Clinical trials: Medicine
Fibromyalgia
Efficacy and Safety of an Oral Growth Hormone Drug in the Treatment of Fibromyalgia
This is a 24-week, randomized, double-blind, placebo-controlled, trial to evaluate the safety, tolerability and efficacy of an orally administered growth hormone stimulating drug, (code named MK-0677) in the treatment of female…
- Trial name
- NCT00116129
- Testing
- Ibutamoren Mesylate (MK-0677)
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Bennett, Robert, M.D.
Osteoporosis
Comparison of Raloxifene and Lasofoxifene - A Randomized, Blinded Study of These Drugs and Placebo on Bone Loss
To compare the effects of 2 years of lasofoxifene treatment with 2 years of raloxifene 60 mg/day use and 2 years of placebo use on bone mineral density (BMD) of the lumbar spine.
- Trial name
- CORAL (NCT00163137)
- Testing
- lasofoxifene, raloxifene
- Where
- 72 sites in United States
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Ligand Pharmaceuticals
Chronic Hepatitis B - Antiviral Drug Resistance - Hepatitis B Virus (HBV) Infection
Prevalence and Risk Factors of Antiviral Resistance in Egyptian HBV Patients
This study aims to determine the prevalence of antiviral drug resistance among Egyptian patients with chronic hepatitis B virus (HBV) infection and to identify the associated demographic, clinical, and virological risk factors.
- Trial name
- PRARE-CHB (NCT07274345)
- Volunteers
- 2,000 people
- Sponsor
- Amira Mohamed Zidan
Postoperative Complications
Prospective Validation of ExCARE Model for 30-Day Postoperative Mortality
This prospective observational cohort study aims to validate the ExCARE risk model, derived from four preoperative variables (age, ASA-PS classification, procedure urgency, and surgical magnitude), for predicting in-hospital…
- Trial name
- ExCARE-HNSC (NCT07293377)
- Where
- Brazil
- Volunteers
- 3,000 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Neoplasm Cervix
Topical Curcumin for HPV Related Cervical Disease
The purpose of this study is to see if curcumin can suppress HPV infection in women with low-grade squamous intraepithelial lesions (LSIL) disease or treated high-grade squamous intraepithelial lesions (HSIL) disease.
- Trial name
- NCT04266275
- Testing
- Curcumin C3 Complex
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Lisa Flowers
Diabetes Mellitus, Type 2
Examining Genetic Influence on Response to Beta-Blocker Medications in People With Type 2 Diabetes
Beta-blockers are medications used to treat cardiovascular disease (CVD) symptoms, including high blood pressure and chest pain.
- Trial name
- NCT00925119
- Testing
- Atenolol
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Maryland, Baltimore
GBM, Glioblastoma Multiforme (GBM)
Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy
The goal of this clinical trial is to evaluate the safety and feasibility of focused ultrasound (FUS)-mediated blood-brain barrier (BBB) disruption using the Next Generation Dome Helmet (NGDH) in adults with glioblastoma (GBM)…
- Conditions
- GBM, Glioblastoma Multiforme (GBM), Glioblastoma Multiforme of Brain, Glioblastoma Multiforme Glioma
- Trial name
- NCT07179328
- Testing
- Focused Ultrasound Next Generation Dome Helmet, Definity® Vial for (Perflutren Lipid Microsphere) Injectable Suspension
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Pain
Oxycodone User Registry (OUR)
The purpose of this study is to describe clinical and demographic characteristics of patients receiving prescription medications containing oxycodone immediate release (OXYRX), to characterize patient and prescriber perceptions…
- Trial name
- NCT00978328
- Testing
- oxycodone immediate release (OXYRX)
- Volunteers
- 827 people
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Coronary Disease, Drug Eluting Stent
Comparison One vs Six Months of Dual Antiplatelet Therapy After Implanted Firehawk TM Stent in High Bleeding Risk Patients With Coronary Artery Disease
This study is to assess the clinical non-inferiority of 1 month (short-term) vs 6 months (long-term) of dual anti-platelet therapy in patients undergoing percutaneous intervention implanted sirolimus -eluting stent with abluminal…
- Conditions
- Coronary Disease, Drug Eluting Stent, Percutaneous Coronary Intervention, Dual Antiplatelet Therapy
- Trial name
- NCT03287167
- Testing
- 1 month DAPT, 6 months DAPT
- Where
- China
- Volunteers
- 1,720 people
- Sponsor
- Shanghai MicroPort Medical (Group) Co., Ltd.
Degree of Adherence of Symptomatic OLP Patients to Their Medications
Adherence to Topical and Systemic Medications Among Symptomatic Oral Lichen Planus Patients: A Pilot Randomized Clinical Trial
This trial will assess the effect of adjunctive use of explanatory leaflet or daily text message reminder compared to standard instructions alone in degree of adherence of symptomatic OLP patients to their medications.
