Clinical trials: Modification
Placenta Accreta Spectrum
Comparison Between 3 Conservative Surgeries for Placenta Accreta Spectrum
Comparison between modified one-step surgery vs. Segment Resection vs. placental bed suturing for management of placenta accreta spectrum
- Trial name
- NCT07520201
- Testing
- Modified one-step surgery, Segment Resection, Placental bed suturing
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Assiut University
Hypoxic Ischemic Encephalopathy
Safety and Efficacy of Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia
The purpose of this study is to determine whether the administration of topiramate to newborns with hypoxic-ischemic encephalopathy potentiates the neuroprotective effect of treatment with hypothermia.
- Trial name
- NeoNATI (NCT01241019)
- Testing
- Topiramate in newborns with hypoxic ischemic encephalopathy treated with therapeutic hypothermia
- Where
- 2 sites in Italy
- Volunteers
- 64 people
- Sponsor
- Meyer Children's Hospital IRCCS
Subjective Cognitive Impairment
Tailored Mediterranean Lifestyle Education in Participants With Subjective Cognitive Impairment
It is estimated that 30% of Alzheimer's disease cases globally are associated with changeable risk factors, such as diet and physical activity.
- Trial name
- NCT03569319
- Testing
- "THINK-MED" resource (baseline), "THINK-MED" resource (staged), Control
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Queen's University, Belfast
Obstetric; Injury
Modified Constraint Induced Movement Therapy in Children With Obstetric Brachial Plexus Injury
The aim of this study was to increase and improve the use of affected extremity in obstetric brachial plexus palsy children while restricting the use of less affected arm and the purpose was to improve the function, Range of…
- Trial name
- NCT05411731
- Testing
- Conventional physical therapy treatment, Constraint induced movement therapy
- Where
- Pakistan
- Volunteers
- 16 people
- Sponsor
- Riphah International University
Fever, Malaria
Effectiveness Of Rapid Diagnostic Tests in the New Context of Low Malaria Endemicity in Zanzibar
The purpose of this study is to study the effectiveness of wide scale RDT use at the primary health care level in previously high malaria endemic area during malaria pre-elimination phase for improved targeting of anti-malarial…
- Trial name
- RDTACT (NCT01002066)
- Where
- Tanzania
- Volunteers
- 3,890 people
- Sponsor
- Karolinska University Hospital
Depression - Major Depressive Disorder, Irritability
Teen Vulnerability to Irritability: Brain and Estrogen Changes
Purpose: Risk of severe psychopathology increases dramatically during adolescence, especially for females. Changes in ovarian steroids across the menstrual cycle produce windows of vulnerability to mood disturbances, particularly…
- Trial name
- TeenVIBE (NCT07544966)
- Testing
- Kurvelo
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Post-traumatic Stress Disorder
Qualitative Study on the Perception of Changes in the Psychotherapy of Traumatized Young People
The clinic of psychological trauma in adolescents still requires further development, whereas it is well documented in adults. This clinic is complex, because it must take into account the nature and type of trauma (recent or…
- Trial name
- TRAUMADOPSY (NCT06138522)
- Testing
- Semi-structured interviews, Child Post-Traumatic Stress Response Index (CPTS-RI) scale, - Therapeutic Alliance Questionnaire (HAQ-CP)
- Where
- France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Blood Loss, Surgical, Postoperative Hemorrhage
Study of the Hemorai Vysio Wearable Device for Monitoring Changes Related to Blood Loss in Patients During and After Surgery.
The goal of this clinical trial is to learn whether the Hemorai Vysio wearable device can be used safely and feasibly to track relative changes over time in tissue oxygen, hemoglobin-related signals, blood flow, and oxygen use…
- Trial name
- VYSIO-FEASIBIL (NCT07826637)
- Testing
- Wearable optical hemodynamic monitoring device
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hemorai Inc
Adolescent Obesity, Obesity in Adolescence
A Phase IV Safety and Efficacy Study of VI-0521 in Adolescents With Obesity
This study is being conducted to assess weight loss efficacy, as determined by changes in body mass index (BMI), and safety of VI-0521 (Qsymia®) or placebo, taken for 56 weeks accompanied by a lifestyle modification program in…
- Conditions
- Adolescent Obesity, Obesity in Adolescence, Adolescent Overweight
- Trial name
- NCT03922945
- Testing
- VI-0521 oral capsule, Lifestyle Modification
- Where
- United States
- Volunteers
- 223 people
- Sponsor
- VIVUS LLC
Lyme Disease, Lyme Neuroborreliosis
PEMF Therapy to Treat Lingering Symptoms of Lyme Disease After Treatment With Antibiotics
Overview PEMF Therapy for relief or reduction of lingering symptoms after antibiotic treatment of Lyme disease of participants in the UK.
