Clinical trials: Middle Ear Disease
Otitis Media With Effusion, Food Hypersensitivity
Food Allergy - Tubes - Adenoids (FATA) Trial
The questioned proposed by this study is one of treatment: "To what extent does simultaneous BMT (Bilateral Myringotomy with Tympanostomy Tubes), adenoidectomy, and diagnosis/avoidance of food allergy affect the frequency of…
- Trial name
- FATA (NCT00736112)
- Testing
- Food Allergy Testing, Adenoidectomy, BMT
- Where
- United States
- Sponsor
- University of Missouri-Columbia
Otitis Media
Comparative Study to Evaluate the Efficacy and Safety of Telithromycin Given Once Daily Versus Cefuroxime Axetil Given Twice Daily in Children With Middle Ear Infections
The clinical activity of telithromycin vs. cefuroxime in children with acute infections of the middle ear, ages 6 months to 59 months old will be studied.
- Trial name
- NCT00174811
- Testing
- telithromycin (HMR3647)
- Where
- 2 sites in United States, France
- Volunteers
- 639 people
- Sponsor
- Sanofi
Acute Otitis Media
Clinical Study to Assess the Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Middle Ear Infections in Pediatric Patients
The purpose of this study is to determine if the combination of DF289 plus DF277 is safe and effective in treating middle ear infections in children with ear tubes.
- Trial name
- NCT01395966
- Testing
- DF289, DF277, DF289 plus DF277
- Where
- Spain
- Volunteers
- 331 people
- Sponsor
- Salvat
Middle Ear Effusion, Tympanic Membrane Perforation
PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers to See if it Protects Their Babies From Ear Disease
PneuMum is a randomised controlled trial that aims to find out if pneumococcal vaccination for Australian Indigenous mothers, in the last few months of pregnancy or at delivery, can prevent ear disease in infants.
- Conditions
- Middle Ear Effusion, Tympanic Membrane Perforation, Acute Otitis Media, Pneumococcal Infections
- Trial name
- NCT00310349
- Testing
- 23 valent pneumococcal polysaccharide vaccine
- Where
- Australia
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Eustachian Tube Dysfunction, Middle Ear Barotrauma
Effect of Total Compression Time and Rate (Slope) on Incidence of Symptomatic ETD and MEB: A Phase II Prospective Study.
Eustachian tube dysfunction (ETD) and middle ear barotrauma (MEB) are common reported complications during hyperbaric oxygen treatment.
- Conditions
- Eustachian Tube Dysfunction, Middle Ear Barotrauma, Middle Ear Disease, Middle Ear; Injury
- Trial name
- NCT04776967
- Testing
- Hyperbaric Compression Profile
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Northwell Health
Hearing Disorders
Middle-ear Reflex Testing Using Wideband Acoustic Immittance
This project will assess the middle-ear muscle reflex using wideband acoustic immittance which is a valuable method for evaluating infants, children, and adults.
- Trial name
- WAI-MEMR (NCT04875637)
- Testing
- WAI-MEMR
- Where
- United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Mimosa Acoustics
Otitis Media Recurrent, Middle Ear Infection
Utility of Advanced Ultrasound Otoscope In The Diagnosis of AOM
The objective of this study is to collect ultrasound signal information and visual otoscopic images with an engineering prototype device for children scheduled for tympanostomy tube surgery for the purpose of algorithm…
- Conditions
- Otitis Media Recurrent, Middle Ear Infection, Ear Infection
- Trial name
- NCT06429709
- Testing
- Advanced Ultrasound Otoscope
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Baylor College of Medicine
Otitis Media Chronic, Tympanic Membrane Perforation
Use of Autologous Plasma Rich in Platelets and Extracellular Vesicles in the Surgical Treatment of Chronic Middle Ear Infections
This clinical study evaluates the efficacy of the autologous blood-derived product called platelet- and extracellular vesicle-rich plasma as a supplement to the surgical treatment of chronic tympanic membrane perforations.
- Trial name
- NCT04761562
- Testing
- Platelet- and extracellular vesicle-rich plasma, Control group
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Chronic Otitis Media, Tympanic Membrane Perforation
Comparison of Postoperative Outcomes of Interlay vs Underlay Graft in Tympanoplasty
Chronic otitis media is a long-term ear infection that may cause a hole in the eardrum, leading to repeated ear discharge and hearing loss.
