Clinical trials: Microbiota
Bacteria, Microbiota
Standardized Fecal Microbiota Transplantation for Ulcerative Colitis
The gut microbiota is considered to constitute a "microbial organ" which has pivotal roles in the intestinal diseases and body's metabolism.
- Conditions
- Bacteria, Microbiota, Fecal Microbiota Transplantation, Inflammatory Bowel Disease
- Trial name
- NCT01790061
- Testing
- Standardized FMT, Traditional treatments
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Vitamin B 12 Deficiency
The Impact of Vitamin B12 Deficiency on Infant Gut Microbiota
Vitamin B12 plays important roles in DNA synthesis and neurological functions. Vitamin B12 deficiency is one of the most common micronutrient deficiencies and it has become increasingly more frequent in infants.
- Trial name
- NCT03365583
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Marmara University
Crohn Disease, Ulcerative Colitis
Safety and Efficacy of Fecal Microbiota Transplantation
The gut microbiota is critical to health and functions with a level of complexity comparable to that of an organ system. Dysbiosis, or alterations of this gut microbiota ecology, have been implicated in a number of disease…
- Conditions
- Crohn Disease, Ulcerative Colitis, Celiac Disease, Irritable Bowel Syndrome
- Trial name
- NCT04014413
- Testing
- Fecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 450 people
- Sponsor
- Chinese University of Hong Kong
Healthy
Intestinal Microbiota: Immunity, Recovery and Metabolic Health
The aim of this intervention study is to investigate the effect of a specific postbiotic (Lacticaseibacillus rhamnosus GG = LGG) and whey protein on immunity, recovery, and weight management in young adults.
- Trial name
- VAR-MIKRO (NCT06355089)
- Testing
- Whey protein hydrolysate milk product, Postbiotic and whey protein hydrolysate milk product
- Where
- Finland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Turku
Healthy
Immune Health Biomarkers and Fecal Microbiota in Filipino Breastfed Infants
This will be a prospective observational study aiming to investigate immune health biomarkers and fecal microbiota in 48-60 Filipino breastfed infants from birth to 12 months of age.
- Trial name
- NCT06708559
- Testing
- Breast-fed infants
- Where
- Philippines
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
ADHD, Probiotics
Effect of Probiotics on ADHD
Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder. Gut microbiome dysbiosis may be associated with the pathophysiology of ADHD.
- Conditions
- ADHD, Probiotics, Gut Microbiota, Psychiatry
- Trial name
- NCT04958460
- Testing
- BF688
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Wang Liang-Jen
Stress Physiology
Prebiotic and Probiotic Modulation of the Gut Microbiota-gut-brain Axis During Acute Stress
Emerging evidence supports the existence of a microbiota-gut-brain axis through which gut microbes influence cognition, mood and behavior.
- Trial name
- NCT05392556
- Testing
- Probiotic, Prebiotic
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Severe Acute Malnutrition
Ready to Use Therapeutic Food (RUTF) in Severe Malnourished Children
1. RUTF would be more effective (quicker catch-up growth by promoting more tissue accrue resulting decrease stay in rehabilitation ward) in treating children with SAM during the rehabilitation phase than khichuri /halwa; 2.
- Trial name
- RUTF (NCT01331044)
- Testing
- Plumpy Nut, Khichuri and Halwa
- Where
- Bangladesh
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Healthy Children
Study to Evaluate the Effects of a Formula on the Gut Health of Healthy Chinese Infants and Young Children
The infant gut microbiota, a major driver of the maturation of the immune system, is formed through the successive establishment and development during infancy and early childhood.
- Trial name
- NCT04864665
- Testing
- a formula with prebiotics and milk fat
- Where
- 6 sites in China
- Volunteers
- 455 people, healthy volunteers welcome
- Sponsor
- Danone Nutricia
Obesity, Growth
Essential Fatty Acids During Complementary Feeding
The objective of this intervention study is to examine the effect of n-3 LCPUFA on growth and body composition, intestinal health and microbiotic composition, immune function and risk markers for later diseases in 9-18 months old…
- Conditions
- Obesity, Growth, Metabolic Syndrome, Cardiovascular Disease
- Trial name
- EFiON (NCT00631046)
- Testing
- Fish Oil, Sunflower Oil
- Where
- Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Autism Spectrum Disorder
Effect of a Casein and Gluten Free Diet in Mexican Children With Autism Spectrum Disorder
Assess the effect of a casein-free and gluten-free diet on gastrointestinal symptoms, clinical variables, and the composition of the intestinal microbiota in Mexican children with autism spectrum disorder.
