Clinical trials: Mechanism
Smoking, Sleep Disturbance
Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal
The number one preventable cause of death in the world is tobacco use. Cigarette smoking in particular, costs an estimated $300 billion due to expenses related to medical care and lost productivity.
- Conditions
- Smoking, Sleep Disturbance, Nicotine Dependence
- Trial name
- NCT03968900
- Testing
- Sleep restriction condition, Sleep extension condition
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Alabama at Birmingham
Sleep Apnea
Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study D
In obstructive sleep apnea (OSA), the upper airway recurrently closes during sleep. The mechanisms that lead to airway closure are not completely understood.
- Trial name
- NCT01733784
- Testing
- Induced central apneas
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Heart Failure, Congestive, Renal Insufficiency, Chronic
Mechanisms of Erythropoietin Action in the Cardiorenal Syndrome
Erythropoietin (EPO) treatment in patients with the severe cardiorenal syndrome increases cardiac performance and decreases progression of renal failure by dampening the main driving forces of the cardiorenal syndrome in part via…
- Trial name
- NCT00356733
- Testing
- Erythropoietin administration
- Where
- 2 sites in Netherlands
- Volunteers
- 62 people
- Sponsor
- UMC Utrecht
Asthma in Children
The Effect of 10-Week Exercise Training on Children With Asthma
The goal of this research is to determine whether 10-weeks of exercise training can benefit asthmatic children and young adults with a history of exercise-induced bronchoconstriction (EIB).
- Trial name
- NCT03716219
- Testing
- Exercise Training
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Hepatitis E Infection in Humans and in Environment
Hepatitis E Infection : Emergence Mechanisms in North-Eastern France of Polymorphic Clinical Forms.
The present research aims to collect virological and clinical data on hepatitis E virus (HEV) infections, either in acute or chronic forms of HEV infection in North-Eastern France, with liver- or non liver-related symptoms, plus…
- Trial name
- VHENE (NCT03524014)
- Testing
- Only advice for diagnosis and prevention
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Central Hospital, Nancy, France
Preventable Disease, Vaccine
Addressing Unfunded Vaccines Through a Co-payment Mechanism in Pharmacies
The goal of this pilot demonstration and evaluation project is to determine the acceptability and feasibility of a co-payment model among the public and providers and assess whether a co-payment model in community pharmacies in…
- Trial name
- NCT06489964
- Testing
- Co-payment Model - Step 1, Co-payment Model - Step 2, Co-payment Model - Step 3
- Where
- 2 sites in Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Canadian Immunization Research Network
Recurrent Urinary Tract Infection, Urinary Tract Infections
Preventing Recurrent UTI With Vaginal Estrogen
Among postmenopausal women who suffer from recurrent urinary tract infections (UTI), vaginal estrogen therapy prevents UTI recurrences for 50% of sufferers.
- Conditions
- Recurrent Urinary Tract Infection, Urinary Tract Infections, Cystitis Recurrent
- Trial name
- PRUVE (NCT05551949)
- Testing
- Vaginal estradiol tablets
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Johns Hopkins University
COVID-19
Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine
This is a double blind, placebo controlled study in approximately 2,000 health care workers at risk for being exposed to COVID-19.
- Trial name
- HERO-HCQ (NCT04334148)
- Testing
- Hydroxychloroquine
- Where
- 34 sites in United States
- Volunteers
- 1,360 people, healthy volunteers welcome
- Sponsor
- Adrian Hernandez
Oesophageal Cancer
Unintentional Weight Loss After Oesophagectomy
The incidence of cancer of the oesophagus is increasing. While surgical removal of the tumour (oesophagectomy) may offer the best chance of cure, such major operations are associated with long-term complications such as poor…
- Trial name
- UWL (NCT05074914)
- Testing
- oesophagectomy
- Where
- Ireland
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University College Dublin
ALK-Positive NSCLC
Resistance Mechanisms and Sequential Treatment Strategies Following First-Line Lorlatinib in ALK-Positive NSCLC
This is a prospective, multicenter, non-interventional, single-arm, real-world study planned to be conducted in China, aimed at exploring the resistance mechanisms of first-line lorlatinib treatment in patients with ALK-positive…
- Trial name
- NCT06904547
- Testing
- No intervention administered, Non Interventional Study
- Volunteers
- 100 people
- Sponsor
- Shanghai Chest Hospital
Eating Disorders, Anorexia Nervosa
Online Relapse Prevention Study
The purpose of this study is to collect preliminary data on the feasibility and acceptability of the randomization of two relapse-prevention treatment conditions after discharge from intensive eating disorder (ED) treatment: an…
- Conditions
- Eating Disorders, Anorexia Nervosa, Bulimia Nervosa, Anorexia Nervosa, Atypical
- Trial name
- ORP (NCT04862247)
- Testing
- Imaginal Exposure Condition, Writing and Thinking Condition
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Louisville
Intracerebral Hemorrhage
Effects and Mechanisms of Celecoxib on Intracerebral Hemorrhage
This trial is a phase IIa human clinical study, in which 60 patients with intracerebral hemorrhage (ICH) at basal ganglion or thalamus within 6 h after onset will be enrolled.