- Conditions
- Lyme Disease, Lyme Neuroborreliosis, Lyme Arthritis, Unknown Origin Fever
- Trial name
- PEMF (NCT04577053)
- Testing
- Scientific Consciousness Interface Operations (SCIO) Class II FDA approved medical device
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kasey Phifer
Thoracic Cancers, Malignant Pleural Mesotheliomas NOS
Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining
Background: Chromatin is is the structural building block of a chromosome. It is found inside the nucleus of the cell and consists of a complex of DNA and protein.
- Conditions
- Thoracic Cancers, Malignant Pleural Mesotheliomas NOS, Lung Cancer NOS, Esophageal Cancers NOS
- Trial name
- NCT00242723
- Where
- United States
- Volunteers
- 1,559 people
- Sponsor
- National Cancer Institute (NCI)
Autism Spectrum Disorder
Folinic Acid in Autism
An examination of changes in urinary metabolites with use of folinic acid in children with autism spectrum disorder (ASD). Investigators will also measure behavioral measures and academic measures monthly at school with teachers…
- Trial name
- NCT03771560
- Testing
- folinic acid
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of California, San Francisco
Infection, Candida
Changing Patterns of Candida Infections in Urban Medical Centers
The purpose of this study is to determine the changing patterns of infection caused by Candida species in urban medical centers and its influence on patient outcomes.
- Conditions
- Infection, Candida, Non Albicans Species
- Trial name
- NCT00366223
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pittsburgh
Movement Disorders, Parkinson Disease
Sedation During Microelectrode Recordings Before Deep Brain Stimulation for Movement Disorders.
The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to sedation during deep brain stimulation surgery.
- Conditions
- Movement Disorders, Parkinson Disease, Parkinsonian Disorders, Dystonia
- Trial name
- NCT00355927
- Testing
- Sedation with IV propofol
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Postpartum Hemorrhage
Fever After Misoprostol Administration for the Treatment of Primary Postpartum Hemorrhage
This study will evaluate side effects after sublingual misoprostol (600 mcg) as a first-line treatment for primary postpartum hemorrhage (PPH) due to suspected uterine atony.
- Trial name
- NCT01080846
- Testing
- Misoprostol
- Where
- Ecuador
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Autism Spectrum Disorder (ASD)
Modified and Context-Focused Sports Intervention in Adolescents With Autism: Study Protocol
Adolescents with Autism Spectrum Disorder (ASD) typically engage less in physical activities than their typically developing peers, influenced by intrinsic and extrinsic factors.
- Trial name
- ASD (NCT06916988)
- Testing
- Sports Stars Brazil, context-centered therapy
- Where
- Brazil
- Volunteers
- 52 people
- Sponsor
- Federal University of Minas Gerais
Athletic Injuries
Implementation of the I-PROTECT Model
Evidence-based injury prevention training is highly effective in reducing sport-related musculoskeletal injuries in youth. However, this training has so far had limited public health impact because it is not widely or properly…
- Trial name
- I-PROTECT (NCT04481958)
- Testing
- I-PROTECT
- Where
- Sweden
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Lund University
Cerebral Palsy
Early Powered Mobility for Toddlers With Cerebral Palsy Using the Permobil® Explorer Mini and a Modified Ride-On Car
The use of powered mobility devices for young children with cerebral palsy (CP) has been gaining traction, with evidence that the use of powered mobility at young ages complements (rather than detracts from) other interventions…
- Trial name
- NCT04684576
- Testing
- Permobil Explorer Mini, Modified Ride-On Car
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Washington
Pregnancy, Obesity
Fit For Delivery: A Study of the Effect of Exercise Sessions and Nutritional Counselling on Pregnancy Outcome
"Fit for Delivery" is a randomized, controlled study to examine the effects of an intervention during pregnancy which consists of exercise groups and nutritional counselling.
- Conditions
- Pregnancy, Obesity, Diabetes
- Trial name
- FFF (NCT01001689)
- Testing
- Nutritional counseling + exercise groups
- Where
- Norway
- Volunteers
- 606 people
- Sponsor
- Sorlandet Hospital HF
Delirium on Emergence
Post Anesthesia Emergence and Behavioral Changes in Children Undergoing MRI
Children who receive general anesthesia may become agitated (emergence delirium) in the recovery period. This occurs more often after inhalational anesthetics, particularly sevoflurane and desflurane than after propofol.
- Trial name
- NCT02111447
- Testing
- Propofol, Sevoflurane, Isoflurane
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- State University of New York at Buffalo
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