- Trial name
- NCT07879300
- Testing
- standard verbal instructions, Explanatory leaflets, text msgs
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Cairo University
Atopic Dermatitis
Drug-drug Interaction Trial With Tralokinumab in Moderate to Severe Atopic Dermatitis - ECZTRA 4
The purpose of this trial is to investigate if tralokinumab changes the metabolism of selected CYP substrates in adults with moderate-to-severe AD after: 14 weeks of treatment with tralokinumab a single dose of tralokinumab
- Trial name
- NCT03556592
- Testing
- Tralokinumab, Caffeine, Warfarin
- Where
- 12 sites in United States, France and 1 more
- Volunteers
- 40 people
- Sponsor
- LEO Pharma
Fibromyalgia Syndrome
Mechanism Study of Yangyin Roujin Formula in the Treatment of Fibromyalgia Syndrome
This prospective randomized, double-blind, controlled clinical trial is designed to address the current challenges in the clinical management of fibromyalgia (FM).
- Trial name
- NCT07736144
- Testing
- Yangyin Roujin Decoction
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Juan Jiao
Anovulation
Protocol for Drug Use Investigation of Follistim Injection (Study P06132)(COMPLETED)
The main purpose of this investigation is to collect information about safety and efficacy of Follistim Injection from actual clinical use to induce ovulation in patients with anovulation and oligoovulation due to…
- Trial name
- NCT00920634
- Testing
- Follitropin beta
- Volunteers
- 384 people
- Sponsor
- Organon and Co
Bronchial Asthma
Clinical Study on Treatment of Chronic Persistent Bronchial Asthma
Investigators aimed to evaluate the clinical efficacy of integrated traditional Chinese and Western medicine in the treatment of asthma, and to further optimize the prescription of Chinese medicine treatment.
- Trial name
- NCT03228134
- Testing
- Ke Chuan Liu Wei Granule, Yang He Ping Chuan Granule
- Where
- 5 sites in China
- Volunteers
- 320 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Sepsis
Early Vasopressors in Sepsis
Sepsis is a life-threatening reaction to an infection. It happens when the immune system overreacts to an infection and starts to damage the body's tissues and organs.
- Trial name
- EVIS (NCT05179499)
- Testing
- Norepinephrine, Balanced Crystalloid
- Where
- 25 sites in United Kingdom
- Volunteers
- 1,006 people
- Sponsor
- NHS Greater Glasgow and Clyde
Atopic Dermatitis
Exploratory Study of the Cutaneous Penetration of Biodegradable Polymeric Microparticles in Atopic Dermatitis
This proof of concept study aims to assess in patients suffering from atopic dermatitis if polymeric microparticles reach the pilosebaceous follicles of inflamed skin.
- Trial name
- MicroIskin (NCT02369432)
- Testing
- Biodegradable and biocompatible polymeric microparticles containing a fluorochrome applied to the skin followed by a skin biopsy
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
mHealth
VR-3D Movie-based Education
Atrial fibrillation (AF), which is the most common cardiac arrhythmia in adults, is associated with a high risk of stroke and other thromboembolic complications.
- Trial name
- NCT03104231
- Testing
- three-dimensional (3D) movie
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Healthy
Safety Study of 7 Botulinum Antitoxin Serotypes Derived From Horses
The primary purpose of the study is to evaluate the safety of the 7 Botulinum Antitoxin Serotypes derived from horses using various laboratory measurements, clinical examinations and adverse events.
- Trial name
- NCT00360737
- Testing
- Botulinum Antitoxin Heptavalent (A B C D E F G) - (EQUINE)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Critical Illness, Infections
A Model for Drug Concentration Prediction of Vancomycin
Objective: This study aims to use machine learning methods to establish an optimal model for predicting serum vancomycin trough concentrations in critically ill patients. Methods: This is a single-center, retrospective study.
- Conditions
- Critical Illness, Infections, Drug Use
- Trial name
- NCT06431412
- Testing
- no intervention
- Where
- China
- Volunteers
- 401 people
- Sponsor
- Peking Union Medical College Hospital
Quality of Life, Health Education
The Effect of Health Education and Yoga on Menopause Symptoms and Quality of Life According to Pender's Model
The aim of the study is to examine the effect of health education and yoga intervention prepared according to Pender's Health Promotion Model on menopausal women's "menopause-specific quality of life" compared to routine care.
- Conditions
- Quality of Life, Health Education, Yoga, Menopause Symptoms
- Trial name
- NCT06210412
- Testing
- health education and yoga intervention group
- Where
- Cyprus
- Volunteers
- 66 people
- Sponsor
- Eastern Mediterranean University
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