pulmonary Hypertension With Single Ventricular Physiology After Fontan Surgery
The aim of this study is to determine the safety and efficiency of Remodulin®（Treprostinil Injection）to reduce the pulmonary arterial pressure and prevent pulmonary hypertension (PH) after Fontan operation with univentricular…
- Trial name
- NCT02865733
- Testing
- Remodulin, distilled water
- Volunteers
- 36 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Pulmonary Disease
p450 Mediated Lung Toxicity
The purpose of this project is to do cross species comparisons of the metabolism and toxicity of a number of toxicants which require metabolism for toxicity.
- Trial name
- NCT00023114
- Volunteers
- 10 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Asthma
The Effect of Cow Milk Consumption on Respiratory Symptoms and Pulmonary Functions in Asthmatic and Non Asthmatic Children
the investigators hypothesis is that milk consumption, either in the acute phase and through prolonged exposure, does not cause or increase respiratory symptoms or airway inflammation.
- Trial name
- NCT02745899
- Testing
- Cow milk, Soy milk
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Bronchial Asthma
Comparative Effectiveness Study of Constant-Load Versus Graded Aerobic Exercise in Obese Children With Bronchial Asthma
This study aimed to compare the effect of constant-load aerobic exercise (CL-AE) and graded aerobic exercise (G-AE) on cardiopulmonary fitness, and functional capacity in a cohort of obese children with bronchial asthma (BA).
- Trial name
- NCT06326632
- Testing
- Constant-load Aerobic Exercise, Graded Aerobic exercise, Respiratory Re-training
- Where
- Saudi Arabia
- Volunteers
- 78 people
- Sponsor
- Cairo University
Cystic Fibrosis, Diabetes Mellitus
Diabetes Therapy to Improve BMI and Lung Function in CF
To recruit 150 adult patients with cystic fibrosis related diabetes (CFRD) without fasting hyperglycemia for a multi-center, twelve month, placebo-controlled intervention trial testing the ability of insulin or repaglinide to…
- Trial name
- NCT00072904
- Testing
- Insulin Asparte, Repaglinide
- Where
- 7 sites in United States, Canada
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)