Clinical trials: Microbiota
Skin Microbiota
Comparison of the Permanent Skin Flora of Children Who Had Bathing With Two Different Products
This study was carried out as a randomized controlled experimental study to compare the effect of wiping bath with 2% daily chlorhexidine gluconate and soap-free body wash on the permanent skin flora of children hospitalized in…
- Trial name
- NCT04845672
- Testing
- 2% chlorhexidine gluconate, soap-free body cleaning solution
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Marmara University
Autism Spectrum Disorder
Application of Fecal Microbiota Transplantation in Children With ASD
Autism Spectrum Disorder (ASD) is a group of serious neurodevelopmental disorders. Intestinal microbial disturbance is common in children with ASD, and about 40% of ASD children suffer from gastrointestinal dysfunction.
- Trial name
- NCT04948814
- Testing
- Fecal microbiota transplantation, Vancomycin
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Allergic Diseases
Oral Probiotics to Allergic Pregnant Mother and Their Offspring to Prevent Allergic Disease
The aim of the study is first to detect the difference of the intestinal microbiome between allergic pregnant mother and the non-allergic pregnant mother using the next generation sequence, all postnatal infants will collect the…
- Trial name
- NCT03873792
- Testing
- Physician diagnoses a history of asthma or eczema or allergic rhinitis or health pregnant women
- Where
- Taiwan
- Volunteers
- healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Juvenile Idiopathic Arthritis
Oral Health, Saliva Bacteria, and Disease Activity in Children With JIA: A Cross-Sectional Study.
The goal of this observational study is to learn about the relationship between disease activity and oral health status in children with juvenile idiopathic arthritis (JIA).
- Trial name
- JIA (NCT07799831)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Clostridium Difficile Infection
Fecal Microbiota Transplant (FMT) for Relapsing C. Difficile Infection in Adults and Children Using a Frozen Inoculum
Fecal microbiota transplantation (FMT) is the reconstitution of normal flora by a "stool transplant" from a healthy individual to a C.
- Trial name
- NCT01704937
- Testing
- Fecal Microbiota Transplant (FMT)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Pre Proof of Concept Clinical Trial
'Pre-Proof of Concept (Pre-POC)' Clinical Trials to Optimize Lead Microbiota-directed Complementary Food (MDCF) Prototypes for Their Ability to Repair Microbiota Immaturity and Establish Their Organoleptic Acceptability
Burden: According to Bangladesh Demographic Health Survey 2014, prevalence of stunting in under-five children is 36%. Severe acute malnutrition (SAM) is prevalent in about 3% of them.
- Trial name
- MDCF (NCT03084731)
- Testing
- Microbiota Directed Complementary Food (MDCF)
- Where
- Bangladesh
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Healthy
Differences Between Breastfed and Formula Fed Infants
This study will help us learn how a child's diet affects growth and development.
- Trial name
- NCT03493711
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Obesity
Effects of VSL#3 on Metabolic, Endocrine, Lipidomic and Inflammatory Parameters of Pediatric Patients With BMI>90°
Obesity in children has become a significant social problem considering that nowadays 4 to 5 % of all children are obese in the industrialized countries with increased incidence in Europe by 10 to 50% over the past 10 years.
- Trial name
- VAIIO (NCT01650025)
- Testing
- VSL#3 active probiotic
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Graft vs Host Disease
Fecal Microbiota Transplantation for Steroid-Refractory Acute GI GVHD
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for various hematologic diseases. However, one of the major challenges of allo-HSCT is the occurrence of graft-versus-host disease (GvHD)…
- Trial name
- NCT07364617
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- Chang Gung Memorial Hospital
Preterms With Gestational Age Ranging From 30 to 35 Weeks
Evaluation of Safety, Tolerance and Effects on the Intestinal Flora of a New Fermented Milk for Preterm Infants
The intestinal flora is a complex ecosystem which is known to play various important functions in the gut. Recent data have reported a delay in intestinal colonization in preterm.
