Clinical trials: Moderately Malnourished Children
Severe Acute Malnutrition, Moderate Acute Malnutrition
Alternative RUTFs for Treatment of Child Wasting
Acute malnutrition is the most life-threatening form of undernutrition. Moderate and severe acute malnutrition (MAM, SAM) are effectively treated with ready-to-use therapeutic foods (RUTFs) but there is a need to lower the cost…
- Conditions
- Severe Acute Malnutrition, Moderate Acute Malnutrition, Wasting
- Trial name
- NCT06912620
- Testing
- Soy-based RUTF, Soy-maize-sorghum-based RUTF, Standard RUTF
- Where
- Burkina Faso
- Volunteers
- 2,269 people
- Sponsor
- International Food Policy Research Institute
Moderate Acute Malnutrition
Acceptability and Efficacy of 'Fish Surimi Peptide' in Under Five Children Suffering From Moderate Acute Malnutrition
Protein-energy malnutrition (PEM) including moderate acute malnutrition (MAM: weight-for-height z-score <-2 to -3, or mid upper arm circumference (MUAC) 115 to < 125 mm) is a major cause of morbidity and mortality in under-5…
- Trial name
- NCT02272543
- Testing
- Fish surimi peptide
- Where
- Bangladesh
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Immunity to Polio Vaccines in Malnourished Infants, Immunity to Polio Vaccines in Non-malnourished Infants
IPV in Moderate to Severe Chronic Malnourished 9-12 Month Old Children in Karachi.
Chronic malnutrition is associated with lack of effective gut immunity which is a possible explanation for why we see polio cases among a proportion of children who have received 7 or more doses of OPV.Our proposed idea is to…
- Trial name
- MIPV (NCT01695798)
- Testing
- Injectable polio vaccine and Bivalent oral polio vaccine
- Where
- Pakistan
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Moderate Acute Malnutrition
Choline to Prevent SAM in Children With MAM
The goal of this clinical trial is to test choline supplementation in children with moderate acute malnutrition in Malawi. The main question it aims to answer is: Will provision of RUSF with added choline (500mg/day) throughout…
- Trial name
- CHOP-MAM (NCT06214897)
- Testing
- C-RUSF (Ready-to-use Supplemental Food with added Choline), S-RUSF (Ready-to-use Supplemental Food without added Choline)
- Where
- 10 sites in Malawi
- Volunteers
- 1,515 people
- Sponsor
- Washington University School of Medicine
Moderately Malnourished Children
Development and Acceptability Testing of Ready-to-use-complementary Food Supplement (RUCFS) for Children in Bangladesh
The prevention of malnutrition among children under 5 years of age requires consumption of nutritious food, including exclusive breast feeding for the first six months of life, followed by breastfeeding in combination with…
- Trial name
- NCT01553877
- Testing
- Pushti packet, Rice based Ready to Use Complementary Food Supplements, Chick-pea based Ready to Use Complementary Food Supplements
- Where
- Bangladesh
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Malnutrition
Whey Permeate Study
This is a prospective, randomized, double-blinded, controlled clinical effectiveness trial of two supplementary foods in the treatment of MAM.
- Trial name
- NCT01790048
- Testing
- Whey permeate RUSF, Soy Protein RUSF
- Where
- Malawi
- Volunteers
- 2,259 people
- Sponsor
- Washington University School of Medicine
Moderate Acute Malnutrition
Alternative Feeding Regimen on Recovery of Children Aged 6-59 Months With Moderate Acute Malnutrition in Bangladesh.
In spite of the large burden of acute malnutrition in the country, the Community-based Management of Acute Malnutrition (CMAM) protocol approved in Bangladesh highly deviates from the WHO normative guidance, in that it does not…
- Trial name
- NCT06045104
- Testing
- Wheat Soy Blend Plus Plus (WSB++) with nutrition counselling, 15 Micro Nutrient Powder (15 MNP) with improved nutrition counselling
- Where
- Bangladesh
- Volunteers
- 560 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Moderate Acute Malnutrition (MAM)
Management of Children With Moderate Acute Malnutrition in Mali
The objectives of the study are to assess the impact of different dietary strategies for the management of children with MAM on: the children's continued participation in the nutritional rehabilitation program and their physical…
- Trial name
- Mali-MMAM (NCT01015950)
- Testing
- Plumpy'Sup, Local food supplement, Misola
- Where
- Mali
- Volunteers
- 1,260 people
- Sponsor
- Helen Keller International
Malnutrition
Comparison of a Two Ready-to-use Supplementary Foods of Differing Protein Quality for the Treatment of MAM.
This is a prospective, randomised, double-blinded, controlled clinical effectiveness trial of two supplementary foods in the treatment of MAM. The setting will be 21 rural sites in southern Malawi.
- Trial name
- NCT03549156
- Testing
- C-RUSF, HIPRO RUSF
- Where
- Malawi
- Volunteers
- 1,858 people
- Sponsor
- Washington University School of Medicine
Malnutrition
Effectiveness Trial on Alleviation of Infant Malnutrition With Fortified Spread or Maize-Soy Flour Food Supplements
This study tests the hypothesis that moderately underweight but not severely wasted 6-17-month old infants receiving fortified spread or maize-spy flour as a food supplement for 12 weeks grow better during the supplementation…
- Trial name
- NCT00420758
- Testing
- Food supplement: fortified spread, Food supplement: maize-soy flour
- Where
- Malawi
- Volunteers
- 299 people
- Sponsor
- Tampere University
Moderate Acute Malnutrition
Comparison of Four Different Supplementary Foods in the Treatment of Moderate Acute Malnutrition
The research seeks to determine the relative effectiveness and cost effectiveness of alternative supplementary foods in the treatment of moderate acute malnutrition (MAM) in normal program settings.
