Clinical trials: Lymphoedema
Lymphedema, Lymphatic Filariasis
A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali
Current lymphedema management protocols are based on the use of simple measures of hygiene (regular washing with soap and water, skin and nail care), use of topical antibiotics or antifungal agents, exercise and footwear.
- Conditions
- Lymphedema, Lymphatic Filariasis, Filariasis
- Trial name
- LeDoxy-Mali (NCT02927496)
- Testing
- Doxycycline
- Where
- Mali
- Volunteers
- 220 people
- Sponsor
- The Task Force for Global Health
Lymphatic Diseases, Lymphatic Abnormalities
A Prospective Natural History Study of Lymphatic Anomalies
Background: The lymphatic system is a network of vessels that carry a clear fluid called lymph through the body. Problems in the lymphatic system can cause pain, fluid buildup, and issues with immunity.
- Trial name
- NCT05731141
- Where
- 2 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Malaria, Lymphatic Filariasis
Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study
The purpose of this study is to determine whether repeated ivermectin mass drug administrations to Burkinabé villagers, performed in three week intervals over the rainy-season, is well-tolerated and safe, and also effective in…
- Trial name
- RIMDAMAL (NCT02509481)
- Testing
- Ivermectin, Albendazole
- Where
- 2 sites in United States, Burkina Faso
- Volunteers
- 2,712 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Breast Cancer
Assessment of Breast Cancer-Related Arm Lymphedema
Lymphedema is a serious complication of breast cancer treatment. Reported prevalence of lymphedema following treatment for breast cancer varies, ranging from 7-45%.
- Trial name
- NCT03978754
- Testing
- ICG lymphography、CM、VD、Bioelectrical impedance technology、self-report, Bioelectrical impedance technology、CM
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Peking University People's Hospital
Trachoma, Lymphatic Filariases
Cluster RCT of Co-administration Azithromycin, Albendazole & Ivermectin
Cluster-randomised trial comparing co-administration of Azithromycin/Ivermectin/Albendazole with separate administration of Azithromycin and Ivermectin/Albendazole.
- Trial name
- NCT03570814
- Testing
- Administration of Albendazole on Day 1, Administration of Ivermectin on Day 1, Administration of Azithromycin on Day 1
- Where
- Ethiopia
- Volunteers
- 13,511 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Breast Cancer Related Lymphedema, Deep Learning
Study on Classification Method of Indocyanine Green Lymphography Based on Deep Learning
Breast cancer related lymphedema (BCRL) is the most common complication after breast cancer surgery, which brings a heavy psychological and spiritual burden to patients.
- Trial name
- BCRL；ICG (NCT04824378)
- Testing
- No Intervention.
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Lymphatic Filariasis, Onchocerciasis
Mass Drug Administration for Lymphatic Filariasis and Onchocerciasis for Liberia
Approximately 5,200 people will participate per year. The study population will include females and males over 5 years of age who live in filariasis and onchocerciasis endemic areas.
- Conditions
- Lymphatic Filariasis, Onchocerciasis, Soil Transmitted Helminth (STH) Infections
- Trial name
- DOLF-LIBERIA (NCT01905436)
- Testing
- Annual versus Semiannual Albendazole plus Ivermectin Mass Drug Administration
- Where
- Liberia
- Volunteers
- 21,862 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Dengue, Chikungunya
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics.
- Conditions
- Dengue, Chikungunya, Zika Virus Infection, Japanese Encephalitis
- Trial name
- RACSMEI (NCT07358910)
- Where
- Cambodia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Secondary Lymphedema, Breast Cancer
Supermicrosurgery for Breast Cancer Survivors With Lymphedema.
A randomised prospective investigation of volume and quality of life results with lymphovenous anastomosis in patients with unilateral arm lymphedema after breast cancer using Indocyanine Green lymphangiography and MD Anderson…
- Trial name
- NCT03578380
- Testing
- Surgery, Compression and drainage therapy
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Sykehuset Telemark
Breast Cancer, Lymphedema
Flexitouch Lymphedema System in Treating Stage II Lymphedema in Patients With Breast Cancer
RATIONALE: The Flexitouch lymphedema system may lessen lymphedema caused by treatment for breast cancer. It is not yet known whether the Flexitouch lymphedema system is more effective than complex decongestive therapy in treating…
- Trial name
- NCT01019512
- Testing
- questionnaire administration, lymphedema management
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Meige Syndrome, Meigs Syndrome
A Comparative Study of GPI's DBS and Pallidotomy in the Treatment of Meige Syndrome
In this study, we will compare the degree of postoperative symptom improvement, postoperative complication rate, postoperative quality of life improvement degree of patients with Meige syndrome undergoing pallidotomy (unilateral…
- Conditions
- Meige Syndrome, Meigs Syndrome, Meige Disease, Meig Syndrome
- Trial name
- NCT04618887
- Testing
- pallidotomy, deep brain stimulation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Breast Cancer, Lymphedema
Development of Personalized Health Care Service in Patients With Breast Cancer
In order to develop effective personalized healthcare service program for breast cancer rehabilitation, we designed this study using mobile phone and clinical intervention(feedback coaching).
