Clinical trials: Membranous
Otosclerosis, Tympanic Membrane Perforation
Audiometric Parameters in Conductive Hearing Loss and Middle Ear Disease
We study audiometric parameters including Transient Otoacoustic emissions, pure-tone audiometry for air- and bone-conduction, and spondaic speech recognition thresholds for air- and bone conduction in a pre- and postoperative…
- Trial name
- NCT00222417
- Testing
- myringoplasty, Stapes surgery
- Where
- Norway
- Sponsor
- University Hospital of North Norway
Tympanic Membrane Perforation
Endoscopic Overlay Tympanoplasty for TM Perforation
Minimally invasive surgery is becoming more common in many surgical fields. The wide view of endoscope allows for minimally invasive transcanal approach instead of large postauricular opening.
- Trial name
- NCT02331797
- Testing
- Endoscopic Technique, Microscopic Technique
- Where
- Thailand
- Volunteers
- 64 people
- Sponsor
- Prince of Songkla University
PPROM
Digital vs. Speculum Exams for PPROM
After preterm prelabor rupture of membranes (PPROM)[breaking of the amniotic sac prior to 37 weeks gestation in pregnancy], patients are recommended for inpatient admission and close monitoring for complications including preterm…
- Trial name
- MOCA (NCT05773014)
- Testing
- Speculum Exams, Digital Exams
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Symblepharon
Transplant of Epithelium Conjunctival Human Autologous Cultivated ex Vivo in Amniotic Membrane for the Treatment of Symblepharon
The purpose of this study is to investigate the safety and efficacy of human conjunctival epithelial autologous cultivated ex vivo for reconstruction of the ocular surface in patients with symblepharon.
- Trial name
- NCT00799526
- Testing
- Autologous Ex Vivo Conjunctival for Symblepharon Transplantation, Ex Vivo Conjunctival for Symblepharon Transplantation
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Respiratory Distress Syndrome (& [Hyaline Membrane Disease]), Respiratory Distress Syndrome (Neonatal)
Surfactant Administration Methods in Preterm Infants With RDS: A Swedish Cohort Study
The goal of this observational study is to evaluate different methods of surfactant administration in preterm infants with respiratory distress syndrome (RDS).
- Conditions
- Respiratory Distress Syndrome (& [Hyaline Membrane Disease]), Respiratory Distress Syndrome (Neonatal), Respiratory Distress Syndrome (RDS), Respiratory Distress Syndrome of Newborn
- Trial name
- NCT07550218
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Vastra Gotaland Region
Preterm Premature Rupture of Membrane
Bed Rest After Preterm Premature Rupture of the Membranes
Antepartum bed rest is widely prescribed after preterm premature rupture of the membranes (PPROM), although its effectiveness to prevent preterm birth has not been demonstrated.
- Trial name
- NCT03814278
- Testing
- complete bed rest, activity restriction
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar Lisboa Norte
Hyaline Membrane Disease, Necrotizing Enterocolitis of Newborn
The Effect of β-Carotene, Vitamin D3 and Zinc on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates
Hyaline membrane disease, now commonly called respiratory distress syndrome (RDS), and feeding intolerance, which can lead to necrotizing enterocolitis (NEC), are two key morbidities found in premature neonates which resulted in…
- Trial name
- NCT03366584
- Testing
- Beta carotene, Vitamin D3, Zinc
- Where
- Indonesia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Preterm Premature Rupture of Membranes, Pregnant State
Pomegranate to Reduce Maternal and Fetal Oxidative Stress and Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of the Membranes
In this study the investigators sought to determine the effects of Pomegranate (Natural pomegranate polyphenol (P. granatum L) extract) : 1. On the maternal and fetal oxidative stress and inflammation associated with PPROM. 2.
- Trial name
- NCT01584323
- Testing
- Pomgranate pills
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Apicomarginal Defects
Effect of Combined Use of an Allograft and Membrane on the Healing Outcome of Apicomarginal Defects
Healing of apicomarginal defects using 2 different groups, one being treated with the use of an allograft and a membrane and a control group, will be assessed and compared using 2D and 3D criteria.
- Trial name
- NCT05171543
- Testing
- Periapical surgery with placement of an allograft and a membrane
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Macular Holes, Epiretinal Membrane
Intraoperative OCT Guidance of Intraocular Surgery II
The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes.