- Trial name
- NCT03146897
- Testing
- Supplementary Food
- Where
- Sierra Leone
- Volunteers
- 2,691 people
- Sponsor
- Tufts University
Child, Malnutrition
Effectiveness of a Ready-to-Use-Food (RUF) Supplement to Prevent Acute Child Malnutrition
The overall objective of this project is to assess the effectiveness and cost-effectiveness of RUF (ready-to-Use Food, Plumpy Doz(r)) to prevent moderate acute malnutrition in children aged 6-36 months if embedded in a program of…
- Trial name
- PREAMA (NCT01154595)
- Testing
- Plumpy Doz(r) - Ready-to-Use Food, Food-for-Training
- Where
- Chad
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Action Contre la Faim
Severe Acute Malnutrition, Moderate Acute Malnutrition
Optimizing Acute Malnutrition Management in Children Aged 6 to 59 Months in Democratic Republic of Congo
Acute malnutrition affects 51 million children under the age of 5 worldwide. Malnutrition contributes to nearly half of all child deaths each year, with the forms characterized by wasting or oedema (acute malnutrition) associated…
- Conditions
- Severe Acute Malnutrition, Moderate Acute Malnutrition, Child Malnutrition, Acute Malnutrition
- Trial name
- OptiMA-DRC (NCT03751475)
- Testing
- Nutritional Strategy - OptiMA, Effective nutritional standard strategy
- Where
- Democratic Republic of the Congo
- Volunteers
- 896 people
- Sponsor
- Alliance for International Medical Action
Malnutrition, HIV/AIDS
Nutritional Rehabilitation in Senegalese HIV-infected Children and Adolescents
Severe (SAM, Body Mass Index-z < -3) and moderate (MAM, -3 ≤ BMI-z < -2) acute malnutrition, highly prevalent in HIV-infected children and adolescents, is an independent risk factor of death, even when antiretroviral treatment…
- Trial name
- SNAC'S (NCT03101852)
- Testing
- Plumpy Nut, Plumpy Sup
- Volunteers
- 185 people
- Sponsor
- Institut de Recherche pour le Developpement
Moderate Acute Malnutrition
Comparing Several Strategies to Manage Moderate Acute Malnutrition Among Children From 6 to 24 Months Old
The aim of this open-label randomized controlled trial conducted in four African countries (Madagascar, Niger, Central African Republic and Senegal) is to compare three strategies of renutrition for moderate acute malnutrition…
- Trial name
- MALINEA (NCT03474276)
- Testing
- Azythromycin, Inuline and fructo-oligosaccharides, Albendazole
- Where
- 4 sites in Central African Republic, Madagascar and 2 more
- Volunteers
- 1,357 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Microbiota, Complementary Food
Community-based Clinical Trial With Microbiota-directed Complementary Foods (MDCFs) Made of Locally Available Food Ingredients for the Management of Children With Primary Moderate Acute Malnutrition
Background (brief): Burden: A total of 52 million children under 5 are suffering from acute malnutrition globally, of whom 33 million have moderate acute malnutrition (MAM).
- Conditions
- Microbiota, Complementary Food, Nutrition
- Trial name
- NCT04015999
- Testing
- Microbiota Directed Complementary Food (MDCF), Ready to Use Supplementary Food (RUSF)
- Where
- Bangladesh
- Volunteers
- 124 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Moderate Acute Malnutrition (MAM)
Comparison of Four Different Supplementary Foods in the Treatment of Moderate Acute Malnutrition (MAM) in Children in Sierra Leone: a Cluster-randomised, Controlled Clinical Effectiveness Trial
The objective of this study is to test and compare the effectiveness and cost-effectiveness of four supplementary foods for the treatment of moderate acute malnutrition (MAM) in normal programmatic settings in Sierra Leone.
- Trial name
- NCT02077907
- Testing
- Super Cereal Plus (SC+), Super Cereal (SC), fortified oil, sugar, Plumpy Sup
- Volunteers
- 1,147 people, healthy volunteers welcome
- Sponsor
- Tufts University
Malnutrition, Child, Tuberculosis
The Impact of Malnutrition on Immune Responses to Tuberculosis
The aim of this study is to assess immune responses to Mtb in children with MAM compared to well-nourished children and to evaluate the impact of a nutrition intervention on these immune responses.
- Trial name
- TBMAM (NCT05044910)
- Testing
- Ready to Use supplementary food (RUSF)
- Where
- 2 sites in India
- Volunteers
- 200 people
- Sponsor
- Tuberculosis Research Centre, India
Moderate Acute Malnutrition
Modified Dosage for Moderate Acute Malnutrition (MODAM-MAM)
Protocols for the community-based management of acute malnutrition (CMAM) have not changed significantly for more than 20 years, with relatively complex treatment protocols and persistent supply chain challenges that have limited…
- Trial name
- MODAM-MAM (NCT06056089)
- Testing
- ready-to-use supplementary food (RUSF), ready-to-use therapeutic food (RUTF)
- Where
- 3 sites in Ethiopia
- Volunteers
- 2,400 people
- Sponsor
- Action Against Hunger USA
Moderate Acute Malnutrition
Microbiota Directed Food for Children With Moderate Acute Malnutrition
Moderate acute malnutrition (MAM) refers to a condition characterized by a significant deficit in weight-for-length measurements in children aged 6 to 59 months.
- Trial name
- NCT06305442
- Testing
- Microbiota-Directed Food, Ready-to-Use Supplementary Food
- Where
- Bangladesh
- Volunteers
- 230 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh