Clinical trials: Modification
Junctional Epidermolysis Bullosa
Clinical Trial to Assess Safety and Efficacy of Autologous Cultured Epidermal Grafts Containing Epidermal Stem Cells Genetically Modified in Patients With JEB (HOLOGENE17)
Prospective open-label, uncontrolled clinical study to assess the safety and efficacy of autologous cultured epidermal grafts containing epidermal stem cells genetically modified with the aid of a gamma-retroviral vector carrying…
- Trial name
- HOLOGENE17 (NCT03490331)
- Testing
- Transplantation surgery of genetically corrected cultured epidermal autograft (ATMP)
- Where
- Austria
- Volunteers
- 1 people
- Sponsor
- Holostem s.r.l.
Tooth Discoloration, Quality of Life
Influence of Tooth Whitening on Changes in Quality of Life
Lighter tooth color may improve patient satisfaction with facial aesthetics. Few data exist regarding the impact and association of of tooth color connection with quality of life.The purpose of this research is to explore the…
- Trial name
- NCT03380702
- Testing
- whitening photoactivation gel
- Where
- Croatia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Daniela Kovacevic Pavicic
Ptosis, Eyelid, Ptosis; Eyelid, Congenital
Modified Müller's Muscle-conjunctival Resection Internal Ptosis Repair Using Fibrin Glue
Fibrin glue is widely used in ophthalmology for homeostasis and tissue recovery. It is commonly used in ocular surface surgeries such as pterygium removal and conjunctival lesions excisions.
- Conditions
- Ptosis, Eyelid, Ptosis; Eyelid, Congenital, Surgical Procedure, Unspecified
- Trial name
- NCT03392272
- Testing
- Using of Tisseel fibrin glue, Using sutures
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Pancreatic Cancer
Study to Evaluate Adverse Events and Change in Disease Activity When Intravenous (IV) Infusion of ABBV-927 is Administered in Combination With IV Modified FOLFIRINOX (mFFX) With or Without IV Budigalimab Compared to mFFX in Adult Participants With Untreated Pancreatic Cancer Metastasis
Metastatic Pancreatic Cancer Disease is one of the most aggressive and deadliest forms of cancer with very poor survival. This study will evaluate adverse events and change in disease activity in participants 18 to 75 years of…
- Trial name
- NCT04807972
- Testing
- ABBV-927, Budiglimab, modified FOLFIRINOX
- Where
- 15 sites in United States, Australia and 4 more
- Volunteers
- 40 people
- Sponsor
- AbbVie
Relapse
"Comparative Evaluation of 3 Dimensional Changes of Dentition in Post Orthodontic Patients With Immediate vs Delayed (Post 24 Hours) Retainer Delivery
Orthodontic treatment goals can be expressed as achieving ideal tooth alignment, esthetic, functional occlusion and stability. Various occlusal changes occur after active phase of orthodontic treatment, these unwanted changes are…
- Trial name
- NCT05879601
- Testing
- immediate orthodontic retainer delivery, delayed orthodontic retainer delivery.
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Newborn; Vitality, Iron Deficiency Anemia
The Importance of Delayed Cord Clamping
After birth, the umbilical cord is usually clamped and separated from the placenta within the first 30 seconds. Although the exact time to clamp the umbilical cord is unknown, allowing placental transfusion after birth has many…
- Trial name
- NCT06405867
- Testing
- delayed cord clamping (> 60 sec)
- Where
- Turkey (Türkiye)
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- Goztepe Prof Dr Suleyman Yalcın City Hospital
Traumatic Brain Injury
IRB-HSR# 14299: The Use of the Intrathoracic Pressure Regulator (ITPR) to Improve Cerebral Perfusion Pressure in Patients With Altered Intracranial Elastance
Patients who have a functioning intracranial pressure-monitoring device (either a subarachnoid bolt, or an intraventricular catheter) in place, and are either sedated, intubated, and mechanically ventilated (i.e.
- Trial name
- NCT01205607
- Testing
- ITPR -5 mm Hg then -9 mm Hg, ITPR -9 & then -5mm Hg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Methicillin-resistant Staphylococcus Aureus
Project CLEAR - Changing Lives by Eradicating Antibiotic Resistance
This randomized controlled trial will compare strategies to reduce the risk of methicillin-resistant Staphylococcus aureus (MRSA) infection and re-hospitalization in MRSA carriers.
- Trial name
- CLEAR (NCT01209234)
- Testing
- Standard-of-Care Education, MRSA Decolonization
- Where
- 24 sites in United States
- Volunteers
- 2,140 people
- Sponsor
- University of California, Irvine
Migraine
Retinal Nerve Fiber Layer Thickness Changes in Migraine: A Meta-Analysis of Case-control Studies
Optical coherence tomography (OCT) is a non-invasive retinal imaging technology that can provide high-resolution cross-sectional images of the peripapillary retinal nerve fiber layer (RNFL) and measure its thickness.
