Clinical trials: Metabolic Regulation
Bariatric Surgery Candidate, Lipid Metabolism Disorders
Lipid Metabolism in Obese Subjects Undergoing Bariatric Surgery
The aim of the study is to evaluate modifications in the metabolism of polyunsaturated fatty acids (PUFA) and biosynthesis of the lipid mediators N-acylethanolamines (NAE), both known to induce and be induced by the nuclear…
- Conditions
- Bariatric Surgery Candidate, Lipid Metabolism Disorders, Obesity
- Trial name
- NCT04984785
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- University of Cagliari
Obesity and Type 2 Diabetes, Diet Modification
Mobile Regulation of Craving Training (mROC-T) to Improve Dietary Intake in Rural Adolescent Girls
The goal of this clinical trial is to test if a regulation of craving training intervention in the form of a mobile phone app can increase fruit and vegetable intake in adolescent girls ages 14-18 years of age.
- Trial name
- ROC Teens! (NCT06723028)
- Testing
- Regulation of craving training
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Wyoming
Obesity, Childhood
Development of an Eating Behavior Risk Score
This study will explore how children's eating behaviors are connected to brain activity and body fat levels. Researchers are especially interested in a behavior pattern called the PACE phenotype, which includes how much children…
- Trial name
- PACE (NCT07266506)
- Testing
- Assessment of PACE Eating Phenotype and Related Behavioral and Neurobiological Measures
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Penn State University
Self-regulation, Medication Adherence
Adolescent Interventions to Manage Self-regulation of T1D (AIMS T1D)
This goal of this project is to test whether self-regulation assays and interventions can be delivered and change self-regulation in a sample of adolescents, specifically to test in a small randomized clinical trial (RCT) whether…
- Trial name
- NCT03688919
- Testing
- Self-Regulation Intervention
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Michigan
Executive Function Disorder, Emotional Regulation
Evaluation of Executive Function and Emotional Regulation in Children in Bangladesh
The study explores the impact of malnutrition at enrollment on executive function (EF) and emotional regulation (ER) in malnourished 1-year-old children and whether specially designed brain directed therapeutic feeds improve…
- Conditions
- Executive Function Disorder, Emotional Regulation, Malnutrition, Child
- Trial name
- NCT05629624
- Testing
- Chickpea based RUSF, E-RUSF, Outcome reference group/RUSF
- Where
- Bangladesh
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Type 1 Diabetes
Effects of Circadian Rhythm on Glycemic Regulation During Continuous Moderate Exercise and Intense Intermittent Disease in Adolescents Living With Type 1 Diabetes
Interventional research with minimal risks and constraints on the effects of circadian rhythm on glycemic regulation during intense moderate, continuous and intermittent exercise in adolescents living with type 1 diabetes
- Trial name
- CHRONODIAB1 (NCT06803446)
- Testing
- physical test
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Lille University
Intellectual Disability, Rubinstein-Taybi Syndrome
Functional Tests to Resolve Unsolved Rare Diseases. Rares.
Rares diseases are a heterogeneous group of conditions which need important tools for diagnosis. The use of high-throughput sequencing is able to diagnose half of the patients.
- Conditions
- Intellectual Disability, Rubinstein-Taybi Syndrome, Cystic Fibrosis, Congenital Heart Defect
- Trial name
- RID (NCT05696912)
- Testing
- Ex-vivo approach concerning 25 patients, In-vitro approach concerning 25 patients
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Childhood Obesity
Genetic Predisposition to Food Cue Reactivity in Children
This study assesses the associations between genetic factors, food-cue-related neural reactivity, self-regulatory capacity, eating in the absence of hunger (EAH), and adiposity gain in children.
