Clinical trials: Microbiology
Cystic Fibrosis
Antimicrobial Resistance in Cystic Fibrosis (CF)
People with cystic fibrosis (CF) often develop chronic pulmonary infections which are caused by a variety of organisms, the most predominant being Pseudomonas aeruginosa. Antibiotics are important in managing CF lung infections.
- Trial name
- NCT00360503
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- Seattle Children's Hospital
Dental Caries
Phase 2 Study to Evaluate the Microbiology and Safety of C16G2 Administered to Adult and Adolescent Dental Subjects
The purpose of this study is to evaluate if C16G2 Gel administered over a certain period of time either with a toothbrush or a custom dental tray can effectively kill bacteria in the mouth that cause dental cavities.
- Trial name
- NCT02594254
- Testing
- C16G2 Gel
- Where
- 10 sites in United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Armata Pharmaceuticals, Inc.
Nervous System Lyme Borreliosis
Study on Early Lyme Neuroborreliosis
The purpose of this study is to determine clinical course and the sequelae of early Lyme neuroborreliosis after treatment with ceftriaxone.
- Trial name
- NCT00910533
- Testing
- ceftriaxone
- Where
- Slovenia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Malaria, Pneumocystis, Leishmania
Introduction of Polymerase Chain Reaction (PCR) in Microbiology and Parasitology
The goal is to develop molecular systems to support or replace in microscopic characterization and in vitro tests with molecular biology systems capable of improving performance in parasitology tests.
- Trial name
- NCT07269314
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Treatment, Periodontitis, Apical
Treatment of Young Permanent Teeth With Different Adjuvant Approaches
To determine microbiology assessment of infected root canal in young permanent teeth, as well as antimicrobial efficiency of different adjuvant treatment modalities including photodynamic therapy (PDT), high-power diode laser…
- Conditions
- Treatment, Periodontitis, Apical, Necrotic Pulp
- Trial name
- NCT05291195
- Testing
- Laser-device group, Essential Oil, Sodium hypochlorite group
- Where
- Serbia
- Volunteers
- 40 people
- Sponsor
- University of Belgrade
Acute Tonsillitis, Peritonsillar Cellulitis
Microbiology of Severe Acute Tonsillitis, Peritonsillar Cellulitis, and Infectious Mononucleosis
Prospective, observational study of the microbiology of patients referred to a tertiary care center with severe acute tonsillitis, peritonsillar cellulitis, or infectious mononucleosis.
- Conditions
- Acute Tonsillitis, Peritonsillar Cellulitis, Infectious Mononucleosis
- Trial name
- NCT02715037
- Testing
- Throat swabbing
- Where
- Denmark
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Tejs Ehlers Klug
Topical Fluoride, Orthodontic Patients
Effects of Topical Fluoride in Orthodontic Patients
This study was born from the need to improve caries prevention in orthodontic patients, a group particularly at risk. Fixed orthodontic appliances make daily oral hygiene more difficult, leading to increased plaque accumulation…
- Conditions
- Topical Fluoride, Orthodontic Patients, Antimicrobial Effect, Clinical Effect
- Trial name
- NCT07091890
- Testing
- Fluoride gel, Fluoride varnish
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Pulp Necroses, Tooth, Nonvital
Microbiological Evaluation of Single Versus Multiple Visits Regeneration Using MALDI-TOF Mass Spectrometry
Aim of the study is to assess canal disinfection using matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) in single visit and multiple visit regeneration protocols, and to assess clinical…
- Trial name
- NCT04533074
- Testing
- Single-visit regeneration protocol, Multiple-visits regeneration protocol
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Nourhan M.Aly
Microbiology, Blood Culture
Optimisation of the Blood Culture Pathway Utilising Behaviour Change
Blood culture (BC) is the gold standard for the definitive diagnosis of bacteraemia, providing the opportunity to recover and identify the causative organism, and optimize subsequent antimicrobial treatment.
- Trial name
- NCT07392684
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Gloucestershire Hospitals NHS Foundation Trust
Orthodontic Treatment
Flash-free Brackets and Dental Plaque
This study aimed to compare flash-free bracket system with conventional adhesive-coated bracket system in patients with maxillary crowding.
- Trial name
- NCT03187483
- Testing
- orthodontic treatment
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ege University
Sepsis
Evaluation of the Performance of the IDBIORIV Method in Pathogen Identification and Antibiotic Susceptibility Testing in Patients With Sepsis
Sepsis is a disruption of homeostasis in the human body in response to bloodstream infection and is associated with a high risk of mortality.
