Clinical trials: Modification
Haematological Malignancy, Acute Leukemia
A Study to Assess a Physical Activity Program in Children, Adolescents and Young Adults Requiring Hematopoietic Stem Cell Allografts
To date, allogeneic haematopoietic stem cell transplantation (aHSCT) is the only curative treatment for many paediatric and young adult haematological pathologies (acute leukaemia, myelodysplastic syndromes, haemoglobinopathies…
- Conditions
- Haematological Malignancy, Acute Leukemia, Myelodysplastic Syndromes, Hemoglobinopathy in Children
- Trial name
- EVAADE (NCT04331483)
- Testing
- Physical activity program
- Where
- France
- Sponsor
- Centre Leon Berard
Premature Birth, Electrical Impedance Tomography (EIT)
Lung Volume Changes in Stable Preterm Infants Positioned in Car Seats
Premature infants (infants born <37 weeks' gestational age) are discharged from the hospital and transported home in car seats designed for term babies. The safe transport of these premature infants is an important concern.
- Conditions
- Premature Birth, Electrical Impedance Tomography (EIT), Lung Volume, Car Seat Transition for At-risk Infants
- Trial name
- CarSeat (NCT06724601)
- Testing
- Electrical Impedance Tomography
- Where
- Switzerland
- Volunteers
- 51 people
- Sponsor
- University of Zurich
Fever
Treatment of Hyperpyrexia and in the Pediatric Emergency Department (FEVER_ED)
Fever represents the main cause of admission to the emergency room in older people pediatric. It occurs in the presence of a wide range of pathologies, from infectious forms (the most common, viral or bacterial) up to more…
- Trial name
- FEVER_ED (NCT06194383)
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Tuberculosis
Self-verification and Support Via Mobile Phones Drastically Improves Tuberculosis Treatment Success in LMIC Settings
Each year, 10.4 million patients are diagnosed with and 1.8 million people die from Tuberculosis (TB). Despite the availability of highly effective and accessible medications in the developing world where TB is endemic, the 6-18…
- Trial name
- NCT03135366
- Testing
- Keheala, Standard of Care
- Volunteers
- 1,190 people
- Sponsor
- Yale University
Substance-Related Disorders, Recidivism
Alliances to Disseminate Addiction Prevention and Treatment (ADAPT)
Youth involved in the juvenile justice system (YJJ) bear a disproportionate burden of the addiction crisis. YJJ substance use (SU) is extremely prevalent, with a third of YJJ meeting criteria for a substance use disorder (SUD).
- Conditions
- Substance-Related Disorders, Recidivism, Opioid-Related Disorders, Substance Use
- Trial name
- ADAPT (NCT04499079)
- Testing
- Learning Health System
- Where
- United States
- Volunteers
- 7,316 people
- Sponsor
- Indiana University
Corneal Burn
Modified Corneal EA With Middle LKP for Severe Corneal Burn
The purpose of this pilot study is to explore whether modified corneal epithelial autograft (EA) combined with allogeneic middle lamellar keratoplasty (AMLK) is more effective than limbal autograft (LA) with AMLK for ocular…
- Trial name
- NCT03498846
- Testing
- Modified EA and AMLK, LA and AMLK
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-sen University
Obesity, PreDiabetes
Mechanisms of Inflammation, Immunity, Islet Cell and Intestinal Hormone Changes in Youth at Risk for Diabetes
This study intends to assess the role of inflammation in insulin resistant conditions (i.e., obesity and pre-diabetes) and the subsequent development of disease, such as type 2 diabetes (T2D) and cardiovascular disease (CVD), in…
- Conditions
- Obesity, PreDiabetes, Adolescent Obesity, Inflammation
- Trial name
- MI4D (NCT04031222)
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- The Hospital for Sick Children
Infant, Premature, Diseases
The Effect of Diaper Change Position on Preterm Infants
The purpose of this study is to determine the effect of diaper change position on neonatal comfort and heart rate, respiratory rate and oxygen saturation in preterm infants.
- Trial name
- NCT04528602
- Testing
- Control (Extended leg position) Group, Experimental (Legs are flexed toward abdomen) Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Acibadem University
Cardiovascular Diseases, Cancer
Promoting Healthy Lifestyles Among Firefighters
Promoting Healthy Lifestyles: Alternative Models' Effects (PHLAME) is a research study to evaluate and compare two ways to promote healthy behaviors, (regular physical activity, less than 30% calories from fat, 5 or more servings…
- Conditions
- Cardiovascular Diseases, Cancer, Physical Activity, Nutrition
- Trial name
- PHLAME (NCT00006181)
- Testing
- Team-based intervention, One-on-one intervention
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Sclerotic Graft Versus Host Disease, Imatinib Mesylate
Imatinib Mesylate to Treat Skin Changes in Patients With Chronic Graft-Versus-Host Disease
Background: Chronic graft-versus-host disease (GVHD) is a common complication of stem cell transplant, resulting from the donor's immune cells attacking the cells of the body of the recipient.
