Clinical trials: Mechanism
COVID-19 SARS-CoV-2 Infection
A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease
The purpose of the study is to evaluate whether ibuzatrelvir is effective and safe in adults and adolescents with COVID-19 who do not need to be in the hospital but who are at high risk for progression to severe disease.
- Trial name
- NCT06679140
- Testing
- ibuzatrelvir
- Where
- 256 sites in United States, Argentina and 17 more
- Volunteers
- 2,330 people
- Sponsor
- Pfizer
Prostate Adenocarcinoma
Mechanisms of Metabolic and Hormone Action on Plaque Formation in Brain and Carotid Vessels in Patients With Prostate Adenocarcinoma
This trial studies the mechanisms of metabolic and hormone action on plaque formation in brain and carotid vessels in patients with prostate adenocarcinoma.
- Trial name
- NCT03718338
- Testing
- Evaluation, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Washington
Pollution; Exposure, Neurodevelopmental Disorders
Air Pollution and Development in the Boricua Youth Study
This study seeks to understand the relationship between prenatal maternal air pollution exposure and offspring risk for ADHD and examine two potential -modifiable- mechanisms: prenatal maternal inflammation and offspring sleep…
- Trial name
- NCT05368493
- Testing
- MRI task
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Primary Immune Deficiencies, Autoimmune Diseases
Investigation of Immune Disorders and Deficiencies
The immune system is an intricate system comprised of specialized cells, proteins, tissues and organs. Proper functioning is critical to the body's ability to defend itself against harmful pathogens.
- Conditions
- Primary Immune Deficiencies, Autoimmune Diseases, Inflammatory Diseases, Common Variable Immune Deficiencies
- Trial name
- NCT01981785
- Where
- United States
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- O & O Alpan LLC
Inherited Retinal Dystrophy, Retinitis Pigmentosa
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models
Inherited retinal dystrophies (IRDs), a large group of heterogeneous and rare disorders, may result in irreversible bilateral visual loss and blindness.
- Conditions
- Inherited Retinal Dystrophy, Retinitis Pigmentosa, Macular Dystrophy
- Trial name
- NCT05793515
- Testing
- whole genome sequencing
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Istituto Superiore di Sanità
Giant Cell Tumors
Network Pharmacology Prediction: Mechanism Study of Puerarin in the Treatment of Giant Cell Tumors of Bone
Based on network pharmacology analysis, this study aims to explore the potential therapeutic targets and molecular mechanisms of puerarin on giant cell tumor of bone (GCTB) genes.
- Trial name
- NCT06331104
- Testing
- gene expression levels
- Where
- China
- Volunteers
- 145 people
- Sponsor
- Changye Zou
Osteonecrosis
Molecular Genetic Study of Avascular Necrosis of the Femoral Head
Avascular necrosis of the femoral head (ANFH) is a debilitating disease that commonly leads to destruction of the hip joint in patients at middle age of life and often requires surgical intervention.
- Trial name
- NCT00260897
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Insomnia
Examining the Effectiveness of Two Behavioral Interventions for Sleep Problems in Infants
Behavioral insomnia of childhood affects 15-30% of infants. Behavioral interventions, based on limiting parent-child bedtime and nighttime interactions, are effective in significantly improving infant sleep problems.
- Trial name
- NCT05726890
- Testing
- bedtime intervention for early childhood insomnia, bedtime and nighttime intervention for early childhood insomnia
- Where
- Israel
- Volunteers
- 270 people
- Sponsor
- Ben-Gurion University of the Negev
Systemic Inflammatory Response Syndrome, Ventilator Weaning
The Predictive Effect of the Inflammatory Response on the Evacuation of Mechanical Ventilation and the Mechanism
Infection and trauma take a important role in the acute respiratory failure.There are different causes and degrees of inflammatory reaction in the critically ill patient.
- Trial name
- NCT02820090
- Volunteers
- 300 people
- Sponsor
- Beijing Chao Yang Hospital