- Conditions
- Breast Cancer, Lymphedema, Cancer-related Problem/Condition
- Trial name
- NCT03194399
- Testing
- Personalized health care service
- Volunteers
- 11 people
- Sponsor
- Seoul National University Bundang Hospital
Diabetic Foot, Pressure Ulcer
A Real-World Registry of Chronic Wounds and Ulcers
WOUNDJOURNEY is a longitudinal, real-world, observational registry designed to capture the full clinical course and patient journey associated with chronic wounds and ulcers.
- Conditions
- Diabetic Foot, Pressure Ulcer, Surgical Wound Dehiscence, Vasculitis
- Trial name
- WOUNDJOURNEY (NCT02280733)
- Testing
- Usual care
- Where
- United States
- Volunteers
- 300,000 people
- Sponsor
- U.S. Wound Registry
Malaria,Falciparum, Neglected Tropical Diseases
Adjunctive Ivermectin Mass Drug Administration for Malaria Control
This is a cluster-randomized placebo-controlled clinical trial to evaluate the additive benefit of Ivermectin (IVM) (or Placebo) mass drug administration (MDA) to dihydroartemisinin-piperaquine (DP) MDA for malaria control in a…
- Conditions
- Malaria,Falciparum, Neglected Tropical Diseases, Strongyloidiasis, Lymphatic Filariasis
- Trial name
- MATAMAL (NCT04844905)
- Testing
- Ivermectin, Dihydroartemisinin-piperaquine
- Where
- Guinea-Bissau
- Volunteers
- 24,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Mastectomy Related Lymphedema, Lymphedema of Upper Limb
Testing an Intervention to Foster Hope for Cancer Survivors With Lymphedema
The specific objectives and research questions of the proposed study are: 1. a. Administer a group rehabilitation intervention to address loss and foster hope in 30 participants with upper and lower limb SLC --15 in an…
- Conditions
- Mastectomy Related Lymphedema, Lymphedema of Upper Limb, Lymphedema of Lower Extremity
- Trial name
- NCT02453295
- Testing
- Intervention Group
- Volunteers
- 60 people
- Sponsor
- University of Ottawa
Breast Reconstruction, Mastectomy; Lymphedema
New Era of DIEP With Minimally Invasive Mastectomy
The free deep inferior epigastric artery perforator (DIEP) flap is the gold standard in autologous breast reconstruction. Asian patients often present with a smaller body mass index with relatively insufficient tissue.
- Trial name
- NCT06321549
- Testing
- The reference point of minimally invasive mastectomy procedure conducted
- Where
- Taiwan
- Volunteers
- 278 people
- Sponsor
- Chang Gung Memorial Hospital
Breast Cancer, Lymphedema
Studying if Adding Night Compression to Standard Care Will Have Improved Control of Lymphedema in Breast Cancer Subjects
Lymphedema (significant arm swelling on the surgical side) is one of the most common complications following treatment for breast cancer.
- Trial name
- LYNC (NCT02187289)
- Testing
- Night-time compression bandages, Compression Sleeve, daytime wear, Night-time Compression custom-made garment
- Where
- 3 sites in Canada
- Volunteers
- 120 people
- Sponsor
- AHS Cancer Control Alberta
Parasitic Diseases, Bacterial Diseases
Safety of the Co-administration of Three Drugs for Trachoma and Lymphatic Filariasis Elimination
The purpose of this study is to determine whether the triple co administration of albendazole, ivermectin and azithromycine is as safe as the current treatment scheme that consists to treat with albendazole plus ivermectin…
- Trial name
- AZIVAL (NCT01586169)
- Testing
- triple co administration at once of the combination of Albendazole + ivermectin + azithromycin
- Where
- Mali
- Volunteers
- 3,000 people
- Sponsor
- Centre d'Appui à la lutte contre la Maladie
Lymphatic Filariasis
Death to Onchocerciasis and Lymphatic Filariasis (DOLF) Triple Drug Therapy for Lymphatic Filariasis
The DOLF Triple Drug Therapy for Lymphatic Filariasis study will determine the frequency, type and severity of adverse events following triple-drug therapy (IVM+DEC+ALB, IDA) compared to the standard two-drug treatment (DEC+ALB…
- Trial name
- NCT02899936
- Testing
- 3 drug dose - IDA, 2 drug dose - DA
- Where
- 4 sites in Haiti, India and 2 more
- Volunteers
- 23,789 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Description of an Effective Surgical Strategy to Treat Cancer Related Lymphedema, a High Incidence Pathology
COMBINATION OF LYMPHATICO-VENULAR ANASTOMOSIS AND LIPOSUCTION IN TREATING LYMPHEDEMA
cooperation of an International team with many years of experience in surgical management of lymphedema description of an effective surgical strategy to treat cancer-related lymphedema, a high incidence pathology the combination…
- Trial name
- NCT04536064
- Testing
- LVA and liposuction
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- University of Siena