- Trial name
- NCT05434065
- Testing
- Celecoxib 200mg
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Renal Cell Carcinoma, Hypertension
Novel Mechanisms and Predictors of VEGF Receptor Inhibitor- or Immune Checkpoint Inhibitor-Associated Hypertension and Cardiovascular Disease
The purpose of this study is to understand the effect of vascular endothelial growth factor tyrosine kinase (VEGF) inhibitor, immune checkpoint-inhibitor (ICI), and combination treatment on blood pressure and blood vessel…
- Conditions
- Renal Cell Carcinoma, Hypertension, Melanoma, Cancer
- Trial name
- NCT03709771
- Testing
- Ambulatory Blood Pressure Measurement
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Vanderbilt University Medical Center
Well-Being, Lifestyle, Healthy
An Exploratory Feasibility Study
This study explores the feasibility of ContextWell, a well-being education programme that combines an online webinar with an AI-powered behavioural nudging system.
- Conditions
- Well-Being, Lifestyle, Healthy, Young Adult, Behavior and Behavior Mechanisms
- Trial name
- Contextwell (NCT07009964)
- Testing
- ContextWell Educational Programme
- Where
- Ireland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Acupuncture Therapy
Using Omics Technology to Explore the Mechanism of Acupuncture Treatment of Different Acupoints of Knee Osteoarthritis
In recent years, commonly used Omics techniques, including genomics, proteomics, metabolomics, have been applied in the studies on the mechanism of acupuncture effect.
- Trial name
- NCT04733352
- Testing
- acupuncture
- Where
- 2 sites in Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Pain
Mechanism-based Choice of Therapy for Neuropathic Pain
Mechanism-based choice of therapy for neuropathic pain: Can treatments success in neuropathic post-operative pain be coupled to psychophysical pain modulation profile?
- Trial name
- NCT01359514
- Testing
- Pregabalin, Duloxetine
- Where
- Israel
- Volunteers
- 32 people
- Sponsor
- Rambam Health Care Campus
Limbic Encephalitis With LGI1 Antibodies
Antibody-mediated LGI1 Encephalitis: Symptoms, Biomarkers, and Mechanisms of the Chronic Phase of the Disease
The encephalitis mediated by antibodies against Leucine-rich, glioma inactivated 1 protein (anti-LGI1 encephalitis) predominantly affects men (M:F, 6:4) and mostly older than 60 years.
- Trial name
- NCT06515106
- Testing
- Remote cognitive rehabilitation program
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Influenza, Behavior and Behavior Mechanisms
Nationwide Utilization of Danish Government Electronic Letter System for Increasing InFLUenza Vaccine Uptake
In randomized clinical trials and observational studies, influenza vaccination has been shown to be effective in reducing influenza-related illness, hospitalizations, cardiovascular events, and mortality in select populations.
- Trial name
- NUDGE-FLU (NCT05542004)
- Testing
- Behavioral Economic Principles
- Where
- Denmark
- Volunteers
- 964,870 people, healthy volunteers welcome
- Sponsor
- Tor Biering-Sørensen
Xerostomia Due to Radiotherapy (Disorder)
Screening of Biomarkers and Related Mechanisms for RIX
A large number of patients undergoing radiotherapy and chemotherapy are suffering from dry mouth. Due to reduced saliva secretion, patients may experience symptoms such as difficulty chewing and swallowing.
- Trial name
- RIX (NCT06700863)
- Testing
- Radiation Therapy
- Where
- 4 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Sleep Deprivation, Circadian Rhythm Disorders
PBM Effects on Health and Well-being in Humans
The goal of this clinical study is to assess the effects of different photobiomodulation (PBM) conditions in men and women between 25 and 65 years old with daytime sleepiness/drowsiness and /or mild mood complaints but be…
- Trial name
- NCT05619133
- Testing
- PBM
- Where
- Netherlands
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seaborough Life Science B.V.
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