Clinical trials: Microbiota
Liver Cancer
a Cohort Study (Gut Microbiota and HCC)
To analyze the predictive role of intestinal microbiota in tyrosine kinase inhibitors (TKIs) combined with immunotherapy response in patients with intermediate and advanced liver cancer.
- Trial name
- NCT06557213
- Volunteers
- 100 people
- Sponsor
- Xu Yong, MD
Frail Elderly, Clostridioides Difficile
Clostridioides Difficile and Frailty
CDI is a major cause of antibiotics-associated diarrhoea. More than half of the patients affected are 70 years or older and frail. Mortality among older patients with CDI is high.
- Conditions
- Frail Elderly, Clostridioides Difficile, Geriatric Assessment, Faecal Microbiota Transplantation
- Trial name
- CLODIFRAIL (NCT05447533)
- Testing
- Comprehensive geriatric assessment (CGA), Continued geriatric care, Faecal microbiota transplantation (FMT)
- Where
- Denmark
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
CKD
Study of Oral Uremic Toxin Absorbent and Probiotics to Retard the Progression of Chronic Kidney Disease
In patients with chronic kidney disease (CKD), uremic toxins accumulate when kidney function declines. Those uremic toxins had a greater affinity to circulating proteins are called "protein bound uremic toxins, PBUT." Apart from…
- Trial name
- NCT04819217
- Testing
- Active bamboo charcoal, Probiotics
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- National Taiwan University Hospital
Ascitic Fluid, Microbiota, Microbiota
Ascitic Fluid Microbiome in Liver Cirrhosis
Ascitic fluid microbiome is going to be investigated in this study by using internal transcripted spacer (ITS) and 16S ribosomal RNA (rRNA) polymerase chain reaction (PCR) and sequencing as conventional culture methods are…
- Conditions
- Ascitic Fluid, Microbiota, Microbiota, Sequence Analysis, Polymerase Chain Reaction
- Trial name
- NCT02813590
- Testing
- Ascitic fluid puncture, Skin swaps from puncture side, Stool samples
- Where
- Austria
- Sponsor
- Medical University of Graz
Bone Density, Gut Microbiomes
Linking Dietary Nutrition, Dietary Patterns, Gut Microbiota, and Bone Density: A Cross-Sectional Study
The study aims to understand the current situation of bone health in the Gannan Tibetan primary school student population, to explore the relationship between nutrition, intestinal microorganisms and bone health, to analyze the…
- Trial name
- NCT07256314
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- Jianhua Ma
CKD, PAD
lncRNAs as a Biomarker to Assess the Therapeutic Impact of Oral Absorbent ± Probiotics in CKD Patients With PAD
Participants with chronic kidney disease (CKD) are at a higher risk of developing atherosclerotic peripheral artery disease (PAD).
- Trial name
- NCT04788914
- Testing
- Active bamboo charcoal± probiotics
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- National Taiwan University Hospital
Allergic Rhinitis
Traditional Chinese Medicine for the Treatment of Perennial Allergic Rhinitis on Gut Microbiota and Immune-modulation
40 allergic rhinitis patients in the acute phase will be enrolled in the study. All the allergic patients should be confirmed those who are over 20 years old and hypersensitive to house dust mite allergens confirmed by MAST test…
- Trial name
- NCT04388358
- Testing
- Shin-yi-san + Xiao-qing-long-tang + Xiang-sha-liu-jun-zi-tang by the weight of 9g+3g+3g/day
- Where
- Taiwan
- Volunteers
- 33 people
- Sponsor
- Chang Gung Memorial Hospital
Fibromyalgia, Fibromyalgia Syndrome
PRL2019 in the Treatment of Juvenile Fibromyalgia
Juvenile Fibromyalgia Syndrome (JFS) is a chronic condition affecting children and adolescents, characterised by widespread musculoskeletal pain and a significant impact on daily life and quality of life.
- Trial name
- IGG-microbiota (NCT07738926)
- Testing
- Bifidobacterium adolescentis PRL2019
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Giannina Gaslini
Healthy Diet, Microbiota
The Link Between Diets and Health Indicators
The cohort study investigates the effect of different dietary intake among omnivorous, vegan, vegetarian and low-carb diets on health parameters and on long-term overall health.
- Trial name
- DIETE (NCT04347213)
- Testing
- Regular lifestyle in different circumstances
- Where
- Slovenia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Chronic Periodontitis, Type 2 Diabetes Mellitus
Chronic Periodontitis Microbiota in Type 2 Diabetes Mellitus Patients
This study is a retrospective comparative evaluation of six main periodontal pathogens and total bacterial load in chronic periodontitis patients affected or not by type 2 diabetes mellitus by polymerase chain reaction analysis.