- Trial name
- NCT06556290
- Testing
- Gluten free and casein free diet
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- University of Guadalajara
Juvenile Idiopathic Arthritis
Probiotic Treatment in Juvenile Idiopathic Arthritis (JIA)
This study investigates the efficacy of probiotic VSL#3 as an add on standard care on the activity of the disease in patients with Juvenile Idiopathic Arthritis.
- Trial name
- PERMAJI (NCT03092427)
- Testing
- VSL#3
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pesticide, Breast Milk
Impact of Exposure to Persistent Organic Pollutants During Pregnancy on the Composition of Breast Milk and Consequences on the Newborn
Epidemiological studies link early exposure to persistent organic pollutants (POPs) with health consequences in the newborn. Experimental studies have shown the impact of POPs on the gut microbiota.
- Conditions
- Pesticide, Breast Milk, Pollution; Exposure, Meconium
- Trial name
- PESTIMICOBLAIT (NCT03969459)
- Testing
- breast milk collection, meconium collection, newborn feces collection
- Where
- France
- Volunteers
- 88 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Children With Allergic Rhinitis
Effectiveness of Probiotics in Relieving Allergic Rhinitis in Children
To evaluate the clinical efficacy of probiotic gummies in the trial of allergic rhinitis in children compared to placebo, as well as the modulating effect on gut microbiota, serum metabolic profile, and occurrence of adverse…
- Trial name
- NCT06676111
- Testing
- Probiotic
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Wecare Probiotics Co., Ltd.
Inflammatory Bowel Disease (IBD)
Omics-driven Research on the Gut-Oral Microbiome, Metabolome, Lifestyle, and Clinical Integration in Korean Inflammatory Bowel Disease
The inflammatory bowel disease (IBD) is a condition that afflects approximately 5 million people worldwide, with 1.4 million in the US and 2.2 million in Europe.
- Trial name
- ORIGIN (NCT06124833)
- Where
- South Korea
- Volunteers
- 900 people
- Sponsor
- Chang Kyun Lee
Adhd, ALS
National Multicenter Interventional Study Aimed at Evaluating the Effect on the Intestinal Microbiota in Chronically Frail Patients Who Share Alterations in Intestinal Function.
The objective of the study will be to understand whether a supplementation of the diet with an active symbiotic, i.e. characterized by a mix of probiotics and a specially selected fiber with prebiotic activity combined with a…
- Conditions
- Adhd, ALS, Bronchial Asthma
- Trial name
- sPATIALS3 (NCT06005506)
- Testing
- Prebiotic fiber, Dietary fiber, Probiotic
- Where
- 4 sites in Italy
- Volunteers
- 64 people
- Sponsor
- Institute of Biomedical Technologies-National Research Council, Italy
Bone Density, Gut Microbiomes
Linking Dietary Nutrition, Dietary Patterns, Gut Microbiota, and Bone Density: A Cross-Sectional Study
The study aims to understand the current situation of bone health in the Gannan Tibetan primary school student population, to explore the relationship between nutrition, intestinal microorganisms and bone health, to analyze the…
- Trial name
- NCT07256314
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- Jianhua Ma
Autism Spectrum Disorder
Effect of Probiotic Compound K11T e K11TMax in ASD
The research is characterized as a randomized, double-blind clinical trial (phase III) in which administered the probiotic K11-T (with and without added amino acids, fatty acids and vitamins) to children between 3 and 11 years…
- Trial name
- ASD (NCT06382909)
- Testing
- Inflammatory level, Cognitive assessment, Pedagogical assessment
- Where
- 2 sites in Brazil
- Volunteers
- 505 people
- Sponsor
- Deivis de Oliveira guimaraes
Inflammatory Bowel Diseases, Ulcerative Colitis
Fecal Microbiota Transplant (FMT) in Pediatric Active Ulcerative Colitis and Pediatric Active Crohn's Colitis
The primary aims of this phase I/II, randomized, placebo controlled study are the assessment of safety and tolerability of universal donor FMT compared to placebo in pediatric and young adult subjects (ages 5 years through 30…
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT02330653
- Testing
- Fecal Microbiota Transplant (FMT)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stacy A. Kahn
Miscarriage, Parodontitis
PERIodontal Disease, Microbiota and Miscarriage
Cross-sectional non-interventional observational pilot study recruiting women whom had repeated miscarriages (= at least 3 miscarriages).The information will be collected during a routine maintenance, complete oral clinical and…
- Trial name
- PERI2M (NCT06576622)
- Testing
- biological sampling
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse