Clinical trials: Melanosis
Cutaneous Melanocytic Neoplasm, Large Cutaneous Melanocytic Nevi
Neurocutaneous Melanocytosis Registry
This study will involve collecting information about the regular medical care you receive for large cutaneous melanocytic nevi (LCMN) or neurocutaneous melanocytosis (NCM).
- Conditions
- Cutaneous Melanocytic Neoplasm, Large Cutaneous Melanocytic Nevi, Neurocutaneous Melanocytosis
- Trial name
- NCT04548817
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Melasma, Melasma (Facial Melasma)
Azelaic Acid 20% vs Hydroquinone 4% in Epidermal Melasma
Melasma is a common skin condition that causes dark patches on the face and can significantly affect quality of life. This study compared two commonly used topical treatments, 20% azelaic acid and 4% hydroquinone, in adults with…
- Trial name
- NCT07327983
- Testing
- Topical Azelaic Acid 20% Cream, Topical 4% hydroquinone cream
- Where
- Pakistan
- Volunteers
- 146 people
- Sponsor
- Gujranwala medical college District Headquarters Hospital, Gujranwala
Peutz-Jeghers Syndrome
Efficacy of Rapamycin (Sirolimus) in the Treatment of Peutz-Jeghers Syndrome
A prospective non-randomized open label single arm clinical trial to examine the efficacy and safety of sirolimus in patients with Peutz-Jeghers Syndrome.
- Trial name
- NCT03781050
- Testing
- Rapamycin
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Peking Union Medical College Hospital
Peutz-Jeghers Syndrome, Small Bowel Polyp
Cold Snare Polypectomy for Small Bowel Polyps in Patients With Peutz-Jeghers Syndrome
This study aims to evaluate the feasibility and safety of Cold snare polypectomy for removing 5-9mm small intestinal polyps in patients with Peutz-Jeghers Syndrome (PJS),in order to provide some reference for clinical strategy of…
- Trial name
- NCT06001476
- Testing
- Cold snare polypectomy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shandong University
Obesity, Acanthosis Nigricans
Children's Healthy Living Community Randomized Trial
The goal is to build social/cultural, political/economic, and physical/built environments that will promote active play and intake of healthy food to prevent young child obesity in the Pacific Region.
- Conditions
- Obesity, Acanthosis Nigricans, Central Obesity
- Trial name
- CHL (NCT01881373)
- Testing
- CHL program, Delayed Optimized CHL program
- Where
- United States
- Volunteers
- 9,840 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
RAS Mutation, Neurofibromatosis 1
RASopathy Biorepository
The RASopathies are a group of developmental disorders caused by genetic changes in the genes that compose the Ras/mitogen activated protein kinase (MAPK) pathway. New RASopathies are being diagnosed frequently.
- Conditions
- RAS Mutation, Neurofibromatosis 1, Noonan Syndrome, Noonan Syndrome With Multiple Lentigines
- Trial name
- NCT04395495
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Acanthosis Nigricans
Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With Obesity
Obesity is often accompanied by insulin resistance and/or hyperinsulinemia. Acanthosis nigricans (AN) is a skin condition commonly present on the neck of obese children.
- Trial name
- NCT02438020
- Testing
- Metformin
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Juan Pablo Castanedo-Cazares
Melasma (Facial Melasma)
Comparison of Efficacy of Topical Westerhoff Formula Cream Vs Topical 4% Hydroquinone for the Treatment of Melasma
study was conducted on middle aged male and female, including families and health care professional also.
- Trial name
- NCT07508098
- Testing
- Triple combination cream, Hydroquinone 4% Cream
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Pak Emirates Military Hospital
Peutz-Jeghers Syndrome
Study of Accurate Diagnosis and Treatment of Peutz-Jeghers Syndrome
The mutation of STK11 has been regcognized to be the major cause of Peutz-Jeghers syndrome (PJS).The aim of this study was to confirm the mutation rate of gene associated with gastrointestinal malignancies,including STK11…
- Trial name
- NCT03806075
- Testing
- Second generation sequencing, 16s rRNA gene sequencing
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Yiqi Du
Acute Leukemia, Adenomatous Polyposis
Familial Investigations of Childhood Cancer Predisposition
NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll.
- Conditions
- Acute Leukemia, Adenomatous Polyposis, Adrenocortical Carcinoma, AML
- Trial name
- SJFAMILY (NCT03050268)
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- St. Jude Children's Research Hospital
Basal Cell Carcinoma, Lentigo Maligna
Comparison of 3 in Vivo Microscopic Imaging Techniques for the Diagnosis of Pigmented Tumors
Reflectance confocal microscopy (RCM) is the reference in vivo imaging technique for identifying malignant melanocytic tumors prior to surgical excision.