- Conditions
- Chronic Otitis Media, Tympanic Membrane Perforation, Conductive Hearing Loss
- Trial name
- NCT07149480
- Testing
- Underlay Tympanoplasty, Interlay Tympanoplasty
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Shaikh Zayed Hospital, Lahore
Cholesteatoma, Middle Ear
Evolution of Surgery for Middle-ear Cholesteatoma After the Introduction of Exclusive Endoscopic Ear Surgery
This retrospective observational study describes the evolution of surgical management of middle-ear cholesteatoma at Nice University Hospital over a 12-year period (January 2012 to December 2023), following the introduction of…
- Trial name
- NCT07723547
- Testing
- Cholesteatoma surgery without exclusive endoscopic technique
- Where
- France
- Volunteers
- 443 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Otitis Media, Serous, Negative Middle Ear Pressure
Short Term Relief of Eustachian Tube Dysfunction and Serous Otitis Media Using Intranasal Steroid Sprays
We hypothesize that intranasal steroid application will have a beneficial therapeutic effect in adults with regard to resolution of serous otitis media and/or negative middle ear pressure, as compared to placebo.
- Conditions
- Otitis Media, Serous, Negative Middle Ear Pressure, Rhinitis, Otitis Media With Effusion
- Trial name
- NCT00279916
- Testing
- Triamcinolone acetonide nasal spray
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Mayo Clinic
Otitis Media With Effusion
Osteopathic Otitis Media Research Study
The purpose of this study is to determine if the application of osteopathic manipulative medicine speeds the rate of resolution of middle ear effusion (fluid) in children following an episode of acute otitis media.
- Trial name
- OOMRS (NCT00520039)
- Testing
- osteopathic manipulative medicine (OMM)
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- West Virginia School of Osteopathic Medicine
Otitis Media
Does Topical Otic Drop Use at Time of Tympanostomy Tube Surgery Improve Outcomes When no Middle Ear Effusion is Present
To determine whether the use of topical otic drops intra-operative and post-operative during tympanostomy tube placement reduces the rate of tympanostomy tube occlusion and post-operative otorrhea (ear drainage) during the…
- Trial name
- NCT03655665
- Testing
- Ofloxacin otic solution
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Boston Children's Hospital
Otitis Media With Effusion
A Non-invasive Device to Remove Fluid From the Middle Ear
A feasibility study for evaluating efficacy and satisfaction is treated using a non-invasive device for middle ear ventilation. The study is designed to test the device's effectiveness by encouraging the evacuation of fluid from…
- Trial name
- NCT03978195
- Testing
- Non-invasive device for middle ear ventilation
- Volunteers
- 40 people
- Sponsor
- Yuinvent Innovations Ltd.
Hearing Loss
Evaluation of New Feedback Canceller for Carina™ Implant
The purpose of this study is to evaluate audio quality benefit for the patient implanted with a Cochlear or Otologics Carina implant with the new firmware (feedback canceller algorithm) whatever the patient environment is and to…
- Trial name
- NCT02309541
- Testing
- feedback canceller algorithm (Firmware)
- Where
- 3 sites in France
- Volunteers
- 12 people
- Sponsor
- Cochlear
Otitis Media
A Study of the Effectiness and Safety of Levofloxacin in Treating Children With a Rapid and Severe Onset of Infection and Inflammation of the Middle Ear That is Difficult to Treat
The purpose of the study is to assess the rate of elimination of bacteria by levofloxacin in middle ear fluid of children with a rapid and severe onset of infection and inflammation of the middle ear who are at high risk for…
- Trial name
- NCT00044473
- Testing
- levofloxacin
- Volunteers
- 206 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Upper Respiratory Infection
Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 2
This study will test the hypothesis that constitutionally poorer Eustachian tube function predisposes to middle-ear pathology during a viral upper respiratory infection.
- Trial name
- NCT00694421
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Cuneyt M. Alper
Taste Disturbance
Taste Disorders in Middle Ear Disease and After Middle Ear Surgery
Objectives To evaluate the impact of taste disturbance in different types of chronic middle ear diseases and after middle ear surgery.
- Trial name
- NCT01584011
- Testing
- taste measurement, Symptom questionnaire, Quality of life questionnaire
- Where
- Sweden
- Volunteers
- 310 people
- Sponsor
- Uppsala University
Otitis Media
Genetics of Middle Ear Disease
The goal of this study is to identify the genes that contribute to susceptibility to recurrent/persistent middle ear disease. Five hundred families with at least 2 children who have undergone tympanostomy tube insertion will be…
- Trial name
- NCT00422136
- Where
- United States
- Volunteers
- 2,121 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Middle Ear Effusion, Otitis Media
Evaluating Laser Otoscope for Middle Ear Effusion Detection
The goal of this cross-sectional diagnostic accuracy investigational study is to learn about the usefulness of laser otoscopy in screening for middle ear fluid.
- Trial name
- NCT07454512
- Testing
- Laser otoscope examination
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- MSTATT LLC