Clinical trials: Lymphoedema
Breast Cancer Related Lymphoedema
Manual Lymphatic Drainage Versus Standard Treatment for the Prevention of Breast Cancer-related Lymphoedema in Patients Who Undergo Axillary Node Clearance
Axillary lymph nodes are the main site of metastasis in breast cancer. If positive axillary lymph nodes are present, an axillary lymph node dissection (ALND) is usually performed.
- Trial name
- BCRL (NCT04582565)
- Testing
- Decongestive lymphatic therapy (DLT), Standard Care
- Where
- United Kingdom
- Volunteers
- 110 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Breast Cancer-Related Lymphedema
Effect of Digital Combined Decongestive Therapy in Patients With Breast Cancer-related Lymphedema: a Follow-up Study
This study investigated the short- and long-term effects of digital combined decongestive therapy in breast cancer-related lymphedema.
- Trial name
- NCT07014657
- Testing
- Digital Combined Decongestive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Bezmialem Vakif University
Lymphatic Filariasis
Research for Elimination of Lymphatic Filariasis (ICIDR)
The purpose of this study is to check blood samples for lymphatic filariasis to determine whether the recent Program to Eliminate Lymphatic Filariasis was successful in controlling lymphatic filariasis in areas of Egypt.
- Trial name
- NCT00406627
- Where
- Egypt
- Volunteers
- 117,500 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Lymphedema Primary
Inelastic Compression Use in Primary Lymphedema
Primary lymphedema in children is a rare, chronic condition caused by congenital or inherited developmental abnormalities in the lymphatic system that lead to persistent fluid buildup and swelling.
- Trial name
- Primary LE (NCT07866599)
- Testing
- Compression device with medium pressure (23-32 mmHg)
- Volunteers
- 30 people
- Sponsor
- University School of Physical Education, Krakow, Poland
Lymphedema, Cellulitis
Evaluation of Antibacterial Soap for Treatment of Lymphedema in a Filariasis-Endemic Area
Introduction. Lymphatic filariasis is a devastating mosquito-transmitted parasitic disease that causes lymphedema or elephantiasis of the leg in 15 million persons, the majority of whom are women.
- Trial name
- NCT00139100
- Testing
- antimicrobial agent in soap
- Where
- Haiti
- Volunteers
- 200 people
- Sponsor
- Centers for Disease Control and Prevention
Leprosy, Buruli Ulcer
Integrated Mapping of Skin-presenting Neglected Tropical Diseases in Liberia
Appropriate targeting of interventions for neglected tropical diseases (NTDs) that require innovative and intensified disease management (IDM) requires accurate data on the distribution of these diseases within endemic countries.
- Conditions
- Leprosy, Buruli Ulcer, Yaws, Lymphatic Filariases
- Trial name
- NCT03683745
- Where
- Liberia
- Volunteers
- 56,285 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Lymphatic Filariasis, Onchocerciasis
Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast)
Approximately 4,000 people will participate per year. The study population will include females and males over 5 years of age who live in filariasis and onchocerciasis endemic areas.
- Conditions
- Lymphatic Filariasis, Onchocerciasis, Soil Transmitted Helminth (STH) Infections
- Trial name
- NCT02032043
- Testing
- Annual versus Semiannual Albendazole plus Ivermectin MDA
- Where
- Côte d’Ivoire
- Volunteers
- 14,457 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Primary Lymphedema
Primary Lymphedema and Mutation CELSR1 (Cadherin EGF LAG Seven-pass G-type Receptor 1)
The investigators will describe the expression of mutation CELSR1 with codon stop and amino acids substitution mechanism in primary lymphedema, in both clinical examination and imaging exploration
- Trial name
- CELSR1 (NCT04919655)
- Where
- France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Univentricular Heart, Lymphatic Abnormalities
Lymphatic Function in Patients With a Fontan Circulation From Brazil
It is suggested that the elevated central venous pressure in patients with a Fontan circulation can provoke manifestation of lymphatic dysfunction, met as plastic bronchitis, peripheral oedema and most feared protein-losing…
- Conditions
- Univentricular Heart, Lymphatic Abnormalities, Lymphatic Edema
- Trial name
- NCT04394507
- Testing
- Near-Infrared Fluorescence imaging, Strain Gauge Plethysmography
- Where
- 2 sites in Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Head and Neck Cancer
Home-Based Photo-Biomodulation for Management of Lymphoedema and Radiation Fibrosis in Patients After Head and Neck Cancer: A Single-Arm Feasibility Trial
This feasibility trial will test the use of photo-biomodulation (PBM) therapy, predominantly self-delivered in the patient's home for 12-weeks, following completion of radiotherapy treatment for head and neck cancer.