- Trial name
- NCT00711633
- Testing
- Milk with probiotic and prebiotic activities, Milk without probiotic and prebiotic activities
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Recurrent Pregnancy Loss(RPL)
Genomics and Microbiome Investigation in Cases of Recurrent Pregnancy Losses
Recurrent pregnancy losses (RPL) are characterized by the occurrence of more than one spontaneous pregnancy loss. It is caused by different known factors, but about half of the cases remain without an explanation.
- Trial name
- NCT06604338
- Testing
- Exome test, Microbiota analysis
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Brain Tumor, Microbiota
MICRO-BRAIN 2024: Study on Pediatric Brain Tumors
In recent years, there has been growing interest in the human gut microbiota, whose health is characterised by high microbial diversity.
- Trial name
- NCT07417085
- Testing
- Biological samples, Fecal samples
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Meyer Children's Hospital IRCCS
Inflammatory Bowel Diseases
Efficacy and Mechanism of Fecal Microbiota Transplantation of the Bai Ethnicity in the Treatment of UC
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), affects over 2 million people worldwide .
- Trial name
- NCT06591013
- Testing
- Fecal microbiota transplantation
- Where
- China
- Volunteers
- 102 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Disease
Quantification of Microbiota in Health and Diseases
Microbiota consists of trillions of microorganisms located in all the biological cavity. The relationships between individual health status and microbiota are based on a sort of "mutual cooperation." The balance of the microbiota…
- Trial name
- qMHD (NCT03388424)
- Testing
- quantification of microbiota
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Autism Spectrum Disorder
Intestinal Dysbiosis and BBB Integrity in Autism
Autism Spectrum Disorder (ASD) is characterised by an impairment of social interactions and communication, associated with repetitive behaviour and restrictive interests.
- Trial name
- LEDA (NCT04321915)
- Testing
- Analysis of intestinal microbiota in autism spectrum desorder, Analysis of neuroinflammation markers in autism spectrum desorder
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Inflammatory Bowel Disease, Crohn's Disease
The Role of Gut Microbiome in Predicting Comorbidities and Complications in Children With Inflammatory Bowel Disease
Background: Bacteria and other microorganisms that live in the intestines (the gut microbiome) play an important role in a person s health. The gut microbiome helps to regulate the immune system and control inflammation.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT05652491
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Microbiota, Gut Microbiome
Flourish: Exploring the Early Infant Gut Microbiome
The goal of this clinical trial is to learn whether microbiome analysis, education, and personalized recommendations can improve gut health and reduce early markers of immune-related conditions in infants aged 0-3 months…
- Conditions
- Microbiota, Gut Microbiome, Eczema, Microbiome
- Trial name
- NCT07333482
- Testing
- Tailored Recommendations, Consult Call, Educational Email Series
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Seeding Inc
Iron Absorption, Gut Microbiota
Iron Absorption From a Wheat-based Instant Cereal:Gut and Stable Isotope Studies in Kenyan Infants
The aim of this study is to measure the effect of a prebiotic (high dose/low dose) mixture at different doses within a wheat-based instant cereal, on fractional iron absorption (FIA), gut microbiota and inflammation after three…
- Trial name
- NCT03894358
- Testing
- FeFum and 7.5 g prebiotic mixture, FeFum and 3 g prebiotic mixture, Fefum and no prebiotic mixture
- Where
- Kenya
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Autism Spectrum Disorder
Randomized Double-blind Clinical Trial With L.Reuteri Supplementation in Children With Autism Spectrum Disorder
The aim of this study is to assess the effects of a 6-months probiotic supplementation on behavioral profiles, microbiota and metabolic profiles, inflammatory biomarkers, gastrointestinal disturbances, in children with Autism…
- Trial name
- NCT04293783
- Testing
- L.Reuteri
- Where
- 2 sites in Italy
- Volunteers
- 43 people
- Sponsor
- University of Rome Tor Vergata
Fecal Microbiota Transplantation in GVHD
Fecal Microbiota Transplantation for Treatment of Refractory Graft Versus Host Disease-a Pilot Study
The study evaluates safety and efficacy of fecal microbiota transplantation (FMT) for the treatment of refractory graft-versus-host-disease (GVHD) of the gut.
- Trial name
- NCT03549676
- Testing
- Fecal Microbiota Transplantation
- Volunteers
- 15 people
- Sponsor
- Shanghai Children's Medical Center