Clinical trials: Modification
Pediatric Obesity
Sweet Taste Responsiveness in Relation to Insulin, Leptin and Adiposity Among Obese Treatment Seeking Children
This study will explore whether a relationship exists between insulin and leptin resistance, sweet taste responsiveness, and adiposity.
- Trial name
- NCT04600648
- Testing
- Serum insulin level, Serum Leptin test
- Sponsor
- State University of New York at Buffalo
Retinal Dystrophies, Color Vision Defects
Natural History Study of Inherited Retinal Diseases
This prospective, observational investigation seeks to delineate the interplay between chromatic vision deficits and both functional visual outcomes and anatomical retinal biomarkers in individuals affected by Inherited Retinal…
- Conditions
- Retinal Dystrophies, Color Vision Defects, Vision Disorders, Macular Degeneration
- Trial name
- MojiLVCDT (NCT07085533)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Augelux Therapeutics
Type 1 Diabetes Mellitus
B-Lymphocyte Immunotherapy in Islet Transplantation for Initial Islet Graft Failure
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT01049633
- Testing
- Allogeneic Pancreatic Islet Cells, Sirolimus, Basiliximab
- Where
- United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Fever
SCT02 Clinical Accuracy Validation
The aim of the study is to validate the accuracy of the temporal thermometer of Withings SCT02
- Trial name
- WIBOFE (NCT06637878)
- Testing
- Investigational Device (Withings SCT02) temporal thermometer measurement, Reference Device (Withings SCT01) temperature measurement
- Where
- 5 sites in United States
- Volunteers
- 118 people
- Sponsor
- Withings
Children, Family Engagement
Effective Implementation Control Trial
This study will evaluate the effectiveness and implementation of a theory-driven, WhatsApp-based family engagement intervention designed to improve oral health among primary school children.
- Conditions
- Children, Family Engagement, Oral Health Behavior Change
- Trial name
- NCT07736443
- Testing
- SmileConnect
- Where
- Pakistan
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Myeloproliferative Neoplasm
Cardiac Changes in Myeloproliferative Neoplasms
Myeloproliferative neoplasms are heterogeneous group of clonal hematopoietic stem cell neoplasms with excessive proliferation of one or more of the erythroid, megakaryocytic, or myeloid lineages and relatively normal maturation…
- Trial name
- NCT03177928
- Testing
- Transthorathic echocardiogram
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hypothermia Neonatal
Trial of a Non Electric Infant Warmer for Prevention and Treatment of Hypothermia in Rwanda
Hypothermia contributes to a significant portion of neonatal deaths. Kangaroo Mother Care (KMC) is a safe and effective method of warming; however, it is not always feasible, for example in settings such as resuscitation or…
- Trial name
- NCT03890211
- Testing
- Non-Electric Infant Warmer
- Where
- Rwanda
- Volunteers
- 3,179 people
- Sponsor
- Boston Children's Hospital
Cannabis Use, Adolescent Behavior
Alerta Cannabis: Evaluation of Web-based Tailored Intervention
This study consists in the the design, implementation, and evaluation of the first web-based computer tailored intervention program aimed at the prevention of cannabis use in Spanish adolescents (ALERTA CANNABIS).
- Conditions
- Cannabis Use, Adolescent Behavior, E-health
- Trial name
- NOTCANNABIS (NCT05849636)
- Testing
- ALERTA CANNABIS
- Where
- Spain
- Volunteers
- 1,850 people
- Sponsor
- University of Seville
BPD - Bronchopulmonary Dysplasia, NEC - Necrotizing Enterocolitis
Targeted vs Standard Fortification of Breast Milk
BACKGROUND: Human milk (HM) is recommended for all very low birth infants (VLBW)). Breast-milk is highly variable in nutrient content, failing to meet the nutritional demands of VLBW.
- Conditions
- BPD - Bronchopulmonary Dysplasia, NEC - Necrotizing Enterocolitis, Weight Gain, VLBW - Very Low Birth Weight Infant
- Trial name
- NCT03775785
- Testing
- Tailored enteral nutrition
- Where
- 2 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Princess Anna Mazowiecka Hospital, Warsaw, Poland
Hemodynamics
Electrical Velocimetry (ICON Cardiometry ) Assessment of Hemodynamic Changes During Pediatric Thoracoscopic Surgery
Advances in endoscopic equipment and technique have led to the use of minimally invasive thoracic surgery in an increasing number of pediatric surgical procedures.
- Trial name
- NCT04131699
- Testing
- Cardiotronic ICON continuous non-invasive cardiac output monitor.
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Cairo University
Pediatric Obesity, Adolescent Obesity
The Role of High Intensity Interval Training in the Treatment of Adolescent Obesity
The study will compare the effects of High Intensity Interval Training (HIIT) with Moderate Intensity Continuous Training (CMIT) as part of a lifestyle intervention program on BMI change in adolescents age 12-16 with obesity.
- Conditions
- Pediatric Obesity, Adolescent Obesity, Weight Loss
- Trial name
- NCT03361644
- Testing
- High-Intensity Interval Training, Moderate-Intensity Continuous Training
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Drug Resistant Epilepsy
Dietary Therapy In Epilepsy Treatment (DIET-Trial): A Randomised Non Inferiority Trial Comparing KD, MAD & LGIT for Drug Resistant Epilepsy
This randomised trial is undertaken to assess whether MAD or LGIT is non-inferior to KD with regard to seizure control at twenty-four weeks among children with drug resistant epilepsy.
- Trial name
- DIET (NCT02708030)
- Testing
- Ketogenic Diet, MAD, LGIT
- Where
- India
- Volunteers
- 165 people
- Sponsor
- All India Institute of Medical Sciences
Bronchopulmonary Infection
Clinical Course and Changes in the Respiratory Microbiota Based on Antibiotic Treatment in Patients With Cystic Fibrosis
Bronchopulmonary infection is the most common and serious complication in the evolutionary course of cystic fibrosis (CF). Administration of antibiotics adapted to infecting pathogens is one of the key issues for its management.
- Trial name
- NCT01693965
- Testing
- sputum samples
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Adult Solid Neoplasm, Childhood Solid Neoplasm
Gene-Modified T Cells, Vaccine Therapy, and Nivolumab in Treating Patients With Stage IV or Locally Advanced Solid Tumors Expressing NY-ESO-1
This phase I trial studies the side effects and the best dose of nivolumab when given together with gene-modified T cells and vaccine therapy in treating patients with solid tumors that express the cancer-testes antigen NY-ESO-1…
- Conditions
- Adult Solid Neoplasm, Childhood Solid Neoplasm, Metastatic Neoplasm
- Trial name
- NYM (NCT02775292)
- Testing
- Aldesleukin, Cyclophosphamide, Fludarabine Phosphate
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Health Knowledge, Attitudes, Practice, Drinking Behaviour
Promoting Alcohol-related Attitudinal and Behavioural Change Amongst Adolescents Through Internet Intervention
Objectives The aims of this study are to test the effectiveness of an online quiz competition in changing adolescents' alcohol-related attitudes and behaviour and to explore the fe¬asibility of using Internet viral marketing to…
- Trial name
- NCT02450344
- Testing
- Interactive health promotion, Passive health promotion
- Volunteers
- 7,933 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Healthy Lifestyle, Adolescent Behavior
Living Green and Healthy for Teens
This is a two-group parallel randomized controlled trial testing whether a gamified healthy living smartphone app for youth aged 10-16 representative of the Canadian population and one of their parents is more effective at…
- Trial name
- LiGHT (NCT03996109)
- Testing
- Aim2Be smartphone app system, BnLt smartphone app
- Where
- Canada
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Hemophagocytic Lymphohistiocytosis (HLH)
Dose-modified Emapalumab and Ruxolitinib (E-Ru) Regimens for Hemophagocytic Lymphohistiocytosis
This study is trying to evaluate the efficacy and safety of dose-modified Emapalumab and Ruxolitinib (E-Ru) regimens for the treatment of active hemophagocytic lymphohistiocytosis.
- Trial name
- NCT06951971
- Testing
- dose-modified E-Ru, Salvage treatment and follow-up
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Gender Equity
Chamas for Change: Impact of the COVID-19 Pandemic
In Kenya, the chamas strategy (a peer support approach aimed at improving MNCH and reducing gender and social inequalities) has been shown to significantly improve maternal and child health outcomes while also providing social…
- Trial name
- NCT05787392
- Testing
- Chamas cha MamaToto program
- Where
- 2 sites in Kenya
- Volunteers
- 444 people
- Sponsor
- Moi University
Eco-anxiety
School-based Intervention to Address Climate Change Emotions
The goal of this study was to qualitatively document the social validity of an intervention combining creative arts and philosophy inquiry and to examine its acceptability, the perceived goals, and perceived benefits for…
- Trial name
- NCT06781788
- Testing
- Making room for climate emotions in the classroom
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Université du Québec a Montréal
Obesity, Obesity, Childhood
Community Based Obesity Prevention and Treatment Programme "6-10-14 for Health"
"6-10-14 for Health" is an integrated weight-loss intervention programme for obese children from Gdansk municipality. Both participants of the programme and their family members are offered a 12-month integrated intervention…
- Conditions
- Obesity, Obesity, Childhood, Health Program, Body Weight Changes
- Trial name
- NCT04143074
- Testing
- multidisciplinary behavioral intervention
- Where
- Poland
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Michał Brzeziński
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