- Trial name
- NCT00702689
- Testing
- Gleevec, STI571(Imatinib Mesylate)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
16P11.2 Deletion Syndrome, 16p11.2 Duplications
Online Study of People Who Have Genetic Changes and Features of Autism: Simons Searchlight
Simons Searchlight is an observational, online, international research program for families with rare genetic variants that cause neurodevelopmental disorders and may be associated with autism.
- Conditions
- 16P11.2 Deletion Syndrome, 16p11.2 Duplications, 1Q21.1 Deletion, 1Q21.1 Microduplication Syndrome (Disorder)
- Trial name
- NCT01238250
- Where
- 2 sites in United States
- Volunteers
- 100,000 people
- Sponsor
- Simons Searchlight
Pain, Anxiety
Decreasing REcurrent Pain and Anxiety in Medical Procedures With a Pediatric Population: a Pilot Study
Children with injuries, including burns, experience severe pain intensity during medical procedures despite the increasing doses of analgesics.
- Conditions
- Pain, Anxiety, Burns, Child
- Trial name
- DREAM-P (NCT02977923)
- Testing
- VR distraction via Oculus Rift, Standard pharmacological treatment
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- St. Justine's Hospital
Cerebral Palsy, Diplegic Cerebral Palsy
Validity and Reliability of the Modified Four Square Step Test (mFSST)
Cerebral Palsy (CP) is a non-progressive neurodevelopmental disorder that causes activity limitation resulting from movement and posture deficiencies as a result of a lesion in the immature brain.
- Conditions
- Cerebral Palsy, Diplegic Cerebral Palsy, Hemiplegic Cerebral Palsy, Gait Disorders, Neurologic
- Trial name
- cp (NCT05229523)
- Testing
- repeated assessments
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Autism Spectrum Disorder
Interactive Mirroring Games wIth sOcial Robot (IOGIOCO) and Robotic System Adapted Into a Clinical Scale (RISCALE)
Background: The importance of early intervention in Autism Spectrum Disorders (ASD) has been widely demonstrated, and developmental trajectories in ASD highlight the importance of nonverbal communication, such as intransitive…
- Trial name
- RISCALE (NCT06855446)
- Testing
- Intervention with social robot NAO, Treatment as usual
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Refactory Warts
Local Hyperthermia Combined With Topical 3% Hydrogen Peroxide for Refractory Viral Warts
1. Background of the Problem Viral warts result from infection of the skin or mucous membranes by human papillomavirus (HPV). Some patients develop refractory cases due to abnormal immune function, persistent viral presence, or…
- Trial name
- NCT07565350
- Testing
- An infrared hyperthermia device, Hydrogen Peroxide 3 % Topical Solution, Normal Saline (NS)
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- First Hospital of China Medical University
Focal Segmental Glomerulosclerosis, Nephrotic Syndrome
Genetic Causes of FSGS, Nephrotic Syndrome, or Kidney Failure
The investigators are trying to learn more about the cause of kidney diseases such as Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic syndrome by studying genetics.
- Conditions
- Focal Segmental Glomerulosclerosis, Nephrotic Syndrome, End Stage Renal Disease, Kidney Failure
- Trial name
- FSGS (NCT02194582)
- Where
- United States
- Volunteers
- 2,050 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Acute Febrile Illness
Electronic Algorithms Based on Host Biomarkers to Manage Febrile Children
Health professionals in developing countries have limited ability to identify children at risk of dying and those in need of antibiotics.
- Trial name
- e-POCT (NCT02225769)
- Testing
- Management of febrile children using e-POCT, Management of febrile children using ALMANACH
- Where
- Tanzania
- Volunteers
- 3,192 people
- Sponsor
- Swiss Tropical & Public Health Institute
Acute Lymphoblastic Leukemia
Pegylated Liposomal Doxorubicin Versus Daunorubicin to Treat Acute Lymphoblastic Leukemia:
To determine, compared with Daunorubicin(DNR), whether Pegylated liposomal doxorubicin (PLD) inducing higher complete remission (CR) rate, in untreated primary ALL adult patients with VDCLD regimen induction therapy.
- Trial name
- NCT02070523
- Testing
- VDCLD regimen
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Changzhou Jinyuan Pharmaceutical Manufacturing Co., Ltd.
Oral Hygiene
Oral Health Promotion: Youth as Agents Of Change
This upstream communication study may aid in our understanding of the nature of the parent-adolescent relationship and how we can use this relationship to promote better oral health of the parents and adolescents.
- Trial name
- NCT03947203
- Testing
- Social media
- Volunteers
- healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Obesity
A Family-Based Weight Loss Intervention for Youth With Intellectual Disability
The purpose of this randomized controlled trial is twofold. First, to examine the efficacy of a 24-session, 6-month family-based behavioral intervention (FBBI) - as compared to a waitlist FBBI group, which later receives the same…
- Trial name
- HealthU (NCT02033642)
- Testing
- Family Based Behavioral Intervention, Maintenance
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Boston
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