Clinical trials: Medication Interaction
HIV Prevention
Digital Limited Interaction Efficacy Trial of LifeSkills Mobile to Reduce HIV Incidence in YTW
The LifeSkills Mobile app will be evaluated in a randomized controlled trial (RCT) among 5,000 young transgender women (YTW), ages 16-29 in the United States (U.S.).
- Trial name
- LifeSkills (NCT05018611)
- Testing
- LifeSkills Mobile
- Where
- United States
- Volunteers
- 5,100 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Procedural Pain, Procedural Fear
Social Robot Interaction on Fear and Pain Levels in Children
The goal of this clinical trial is to compare the effectiveness of social robot interaction and digital game-based distraction in reducing fear and pain during venous blood sampling in children aged 4-12 years with chronic…
- Trial name
- NCT07632625
- Testing
- Social Robot, Digital Game
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Trakya University
HIV Infections
Antiviral Activity of and Resistance to Lamivudine in Combination With Zidovudine, Stavudine, or Didanosine
To evaluate the efficacy, safety, and pharmacokinetics of lamivudine (3TC) combined with zidovudine (AZT), stavudine (d4T), or didanosine (ddI) in comparison with d4T or ddI monotherapy in HIV-infected patients with no prior…
- Trial name
- NCT00000838
- Testing
- Lamivudine, Stavudine, Zidovudine
- Where
- 32 sites in United States, Puerto Rico
- Volunteers
- 256 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Type 2, End Stage Renal Disease
Drug Interaction Potential of Pro-Inflammatory Conditions
Pro-inflammatory cytokines, which are elevated in pro-inflammatory disease states (e.g., type II diabetes mellitus [T2DM], irritable bowel diseases [IBD], and end stage renal disease [ESRD]) have been shown to inhibit hepatic…
- Conditions
- Diabetes Mellitus, Type 2, End Stage Renal Disease, Irritable Bowel Syndrome
- Trial name
- DIPPIC (NCT07360938)
- Testing
- None (Observational)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Elevated Lipoprotein(a), Cardiovascular Diseases
Drug-drug Interaction Study to Evaluate the Effect of ISIS 681257 on Warfarin
This is a single center, open label, single sequence, two-treatment, two-period drug-drug interaction study to evaluate the effect of multiple doses of ISIS 681257 on the pharmacokinetics of a single dose of warfarin.
- Trial name
- NCT03426033
- Testing
- ISIS 681257, Warfarin
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Akcea Therapeutics
Autism Spectrum Disorder, Visual Rehabilitation
Visual Rehabilitation in Children With Autism Spectrum Disorder and Visual Disorders
Children with autism spectrum disorder (ASD) often have visual problems that add difficulty to social interaction and communication.
- Conditions
- Autism Spectrum Disorder, Visual Rehabilitation, Vision, Social Communication
- Trial name
- NCT07644468
- Testing
- Visual Rehabilitation
- Where
- Taiwan
- Volunteers
- 9 people
- Sponsor
- National Taiwan University Hospital
Hyperkalemia
Clinical Decision Support System for Quality Assurance in Potassium-Increasing Drug-Drug-Interactions
To investigate the impact of reminders for serum potassium monitoring and of hyperkalemia alerts during potassium-increasing drug-drug-interactions.
- Trial name
- NCT02020317
- Testing
- decision support in potassium-inc. drug-drug-interactions
- Where
- Switzerland
- Volunteers
- 3,341 people
- Sponsor
- University of Zurich
Myocardial Infarction, Stroke
The Brain Heart Interaction in Acute Stroke
Many studies have shown that acute cerebral dysfunction can impair cardiac function and autonomic control of blood pressure, heart rate and vascular tone, however, the size of the stroke is rarely reported.
- Trial name
- NCT02734082
- Where
- Switzerland
- Volunteers
- 204 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Language Development Disorders
Using Video Interaction Guidance (VIG) With Children Who Have Language Delays.
The study aims to explore whether the intervention Video Interactive Guidance (VIG) has an impact on the development of the language and sociocognitive skills of children aged between 2 and 5 with identified language delays.
- Trial name
- NCT06250218
- Testing
- Video Interactive Guidance (VIG)
- Volunteers
- 4 people
- Sponsor
- University of Sheffield
Depression, Postpartum
The Northern Babies Longitudinal Study
Postpartum depression (PPD) is a prevalent disorder. Studying the factors related to PPD will help to identify families at risk and provide preventive interventions.
- Trial name
- NCT02538497
- Testing
- The Newborn Behavioral Observation (NBO), Routine care
- Where
- Norway
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Tromso
Cervical Cancer, Human Papilloma Virus Infection
e- Ab Sensor-based Real-time Detection of Oncogenic Human Papilloma Viruses
To develop a real-time diagnostic technique with e- Ab sensor for high risk human papilloma viruses(high risk HPV) detection, the investigators conduct a prospective clinical study.