- Trial name
- IDBIORIV (NCT06219135)
- Testing
- no intervention - Contamination group, blood sample - Bacteraemia group, no intervention - Emergency group
- Where
- 23 sites in France
- Volunteers
- 1,372 people
- Sponsor
- Hospices Civils de Lyon
Inflammation
Effect of Probiotic Supplementation on Immune Function in Healthy Infants
The purpose of this study is to understand how a probiotic might change the immune response of healthy infants.
- Trial name
- ProBoost (NCT01542320)
- Testing
- Lactobacillus reuteri DSM 17938
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Emory University
Otitis Media in Children
Microbiology of Otitis Media in Costarrican Children After PCV13 Introduction
Studies which describe the bacterial aetiology and antimicrobial susceptibility in AOM children in Latin America are scarce. Interestingly, when the MEF microbiology was analyzed among 1,108 children aged 2-92 months with OM…
- Trial name
- Microbiology (NCT02096848)
- Where
- Costa Rica
- Volunteers
- 387 people
- Sponsor
- Instituto de Atención Pediátrica
Nosocomial Infection, Infection Control
Can Environmental Cleanliness be Assessed by BCA (Bicinchoninic Acid) Method
Effective cleaning of surfaces in the hospital environment is an absolute necessity to reduce pathogen transmission. Multi Drug Resistant Organisms (MDRO) in ICU are among the leading causes of hospital-acquired infections.
- Conditions
- Nosocomial Infection, Infection Control, Multi-antibiotic Resistance
- Trial name
- BCA (NCT04212130)
- Testing
- BCA method for assessing environmental cleanliness
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Cumhuriyet University
Bacterial Infections
Evaluation of a mNGS Workflow for Infection Diagnosis Using Oxford Nanopore Sequencing.
This is a laboratory evaluation of a new testing methodology for microbiological diagnosis, whereby participant samples received as part of routine care will be divided between the standard diagnostic pathway and this new…
- Trial name
- NCT04864873
- Testing
- Metagenomic next generation sequencing using Oxford Nanopore, Standard microbiological diagnostic pathway
- Where
- New Zealand
- Volunteers
- 400 people
- Sponsor
- Capital and Coast District Health board
Malocclusion, Orthodontic Appliance Complication
Microbiological and Epithelial Evaluation Related to the Use of Orthodontic Thermoplastic Device
Thermoplastic devices are used in orthodontic treatment and consists of a series of nearly invisible, removable aligners. However, every device used in the mouth can change the buccal flora and increase the number of bacterias.
- Trial name
- NCT02427763
- Testing
- hours of use (Essix), collect saliva, collect biofilm
- Where
- Brazil
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Universidade Positivo
Keratitis
Microbiological Keratitis in a Countryside City of Brazil
The purpose of this study is to identify the predisposing factors, epidemiological features and clinical and microbiological diagnosis of infectious keratitis in two public referral centers of ophthalmology in a countryside city…
- Trial name
- NCT00949468
- Where
- Brazil
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Sao Jose do Rio Preto Medical School
Dental Caries
A Study to Evaluate the Safety and Microbiology of C16G2 Varnish Administered in Multiple Doses to Dental Subjects
The purpose of this single-blind study is to evaluate whether C16G2 Varnish administered in multiple doses can effectively kill the bacteria in the oral cavity that cause dental caries.
- Trial name
- NCT03004365
- Testing
- C16G2 Varnish
- Where
- 3 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Armata Pharmaceuticals, Inc.
Peri-implant Crevicular Fluid
An Exploratory Clinical Investigation Evaluating Two Abutment Surfaces
A total of 22 subjects will be included in the study. The subjects who were treated with NobelActive TiUnite and On1 machined abutment will be enrolled in the control group and subjects who were treated with NobelActive TiUltra…
- Trial name
- Exploratory (NCT06557447)
- Testing
- Immunological and microbiological sample of peri-implant crevicular fluid; clinical evaluation
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Studio Ban Mancini Fabbri
Dental Pulp Necrosis
Efficacy of Chlorexidine as Intracanal Medicament in Primary Teeth
The purpose of this study is to evaluate the action of the chlorexidine as intracanal medicament in the reduction of the levels of bacteria inside root canals of primary molar teeth with pulpal necrosis.
- Trial name
- NCT00624572
- Testing
- chlorexidine
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Federal do Ceara