- Conditions
- Macular Holes, Epiretinal Membrane, Diabetic Retinopathy, Retinal Detachment
- Trial name
- MIOCT (NCT03713268)
- Testing
- Microscope integrated optical coherence tomography
- Where
- United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Duke University
Chronic Renal Failure, Peritoneal Membrane Disorder
Administration of pH-Neutral Peritoneal Dialysis Solutions Containing Lactate or Bicarbonate in Children
Peritoneal Dialysis (PD) is the preferred treatment modality in children with end-stage renal disease. Unfortunately progressive alterations of the peritoneal membrane occur with time on PD, leading to a continuous loss of…
- Trial name
- BIOKID (NCT01632046)
- Testing
- lactate and bicarbonate buffered dialysis solutions
- Where
- 7 sites in Austria, Finland and 3 more
- Volunteers
- 42 people
- Sponsor
- Heidelberg University
Choroidal Neovascularization
OCTA Insights in CNVM, Morphological Characteristics and Correlation With Structural OCT.
To suggest a novel classification of choroidal neovascular membrane based on optical coherence tomography angiography and to correlate morphological characteristics based on optical coherence tomography with clinical criteria of…
- Trial name
- NCT05055973
- Volunteers
- 80 people
- Sponsor
- Assiut University
Pulp Disease, Dental
Evaluation of Different Materials in Pulpotomy of Primary Molars
The aim of the current study is to evaluate and compare clinical and radiographic success and antibacterial effect of Hyaluronic Acid and Amniotic membrane pulpotomy in primary molars in comparison with MTA pulpotomy (Randomized…
- Trial name
- NCT05981352
- Testing
- mineral trioxide aggregate pulpotomy, Dehydrated amniotic membrane pulpotomy, Hyaluronic acid pulpotomy
- Volunteers
- 36 people
- Sponsor
- Ain Shams University
Meningococcal Infections
Regulation of Mucosal Immune Response to Systemic MenB Vaccine
Meningitis or septicaemia (blood poisoning) caused by group B meningococcal infection (MenB) is an important cause of death and disability in the UK. Prevention through vaccination therefore remains a key public health priority.
- Trial name
- NCT00774384
- Testing
- NZ MenB OMV vaccine (NZ98/254)
- Where
- 2 sites in United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University Hospitals Bristol and Weston NHS Foundation Trust
Extracorporeal Membrane Oxygenation Complication
Monitoring of Cerebral Autoregulation in Pediatric ECMO (ECMOX 1)
Children supported by Extra-Corporeal Membrane Oxygenation (ECMO) present a high risk of neurological complications and cerebral autoregulation (CA) impairment may be a risk factor.
- Trial name
- ECMOX1 (NCT04282525)
- Testing
- ECMO for hemodynamic or respiratory indication
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Premature Rupture of Membranes at Term
Comparison of Misoprostol and PGE2 Gel for Induction of Labour in Women With Premature Rupture of Membranes at Term
Induction of labour with vaginal misoprostol, in women with premature rupture of membranes at term, results in significant shortening of induction to delivery time in comparison to vaginal PGE2 gel induction.
- Trial name
- NCT00355966
- Testing
- Misoprostol, PGE2 gel
- Where
- India
- Volunteers
- 212 people
- Sponsor
- Nilratan Sircar Medical College
Recurrent Pterygia
Amniotic Membrane Associated With Conjunctival Autograft Versus Conjunctival Autograft for Recurrent Pterygia
The purpose of this study is to compare amniotic membrane associated with conjunctival autograft versus conjunctival autograft alone in the treatment of recurrent pterygia.
- Trial name
- NCT00802620
- Testing
- Conjunctival autograft versus conjunctival autograft treatment for recurrent pterygia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Pregnancy, Premature Rupture of Membranes
Cervical Ripening in Premature Rupture of Membranes
Premature rupture of membranes (PROM) is diagnosed by demonstrating amniotic fluid in the vaginal canal before the onset of labor.
- Conditions
- Pregnancy, Premature Rupture of Membranes, Preterm Premature Rupture of Membranes, Unfavorable Cervix
- Trial name
- NCT02314728
- Testing
- Misoprostol, Oxytocin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Respiratory Insufficiency of Prematurity
Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV)
The machines and oxygen used to help very premature babies breathe can have side-effects, such as bronchopulmonary dysplasia (BPD).
- Trial name
- NIPPV (NCT00433212)
- Testing
- nCPAP, NIPPV
- Where
- 35 sites in United States, Austria and 8 more
- Volunteers
- 1,011 people
- Sponsor
- McMaster University
Recirculation, Oxygenator Blood Volume
Recirculation, Oxygenator Blood Volume and Cardiac Output Measurements During Extracorporeal Membrane Oxygenation
This study is to test the usefulness of ultrasound dilution measurements in patients on extracorporeal membrane oxygenation. Measurements may include; efficiency of support (recirculation), amount of clotting in the oxygenator…
- Conditions
- Recirculation, Oxygenator Blood Volume, Cardiac Output, Venoarterial Extracorporeal Membrane Oxygenation
- Trial name
- NCT00920569
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Transonic Systems Inc.