- Trial name
- HOME-PBM (NCT07139782)
- Testing
- Riancorp LTU-904 Laser and Handycure® (Medical Quant)
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Primary Lymhedema
Validation of Metrological Properties of Lymphoqol
The constitutional lymphœdema is a rare disease with an annual incidence before the age of 20 years considered at 1,15/100 000. This chronic, incurable disease without hiring directly the prognosis for survival, alter the body…
- Trial name
- LYMPHOQOL (NCT01922635)
- Testing
- Valadation of the metrological properties of questionnaire of quality of life
- Where
- France
- Volunteers
- 37 people
- Sponsor
- University Hospital, Montpellier
Fibrosis Syndrome, Lymphedema
Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)
To find out if adding medication can help treat or prevent lymphedema and/or fibrosis related to radiation therapy, in survivors of head and neck cancer.
- Conditions
- Fibrosis Syndrome, Lymphedema, Head &Amp; Neck Cancer, Fibrosis
- Trial name
- NCT06912763
- Testing
- Pravastatin (drug), Pentoxifylline, ketoprofen
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- M.D. Anderson Cancer Center
Mastectomy Related Lymphedema, Breast Reconstruction
A Comparison of Dermal Autograft to AlloDerm in Breast Reconstruction
Breast Cancer affects about 1 out of 8 American women. Twenty percent of breast cancer patients undergo some form of breast reconstruction. Several types of reconstructive procedures are available for appropriate patients.
- Conditions
- Mastectomy Related Lymphedema, Breast Reconstruction, Breast Cancer
- Trial name
- NCT01561287
- Testing
- Dermal Autograft, AlloDerm
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Kentucky
Lymphedema of Upper Limb
Effects of Physiotherapy in the Treatment of Lymphedema After Breast Cancer
Lymphedema related to breast cancer is one of the main complications after breast cancer treatment. Manual lymphatic drainage appears as a technique which could be applied in the treatment of lymphedema along with other…
- Trial name
- NCT05037708
- Testing
- Manual lymphatic drainage
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- University of Vigo
Lymphedema
International Lymphatic Disease and Lymphedema Registry
The purpose of the International Lymphatic Disease and Lymphedema Patient Registry and Biorepository is to collect health information in order to study the disease classification, natural history, and impact of Lymphatic Disease…
- Trial name
- NCT01336790
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Stanford University
Podoconiosis, Non-Filarial Elephantiasis
Promoting Consistent Shoe Use Among Children At High Risk for Podoconiosis
Background: Podoconiosis is a debilitating condition affecting one million people in Ethiopia. Podoconiosis is preventable if those at genetically high risk consistently protected their feet from exposure to silica nanoparticles…
- Trial name
- NCT01160523
- Where
- Ethiopia
- Volunteers
- 2,106 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Mansonelliasis, Pruritus
Epidemiology and Control of Mansonella Perstans Infection in Uganda
Mansonella perstans (M. perstans) infection is widespread in Uganda. Knowledge about the epidemiology of this infection, and of the morbidity it induces is poor, and no effective treatment is available.
- Conditions
- Mansonelliasis, Pruritus, Lymphoedema, Abdominal Pains
- Trial name
- NCT00215280
- Testing
- ivermectin and albendazole
- Where
- Uganda
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- DBL -Institute for Health Research and Development
Lymphedema, Lymphatic Disorders
Imaging Lymphatic Function in Normal Subjects and in Persons With Lymphatic Disorders
The purpose of this study is to demonstrate the feasibility of near-infrared fluorescence imaging in subjects with acquired or hereditary lymphedema, in subjects with lipidema and other lymphovascular disorders and in normal…
- Conditions
- Lymphedema, Lymphatic Disorders, Lipedema, Vascular Malformation
- Trial name
- NCT00833599
- Testing
- NIRFLI with ICG
- Where
- 3 sites in United States
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Lymphedema, Lymphatic Filariasis
A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka
Current lymphedema management protocols are based on the use of simple measures of hygiene (regular washing with soap and water, skin and nail care), use of topical antibiotics or antifungal agents, exercise and footwear.
- Conditions
- Lymphedema, Lymphatic Filariasis, Filariasis
- Trial name
- LeDoxy-SL (NCT02929134)
- Testing
- Doxycycline
- Where
- Sri Lanka
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- The Task Force for Global Health
Lymphedema
Comparison of a SegNet-based Algorithm Estimating Epifascial Fibrosis
To approval for detecting lymphedema fibrosis before its progression, verification of CT-based quantification of suprafascial microscopic fibrosis has been tried.
- Trial name
- NCT04811677
- Testing
- radiology
- Where
- South Korea
- Volunteers
- 27 people
- Sponsor
- Chungnam National University Sejong Hospital