- Trial name
- NCT01387997
- Testing
- Electrosensing antibody probing system (e- Ab sensor)
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- National Taiwan University Hospital
Acute Lymphoblastic Leukemia (ALL), Critical Illness
Animal Assisted Interactions With Animal Robot in the Intensive Care Unit (ICU)
The purpose of this study is to: 1. Establish the feasibility and acceptability of a therapeutic robot, Paro, for critically ill patients admitted to the Pediatric Intensive Care Unit 2.
- Conditions
- Acute Lymphoblastic Leukemia (ALL), Critical Illness, Physical Therapy Modalities, Occupational Therapy
- Trial name
- PARO (NCT05075395)
- Testing
- PARO therapy seal
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Nebraska
Atherosclerosis, Coronary Disease
Study of the Interaction Between the Cells Lining Blood Vessels and Angiotensin-Converting Enzyme
The walls of blood vessels are lined by flat cells that are responsible for releasing substance(s) that control the activity of the blood vessel. These cells are referred to as the endothelium of the blood vessel.
- Trial name
- NCT00001461
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Behavior Problems in Children, Parent-Child Relations
Dino Study: Daily Intervention-based Research on Nurturing Opportunities in Young Children
The goal of this clinical trial is to evaluate the effectiveness of the Incredible Years Dinosaur Program in children aged 4 to 8 years with conduct problems.
- Conditions
- Behavior Problems in Children, Parent-Child Relations, Oppositional Behavior, Social Skills
- Trial name
- Dino (NCT07051642)
- Testing
- Incredible Years Dinosaur Child Program
- Where
- Netherlands
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Tilburg University
Autism Spectrum Disorder
Effect of ESDM and PCIT-A in Autism Spectrum Disorder
Children with ASD often show disruptive behaviors. However, interventions that were specifically designed to improve these symptoms have not been sufficiently investigated, especially in children with level 1 to level 3 ASD.
- Trial name
- TAFF (NCT04722783)
- Testing
- Parent-Child-Interaction Therapy adapted for children with autism spectrum disorder (PCIT-A), Early Start Denver Model (ESDM) intervention, 1-hour ESDM
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Bruno Rhiner
Language Delay, Language Development
Combined Oral Motor Stimulation and Language on Preterm Infant Feeding
This is a randomized controlled trial to study an oromotor stimulation in combination with a reading curriculum in the NICU among preterm infants using oral muscle exercises, Language Environment Analysis (LENA) recordings…
- Conditions
- Language Delay, Language Development, Feeding; Difficult, Newborn, Mother-Infant Interaction
- Trial name
- NCT05861531
- Testing
- Oromotor stimulation, Reading curriculum, LENA recording
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Work Stress, Sleep Disturbance
The Use of Worktime Planning Tools in the Finnish Public Sector. A Quasi-experimental Study (PLANTOOLS)
This study aims to investigate whether use of interactive worktime planning tools that support work-time control (possibilities to influence individual shift rosters, i.e., participatory rostering) and guide for health-supporting…
- Trial name
- PLANTOOLS (NCT02775331)
- Testing
- Shift planning with self-rostering and shift ergonomics, Shift planning with shift ergonomics
- Volunteers
- 9,000 people, healthy volunteers welcome
- Sponsor
- Finnish Institute of Occupational Health
Cystic Fibrosis in Children, Respiratory Bacterial Infection
Viral Infections and Airway Microbiome in Young Children With Cystic Fibrosis
Cystic fibrosis (CF) is the most common hereditary life-threatening condition in Belgium. Because of a dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) channel, chloride is unable to move to the cell…
- Conditions
- Cystic Fibrosis in Children, Respiratory Bacterial Infection, Respiratory Viral Infection, Inflammation Lungs
- Trial name
- NCT06188988
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- University Hospital, Antwerp
Language Development, Language Delay
A Language Intervention Study of Preterm Infants
This is a randomized controlled trial to study a reading intervention in the NICU among preterm infants using LENA (Language Environment Analysis) recordings, linguistic feedback, and a language curriculum to improve the neonatal…
- Conditions
- Language Development, Language Delay, Mother-Infant Interaction, Maternal Behavior
- Trial name
- NCT03688386
- Testing
- Reading intervention, Infant bonding, LENA recording
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Autism
Improving Attention Skills of Children With Autism
Toddlers with autism have poor joint attention skills. Joint attention skills include pointing to objects, following another person's gaze, and responding to invitations to join in a social interaction.
- Trial name
- NCT00065910
- Testing
- Caregiver joint attention intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)