Clinical trials: Movement Abnormalities
Parkinson Disease (PD), Deep Brain Stimulation
One-Year Effect on Levodopa Equivalent Daily Dose of Thalamic VIM Nucleus Stimulation Compared to Subthalamic Nucleus Stimulation in Patients With Parkinson's Disease
This study compares the effects of deep brain stimulation (DBS) of the thalamic VIM nucleus versus the subthalamic nucleus (STN) on the levodopa equivalent daily dose (LEDD) in patients with Parkinson's disease.
- Trial name
- VIM vs NST (NCT06936254)
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Central Hospital, Nancy, France
Parkinson Disease
Parkinson's Disease in Home Rehabilitation Services
Introduction: Home rehabilitation is a form of care that is part of most health systems. Patients with Parkinson's disease can be referred to these Home Rehabilitation Services given the characteristics of the pathology they…
- Trial name
- NCT05340283
- Testing
- physiotherapy
- Volunteers
- 145 people
- Sponsor
- University of Oviedo
Parkinson's Disease
Tryptophan Depletion in PD Patients Treated With STN DBS
The purpose of this study is to assess the effect of tryptophan depletion on mood and behavior in Parkinson's disease (PD) patients treated with deep brain stimulation (DBS) of the subthalamic nucleus (STN).
- Trial name
- NCT02632279
- Testing
- Tryptophan (TRP) depletion, Stimulator ON, Stimulator OFF
- Where
- Netherlands
- Volunteers
- 7 people
- Sponsor
- Maastricht University Medical Center
Wilson's Disease
A Phase 1 Study to Assess the Effects in the Body of a Single Dose of Trientine Dihydrochloride in Wilson's Disease Patients
To evaluate the effects of a single dose of trientine in children ≥6 years and adult patients with Wilson's disease.
- Trial name
- NCT01874028
- Testing
- trientine dihydrochloride
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Univar BV
Parkinson Disease
Safety and Efficacy of Adaptive Deep Brain Stimulation
The aim of this study is to assess the safety and the potential efficacy of personalized Local Field Potential (LFP)-based adaptive Deep Brain Stimulation (aDBS), using the implantable pulse generator (IPG) of the "AlphaDBS"…
- Trial name
- NCT04681534
- Testing
- AlphaDBS System
- Where
- 8 sites in Italy, Netherlands and 1 more
- Volunteers
- 15 people
- Sponsor
- Newronika
Parkinson Disease, Freezing of Gait Symptoms in Parkinson's Disease
Brain-Machine Interface for Freezing of Gait
Gait problems in Parkinson's disease (PD), especially freezing of gait (FOG), greatly affect quality of life. While deep brain stimulation (DBS) is a highly effective treatment for many motor symptoms of PD, it is less effective…
- Trial name
- NCT06642519
- Testing
- Brain Stimulation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Toronto
Tic Disorders
Efficacy of Amoxicilline/Clavulanic Acid in Patients Affected by Tic Disorder Colonized by Group A Streptococcus
This study is an extension of the European Multicentre Tics In Children Studies (EMTICS) COURSE study for which a separate study protocol exists; Aim of this clinical trial is to study the efficacy of treatment with antibiotics…
- Trial name
- AntibioTICS (NCT01860300)
- Testing
- Amoxicillin-Potassium Clavulanate Combination
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- University of Roma La Sapienza
Tourette Syndrome, ADHD
Modified Comprehensive Behavioral Intervention for Tics (M_CBIT)
The main purpose of this trial is to develop and investigate the effects of a modified comprehensive behavioral intervention for tics (CBIT) protocol for children and adolescents with chronic tic disorders and ADHD.
