Clinical trials: Medicine
Substance Use (Drugs, Alcohol)
Adaptation of the Family Check-Up Online
Latinx people are the largest and fastest growing minority population in the U.S., yet most lack access to community responsive preventative interventions to reduce substance use among youth.
- Trial name
- NCT07025083
- Testing
- Adapted Family Check-Up Online, Original Family Check-Up Online
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Diabetic Macular Edema
Special Drug Use Observational Study With Beovu Kit for Intravitreal Injection
This was a primary data collection-based observational special drug-use surveillance to be conducted in accordance with the Good Post-marketing Study Practice (GPSP) ordinance.
- Trial name
- NCT05526729
- Testing
- Beovu
- Where
- 76 sites in Japan
- Volunteers
- 222 people
- Sponsor
- Novartis Pharmaceuticals
HIV Infections
A Randomized Trial to Evaluate the Safety and Efficacy of Combination Therapy With Retrovir ( AZT ) and HIVID ( ddC ) Versus Retrovir, HIVID, and Wellferon ( Interferon Alfa-n1 ) for the Treatment of HIV Infection
Primary: To determine whether the combination of zidovudine/zalcitabine/interferon alfa-n1 (Retrovir/HIVID/Wellferon) can produce complete responses (i.e., CD4 counts return to >= 800 cells/mm3 for more than 24 weeks) in patients…
- Trial name
- NCT00002086
- Testing
- Zidovudine, Zalcitabine, Interferon alfa-n1
- Where
- 13 sites in United States
- Volunteers
- 256 people
- Sponsor
- Glaxo Wellcome
Fontan Circulation
IMProving DRug Dosing and Outcomes for Single VEntricle Patients With Fontan Associated Liver Disease
This is a single center, open-label, prospective, investigation to quantify the effects liver congestion and fibrosis has on hepatic drug metabolism and transport in children, adolescents, and young adults with Fontan circulation.
- Trial name
- IMPROVE-FALD (NCT06324396)
- Testing
- Sildenafil 10mg oral tablet (participants <20kg), or 20mg oral tablet (participants ≥20kg), Pravastatin 20 mg oral tablet (ages <13 years), or 40 mg oral tablet (≥14 years)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Mercy Hospital Kansas City
Eating Disorders, Body Image Dissatisfaction
Development, Implementation, and Evaluation of the HADAS Program for the Prevention of Eating Disorders in Adolescent Female Athletes, Coaches, and Families.
Adolescent female athletes in aesthetic sports disciplines (such as rhythmic gymnastics, artistic gymnastics, synchronized swimming, and figure skating) face a complex interaction between general sociocultural beauty pressures…
- Trial name
- The HADAS (NCT07750301)
- Testing
- The HADAS Program
- Where
- Spain
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
HIV Infections
Safety and Effectiveness of Giving an Anti-HIV Drug Combination of Adefovir Dipivoxil Plus Didanosine Plus Efavirenz Plus Lamivudine Once Daily to HIV-Infected Patients
The purpose of this study is to see if it is safe and effective to give HIV-infected patients a new combination of anti-HIV drugs taken once daily.
- Trial name
- NCT00002234
- Testing
- Efavirenz, Adefovir dipivoxil, Lamivudine
- Where
- 5 sites in United States
- Volunteers
- 25 people
- Sponsor
- Gilead Sciences
Autism Spectrum Disorders
A Trial of the Drug Donepezil for Sleep Enhancement and Behavioral Change in Children With Autism
Background: Some children with autism spectrum disorders (ASD) do not have normal sleep cycles. Some of these children spend very little time in the rapid eye movement (REM) stage of sleep.
- Trial name
- NCT01887132
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Mental Health (NIMH)
mHealth, PMTCT
Mobile Strategies for Women's and Children's Health: Optimizing Adherence and Efficacy of PMTCT/ART
The investigators are conducting a 3-arm randomized trial comparing the effects of unidirectional SMS (ie: "push" messaging to participant) vs. bidirectional SMS dialogue between participant and provider vs.
- Conditions
- mHealth, PMTCT, Adherence, Medication, SMS
- Trial name
- Mobile WAChx (NCT02400671)
- Testing
- SMS messaging
- Where
- 6 sites in Kenya
- Volunteers
- 825 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cardiovascular Diseases
Precision Medicine Study on Cardiovascular Disease (PRECISE)
Cardiovascular diseases are the leading cause of death in China and have become a financial burden on society under the traditional medical model.
- Trial name
- PRECISE (NCT04434911)
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Medication Adherence, Kidney Transplantation
Teen Adherence in KidnEy Transplant Improving Tracking To Optimize Outcomes - Stage 3
Medication non-adherence is a major problem in kidney transplant recipients; young people 12-24 years of age are at particularly high risk for non-adherence and graft failure compared to young children and adults.
- Trial name
- NCT04288271
- Testing
- Adherence Intervention, Healthy living education intervention
- Where
- 8 sites in United States, Canada
- Volunteers
- 96 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Opioid-related Disorders, Opioid Addiction
Surveillance Monitoring of Opioid Abuse in Poison and Drug Treatment Centers
To conduct surveillance for abuse, misuse, overdose, addiction, and death and to evaluate if the REMS meets its surveillance goals, and if it does not, to modify it appropriately based on the metrics.