- Trial name
- NCT03786133
- Testing
- Analysis of microbiological tests
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Bologna
Hidradenitis Suppurativa (HS), Fecal Microbiota Transplantation (FMT)
FEcal tranSplantation in HidradeniTIs suppuratiVA : a piLot Study
The medical and surgical treatment of hidradenitis suppurativa (HS) remains difficult to date. The search for new therapies for HS is a major challenge.
- Trial name
- FESTIVAL (NCT07668713)
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- 7 sites in France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Clermont-Ferrand
Sepsis, Nutrition
Personalized Nutritional Formula for ICU Patients: A Study on Prognosis and Multidimensional Health Markers
This study aims to evaluate the effects of an individualized enteral nutrition formula on clinical outcomes in critically ill adult patients in the intensive care unit (ICU).
- Conditions
- Sepsis, Nutrition, Gut -Microbiota
- Trial name
- NCT07755033
- Testing
- Individualized Enteral Nutrition Formula, Standard Enteral Nutrition Formula
- Volunteers
- 1,200 people
- Sponsor
- Chinese Medical Association
Crohn Disease
Mother-to-Infant Transfer of Bacteriome, Fungome, Virome, and Metabolome in Health and Crohn's Disease
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are caused by the loss of mucosal tolerance towards the commensal microbiota resulting in inflammatory responses.
- Trial name
- NCT05112497
- Testing
- No intervention procedure
- Where
- Hong Kong
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Papillomavirus Infections
Diversity Analysis of Vaginal Microbiota on Women With High-risk Human Papillomavirus Infection
Since other genital infections enhance HIV susceptibility by inducing inflammation, the investigators study the relationship between the vaginal microbiota composition and the risk of HPV infection, cervical cytological…
- Trial name
- NCT03548740
- Testing
- Human Papillomavirus
- Where
- China
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Parkinson Disease
A Trial of Fecal Microbiome Transplantation in Parkinson's Disease Patients
48 PD patients (age 35-75y; H\&Y 1-3) testing positive in a stool PD-dysbiosis test will be randomized in a 2:1 ratio to receive either donor FMT or their own stool through intracaecal infusion.
- Trial name
- NCT04854291
- Testing
- Administration of donor FMT
- Where
- 4 sites in Finland
- Volunteers
- 51 people
- Sponsor
- Helsinki University Central Hospital
Inflammatory Bowel Disease, Rheumatoid Arthritis
A Trial to Determine the Effects of Exercise in Inflammatory Bowel Disease and Rheumatoid Arthritis
The purpose of this study is too determine the effects of exercise on the gut microbiota and immunological markers in patients with inflammatory bowel disease and rheumatoid arthritis.
- Trial name
- ExMET-IBD (NCT02463916)
- Testing
- Exercise
- Where
- Ireland
- Volunteers
- 60 people
- Sponsor
- University College Cork
Leishmaniasis, Cutaneous
Antimicrobial Adjuvants to Revert the Imbalance of Skin Microbiota for Improved Outcomes of Complicated Cutaneous Leishmaniasis Treatment in Ethiopia
This clinical trial aims to evaluate the effectiveness of combining the standard treatment for complicated cutaneous leishmaniasis (CL), sodium stibogluconate (SSG), with either topical fusidic acid 2% cream or a vehicle cream…
- Trial name
- AIM-CL (NCT06695143)
- Testing
- Fusidic Acid, Vehicle cream
- Where
- 2 sites in Ethiopia
- Volunteers
- 180 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Severe Acute Malnutrition
Rice Bran-based Supplemental Foods for the Treatment of Childhood Malnutrition
The purpose of this study is to assess the efficacy of treating children with severe acute malnutrition (SAM) with a locally produced ready-to-use therapeutic food (RUTF) with or without rice bran.
- Trial name
- NCT05319717
- Testing
- Ready-to-use therapeutic food with heat stabilized rice bran, Ready-to-use therapeutic food (no rice bran)
- Where
- Indonesia
- Volunteers
- 200 people
- Sponsor
- Colorado State University
Exposures Associated With Pregnancy, Delivery and Lactation
Impact of Perinatal Exposure to Non-caloric Sweeteners on Food Preferences and Weight Gain in the First Year of Life
During last years, non-caloric sweeteners (NCSs) have been increasingly incorporated into foodstuffs in replacement of sucrose in Chile.
- Trial name
- NCT03972176
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- University of Chile
Infertility Unexplained
Modulation of Reproductive Microbiota by Ligilactobacillus Salivarius CECT5713
The objective of the project is to elucidate if the oral administration of Ligilactobacillus salivarius CECT5713 is capable of improving the rates of term pregnancies in couples with infertility problems of unknown cause.
- Trial name
- NCT06290518
- Testing
- Ligilactobacillus salivarius CECT5713
- Where
- 3 sites in Spain
- Volunteers
- 72 people
- Sponsor
- Biosearch S.A.
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