Clinical trials: Metabolic Adaptation
Hypoxia, Erythropoiesis
Effects of Intermittent Hypoxia Training With Iron Supplementation on Red Blood Cells and Iron Levels in Trained Athletes
This study investigates how training under conditions of reduced oxygen (intermittent hypoxia) affects the body's ability to produce red blood cells and manage iron levels, compared to training under normal oxygen conditions.
- Conditions
- Hypoxia, Erythropoiesis, Iron Metabolism Disorders
- Trial name
- IHIT-IRON (NCT07720960)
- Testing
- Control group (CG), Hypoxia group (HG): trained at simulated altitudes between 4,450 and 5,850 m
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Néstor Vicente-Salar
Overweight
Evaluation of SODB® in Metabolic Adaptations in Overweight Women
The objective of this study is to evaluate the influence of a 3 months SODB® supplementation in adipose tissue modulations of overweight women, in comparison to a placebo.
- Trial name
- SORESCAL (NCT02667691)
- Testing
- SODB Dimpless, caloric restriction
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Robertet SA
Childhood Obesity
The ADAPT Trial: Adapting Evidence-Based Obesity Interventions in Community Settings
Evidence-based obesity treatment is inaccessible to most children in the United States. This lack of access is a source of health inequity, whereby children from rural and minority communities, who have the highest rates of…
- Trial name
- NCT06546696
- Testing
- Competency Based Approaches to Community Health (COACH)
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Amyotrophic Lateral Sclerosis, Psychological Stress
Psychological Therapy for Patients With ALS
Amyotrophic lateral sclerosis (ALS) is a disease that is inevitably fatal. To be diagnosed with a terminal illness such as ALS deeply affects one's personal existence and goes along with significant changes regarding the…
- Trial name
- NCT03975608
- Testing
- Adaptation of "CALM"
- Where
- Germany
- Volunteers
- 5 people
- Sponsor
- University of Leipzig
Chronic Obstructive Pulmonary Disease (COPD)
Oral β-Alanine Supplementation in Patients With COPD
Preliminary evidence suggest that patients with chronic obstructive pulmonary disease (COPD) suffer from lower-limb muscle dysfunction.
- Trial name
- BACOPD (NCT02770417)
- Testing
- beta-alanine, control
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Multiple Myeloma, Amyloidosis
Minimal Residual Disease Response-adapted Deferral of Transplant in Dysproteinemia (MILESTONE)
This is a phase II interventional study evaluating the use of minimal residual disease by next generation sequencing to defer autologous hematopoietic stem cell transplantation (AHCT) in patients with newly diagnosed multiple…
- Trial name
- NCT04991103
- Testing
- DaraVRD/DaraVCD
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Overweight and Obese Adults, Physical Inactivity
A 12-week Field Trial of the Movámonos Physical Activity Support Program
The objective of this study is to design and refine an activity support program, called Movámonos, for adults with overweight or obesity who speak Spanish.
- Trial name
- Movámonos (NCT07561996)
- Testing
- Movámonos Physical Activity Support Program
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Dyslipidemias
Effect of Vitamin D Supplementation on Exercise Adaptations in Patients on Statin Therapy
Statins along with lifestyle modifications including exercise are commonly prescribed to patients with type 2 diabetes. American diabetes association recommends using moderate-intensity statin and lifestyle therapy for patients…
- Trial name
- NCT02030041
- Testing
- Vitamin D, Simvastatin
- Where
- India
- Volunteers
- 33 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Obesity, Overweight and Obesity
Physical Exercise in Obesity for Health and Quality of Life.
This project aims to develop an intervention on healthy habits based on physical exercise and nutritional education in people with obesity. It is accepted that exercise and nutrition are keys to controlling body weight.
- Conditions
- Obesity, Overweight and Obesity, Overweight or Obesity
- Trial name
- OBEFYSA (NCT05713461)
- Testing
- exercise training program, Feeding training
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Pablo de Olavide
Gut Microbiota, Metabolic Syndrome
Effect of Mango on Gut Microbiota and Metabolic Health
Mango is rich in bioactive compounds such as dietary polyphenols and carotenoids, which may explain its beneficial effect on health. Polyphenols accumulate in the gut where they can positively modulate the microbiota.
- Trial name
- NCT03825276
- Testing
- Mango consumption
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Laval University
Ketogenic Diet, Weight Loss
Impact of Exogenous Ketones on Indices of Keto-Adaptation in Obese Subjects on Weight Reducing Diets.