- Trial name
- NCT03766191
- Testing
- Food Ads, Non-food Ads
- Where
- United States
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Vitamin D Deficiency, Immunosuppression
Helminth Infection During Pregnancy on Vitamin D Regulation: HELMVIT Study
Purpose: To examine whether helminth infection during pregnancy alters Vitamin-D-metabolism and reactivity of the child's immune system Hypothesis: Helminth infection during pregnancy is associated with altered Vitamin D levels…
- Trial name
- HELMVIT (NCT04324853)
- Testing
- Microscopy ( Urine filtration), UCAA test, qPCR,, Microscopy (Kato Katz, Coproculture, Harada Mori, MIF), qPCR,
- Where
- Gabon
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche Médicale de Lambaréné
Type 1 Diabetes
The Effect of Saxagliptin on Glucose Fluctuation and Immune Regulation in Patients With Type 1 Diabetes
To investigate whether saxagliptin could reduce the fluctuation of glycemia and improve the glycemic control in those type 1 diabetes through mechanisms of suppressing glucagon secretion, improving beta cell function, and…
- Trial name
- NCT02307695
- Testing
- Saxagliptin, Insulin
- Where
- China
- Volunteers
- 184 people
- Sponsor
- Nanjing Medical University
Obesity, Prader Willi Syndrome
Macronutrient Regulation of Ghrelin and Peptide YY
The hyperghrelinemia of children with PWS provides a unique model by which to explore the hormonal and metabolic effects of orexigenic hormones in normal and pathologic conditions.
- Trial name
- NCT02464514
- Testing
- High carbohydrate meal, High fat meal
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Duke University
Appetite Regulation
Metabolic, Endocrine and Appetite-related Responses in Healthy, Adolescent Males After Acute and Daily Milk Consumption
Comprising two experiments, the investigators assessed the metabolic, endocrine and appetite-related responses to acute (1-d, part 1) and daily mid-morning milk consumption (28-d, part 2) in adolescent males (15-18 y).
- Trial name
- NCT02487342
- Testing
- milk, orange fruit-juice
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Sepsis, Critical Illness
Regulation of Endocrine, Metabolic, Immune and Bioenergetic Responses in Sepsis
The hypothesis of this study is that bioenergetic failure in human sepsis, related to endocrine, metabolic and mitochondrial dysfunction, is a major determinant of defective host immune responses, increasing disease severity and…
- Trial name
- NCT00187824
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College London Hospitals
Childhood Obesity
Physical Activity and Screen-Time Regulations in Childcare Centers - Aim 2
Objective is to examine the physical activity and screen-time behaviors of children enrolled in licensed childcare centers before and after the enactment of new state regulations.
- Trial name
- Pause and Play (NCT02751814)
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity
The Effect of 1 Year of Multiprofessional Therapy on Obesity
Obese adolescents are submitted to a multiprofessional weight loss program, which is formed by doctors, nutritionists, physiotherapists, psychologists,and physiologists.
- Trial name
- NCT01358773
- Testing
- multidisciplinary intervention
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Ana R. Damaso
Type 2 Diabetes, Obesity
Obesity and Diabetes Prevention Through Science Enrichment
Type 2 diabetes and obesity in children continue to increase at alarming rates with devastating results. However, both these metabolic diseases are largely preventable through adoption of a healthy lifestyle, an understanding of…
- Trial name
- DKENERGY (NCT00541879)
- Testing
- Program ENERGY, comparison
- Where
- United States
- Volunteers
- 2,909 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Obesity
Effect of a Physical Activity Program on the Hormonal Regulation of Food Intake
The primary purpose of this protocol is to assess the hormonal regulation of satiety by an intense exercise before and after a 3 month physical activity program.
- Trial name
- APHRO (NCT01824680)
- Testing
- Physical activity
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Diabetes, Prediabetes
Meta-analyses of the Effect of Dietary Pulses on Acute Postprandial Metabolic Control
Dietary pulses (beans, peas, chickpeas, and lentils), more commonly known as "legumes", are generally recognized as healthy components of the diet.
- Conditions
- Diabetes, Prediabetes, Dysglycemia, Overweight
- Trial name
- NCT01605422
- Testing
- Dietary pulses
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Obesity
Learning Theory to Improve Obesity Treatment
The purpose of this study is to optimize an obesity treatment program targeting overweight 8-12 year old children using "Cue Exposure Training".
- Trial name
- iROC (NCT01708785)
- Testing
- Single food Cue Exposure Treatment, Multiple food Cue Exposure Treatment, Partial Reinforcement - Enhanced Cue Exposure Treatment
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obesity
Sleep and Obesity in Teenagers
This study aims to investigate 1. whether sleep extension results in improvements of endocrine and metabolic markers of obesity and diabetes in obese teenagers, 2.
- Trial name
- NCT00841347
- Testing
- habitual sleep length period + extended sleep length period, extended sleep length period + habitual sleep length period
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon