Clinical trials: Modification
Primary Immune Deficiency Disorder
Study to Monitor Subcutaneous Human Immunoglobulin Administered at Modified Dosing Regimens in Patients With Primary Immunodeficiency Diseases
CLINICAL PHASE 3 STUDY TO MONITOR THE SAFETY, TOLERABILITY, AND EFFICACY OF SUBCUTANEOUS HUMAN IMMUNOGLOBULIN (CUTAQUIG®) ADMINISTERED AT MODIFIED DOSING REGIMENS IN PATIENTS WITH PRIMARY IMMUNODEFICIENCY DISEASES
- Trial name
- NCT03939533
- Testing
- CUTAQUIG
- Where
- 18 sites in United States
- Volunteers
- 64 people
- Sponsor
- Octapharma
Obsessive-Compulsive Disorder (OCD)
Neural Predictors and Neural Changes Associated With Cognitive Behavior Therapy for Obssesive Compulsive Disorder
The goals of the project are 1) to understand what are the neural mechanisms involved in the psychological treatment of obsessive-compulsive disorder (OCD) in children/adolescents and adults, 2) to assess potential differences in…
- Trial name
- NCT04042038
- Testing
- Cognitive-behavior therapy (psychological treatment)
- Where
- 3 sites in Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Carotid Endarterectomy, Percutaneous Transluminal Angioplasty
Study of Blood Flow Changes and Microemboli During Carotid Surgery
The purpose of this study is to determine the clinical and radiologic implications of the intraoperative microemboli during carotid revascularization.
- Conditions
- Carotid Endarterectomy, Percutaneous Transluminal Angioplasty, Cognitive Aspects, Diffusion Weighted MRI
- Trial name
- NCT01343615
- Testing
- carotid stenting, carotid endarterectomy
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Campinas, Brazil
Obesity, Pregnancy
Starting Pediatric Obesity Prevention in Pregnancy
The purpose of this study is to examine whether we can use social networks to spread health information and health behaviors during pregnancy to prevent excessive gestational weight gain.
- Trial name
- NCT01279109
- Testing
- Social network building intervention, Home visit
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Parent-Child Relations, Dental Fear
Parental Presence and Preschoolers' Behavior
Purpose: This study aimed to assess the effect of parental active/passive presence technique (PAP/PPP) on the overall behavior of preschool children with different intelligence and fear levels.
- Trial name
- NCT04580316
- Testing
- Parental active presence, Parent passive presence
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Alexandria University
Behavior, Child, Physical Inactivity
Developing a Physical Activity Program Based on Behavior Change Models in Children and Investigation of Its Efficiency
The aim of our study is to develop a physical activity program based on behavioral change models for children and to investigate the effectiveness of the physical activity program we have developed for children attending primary…
- Trial name
- NCT05681832
- Testing
- Intervention group
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Istanbul University - Cerrahpasa
Liver Neoplasms, Neoplasm Metastasis
A Phase I Study of Isolated Hepatic Portal and Arterial Perfusion (IHP) With Escalating Dose Melphalan for Primary or Metastatic Unresectable Cancers of the Liver
Patients with unresectable primary or metastatic cancer confined to the liver will undergo a 1 hour hyperthermic isolated hepatic perfusion (IHP) via the portal vein and hepatic artery with escalating dose melphalan.
- Trial name
- NCT00001587
- Testing
- Isolated hepatic portal and arterial perfusion, Melphalan
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Gestational Diabetes, Pregestational Diabetes
Possible Epigenetic Changes in Offspring of Women With Pregestational and Gestational Diabetes
Pregestational diabetes (PGD) during pregnancy may be associated with an increased rate of spontaneous abortions, intrauterine death and congenital anomalies among the offspring.
- Conditions
- Gestational Diabetes, Pregestational Diabetes, IDM (Infant of Diabetic Mothers), Neurodevelopmental Outcome
- Trial name
- NCT01255384
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Pediatric Obesity, Pediatric Overweight
BasketballRx: Game Changing Health
The goal of this study is to learn if BasketballRx, a basketball and health program, works well for children and teens who are overweight or have obesity.
- Conditions
- Pediatric Obesity, Pediatric Overweight, Anxiety, Depression Disorders
- Trial name
- NCT07778433
- Testing
- BasketballRx
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Ulcerative Colitis
An Observational Study to Assess Change in Disease Activity and Adverse Events of Rinvoq in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Japan
Ulcerative colitis (UC) is an idiopathic, chronic, inflammatory disease affecting the colon. Participants with UC have mucosal inflammation starting in the rectum that can extend continuously to proximal segments of the colon.