This project will be a three-group controlled 6-wk feeding study where all meals are prepared and provided to obese participants. All participants will be fed a 25% energy-restricted diet.
- Trial name
- STAK (NCT06449287)
- Testing
- Diet, Blood Draw, Ketone/Glucose Monitoring
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Vitamin A Deficiency, Low Serum Retinol
Efficacy of β-carotene Biofortified Maize in Reducing Vitamin A Deficiency Among Children
The purpose of this cluster-randomized trial is to examine whether daily consumption of β-carotene biofortified maize flour can reduce the prevalence of vitamin A deficiency and improve the vitamin A status and among 4-8 year old…
- Trial name
- NCT01695148
- Testing
- β-Carotene Biofortified Maize Flour, White Maize Flour
- Where
- Zambia
- Volunteers
- 1,228 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Obesity, Physical Inactivity
Effects of Short Isokinetic Eccentric Resistance Training on Neuromuscular Induced Adaptations
The study compares the impact of isokinetic resistance training (RT) -induced neuromuscular adaptation following an 8-week short ECC ISO RT and CON ISO RT among obese, untrained women. The main question it aims to answer is: 1.
- Trial name
- NCT07407621
- Testing
- ECC ISO, CON ISO
- Where
- Malaysia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Weight Loss, Obesity
Risk of Metabolic Adaptation After Weight Loss
This study aims at identifying the neurohormonal biomarkers that characterize individuals at risk of greater metabolic adaptation to weight loss, a disproportionate decline in resting metabolic rate during and after weight loss.
- Trial name
- NCT05139420
- Testing
- lifestyle intervention with meal replacement program
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical College of Wisconsin
Diabetes Mellitus, Type 2
Diabetes Resistance Training Adaptations in Elderly
This study aims to verify the effects of resistance training on neuromuscular, vascular and functional adaptations of elderly diabetics type 2.
- Trial name
- DRTAE (NCT02548000)
- Testing
- Resistance training, Stretching control
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Cardiovascular Disease, Heart Failure
Integration of Chronic Disease Rehabilitation Services Into Primary Care
The aim of PR1MaC is to establish a clinical intervention that will adapt and permanently integrate rehabilitation services into primary care settings, which would be the reference point in the health care system for people with…
- Conditions
- Cardiovascular Disease, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- PR1MaC (NCT01319656)
- Testing
- Support, management, educational, counselling, follow-up
- Where
- Canada
- Volunteers
- 326 people
- Sponsor
- Martin Fortin
Diabetes Mellitus, Arthritis, Rheumatoid
Psychosocial Treatment Intervention in Persons Newly Diagnosed With Rheumatoid Arthritis or Diabetes
The aim of this study is to evaluate the results of psychosocial treatment in patients with newly diagnosed rheumatoid arthritis and/or diabetes.
- Conditions
- Diabetes Mellitus, Arthritis, Rheumatoid, Coping Skills
- Trial name
- NCT01066130
- Testing
- Intensive individualized psychosocial treatment, Minimal treatment arm
- Where
- 2 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
Obesity & Overweight
Long-term Adaptations of Skeletal Muscle After Hybrid Training
Obesity is a major challenge for public health and renders it imperative to reduce its prevalence. High intensity interval training (HIIT) is a form of exercise training that can efficiently induce weight loss in adults with…
- Trial name
- NCT07341711
- Testing
- Exercise training, Control group
- Where
- Greece
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Magnetic Resonance Spectroscopy
Non-Invasive Monitoring Of Metabolite Levels Using Novel And Adapted MR Spectroscopy Techniques
This Swiss National Science Foundation (SNF) funded project and the linked European project aim to improve magnetic resonance (MR) methods, specifically MR spectroscopy and metabolic imaging (making them more sensitive and…
- Trial name
- NIMM_MRS (NCT05165537)
- Testing
- NIMM_MRS
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Prediabetes
The Avoiding Diabetes Thru Action Plan Targeting Pilot Randomized Control Trial
The goal of this randomized control trial is to study the impact of an electronic health record embedded tool's ability to facilitate shared provider-patient goal setting to promote lifestyle behavior change and prevent diabetes…
- Trial name
- ADAPT (NCT01473654)
- Testing
- ADAPT tool
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Boston University