Clinical trials: Metabolomics
Asthma
Metabolomics in the Diagnosis and Treatment of Asthma in Children
The goal of this observational study is to learn about the metabolomic profile of blood and urine in children 12-17 years with asthma.
- Trial name
- NCT07280364
- Testing
- Standart medical treatment
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Sarcopenia
Sarcopenia Physical Activity and Metabolomic
Muscle failure (sarcopenia or dynapenia) is a factor of frailty and therefore, ultimately, of loss of autonomy in the elderly. Currently, no biomarker of muscle failure has a high sensitivity, specificity and positive predictive…
- Trial name
- SPAM (NCT05199207)
- Testing
- Physical activity programm
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Pancreatic Exocrine Insufficiency
The Development of a Metabolomic Test to Diagnose and Quantify Pancreatic Exocrine Insufficiency (The DETECTION Study)
DETECTION. The development of a metabolomic test to diagnose and quantify pancreatic exocrine insufficiency.
- Trial name
- DETECTION (NCT05980221)
- Testing
- Metabolomics, 13C MTGT
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Pre-eclampsia, Pregnancy
IMproved PRegnancy Outcome by Early Detection
The overall objective of the IMPROvED project is to develop a sensitive, specific, high-throughput and economically viable early pregnancy screening test for preeclampsia.
- Conditions
- Pre-eclampsia, Pregnancy, Pregnancy, High-risk, Pregnancy Complications
- Trial name
- IMPROvED (NCT01891240)
- Where
- 6 sites in Ireland, Netherlands and 2 more
- Volunteers
- 5,000 people
- Sponsor
- Louise Kenny
Type1diabetes
Metabolic Profiling of Type 1 Diabetes Mellitus in Children and Adolescents
The aim of this study was to look for discriminating variation in the concentrations of small-molecule metabolites in the plasma of T1DM children compared with non-diabetic matched controls using proton nuclear magnetic resonance…
- Trial name
- T1DM (NCT03014908)
- Testing
- Blood sampling
- Where
- Belgium
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Formula Milk, Breast Milk Collection
Metabolomic Profile in Breastfed Late Preterm Infants
Exclusive breast milk is recommended from birth to 6 months of life to promote the development of a balanced intestinal microbiota.
- Conditions
- Formula Milk, Breast Milk Collection, Postbiotic Supplemented Formula Milk
- Trial name
- NCT06052592
- Testing
- Milk
- Where
- 2 sites in Italy
- Volunteers
- 54 people
- Sponsor
- Ospedale Buon Consiglio Fatebenefratelli
Pregnancy Related, Pregnancy Loss
Microbiome and Malnutrition in Pregnancy
This study is being conducted to investigate how a mother's nutritional status and her gut microbiome during pregnancy contribute to the birth outcomes and health of her baby.
- Conditions
- Pregnancy Related, Pregnancy Loss, Pregnancy Complications, Pregnancy; Parasitic Disease
- Trial name
- MMIP (NCT04992104)
- Where
- 2 sites in Canada
- Volunteers
- 800 people
- Sponsor
- The Hospital for Sick Children
Pain (Visceral, Somatic, or Neuropathic), Women of Reproductive Age
Virtual Menstrual Pain Approaches in Females
This research study is testing two self-care approaches that may help prevent or reduce period pain in young females with recurrent painful menstrual cramps.
- Conditions
- Pain (Visceral, Somatic, or Neuropathic), Women of Reproductive Age, Mental Disorder, Digital Health
- Trial name
- AABQ (NCT07497711)
- Testing
- Virtual Auricular Acupressure, Virtual Baduanjin Qigong Exercise, Self Education
- Where
- Singapore
- Volunteers
- 145 people
- Sponsor
- Nanyang Technological University
Cardiomyopathies, Pediatric ALL
Ventricular Remodelling and Metabolomics in Pediatric Cardiomyopathies (PROGRESS-OMICS)
The pathogenesis of cardiomyopathies is complex and a simple approach cannot describe the whole picture. Different etiologies are reported in pediatric age and heart failure onset can lead to poor prognosis in term of need of…
- Trial name
- PRO-OMICS (NCT04670731)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bambino Gesù Hospital and Research Institute
Osteoporosis, Postmenopausal, Osteoporosis Fracture
New Biomarkers and Therapeutic Targets in Osteoporosis Via Omics Technologies
This study aims to discover novel biomarkers and therapeutic targets for osteoporosis through the use of advanced omics technologies, including proteomics and metabolomics.
