Clinical trials: Metabolic Adaptation
Childhood Obesity
The ADAPT Trial: Adapting Evidence-Based Obesity Interventions in Community Settings
Evidence-based obesity treatment is inaccessible to most children in the United States. This lack of access is a source of health inequity, whereby children from rural and minority communities, who have the highest rates of…
- Trial name
- NCT06546696
- Testing
- Competency Based Approaches to Community Health (COACH)
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Vitamin A Deficiency, Low Serum Retinol
Efficacy of β-carotene Biofortified Maize in Reducing Vitamin A Deficiency Among Children
The purpose of this cluster-randomized trial is to examine whether daily consumption of β-carotene biofortified maize flour can reduce the prevalence of vitamin A deficiency and improve the vitamin A status and among 4-8 year old…
- Trial name
- NCT01695148
- Testing
- β-Carotene Biofortified Maize Flour, White Maize Flour
- Where
- Zambia
- Volunteers
- 1,228 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
type1diabetes, Adolescent Behavior
Disease Management in Adolescents With Type 1 Diabetes
Adolescence period; It is a transition period of rapid growth, development and maturation in biochemical, physical, social and spiritual terms, which lasts from the beginning of puberty to young adulthood.
- Conditions
- type1diabetes, Adolescent Behavior, Self Efficacy
- Trial name
- NCT06246279
- Testing
- Adaptation to Adolescence and Type 1 Diabetes Management Training Program
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Akdeniz University
Type 1 Diabetes Mellitus
Cognitive Adaptations to Reduce Emotional Stress Associated With Type 1 Diabetes
The purpose of this study is to evaluate a new intervention (CARES: Cognitive Adaptations to Reduce Emotional Stress Associated with Type 1 Diabetes) designed to reduce caregiver depressive symptoms in families of children with…
- Trial name
- CARES (NCT03698708)
- Testing
- CARES Intervention
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Kansas Medical Center
Energy Expenditure, Atrophy, Muscular
Energy Balance in Extreme Environments: Finding the EI Limit
This project is feasibility study looking at extreme exercise and possible diet intervention study to counter muscle and weight loss during a 2 person Greenland Ski Traverse in April 2023.
- Conditions
- Energy Expenditure, Atrophy, Muscular, Energy Intake
- Trial name
- StOMPE (NCT05773469)
- Testing
- Exercise, Nutrition
- Where
- United Kingdom
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Childhood Obesity
Development and Pilot Testing of a Childhood Obesity Treatment Program
The primary aims were to assess community capacity to develop, implement, and sustain a childhood obesity reduction initiative in the health-disparate Dan River Region as well as to pilot test iChoose to determine the potential…
- Trial name
- NCT03513510
- Testing
- iChoose
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Obesity & Overweight, Childhood Obesity
Combined Inspiratory Muscle Training and Functional High-Intensity Interval Training in Boys With Obesity
Childhood obesity is associated with reduced cardiorespiratory fitness, impaired exercise tolerance, and altered respiratory mechanics.
- Trial name
- IMT and HIIT (NCT07810361)
- Testing
- Inspiratory Muscle Training, Functional High-Intensity Interval Training
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gümüşhane Universıty
Type 1 Diabetes
Adaptation of REDCHIP Intervention for the Portuguese Context
The present Feasibility Randomized Controlled Trial (FRCT) aims to assess the acceptability and effectiveness of REDCHiP intervention, targeting parents of young children with T1D, followed in two major Portuguese hospitals.
- Trial name
- REDCHIP (NCT07201779)
- Testing
- REDCHiP, Treatment As Usual Control Group
- Volunteers
- 44 people
- Sponsor
- ISPA - Instituto Universitario de Ciencias Psicologicas, Sociais e da Vida
Neurodegenerative Diseases, Leukodystrophy
Home Exercise for Individuals With Neurodegenerative Disease
The primary goal of this study is to address the need for targeted therapeutic interventions for impairments that impact walking in related neurodegenerative diseases.
- Conditions
- Neurodegenerative Diseases, Leukodystrophy, Ataxia, LBSL
- Trial name
- NCT05443906
- Testing
- Home exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Diabetes Mellitus
Measuring Retinal Vessel Caliber in Relation to Dark Adaptation and Blood Glucose Level
The overall objective is to investigate, whether retinal blood vessel diameter change during the energy consuming dark adaptation process and if responses vary between low and high blood glucose.