- Trial name
- NCT02196532
- Testing
- Device: Optical coherence tomography
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yifan Feng
Asphyxia Neonatorum, Birth Asphyxia
Augmented Infant Resuscitator (AIR): Transitioning a Novel Behavior Change Innovation to Drive Newborn Ventilation Skills Enhancement
Augmented Infant Resuscitator (AIR) is an inexpensive add-on, compatible with nearly every existing bag-valve mask and many types of ventilation equipment.
- Conditions
- Asphyxia Neonatorum, Birth Asphyxia, Perinatal Asphyxia
- Trial name
- NCT05349175
- Testing
- Augmented Infant Resuscitator (AIR)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Premature Ejaculation
Investigation of the Changes of Brain Structure and Function in Premature Ejaculation Patients and the Effects of Dapoxetine on Central Neural Activity in Premature Ejaculation Patients
Lifelong premature ejaculation (LPE) is a common male sexual dysfunction with a high prevalence in global. Up to now, the etiology of LPE remains unclear.
- Trial name
- NCT03583112
- Testing
- Dapoxetine Hydrochloride Tablet
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xidian University
Oral Health Literacy
Evaluation of the Know Your OQ™ Oral Health Literacy Tool in an Indian Population
This was a research study to evaluate the effectiveness of the questionnaire "Know Your OQ™" (Know Your Oral Health Quotient™) in changing people's level of knowledge about oral health in India and to evaluate the readability…
- Trial name
- KYOQIN (NCT06534112)
- Where
- India
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Breast Cancer
Breast Reconstruction and Neoadjuvant Radiotherapy
The purpose the BRENAR pilot study is to assess acute post-surgical complications following mastectomy and immediate breast reconstruction after neoadjuvant radiotherapy (NART).
- Trial name
- BRENAR (NCT05216900)
- Testing
- Neoadjuvant radiotherapy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- UMC Utrecht
Vision Disorder
A Novel Acuity Testing Method
The purpose of this protocol is to develop a valid, reliable, better standardized, and more efficient test of visual acuity (ability to see fine details) for use in clinical trials.
- Trial name
- NCT00013936
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Eye Institute (NEI)
Hypoxic Ischaemic Encephalopathy
Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth
This study examines the effect of inhaled xenon gas in the treatment of newborn infants with hypoxic-ischemic encephalopathy (HIE) in combination with cooling, which is the standard treatment for this condition.
- Trial name
- CoolXenon2 (NCT01545271)
- Testing
- xenon gas, Whole body cooling
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University Hospitals Bristol and Weston NHS Foundation Trust
Breast Cancer Female
A Study to Evaluate Changes in Human Breast Cancer Tissue Following Short-Term Use of Darolutamide
The purpose of this study is to evaluate the effect of short-term treatment with darolutamide on breast cancer cells (i.e., how the treatment may change the genes or proteins in breast cancer cells) and to evaluate its safety and…
- Trial name
- NCT03004534
- Testing
- darolutamide
- Where
- 14 sites in United States, Canada and 1 more
- Volunteers
- 36 people
- Sponsor
- Translational Research in Oncology
Weight Loss, Insulin Resistance
Effect of Low-calorie Diet on Serum Lipids, Adipokines, Insulin Resistance and Also Body Composition in Women With Metabolic Syndrome
The purpose of this study is to evaluate the effect of a hypocaloric diet on biomarkers associated with insulin resistance, metabolic profile and body composition in women with Metabolic Syndrome.
- Conditions
- Weight Loss, Insulin Resistance, Adipokines
- Trial name
- NCT02087709
- Testing
- Low-calorie diet
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Gingivitis, Plaque, Dental
Investigation of Clinical Efficacy of a New Mouthwash on Reducing Dental Plaque and Helping Prevent Gum Problems as Compared to a Control Mouthwash
Qualified subjects will be enrolled and randomized to either one of the two study groups described above based on their initial modified gingivitis and plaque scores.
- Trial name
- NCT07263698
- Testing
- cetylpyridinium chloride (CPC), zinc lactate and sodium fluoride Mouthwash, sodium fluoride Mouthwash
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Pain, Postoperative
mTLIP vs QIPB for Postoperative Analgesia After Lumbar Instrumentation Surgery
Lumbar instrumentation surgery is associated with severe postoperative pain due to extensive tissue dissection and prolonged muscle retraction during the procedure.
- Trial name
- NCT07370415
- Testing
- Modified Thoracolumbar Interfascial Plane Block (mTLIP), Quadro-Iliac Plane Block (QIPB):
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bursa City Hospital
Mild Cognitive Impairment, Insulin Resistance
Effect of a Modified Ketogenic-Mediterranean Diet on Alzheimer's Disease
The purpose of the BEAM study is to compare the effects of a low-carbohydrate diet and a lowfat diet for adults with mild memory loss and adults with pre-diabetes.
- Trial name
- BEAM (NCT02984540)
- Testing
- Low-Carbohydrate Diet, Low-Fat Diet
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
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