Clinical trials: Modification
Brain Tumor, Primary
A Pilot Study to Evaluate Neurocognitive Injury and Longitudinal Changes in White Matter During Radiation Therapy in Children With Primary Brain Tumors
This is a pilot study to assess the changes in white matter, in the brain, in response to radiation therapy and correlate these changes with later declines in cognitive function.
- Trial name
- NCT02006407
- Testing
- Cranial Radiotherapy, MRI with Diffusion Tensor Imaging (DTI), Neuro-cognitive Testing (CogState)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Michigan Rogel Cancer Center
Non-alcoholic Fatty Liver Disease
Fructose and Liver Diseases in Youth: Help Them FLY
Obesity has been increasing all over the world. This has lead to a significant increase of a liver disease in children called non-alcoholic fatty liver disease (NAFLD).
- Trial name
- FLY (NCT05528471)
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of Alberta
Bronchiolitis, Pneumonia
A Study of Tobacco Smoke and Children With Respiratory Illnesses
This study aims to assess the feasibility of using an intervention for environmental smoke exposure in children that uses cotinine testing results with written materials and telephone counseling for a potential future study of…
- Conditions
- Bronchiolitis, Pneumonia, Reactive Airway Disease, Asthma
- Trial name
- NCT03062709
- Testing
- Breathe Easy Coalition written materials, Maine Tobacco Helpline, Urine cotinine testing
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- MaineHealth
Hospital Acquired Infection
Investigation on the Dynamic Changes in Air Microbiome in Intensive Care Unit
The microbiome of ICU, especially the air microbiome of ICU is not clear. The relationship between the microbiome of ICU and the hospital- acquired infection needs to be clarified.
- Trial name
- NCT04954300
- Testing
- no intervention
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Peking University Third Hospital
Circumcision, Meatotomy or Distal Coronary Correction of Hypospadia
DPNB vs. Modified DPNB With Ventromedial Infiltration (DPNB According to Dalens' Technique)
Dorsal penile nerve block (DPNB) is a regional nerve block probably most often performed throughout the world. There are several different methods described in the literature.
- Trial name
- NCT01974011
- Testing
- Performing dorsal penile nerve block (DPNB)
- Where
- Germany
- Volunteers
- 86 people
- Sponsor
- Claudia Spies
Acute Lymphoblastic Leukemia, Hodgkin Disease
Imaging of Chemotherapy-induced Morphological and Functional Lung Changes in Childhood ALL and HD
With increasing cure rates of childhood cancer there is growing recognition of late effects of treatments. However, there is a lack of non-invasive and child-friendly procedures that can indicate possible late damage.
- Conditions
- Acute Lymphoblastic Leukemia, Hodgkin Disease, Allogeneic Stem Cell Transplantation
- Trial name
- MinimALL (NCT06093334)
- Testing
- Low-field magnetic resonance imaging, Cardiopulmonary testing, Pulmonary testing
- Where
- Germany
- Volunteers
- 27 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Expansion of Maxillary Arch, Maxillary Hypoplasia
Dentoskeletal Changes Expansion Using Invisalign Versus Conventional Expander
Cbct evaluation of dentoskeletal changes after expansion using Invisalign versus conventional expander
- Trial name
- NCT05899530
- Testing
- Invisalign, Conventional expander
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
ADD, ADHD
Neurocognitive and Neurobiological Improvement in ADHD Children by Modification of Dietary Protein
Multicenter, Prospective, randomized, comparative and controlled study about the beneficial effects in behavior and brain connectivity of different dietary patterns in 100 children with ADHD between 7 and 12 years, followed up…
- Trial name
- BrainProtein (NCT01856686)
- Testing
- BP22042013, Low carbohydrate diet
- Where
- United Kingdom
- Volunteers
- 64 people
- Sponsor
- Spanish Foundation for Neurometrics Development
Peanut Allergy, Milk Allergy, Cow's
Investigating Modified Protocols of Oral Immunotherapy to Validate Efficacy and Safety
Protocols for Oral Immunotherapy (OIT) for the main food allergens have been recently incorporated in clinical practice for food allergies and their clinical benefits have been acknowledged in European and Canadian official…
- Conditions
- Peanut Allergy, Milk Allergy, Cow's, Egg Allergy
- Trial name
- IMPROVES (NCT06256146)
- Testing
- Food allergy desensitization / Oral Immunotherapy
- Where
- Canada
- Volunteers
- 360 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Obesity
Study to Evaluate the Efficacy and Safety of Belviq XR® in Conjunction With Lifestyle Modification for Weight Loss in Obese Adolescents, Age 12 to 17 Years
This study will be conducted to demonstrate weight loss efficacy by change in body mass index (BMI) and safety in adolescents age 12 to 17 years (inclusive) during 52 weeks of treatment with Belviq XR 20 milligrams (mg)…
- Trial name
- NCT03338296
- Testing
- lorcaserin hydrochloride XR
- Where
- 16 sites in United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Physical Inactivity, Sedentary Behavior
ASDactive: An Integrated Theory-based Intervention to Promote Habitual Physical Activity
ASDactive is a theory-based behaviour change intervention aimed at improving the physical activity behaviours of autistic youth.
- Conditions
- Physical Inactivity, Sedentary Behavior, Autism, Autism Spectrum Disorder
- Trial name
- ASDactive (NCT05958680)
- Testing
- ASDactive
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aberystwyth University
Lifestyle-related Condition, COVID-19 Pandemic
Lifestyle Changes by the COVID-19 (Coronavirus Disease 2019) Pandemic in Children With Developmental Delays
To evaluate the lifestyle changes caused by the COVID-19 pandemic in children with developmental delays in Taiwan.
- Conditions
- Lifestyle-related Condition, COVID-19 Pandemic, Children With Developmental Delays
- Trial name
- COVID-19 (NCT05770362)
- Testing
- lifestyle questionnaire
- Where
- Taiwan
- Volunteers
- 260 people
- Sponsor
- Taipei Medical University
Pediatric Obesity
Quincy Family, Youth & Technology For Lifestyle Change (FYT-4-LIFE) Study
To date, approaches that show the most promise for preventing and/or reversing the course of childhood obesity involve the delivery of intensive lifestyle interventions within a family-based context, emphasizing the necessity of…
- Trial name
- QFYT (NCT02324361)
- Testing
- Physical Activity, Evidence-based information on healthy family routines
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cava-pulmonary Anastomosis
Surgical Site Infection Study
The purpose of this study is to investigate the pharmacokinetics of cefazolin using both plasma and microdialysate sampling methods in children with single ventricle physiology undergoing their second palliation procedure.
- Trial name
- SSI (NCT01449669)
- Volunteers
- 14 people
- Sponsor
- Children's Hospital of Philadelphia
Attention Deficit Hyperactivity Disorder
Attention-Deficit/Hyperactivity Disorder (ADHD) Brain Activity Changes to Psychostimulants
The purpose of this study is to examine the neural basis of response inhibition, working memory, and sustained attention in adolescents and adults with Attention-Deficit/Hyperactivity Disorder (ADHD), with particular emphasis on…
- Trial name
- NCT01310439
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Hartford Hospital
Attention Deficit Hyperactivity Disorder
BUILT Family Lifestyle Program for Children With ADHD
The investigators have developed BUILT in hopes of empowering families to adopt and sustain healthy food, sleep, and exercise routines that optimize child focus, attention, and behavior.
- Trial name
- BUILT (NCT05464056)
- Testing
- Be Unstoppable in Life Together (BUILT)
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Concussion, Brain
One Team: Changing the Culture of Youth Sport With Pregame Safety Huddles
Randomized controlled trial of a behavioral intervention (Pre-Game Safety Huddles) designed to study the impact of huddles on concussion safety in youth sport, primarily regarding intention to report concussive symptoms.
- Trial name
- NCT04099329
- Testing
- Pre-game Safety Huddles
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Seattle Children's Hospital
Anorexia, Weight Changes
Megestrol Acetate in Treating Weight Loss or Anorexia in Young Patients With Malignancies Who Are Undergoing Radiation Therapy and/or Chemotherapy
RATIONALE: Megestrol acetate may help improve appetite and lessen weight loss caused by cancer. PURPOSE: This clinical trial studies megestrol acetate in treating weight loss or anorexia in young patients with malignancies who…
- Trial name
- NCT01200602
- Testing
- megestrol acetate, clinical observation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Moderate Acute Malnutrition (MAM)
Development, Feasibility and Acceptability of Recipes for Locally Available, Specially Formulated Foods for the Management of Moderate Acute Malnutrition in Niger (Related to NCT06382857 Protocol)
The study consisted of two phases. Phase 1 was a recipe development phase, which aimed to identify recipes that meet ≥80% of the recommended nutrient profile for Specially Formulated Foods (SFF) used in the standard management of…
- Trial name
- LAF (NCT07506213)
- Testing
- Locally Available Food
- Where
- Niger
- Volunteers
- 30 people
- Sponsor
- Epicentre
Pulmonary Disease, Chronic Obstructive
Changes in Blood Gases, Disturbance of Breath During Sleep and Cardiovascular Co-morbidity in COPD Patients
Respiration failure type 2 is loss of the lungs ability to take up oxygen (O2) and get rid of carbon dioxide (CO2). The diagnosis is based on blood gas measurement of pressures of O2 and CO2.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Hypercapnia, Hypoxemia
- Trial name
- NCT00888342
- Testing
- supplementary oxygen, zopiclone, alcohol
- Where
- 2 sites in Norway
- Volunteers
- 150 people
- Sponsor
- LHL Helse
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