- Conditions
- Basal Cell Carcinoma, Lentigo Maligna, Melanoma, Nevus
- Trial name
- Micro3 (NCT06046144)
- Testing
- Fluorescence-Advanced videodermatoscopy, Reflectance confocal microscopy, Super-high magnification dermoscopy
- Where
- France
- Volunteers
- 161 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Melasma
Tissue-resident Memory T Cells Expression in Melasma
The treatment of melasma and the maintenance of depigmentation represent a challenge due to its frequent recurrences. Pathophysiological mechanisms and factors have been linked to melasma such as inflammation, sun exposure…
- Trial name
- NCT05698342
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Freckles
Efficacy and Safety of Fractional Carbon Dioxide Laser for Treatment of Facial Freckles.
Freckles are clusters of melanin in the superficial epidermis. They affect mostly face and sun exposed areas, and appear as flat brown or red macules that fade in winter, usually in a fair complexion patient, but may be present…
- Trial name
- NCT01545869
- Testing
- Fractional carbon dioxide laser
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Melasma
Fractional Photothermolysis for Treating Melasma
In several observational studies, non-ablative fractional photothermolysis (FP) has been reported to bridge the gap between efficacy and tolerability in the treatment of melasma.
- Trial name
- NCT01245881
- Testing
- Non-ablative fractional photothermolysis laser, broad-spectrum sunblock (SPF 50+)
- Where
- Germany
- Volunteers
- 51 people
- Sponsor
- Laserklinik Karlsruhe
Peutz-Jeghers Syndrome, Celecoxib
Celecoxib for Prevention of Progression in Peutz-Jeghers Syndrome
The Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant syndrome characterized by mucocutaneous pigmentations, multiple gastrointestinal hamartomatous polyps, and an elevated risk of developing malignancies.
- Conditions
- Peutz-Jeghers Syndrome, Celecoxib, Small Bowel Polyp
- Trial name
- NCT06722534
- Testing
- Celecoxib 400mg
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Air Force Military Medical University, China
Cushing's Syndrome, Pituitary Adenoma
Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
Lentiginosis refers to groups of diseases marked by the presence of pigmented spots on the skin. These conditions are most commonly associated with multiple tumors and changes in hormone producing glands.
- Conditions
- Cushing's Syndrome, Pituitary Adenoma, Carney Complex, Primary Pigmented Nodular Adrenocortical Disease
- Trial name
- NCT00001452
- Testing
- oCRH
- Where
- United States
- Volunteers
- 1,387 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Acanthosis Nigricans, Hyperinsulinemia
Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With Hyperinsulinemia
Acanthosis Nigricans is skin disease that associated with hyperinsulinemia. Clinical is velvety hyperpigmented plaques on neck, axilla, groin.
- Conditions
- Acanthosis Nigricans, Hyperinsulinemia, Spectroscopic Analysis
- Trial name
- NCT01125150
- Testing
- Metformin, Dietary Modification
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Melasma
Efficacy of New Trio Combination for Melasma
The goal of this clinical trial is to learn if the drug New Trio Combination (0.1% isobutylamido-thiazolyl-resorcinol, 0.1% retinoic acid and 0.1% dexamethasone) works to treat melasma.
- Trial name
- NCT07676994
- Testing
- New trio combination, Kligman's formula (trio)
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- Ghurki Trust and Teaching Hospital
Peutz-Jeghers Syndrome
Chinese Multicenter Registry for Peutz-Jeghers Syndrome
This prospective, observational patient registry will enroll approximately 1,000 individuals with a clinical or molecular diagnosis of Peutz-Jeghers syndrome (PJS) at participating hospitals in China.
- Trial name
- NCT07889596
- Where
- 9 sites in China
- Volunteers
- 1,000 people
- Sponsor
- First People's Hospital of Hangzhou
Acanthosis Nigricans
Systemic and Topical Metformin Versus Glycolic Acid Peel for the Treatment of Acanthosis Nigricans
Acanthosis nigricans (AN) is a common dermatologic condition associated with insulin resistance and obesity. Existing treatment options often provide inconsistent results.
- Trial name
- MET-AN (NCT07751549)
- Testing
- systemic metformin, topical intervention, glycolic acid 70% peeling
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Tanta University