Clinical trials: Modification
Proportional Reasoning
Modifying Cognitive Strategies for Comparing Proportions
The goal of this study is to understand the cognitive processes underlying quantitative and relational reasoning, including the understanding of mathematical information (e.g., numbers, proportions, percentages, geometry) and…
- Trial name
- NCT06635577
- Testing
- Verbal Interference Task
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Michelle Hurst, PhD
Physical Conditioning, Human
Effect of Rhythmic Gymnastics Training in Children With Down Syndrome
Some of the clinical characteristics of people with Down syndrome (DS) are orthopedic, cardiovascular, neuromuscular, visual, cognitive and perceptual disorders, which directly affect the quality of their movements.
- Trial name
- NCT06284707
- Testing
- swimming training, rhythmic gymnastics training
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Mandibular Retrognathism, Mandibular Hypoplasia
Twin Block Appliance in Incremental Versus Maximum Bite Advancement in Skeletal Class II
The aim of this study is to compare to different protocols to treat Class II malocclusion in growing subjects using the twin block appliance
- Trial name
- NCT04562545
- Testing
- Modified Twin Block, Twin Block Appliance set to maximum bite
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
in Situ Breast Cancer, Invasive Breast Cancer
Suction Drain Versus the Use of Adaptive Skin Sutures After Mastectomy ± Axillary Lymphadenectomy; a Prospective Randomised Study
The objective of this prospective randomized study is to perform qualitative and quantitative comparisons between the insertion of traditional suction drains (Arm: Suction drain) versus the application of absorbable adaptive…
- Trial name
- NCT01509781
- Testing
- Insertion of suction drain(s) following mastectomy, Adaptive skin sutures.
- Where
- Hungary
- Volunteers
- 400 people
- Sponsor
- National Institute of Oncology, Hungary
Crohn's Disease
Diet for Induction and Maintenance of Remission and Re-biosis in Crohn's Disease
The modified-Exclusive Enteral Nutrition (mEEN) is an open label randomized controlled trial in mild to severe Crohn's Disease patients.
- Trial name
- DIETOMICS-CD (NCT02843100)
- Testing
- Modified Exclusive Enteral Nutrition, Crohn's Disease Exclusion Diet, Partial Enteral Nutrition
- Where
- 7 sites in Canada, Ireland and 2 more
- Volunteers
- 63 people
- Sponsor
- Prof. Arie Levine
Autism Spectrum Disorder, Life Change Events
Animal-assisted Resilience Training for Children With Stressful Life Events or Autism Spectrum Disorder
The goal of this clinical trial is to learn about the effects of an animal-assisted resilience training in children who experienced stressful life events or who have a diagnosis of autism spectrum disorder.
- Trial name
- AART (NCT06025539)
- Testing
- Animal-assisted resilience training
- Where
- Switzerland
- Volunteers
- 107 people
- Sponsor
- University Hospital, Basel, Switzerland
Athletic Injuries, Health Behavior
Implementing Injury Prevention Training in Youth Handball (I-PROTECT) Using the RE-AIM Evaluation Framework
The aim of this two-armed cluster-randomized controlled trial is to investigate the implementation of the I-PROTECT using the RE-AIM evaluation framework that addresses five dimensions of effectiveness and implementation of…
- Trial name
- I-PROTECT (NCT05696119)
- Testing
- I-PROTECT, Control
- Where
- Sweden
- Volunteers
- 4,225 people, healthy volunteers welcome
- Sponsor
- Lund University
Minimal Change Disease (MCD), Membranous Nephropathy
Nephrotic Syndrome Study Network
Minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), and Membranous nephropathy (MN), generate an enormous individual and societal financial burden, accounting for approximately 12% of prevalent end stage…
- Conditions
- Minimal Change Disease (MCD), Membranous Nephropathy, Glomerulosclerosis, Focal Segmental
- Trial name
- NEPTUNE (NCT01209000)
- Testing
- Kidney Biopsy
- Where
- 44 sites in United States, Canada
- Volunteers
- 1,200 people
- Sponsor
- University of Michigan
Spinal Deformity
Spinal Deformity Intraoperative Monitoring.
A multicenter, international prospectively collected patient cohort undergoing high-risk spinal cord level surgery or spinal osteotomy procedures will be enrolled to establish the incidence of intraoperative alerts in high-risk…
- Trial name
- NCT03880292
- Testing
- Document intraoperative Maneuvers
- Where
- 24 sites in United States, Australia and 12 more
- Volunteers
- 592 people
- Sponsor
- AO Foundation, AO Spine
Epilepsy
Clinical and Electrographic Changes in Responsive Neurostimulation System (RNS) Patients With Acupuncture Treatment
The purpose of this study is to determine effects of Acupuncture on a Patient's mood and cognition,evaluate changes in clinically-reported seizure frequency and severity and analyze effects of Acupuncture on electrographic…
- Trial name
- NCT04677751
- Testing
- Acupuncture intervention
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cardiovascular Shock
Central Venous Pressure (CVP) Changes do Not Predict Preload Unresponsiveness
Passive leg raising (PLR) is routinely used to predict preload responsiveness in critically ill patients. However, real-time measurements of cardiac output are required to assess its effects.
