Clinical trials: Mental Processes
Adolescents, Mental Disorder Diagnosed in Childhood
Detecting Risk of Suicide in a Pediatric Emergency Department
Objective: The ultimate goal of this project is to enhance the capacity of non-mental health clinicians working in an Emergency Departments (ED) to recognize and initiate further evaluation of children and adolescents at risk for…
- Conditions
- Adolescents, Mental Disorder Diagnosed in Childhood, Suicide Prevention
- Trial name
- NCT00623493
- Where
- 3 sites in United States
- Volunteers
- 524 people
- Sponsor
- National Institute of Mental Health (NIMH)
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
ADHD, Obsessive Compulsive Disorder (OCD)
Role of Theta Frequency Oscillations in Proactive and Reactive Control Processes in Youth With Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)
Background: Attention deficit hyperactivity disorder (ADHD) is common in children. It can cause problems with attention and the ability to control actions and impulses.
- Conditions
- ADHD, Obsessive Compulsive Disorder (OCD), Healthy Volunteer
- Trial name
- NCT07566468
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Low Flow Anesthesia, Sevoflurane
Low Flow Anesthesia in Children Undergoing Strabismus Surgery
Emergence agitation (EA) involves restlessness, disorientation, excitation, non-purposeful movement, inconsolability, thrashing, and incoherence during early recovery from general anesthesia.
- Conditions
- Low Flow Anesthesia, Sevoflurane, Strabismus, Emergence Delirium
- Trial name
- LFA in child (NCT06560268)
- Testing
- Sevoflurane; In our study, the effects of sevoflurane in different FGFs administered in children undergoing strabismus surgery on EA and anesthetic agent consumption will be investigated.
- Volunteers
- 150 people
- Sponsor
- Cukurova University
Inflammation, Psychosocial Functioning
Mindfulness Meditation Neuroimaging Study for Undergraduates
This study is designed to test the effectiveness of mindfulness meditation intervention classes on psychosocial health outcomes.
- Conditions
- Inflammation, Psychosocial Functioning, Depression, Anxiety
- Trial name
- NCT05304052
- Testing
- Mindfulness Meditation classes
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Idiopathic Normal Pressure Hydrocephalus (INPH)
Change in Cognition and Frailty After Shunt Surgery in Idiopathic Normal Pressure Hydrocephalus (iNPH)
The goal of this observational study is to describe changes in cognitive profile and frailty from pre shunt to one year after the shunt surgery and to identify clinical predictors of an improvement in terms of cognition and…
- Trial name
- NCT07642726
- Testing
- Ventriculoperitoneal shunt
- Where
- Norway
- Volunteers
- 276 people
- Sponsor
- Oslo University Hospital
Cardiovascular Diseases, Coronary Disease
Honolulu Heart Program
To investigate coronary heart disease and stroke among American men of Japanese ancestry who were living on the island of Oahu in 1965. Morbidity and mortality surveillance of the original cohort is continuing.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Cerebrovascular Accident, Heart Diseases
- Trial name
- NCT00005123
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
HIV, Substance Abuse
Young Women's Health CoOp (Cooperative) in Cape Town
This supplement study is an adaptation of the larger NIH-funded parent study, the Women's Health CoOp+, which tests a combination biobehavioral HIV prevention approach to enhance standard HIV testing practices for alcohol and…
- Trial name
- YWHC (NCT02677025)
- Testing
- Young Women's Health CoOp (YWHC), HIV Counseling/Testing
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- RTI International
White Matter Abnormalities, Nonspecific, ADHD
Predicting the Outcome of ADHD in White Matter Injure Neonates With Multi-modality MRI
The goal of this bidirectional observational cohort study is to investigate the longitudinal relationship between neonatal white matter injury (WMI) and the subsequent development of attention-deficit/hyperactivity disorder…
- Conditions
- White Matter Abnormalities, Nonspecific, ADHD, Neurodevelopment Outcome
- Trial name
- NCT07836244
- Where
- 9 sites in China
- Volunteers
- 348 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Long COVID, Long Covid19
Stellate Ganglion Block to Treat Long COVID 19 Case Series
An assessment of the effectiveness of Stellate Ganglion Block in alleviating symptoms of Long COVID-19.
- Conditions
- Long COVID, Long Covid19, Post-COVID-19 Syndrome, Post Acute COVID-19 Syndrome
- Trial name
- NCT05812209
- Testing
- Stellate Ganglion Block
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Metamorphosis LTD
Postoperative Confusion, Postoperative Delirium
Autonomous Nervous System Regulated Paediatric Anaesthesia With Dexmedetomidine or Placebo
The goal of this randomized, double blinded study is to examine in children whether postoperative agitation can be reduced. The main question it aims to answer is Will optimized, monitor guided analgesic treatment and…
- Conditions
- Postoperative Confusion, Postoperative Delirium, Postoperative Pain, Acute, Postoperative Complications
- Trial name
- ANNA (NCT05785689)
- Testing
- Dexmedetomidine
- Where
- Denmark
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Depression
Reward-Related Processes and Brain Function
This study will examine and compare brain changes during decision-making in healthy adolescents and adolescents who are anxious or depressed.
- Trial name
- NCT00029588
- Where
- 2 sites in United States
- Volunteers
- 241 people
- Sponsor
- National Institute of Mental Health (NIMH)
Autism
Validation of Indiana's Early Evaluation Hub System
The investigators' objective is to test an innovative method of autism diagnosis that integrates clinical evaluation and assessment of biobehavioral markers in a large high-risk community-referral sample of children in the…
- Trial name
- EAER21 (NCT06586788)
- Testing
- Eyelink Portable Duo, Integrated PCP Diagnosis and Eye-tracking Biomarker
- Where
- 7 sites in United States
- Volunteers
- 154 people
- Sponsor
- Indiana University
HIV Infections, Pregnancy Related
Reaching 90 90 90 in Adolescents in Zambia: Using All Our SKILLZ
"SKILLZ," is a mixed methods evaluation of the Grassroots Soccer (GRS) SKILLZ Package based in Lusaka, Zambia. The package is made up of three football-based programs: (1) SKILLZ-Girl - implemented in schools as part of a 10-week…
- Conditions
- HIV Infections, Pregnancy Related, STI, Mental Health Wellness 1
- Trial name
- SKILLZ (NCT04429061)
- Testing
- SKILLZ-Girl curriculum
- Where
- Zambia
- Volunteers
- 2,153 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pain, Anxiety
Vibrating, Cold Device for Pediatric Intravenous (IV) Cannulation Pain Relief
The purpose of this study is to test the effectiveness of Buzzy®, a battery-powered reusable device that provides cold and vibration, in reducing the pain associated with intravenous (IV) cannulation.
- Trial name
- NCT01394250
- Testing
- Buzzy, Topical Lidocaine 4% Cream
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Tonsillectomy
Dexmedetomidine as a Rapid Bolus in Children for Emergence Agitation
To Determine The Efficacy of a Rapid Bolus Injection of Dexmedetomidine on the Incidence of Emergence Agitation in Anesthetized Children and the Cardiovascular Profile of a Rapid Bolus Injection of Dexmedetomidine.
- Trial name
- NCT01528891
- Testing
- Dexmedetomidine
- Where
- 2 sites in United States
- Volunteers
- 418 people
- Sponsor
- Peter Davis
Rare Genetic Disease
Transcriptomic Analysis of Fibroblasts and Blood in Patients With Rare Diseases
This study aims to answer a key question in the field of rare genetic diseases by determining the prevalence of deleterious variants at RNA level in undiagnosed patients with intellectual disability and/or neonatal hypotonia.
- Trial name
- ARNseqFibroSan (NCT07075107)
- Testing
- Blood collection, skin biopsy
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Oral Melatonin, Nebulized Dexmedetomidine
Oral Melatonin Versus Nebulized Dexmedetomidine on Emergence Agitation in Children Undergoing Adenotonsillectomy
This study aims to compare the efficacy of using oral Melatonin versus nebulized Dexmedetomidine in limitation of emergence agitation in children undergoing adenotonsillectomy.
- Conditions
- Oral Melatonin, Nebulized Dexmedetomidine, Emergence Agitation, Children
- Trial name
- NCT07345715
- Testing
- Normal saline, Oral melatonin syrup, Nebulized dexmedetomidine
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Tanta University
Post-Traumatic Seizure Disorder, Head Injuries
Phase III Double Blind Trial of Valproate Sodium for Prophylaxis of Post Traumatic Seizures
OBJECTIVES: I. Determine whether treating head injured patients with valproate sodium will reduce the risk of developing seizures as a result of the head injury. II.
- Trial name
- NCT00004817
- Testing
- phenytoin, valproate sodium
- Volunteers
- 385 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Tourette Syndrome
Phase III Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine for Tourette Syndrome and Attention Deficit Hyperactivity Disorder
OBJECTIVES: I. Evaluate the safety and efficacy of the alpha-2 adrenergic agonist guanfacine in children and adolescents with Tourette syndrome or other chronic tic disorder, and attention deficit hyperactivity disorder.
- Trial name
- NCT00004376
- Testing
- guanfacine
- Volunteers
- 35 people
- Sponsor
- National Center for Research Resources (NCRR)