- Trial name
- NCT05791526
- Where
- 114 sites in Japan
- Volunteers
- 308 people
- Sponsor
- AbbVie
Glycogen Storage Disease Type IA, Glycogen Storage Disease Type IB
Sleep and Quality of Life in Patients With Glycogen Storage Disease on Standard Versus Modified Uncooked Cornstarch
The aim of the present study is to determine if there is a change in quality and quantity of sleep perceived by adults and children with GSD and their parents while starting a modified UCCS (Glycosade) to prevent nocturnal…
- Conditions
- Glycogen Storage Disease Type IA, Glycogen Storage Disease Type IB, Glycogen Storage Disease Type III, Glycogen Storage Disease Type 0
- Trial name
- NCT02054832
- Testing
- Glycosade
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- John Mitchell
Vital Pulp Therapies, pH
Prognostic Value of Pulpal Blood pH and Oxygen Saturation in Vital Pulp Therapy: Determination of Clinically Relevant Thresholds in a Prospective Clinical Study
The increasing emphasis on biological tissue preservation in contemporary endodontics has positioned vital pulp therapy (VPT) as an important treatment strategy for maintaining pulp vitality and preserving the functional…
- Conditions
- Vital Pulp Therapies, pH, pH Changes, Oxygen Saturation
- Trial name
- NCT07848698
- Testing
- vital pulp therapy
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- ertuğrul karataş
Tobacco Dependence, Schizophrenia
The Pharmacogenetic Study , Readiness to Change, and Pharmacological Intervention for Smoking Cessation in Schizophrenia
Cigarette smoking represents a major health problem for patients suffering from schizophrenia. Compared to the general population, schizophrenic patients are significantly more likely to be addicted to nicotine.
- Trial name
- PSIAARP (NCT00495352)
- Testing
- Hihg-doseNRT, Low-dose NRT, bupropion
- Where
- Taiwan
- Volunteers
- 360 people
- Sponsor
- Yu-Li Hospital
Diabetes Mellitus, Type 1
ECG Changes in Children and Adolescents With Type 1 Diabetes
Diabetes Mellitus type 1 is characterized by an absolute insulin deficiency caused by T-cell-mediated autoimmune destruction of pancreatic β-cells .
- Trial name
- NCT03260998
- Testing
- electrocardiogram
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Childhood Obesity, Life Style Modification
Lifestyle Modification Intervention for Obese Children
Interventions that encompass behavioral modifications of dietary intake and physical activity dietary management are essential for the management of obese children.
- Trial name
- NCT03429699
- Testing
- Stage-based Lifestyle Modification Intervention for the Management of Childhood Obesity, Existing practice for the management of childhood obesity
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Weight Loss, Weight Gain
Effect of Ready to Use Therapeutic Food (RUTF) Supplement After an Episode of Malaria Falciparum on Weight
The primary objective of this study is to determine to what extent provision with RUTF will promote catch up growth in children following an acute uncomplicated episode of P. falciparum malaria.
- Conditions
- Weight Loss, Weight Gain, Convalescence, Malaria
- Trial name
- NCT00819858
- Testing
- RUTF (Plumpynut®)
- Where
- Republic of the Congo
- Volunteers
- 180 people
- Sponsor
- Medecins Sans Frontieres, Netherlands
Children, Only, Behavior, Eating
School Lunch Salad Bars and Fruit and Vegetable Consumption
The investigators propose an efficacy study (i.e., do salad bars work under controlled conditions in naturalistic settings) to test whether introducing salad bars in elementary, middle, and high schools that have never had salad…
- Conditions
- Children, Only, Behavior, Eating, School, Obesity
- Trial name
- NCT03283033
- Testing
- New salad bar, Marketing
- Where
- United States
- Volunteers
- 7,491 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Carcinoma, Nasopharyngeal
Randomized Trial to Evaluate Accelerated Radiotherapy in Locally Advanced Carcinoma of Nasopharynx
The present study is designed as a two arm randomized trial to evaluate the impact of accelerated radiotherapy delivered by image guided radiotherapy with rapid arc technique in carcinoma nasopharynx.
- Trial name
- EARN (NCT04538547)
- Testing
- Accelerated Radiotherapy, Non Accelerated Radiotherapy
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Genital Prolapse
Modified Technique in Sacrospinous Fixation for Treatment of Apical Genital Prolapse
Pelvic organ prolapse is one of the most common benign gynecological disorders and affects approximately 40% of women over 50 years of age.
- Trial name
- NCT05691543
- Testing
- sacrospinous fixation Using Posterior Vaginal wall flap
- Volunteers
- 15 people
- Sponsor
- Assiut University
Asthma, Health Personnel
Changes in Physician Performance Through Continuous Professional Development
The purpose of this study is to determine whether having physicians evaluate their management of certain diseases as part of board recertification results in improved patient care.
- Trial name
- NCT00115284
- Testing
- ABIM asthma practice improvement module
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
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