- Trial name
- NCT03753672
- Testing
- preload responsiveness
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Hopital Antoine Beclere
Surgery, Anesthesia
Comparing the Effectiveness of Modified ERAS Protocols vs. Standard Management in Pediatric Gastrointestinal Surgery
Perioperative management of pediatric patients with gastrointestinal diseases involves a fairly length process and which can lead to rapid deterioration even death.
- Trial name
- NCT06981572
- Testing
- Modified Enhanced Recovery After Surgery Protocol
- Where
- Indonesia
- Volunteers
- 82 people
- Sponsor
- Universitas Indonesia
Epilepsy
Heart Rate Changes in Subjects With Epilepsy
The purpose of this study is to collect continuous observational data during a clinical Epilepsy Monitoring Unit evaluation.
- Trial name
- NCT01202669
- Testing
- No intervention planned, observational study only.
- Where
- 2 sites in United States
- Volunteers
- 98 people
- Sponsor
- Cyberonics, Inc.
Acute Malnutrition, Severe, Malnutrition, Child
Expanding Coverage of Severe Acute Malnutrition (SAM) Treatment in Kenya
Child wasting is a type of malnutrition which occurs when a child becomes too thin. This medical condition increases the risk of becoming sick or dying.
- Conditions
- Acute Malnutrition, Severe, Malnutrition, Child, Wasting
- Trial name
- R-SWITCH (NCT06441305)
- Testing
- SWITCH intervention package
- Where
- Kenya
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- International Food Policy Research Institute
Myopia, Obesity
Trial of a Novel Family-Based Intervention to Increase Outdoor Time and Fitness
This study aims to implement a new family-based health behavior community program to increase time spent outdoors and physical activity among Singapore children aged 6 to 12 years in a 1-year randomized clinical trial.
- Trial name
- FIT (NCT01388205)
- Testing
- Family-based Outdoor program
- Where
- Singapore
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Recurrent Childhood Neuroblastoma, Recurrent Childhood Osteosarcoma
Testing a New Immune Cell Therapy, GD2-Targeted Modified T-cells (GD2CART), in Children, Adolescents, and Young Adults With Relapsed/Refractory Osteosarcoma and Neuroblastoma, GD2-CAR PERSIST Trial
This phase I trial investigates the side effects and determines the best dose of an immune cell therapy called GD2CART, as well as how well it works in treating patients with osteosarcoma or neuroblastoma that has come back…
- Conditions
- Recurrent Childhood Neuroblastoma, Recurrent Childhood Osteosarcoma, Recurrent Neuroblastoma, Recurrent Osteosarcoma
- Trial name
- NCT04539366
- Testing
- Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration
- Where
- 6 sites in United States
- Volunteers
- 73 people
- Sponsor
- National Cancer Institute (NCI)
Beta-Thalassemia, Thalassemia
A Long-term Follow-up Study in Participants Who Received CTX001
This is a multi-site, open- label rollover study to evaluate the long-term safety and efficacy of CTX001 in pediatric and adult participants who received CTX001 in parent studies 111 (NCT03655678) 141 (NCT05356195) or 161…
- Conditions
- Beta-Thalassemia, Thalassemia, Sickle Cell Disease, Hematologic Diseases
- Trial name
- NCT04208529
- Testing
- CTX001
- Where
- 20 sites in United States, Belgium and 4 more
- Volunteers
- 160 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Pulpotomy
Evaluation of Primary Tooth Pulpotomy With Resin Modified Calcium Silicate
The goal of this clinical trial is to evaluate whether Theracal PT, a resin-modified calcium silicate-based material, can be successfully used in pulpotomy treatment for primary molar teeth.
- Trial name
- NCT06874062
- Testing
- Neoputty MTA Pulpotomy Treatment, ProRoot MTA Pulpotomy Treatment, Theracal PT Pulpotomy Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Central Blood Pressures
Central Arterial Pressure Changes With Use of Regional Anesthesia in Obstetric Patients
Plan to monitor central arterial pressure in women who are undergoing spinal anesthesia for cesarean delivery or epidural anesthesia for vaginal delivery.
- Trial name
- NCT02933541
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Functional Constipation (FC), Chronic Idiopathic Constipation (CIC)
A Study to Assess Adverse Events and Change in Symptoms With Linaclotide Versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, With Functional Constipation
Functional constipation (FC) is a common healthcare problem in children of all ages, potentially due to genetic predisposition, inadequate fiber and fluid intake, and immobility.
- Trial name
- NCT05652205
- Testing
- Linaclotide
- Where
- 48 sites in United States, Bulgaria and 2 more
- Volunteers
- 123 people
- Sponsor
- AbbVie
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