- Conditions
- Opioid-related Disorders, Opioid Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02871232
- Testing
- Researched Abuse, Diversion and Addiction-Related Surveillance (RADARS) System of post-marketing surveillance of prescription medication abuse, misuse, and diversion
- Volunteers
- 26,500 people
- Sponsor
- ER/LA Opioid REMS Program Companies (RPC)
Drug/Agent Toxicity by Tissue/Organ, Leukemia
Growth Factor to Prevent Oral Mucositis in Patients With Hematologic Cancer
RATIONALE: Keratinocyte growth factor may prevent symptoms of mucositis in patients receiving radiation therapy and chemotherapy.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00004132
- Testing
- filgrastim, palifermin, cyclophosphamide
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Shock, Coronary Heart Disease
Safety Study of Shenmai(a Chinese Medicine Injection) Used in Hospitals in China
The purpose of this study is to make a cohort event monitoring to see whether and how Shenmai injection in hospital results in adverse events or adverse drug reactions.
- Trial name
- NCT01612611
- Where
- China
- Volunteers
- 30,000 people
- Sponsor
- China Academy of Chinese Medical Sciences
Asthma
Automated Inhaler Monitoring for Asthma Medication Usage
The goal of this clinical trial is to evaluate the aflo™ digital platform's ability to improve inhaler use technique and asthma control for children, adolescents, and adults with uncontrolled asthma.
- Trial name
- AIM (NCT06825871)
- Testing
- Smart Inhaler Monitoring Platform for Asthma Management
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Boston Children's Hospital
Acne Vulgaris
To Study Generic Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel (Glenmark Generics, Ltd) in the Treatment of Acne Vulgaris.
This is a randomized, double-blind, multiple-site, placebo-controlled, parallel-group study, designed to compare the efficacy and safety of generic Clindamycin 1%/ Benzoyl peroxide 5% topical gel (Glenmark Generics, Ltd), and the…
- Trial name
- NCT02465632
- Testing
- Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel, BenzaClin® Topical Gel, Clindamycin 1%/Benzoyl Peroxide 5%
- Where
- 15 sites in United States, Belize
- Volunteers
- 1,100 people
- Sponsor
- Glenmark Pharmaceuticals Ltd. India
Overdose
Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study (SNAP)
This study is designed to assess the impact of new approaches to therapy for paracetamol poisoning. Standard therapy is currently acetylcysteine by intravenous infusion over 20.25h.
- Trial name
- SNAP (NCT01050270)
- Testing
- Ondansetron, acetylcysteine
- Where
- 3 sites in United Kingdom
- Volunteers
- 222 people
- Sponsor
- University of Edinburgh
Epilepsy
Epilepsy Adherence in Children and Technology (eACT)
Fifty-eight percent of children with new-onset epilepsy do not take their antiepileptic drugs (AEDs) as prescribed, which is associated with continued seizures, mortality, poor quality of life, and high healthcare costs.
- Trial name
- eACT (NCT03817229)
- Testing
- Education microlearning sessions, Automated digital reminders, Problem-solving mHealth module
- Where
- 4 sites in United States
- Volunteers
- 268 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Arthrosis
Topical Versus Intravenous Tranexamic Acid in Total Knee Arthroplasty
This clinical trial investigated two different routes of administration of tranexamic acid in total knee arthroplasty: topical compared to intravenous.
- Trial name
- TRANEXTKA (NCT02323373)
- Testing
- Tranexamic Acid - topical, Tranexamic Acid - intravenous
- Volunteers
- 90 people
- Sponsor
- Irmandade da Santa Casa de Misericordia de Sao Paulo
Orbital Neoplasms, Conjunctival Neoplasms
Artificial Intelligence-assisted Screening of Malignant Pigmented Tumors on the Ocular Surface
Rare diseases generally refer to diseases whose prevalence rate is lower than 1 / 10 000 and the number of patients is less than 140000.
- Conditions
- Orbital Neoplasms, Conjunctival Neoplasms, Eye Neoplasms
- Trial name
- NCT05645341
- Testing
- screening system for ocular surface malignant tumors
- Where
- China
- Volunteers
- 535 people
- Sponsor
- Sun Yat-sen University
Preterm Labor, Preterm Birth
The Efficacy of Nifedipine in the Management of Preterm Labor
Preterm labor is one of the problems of obstetrics, and is one of the leading cause of neonatal morbidity and mortality. The incidence of preterm birth is around 7 to 9 %.
- Conditions
- Preterm Labor, Preterm Birth, Preterm Labor Without Delivery, Preterm Labor With Preterm Delivery in Third Trimester
- Trial name
- BOG/TH/PTL (NCT04644354)
- Testing
- Nifedipine 10 mg
- Volunteers
- 444 people
- Sponsor
- Ethem Unal, M.D., PhD, Associate Prof of Surgery & Surgic
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.