- Conditions
- Osteoporosis, Postmenopausal, Osteoporosis Fracture, Osteoporosis, Severe
- Trial name
- NCT06525688
- Testing
- Bone, Serum and Plasma sample
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- National and Kapodistrian University of Athens
Epilepsy, Microbiota
EPIGUT: EPILEPSY AND GASTROINTESTINAL MICROBIOTA: UNDERSTANDING THERAPY RESPONSE
The goal of this observational study is to learn how the bacteria in the gut and mouth (called the microbiota) are linked to different types of epilepsy and how they may affect how well seizure medicines work.
- Conditions
- Epilepsy, Microbiota, Proteomics, Metabolomics
- Trial name
- EpiGUT (NCT07253701)
- Where
- 6 sites in Sweden
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Congenital Heart Disease, Metabolism Disorder
Metabolic Remodeling in Fontan Patients
Assessment of metabolic alterations in adult Fontan patients with a dominant left ventricle with the help of serum examinations (Metabolomics).
- Trial name
- NCT03886935
- Testing
- Metabolomics
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Solitary Pulmonary Nodules, Lung Cancer
Plasma Metabolomics as a Tool to Distinguish PET-positive Malignant From PET-positive Benign Nodules
Positron emission tomography-computed tomography (PET-CT) is an important technique in lung cancer staging, where almost no lung lesion goes undetected.
- Trial name
- NCT07087080
- Testing
- Blood sampling
- Where
- Belgium
- Volunteers
- 350 people
- Sponsor
- Hasselt University
Fetal Anomaly
Validation of a Test for Fetal Malformations
The investigators have developed a diagnostic test for the evaluation of the presence of fetal malformations through metabolomic analysis of maternal peripheral blood serum by chromatographic techniques and mass spectrometry, and…
- Trial name
- NCT02965287
- Testing
- Serum metabolomics profiling
- Where
- Italy
- Volunteers
- 1,943 people, healthy volunteers welcome
- Sponsor
- Theoreo Srl
Narcolepsy
Proteomics and Metabolomics of Body Fluid in Patients With Narcolepsy
Narcolepsy (NRL) is a rare chronic central nervous system dysfunction disease, which is more common in children and adolescents, and less common in adults.
- Trial name
- NCT06279247
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Dysbiosis, Cardiometabolic Health Indicators
Almonds, Gut Microbiome and Kids
This 8-week parallel-arm randomized controlled trial (N=70; ages 6-13) will determine the impact of daily almond butter consumption on gut microbiome composition and function, intestinal barrier integrity, and cardiometabolic…
- Trial name
- NCT07636850
- Testing
- Creamy Richards 100% Almonds! Creamy Natural Almond Butter, Cadbury Milk Chocolate Spread
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Florida State University
Obesity
Effects of VSL#3 on Metabolic, Endocrine, Lipidomic and Inflammatory Parameters of Pediatric Patients With BMI>90°
Obesity in children has become a significant social problem considering that nowadays 4 to 5 % of all children are obese in the industrialized countries with increased incidence in Europe by 10 to 50% over the past 10 years.
- Trial name
- VAIIO (NCT01650025)
- Testing
- VSL#3 active probiotic
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Anorexia Nervosa
The Fecal Microbiome Transplant (FMT) Study for Anorexia Nervosa
Anorexia Nervosa (AN) is a severe, debilitating and potentially life threatening illness that is difficult to treat. A cardinal symptom of AN is the mistaken belief on the part of the individuals that they are overweight and must…
- Trial name
- NCT07143981
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Femoral Fracture
The Role of Fat Emboli in the Trauma Inflammatory Response
This is an observational study designed to investigate the role of fat emboli in patients who are undergoing a tibial or femoral fracture procedure in the operating room.
- Trial name
- NCT02069327
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Poudre Valley Health System
Growth Failure, Adiposity
Optimal Growth of Preterm Infants With Growth Restriction
In this prospective randomized controlled multi center trial the investigators stratify "Very Low Birthweight " (VLBW)-infants with growth retardation in small for gestational age (SGA) or intrauterine growth restricted (IUGR) …
- Conditions
- Growth Failure, Adiposity, Diabetes, Neurologic Deficits
- Trial name
- OPTIGROW (NCT02999945)
- Testing
- SGA-enhanced nutrients, IUGR-enhanced nutrients, SGA-standard nutrients
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna