Clinical trials: Modification
Healthy
AQUAPed: Validation Study of AQUA© Questionnaire Modified for Childhood
The AQUA© questionnaire developed in 2008 is a validated tools for the screening of allergic diseases in adult athletes. The objective of the present study is to develop and validate a modified version of the AQUA© questionnaire…
- Trial name
- AQUAPed (NCT03286894)
- Where
- Italy
- Volunteers
- 1,264 people
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Obesity
Soft Drink, Milk and Obesity in Chilean Children
The primary aim of this randomized controlled trial is to evaluate the effects of replacing habitual consumption of sugar-sweetened soft drinks with milk over 16 weeks.
- Trial name
- NCT00149695
- Testing
- Weekly home delivery of milk products
- Where
- Chile
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Hypothermia
Amino Acid Infusion in Mothers Before and During Cesarean Delivery
Introduction: Intravenous infusion of amino acids during cesarean delivery in mothers and neonates improves neonatal growth. Amino acid before and during anesthesia also prevents hypothermia and associated untoward effects.
- Trial name
- NCT02575170
- Testing
- Amino acid solution, Ringer's lactate solution
- Where
- Nepal
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Convulsions
A Study of Cardiac Arrhythmia and ECG Changes in Children With Convulsions at Sohag University Hospital
Convulsion is a common pediatric disorder and there is strong relation between convulsion and cardiovascular system which revealed by ECG monitoring and there are many ECG abnormalities attributed to different causes of…
- Trial name
- NCT05322772
- Testing
- ECG
- Volunteers
- 100 people
- Sponsor
- Sohag University
Growth Modification
Three-Dimensional Assessment of Dentoskeletal Changes Associated With a Modified Twin Block Appliance
The aim of the current study is to evaluate the skeletal, dental, soft tissue, TMJ, and upper airway size changes associated with a new design of twin block compared to the conventional twin block appliance.
- Trial name
- NCT06589206
- Testing
- modified design of twin block
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Thermoregulation Impairment, Hypothermia
Incidence and Prevention of Hypothermia in Newborns Bonding During Caesarean Section
This study should evaluate whether newborns during cesarean section are endangered to get hypothermic while bonding on the mothers chest.
- Conditions
- Thermoregulation Impairment, Hypothermia, Postoperative Shivering
- Trial name
- THER5 (NCT01793558)
- Testing
- Forced-air warming
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Early Childhood Caries, Dental Caries
Vertical Dimension Changes After Bioflx vs Stainless Steel Crowns in Primary Molars
this randomized controlled trial will compare Bioflx crowns and stainless-steel crowns in children with pulp-treated primary molars.
- Conditions
- Early Childhood Caries, Dental Caries, Pulp-Treated Primary Molars
- Trial name
- BIOFLX-SSC-RCT (NCT07523776)
- Testing
- Bioflx Crown, Stainless Steel Crown
- Where
- Egypt
- Volunteers
- 18 people
- Sponsor
- Cairo University
Crohn Disease, Ulcerative Colitis
Changes in Faecal Calprotectin Levels and Participation-related Scores Following Three Weeks of Inpatient Rehabilitation
For many people affected by inflammatory bowel disease (IBD), their quality of life and their ability to participate in their professional and social lives are severely restricted.
- Trial name
- NCT05500040
- Testing
- Multimodal Rehabilitation
- Where
- Austria
- Volunteers
- 226 people
- Sponsor
- Pensionsversicherungsanstalt
Epilepsy
An Open-Label, Safety and Tolerability Study of Chronic Intermittent Use of Diazepam Nasal Spray.
This study will assess long-term safety and tolerability of repeat dose diazepam nasal spray in adolescents and adults with cluster seizures, with a focus on potential local effects (changes in nasal mucosa, olfaction, and taste).
- Trial name
- NCT02316847
- Testing
- diazepam nasal spray
- Where
- 33 sites in United States
- Volunteers
- 126 people
- Sponsor
- Acorda Therapeutics
Anxiety Disorder, Depressive Disorder
Sub-Trial of the Youth Readiness Intervention (YRI): Treatment of Control Group and Addition of Stress Biomarkers
This research is a continuation of the Youth Readiness Intervention (YRI) randomized clinical trial by adding additional pre and post intervention data collection upon treatment of the control group (N=222) with the intervention…
- Conditions
- Anxiety Disorder, Depressive Disorder, Social Problems, Stress, Psychological
- Trial name
- NCT02128568
- Testing
- Youth Readiness Intervention
- Where
- Sierra Leone
- Sponsor
- Harvard School of Public Health (HSPH)
Healthy
Brain Maturation and Sleep
In this study, the investigator evaluates whether there are age-specific diurnal changes in markers of cortical plasticity in children, adolescents and adults.
- Trial name
- BMS (NCT02685891)
- Testing
- Playing tones during deep sleep
- Where
- Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Human Microbiome
Microbiome Composition Changes on 4 Week Gluten-free Diet Challenge
Changes in the gut microbiomes of healthy volunteers who followed a gluten-free diet (GFD) for four weeks were studied. Per participant, nine stool samples were collected: one at baseline, four during the GFD period, and four…
- Trial name
- NCT02731976
- Testing
- Dietary intervention
- Where
- Netherlands
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Shortness of Breath, Chest Pain
Checklists Resuscitation Emergency Department
The study will systematically evaluate how an emergency manual-a collection of checklists and fact sheets-affects the performance of resuscitation teams during the management of priority one patients in an emergency department.
- Conditions
- Shortness of Breath, Chest Pain, Abdominal Pain, Altered Mental Status
- Trial name
- NCT05649891
- Testing
- Emergency Manual
- Volunteers
- 2,000 people
- Sponsor
- Region Skane
Malignant Central Nervous System Neoplasm, Malignant Skull Base Neoplasm
Brain Imaging Changes Following Proton Therapy for Pediatric Primary Central Nervous System and Base of Skull Tumors
This trial gathers information from patients with primary central nervous system or base of skull tumors that receive proton beam therapy and see if certain imaging techniques can help detect radiation-related changes over time.
- Trial name
- NCT04296617
- Testing
- Medical Chart Review
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Mayo Clinic
Anaemia
Iron Metabolism in Dragon Boat Athletes
The purpose of the study is: To investigate the effect of sport-specific stress in the iron metabolism of dragon boat athletes To investigate the effects of sport-specific stress in the activity of pro-hepcidin and hepcidin
- Trial name
- NCT01431118
- Testing
- specific dragon boating training intervention, specific dragon boat intervention
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Cerebral Palsy
Robot-assisted Training in Children With CP
Cerebral palsy (CP) is the most common physical disability in early childhood causing serious motor and sensory impairments. Effective interventions for the recovery of motor functions are of profound significance to children…
- Trial name
- NCT06450158
- Testing
- Robot (Amadeo)-assisted Training
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cook Children's Health Care System
Obesity, Childhood, Vitamin D Deficiency
The Changes of Body Composition, Glucolipid Metabolism and Bone Metabolism in Obese Children After Weight Loss
Vitamin D plays a significant role in calcium and phosphorus homeostasis for maintaining structural integrity and function of musculoskeletal system.
- Trial name
- NCT03490448
- Testing
- aerobic exercise and appropriate caloric control
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Antibody-mediated Rejection, NMO Spectrum Disorder
Biorepository and Registry for Plasma Exchange Patients
Patients who have immune mediated diseases commonly undergo plasma exchange (PLEX) procedures to remove pathological substances, typically believed to be antibodies.
- Conditions
- Antibody-mediated Rejection, NMO Spectrum Disorder, TTP, CIDP
- Trial name
- NCT05004493
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Charles M Knudson
Atrial Septal Defect (ASD)
Novel Modified Technique for Transcatheter Closure of Secundum Atrial Septal Defect: A Single Center Experience
Transcatheter closure of secundum atrial septal defects is widely approved worldwide, yet it still has multiple risks like perforation and radiation exposure.
- Trial name
- NCT06655935
- Testing
- Ordinary Transcatheter ASD closure, modified transcatheter ASD closure
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Egyptian Biomedical Research Network
Atopic Dermatitis, Eczema
Evaluating Skin Barrier Dysfunction in Infants at High Risk of Atopy
It is hypothesized that food allergy is preceded by atopic dermatitis (AD), due to a disruption of skin barrier which can predispose one to food sensitization through the skin.
- Conditions
- Atopic Dermatitis, Eczema, Food Allergy
- Trial name
- NCT03089476
- Testing
- Evaluating atopy in infants, Evaluating TEWL and STS in adults
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Jewish Health
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