Clinical trials: Midazolam Premedication
Preoperative Sedation
Nebulized vs. Oral Midazolam Sedation in Pediatric Anesthesia: A Randomized Comparative Study
This study is to be carried out to compare nebulized and oral midazolam in achievement of a satisfactory level of sedation, Ramsey Sedation Score (RSS) of 4, within 30 mins of midazolam administration in pediatrics.
- Trial name
- NCT04760041
- Testing
- Midazolam nebulized, Midazolam oral solution
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cairo University
Deep Sedation, Dexmedetomidine
Intranasal Dexmedetomidine for Deep-sedated Pediatric Dental Patients
It is important to choose an appropriate analgesia/sedation technique in pediatric dental treatment. Premedication combined with intravenous anesthesia is often used in deep sedation technique for pediatric dental treatment and…
- Trial name
- NCT04509414
- Testing
- Dexmedetomidine, Midazolam
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University
Pre Operative Sedation, Mask Acceptance
Effect of Dexmedetomidine Versus Midazolam Versus a Combination of the Two as a Premedication for Children Undergoing Bilateral Myringotomy Tube Insertion
Following an obtained written consent, a child presenting for ear tube surgery will be randomized into one of three groups for receiving a premedication.
- Conditions
- Pre Operative Sedation, Mask Acceptance, Post Operative Delerium
- Trial name
- NCT02134327
- Testing
- Combination of Dexmedetomidine with Midazolam
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Pediatric Anesthesia, Preoperative Anxiety
Intranasal Dexmedetomidine vs Oral Midazolam for Premedication in Pediatric Surgery
This study aims to compare the effects of intranasal dexmedetomidine and oral midazolam as premedication in pediatric patients undergoing elective inguinal and urological surgery under general anesthesia.
- Conditions
- Pediatric Anesthesia, Preoperative Anxiety, Emergence Agitation
- Trial name
- NCT07565116
- Testing
- Dexmedetomidine, Midazolam
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Anxiety State, Perioperative/Postoperative Complications
a Phase III Trial of Safety and Efficacy of Premedication With Dexmedetomidine and Midazolam in Pediatric Patients
This research study to evaluate the relative efficacy of Dexmedetomidine, Midazolam, and compare them to the current KFSH\&RC standard of care. Compare the safety and the frequency of adverse effects of treatment arms.
- Trial name
- NCT04356638
- Testing
- Midazolam, Dexmedetomidine
- Where
- Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Emergence Delirium
Intranasal Dexmedetomidine Versus Intranasal Midazolam for Emergence Delirium Prevention
This study is a double-blind clinical trial, in pediatric patients aged 1-12 years with physical status ASA (American Society of Anesthesiology) 1 and 2 who underwent eye surgery under general anesthesia using Sevoflurane…
- Trial name
- NCT04263844
- Testing
- Intranasal dexmedetomidine, Intranasal Midazolam
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Universitas Indonesia
Anxiety
Effect of Midazolam as Premedication in Patients Undergoing Breast Conservation Study
Patient are randomized into 2 groups under computer registered numbers. Patient anxiety score is calculated through APAIS SCORE.
- Trial name
- NCT07184125
- Testing
- To measure anxiolysis, satisfaction level of patient after receiving Midazolam
- Where
- Pakistan
- Volunteers
- 124 people
- Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
Midazolam
Pharmacokinetic Evaluation of MDZ028
Plasma concentration data were collected from 37 paedriatic patients and 12 healthy adults recruited in a single dose, open-label phase II pharmacokinetic study and in a single dose, randomised, open-label two-peiod crossover…
- Trial name
- MIDAZOLAM (NCT03639428)
- Testing
- Midazolam
- Volunteers
- 37 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Strabismus, Reflex, Oculocardiac
Hydroxyzine Dihydrochloride Premedication is a Necessity for Strabismus Surgery
Oculocardiac reflex (OCR) is usually happening in pediatric strabismus surgery and observed just when the surgent pulls the ocular muscles.
- Conditions
- Strabismus, Reflex, Oculocardiac, Hydroxyzine, Bradycardia Sinus
- Trial name
- NCT03806270
- Testing
- Midazolam, Hydroxyzine Dihydrochloride
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Yeditepe University
Emergence Agitation
Sevoflurane Induced Emergence Agitation
Investigators evaluated the effect of intranasal ketamine or alfentanil addition to oral midazolam for prevention of emergence agitation.Seventy-eight, 1-8 year-old children, undergoing urological surgery with sevoflurane…
- Trial name
- NCT02022488
- Testing
- midazolam, alfentanil, ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Yeditepe University Hospital
Anesthesia
Effect of Oral Dexmedetomidine, Ketamine, Or Midazolam as Preioperative Medications.
Anxiety preceding surgery results in hemodynamic instability, metabolic side effects, increased post-operative pain, and agitation during emergence.
- Trial name
- NCT05874245
- Testing
- oral Dexmedetomidine, oral ketamine, oral Midazolam
- Where
- Egypt
- Volunteers
- 222 people
- Sponsor
- Menoufia University
Emergence Delirium, Anesthesia, Child
Melatonin vs Midazolam in Children Undergoing Tonsillectomy
Used as a premedication to decrease anxiety (Caumo et al., 2007). Midazolam, though has several drawbacks (McCann and Kain, 2001). Hence, an alternative premedication to midazolam will definitely have a widespread appeal.
- Conditions
- Emergence Delirium, Anesthesia, Child, Anxiety, Midazolam Premedication
- Trial name
- NCT07336095
- Testing
- Melatonin group, Midazolam group, Control group
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Dexmedetomidine, Adenotonsillectomy
Nebulized Dexmedetomidine, Ketamine, or Midazolam in Children Undergoing Adenotonsillectomy
The aim of this study is to compare between nebulized dexmedetomidine, ketamine, or midazolam for premedication in children undergoing adenotonsillectomy.
- Conditions
- Dexmedetomidine, Adenotonsillectomy, Midazolam, Children
- Trial name
- NCT07564037
- Testing
- Group K:nebulized ketamine group, Group D:dexmedetomidine group, Group M: midazolam group
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Parental/Caregiver Anxiety, Child's Anxiety
A Comparison of Midazolam and Zolpidem as Oral Premedication in Children
The purpose of this investigator-initiated study is to compare the efficacy of oral midazolam and zolpidem for preoperative sedation, anxiety of patient, and caregiver anxiety at the time of separation, and ease of mask…
- Trial name
- PedsPreMed (NCT02096900)
- Testing
- zolpidem, Midazolam
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Loma Linda University
Adenotonsillectomy
Intranasal Dexmedetomidine, Ketamine or Midazolam for Anxiety and Respiratory Complications in Children
This study is being done to find out which of three medications-dexmedetomidine, ketamine, or midazolam-is best at reducing anxiety and breathing problems in children having surgery to remove their tonsils and adenoids.
- Trial name
- INPERM (NCT07072117)
- Testing
- Intranasal Dexmedetomidine as a Premedication for Prevention of Anxiety & Respiratory Complications, Intranasal Ketamine as a Premedication for Prevention of Anxiety and Respiratory Complications, Intranasal Midazolam as a Premedication for Prevention of Anxiety and Respiratory Complications
- Where
- Egypt
- Volunteers
- 148 people
- Sponsor
- Zagazig University
Premedication, Oculocardiac Reflex
Intranasal Dexmedetomidine vs Midazolam-ketamine Combination for Premedication of Pediatric Patients
The aim of this study is using intranasal dexmedetomidine versus intranasal midazolam-ketamine combination for premedication and preventing the oculocardiac reflex of pediatric patients undergoing strabismus surgery.
- Trial name
- NCT02072083
- Testing
- Dexmedetomidine, Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Anxiety
Interactive Tablet Compared to Oral Midazolam as Premedication in Preoperative Anxiety in Children
preoperative anxiety is an undesirable outcome in pediatric surgical patients.It can lead to behavioral trouble such as enuresis, apathy and sleep disorders.
- Trial name
- NCT04049201
- Testing
- elective surgery, Midazolam, Interactive Tablet
- Where
- Tunisia
- Volunteers
- 112 people
- Sponsor
- Hôpital d'enfants Béchir-Hamza
Preoperative Anxiety Experienced by the Pediatric Patient, Preoperative Anxiety
Comparing Two Doses of Midazolam With Added Dexmedetomidine for Kids Before Surgery
The goal of this randomized controlled trial is to investigate if adding intranasal dexmedetomidine to two different doses of intranasal midazolam provides effective sedation with fewer side effects in pediatric patients aged 1…
- Trial name
- NCT06979791
- Testing
- Dexmedetomidine + Midazolam 0.4 mg/kg, Dexmedetomidine + Midazolam 0.2 mg/kg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University