- Trial name
- NCT01136902
- Testing
- Oral Glucose Tolerance Test (OGTT)
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Overweight, Adolescent Behavior
Family-Based Mindful Eating Intervention for Overweight Adolescents
With currently 35% of U.S. adolescents being overweight and one in six having metabolic syndrome, adolescent obesity is one of the major global health challenges of the 21st century.
- Conditions
- Overweight, Adolescent Behavior, Family Research, Weight Loss
- Trial name
- NCT02114190
- Testing
- Adolescent Mindful Eating Group, Parent Integrated Group
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Oregon Research Institute
Pediatric Cancer
Adapted Physical Activity for Children Treated With Cancer and Insulin Sensitivity
The main objective of this study is to evaluate the evolution of the sensitivity to insulin, a hormone that acts on sugar in the body, as well as other metabolic, motor and nutritional elements of children with cancer, according…
- Trial name
- APACIS (NCT05383092)
- Testing
- Adapted Physical Activity Strong
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Toulouse
GDM, Hypoglycemia
DiGESTnewborn Study
We wish to study the effect of a mothers sugar (glucose) control during pregnancy on her baby's sugar control after birth.
- Trial name
- DiGESTnewborn (NCT04192422)
- Testing
- no intervention
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Pediatric Obesity, Health Behavior, Risky
Growing Healthy Children and Families in Rural Arkansas
Childhood obesity is a national problem with racial and ethnic disparities specifically among Hispanic children. The primary purpose of this study is to develop and implement a culturally appropriate healthy eating intervention…
- Trial name
- NCT06565455
- Testing
- Growing Healthy Children and Families in Rural Arkansas
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Congenital Hyperinsulinism
Effect of Exendin-(9-39) on Fasting Adaptation and Protein Sensitivity
The purpose of this study is to examine the effects of exendin-(9-39) on fasting blood glucose and protein induced hypoglycemia on subjects with Congenital Hyperinsulinism.
- Trial name
- NCT00897676
- Testing
- Exendin-(9-39)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Diva De Leon
Type 1 Diabetes, Adolescent
Roy Adaptation Model in People With Type 1 Diabetes
The study was conducted to determine the effect of Roy adaptation model-based education on disease compliance and metabolic control in adolescents with Type 1 diabetes.
- Trial name
- NCT05336929
- Testing
- Roy adaptation model-based nursing education
- Volunteers
- 60 people
- Sponsor
- Balikesir University
Type 1 Diabetes
The Pediatric Artificial Pancreas Automated Initialization Trial
The goal of this clinical trial is to obtain safety data and exploratory glycemic control data from use of an at-home closed loop control (CLC) system (t:slim X2 with Control-IQ Technology) with periodic parameter adjustments…
- Trial name
- PEDAP-AI (NCT06017089)
- Testing
- AI-based Advisor system
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Marc Breton
Obesity
Fish and Marine Fatty Acids, Genetic Signatures of Diet Adaptation, and Long-term Weight Changes
the investigators tested whether genetic variants near FADS cluster, which were recently identified to be signatures of adaptation to fish- and n-3 PUFAs-rich diet, interacted with these dietary factors on long-term change of…
- Trial name
- NCT03348566
- Testing
- fish
- Volunteers
- 22,000 people
- Sponsor
- Harvard School of Public Health (HSPH)
Pediatric Obesity
Role of Mechanical Load on Metabolic Exercise Adaptations in Response to Weight Loss in Obese Adolescents: The POWELL Study
While interdisciplinary weight loss intervention have been shown successful among adolescents with obesity, a weight regain is most of the time observed within the following weeks or months.
- Trial name
- POWELL (NCT04902001)
- Testing
- Multidisciplinary weight loss
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Clermont-Ferrand
Leukemia, Lymphoblastic, Acute, Osteoporosis
A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia Survivors
Research studies have shown that children who are long-term survivors of childhood leukemia may be at greater risk for early bone loss called osteoporosis.
- Trial name
- NCT00186901
- Testing
- Calcium carbonate (Tums), vitamin D
- Where
- 3 sites in United States
- Volunteers
- 429 people
- Sponsor
- St. Jude Children's Research Hospital