- Trial name
- M_CBIT (NCT02900144)
- Testing
- Modified Comprehensive Behavioral Intervention for Tics, Comprehensive Behavioral Intervention for Tics
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Massachusetts General Hospital
Parkinson Disease
Disease Burden and Cost Consequence of Falls Among Individuals With Parkinson's Disease in Hong Kong: A Prospective Cost-utility Analysis
Objective: Estimate the cost of disease and falls among people with Parkinson's disease living in Hong Kong. Design: Prospective cost-utility analysis (base year 2021) with one baseline and two follow-up assessments at 6 months…
- Trial name
- NCT05094219
- Testing
- No intervention will be offered
- Where
- 2 sites in Hong Kong
- Volunteers
- 90 people
- Sponsor
- The Hong Kong Polytechnic University
Parkinson's Disease
Short Pulse Width DBS in Parkinson's Disease
The aim of this investigation is to explore the effect of reducing conventional pulse width of stimulation on known adverse effects of Subthalamic nucleus Deep Brain Stimulation (STN DBS) treatment such as; slurring of speech…
- Trial name
- NCT03417271
- Testing
- Deep brain stimulation
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University College, London
Parkinson's Disease, Helicobacter Infections
Treating H. Pylori in Parkinson's Patients With Motor Fluctuations
The purpose of this study is to determine whether treatment of H. pylori (an infection of the stomach) improves treatment effectiveness in patients with Parkinson's disease and motor fluctuations.
- Conditions
- Parkinson's Disease, Helicobacter Infections, Motor Fluctuations
- Trial name
- NCT00664209
- Testing
- clartihromycin, amoxicillin, and omeprazole
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of California, Los Angeles
Angelman Syndrome
Long-term Extension of GTX-102 in Angelman Syndrome
The primary objective of the study is to evaluate the long-term safety profile of GTX-102 in participants with Angelman Syndrome (AS)
- Trial name
- NCT06415344
- Testing
- GTX-102
- Where
- 23 sites in United States, Australia and 6 more
- Volunteers
- 66 people
- Sponsor
- Ultragenyx Pharmaceutical Inc
Serotonin Syndrome
Azilect + Antidepressant Chart Review
To identify the occurrence of serotonin toxicity in Parkinson's Disease (PD) patients receiving antidepressant therapy and rasagiline, compared to those receiving rasagiline without antidepressant medications and compared to PD…
- Trial name
- STACCATO (NCT00955604)
- Testing
- Group R+AD Rasagiline + Antidepressant, Group R Rasagiline, Group AD Anti-PD + Antidepressant
- Volunteers
- 1,500 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Tic Disorders, Tourette Syndrome
An Exploratory Study of Continuous Theta Burst Stimulation (cTBS) Based on fMRI in the Treatment of Tic Disorder
continuous theta burst stimulation (cTBS) is a safe and effective device for Gilles de la Tourette's syndrome treatment. GPi is an agreed curative target of deep brain stimulation.
- Trial name
- NCT04128397
- Testing
- traditional stimulation site continuous theta burst stimulation (cTBS), precise stimulation site cTBS
- Where
- 2 sites in China
- Volunteers
- 95 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Parkinson´s Disease
The Effect of High-Volume Walking With Visual Cues (VC) in Parkinson´s Disease (PD)
People with disease (PD) tend to walk with short steps, decreased velocity, and increased stride time variability. Short steps and increased variability are related to greater fall risk.
- Trial name
- NCT01391741
- Testing
- Visual Cues, Walking without visual cues
- Where
- Iceland
- Volunteers
- 26 people
- Sponsor
- University of Iceland
Autism Spectrum Disorder
Effectiveness of Aerobic Exercises on the Autistic Children
Autism spectrum disorder (ASD) is a neurodevelopmental disorder manifesting stereotypic behaviors and problem in communication and social interaction.
- Trial name
- NCT05067361
- Testing
- Aerobic Exercise, Ball Exercises
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- University of Faisalabad
Rett Syndrome, Prader-Willi Syndrome
Sleep Abnormalities in Rare Genetic Disorders: AS, RTT, and PW
This study will investigate sleep behavior in subjects with Angelman Syndrome, Rett Syndrome or Prader-Willi Syndrome. The study will also investigate sleep behavior in healthy siblings of subjects with Angelman Syndrome, Rett…
- Conditions
- Rett Syndrome, Prader-Willi Syndrome, Angelman Syndrome, Sleep Problems
- Trial name
- RDCRN (NCT02670694)
- Where
- 9 sites in United States
- Volunteers
- 804 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Parkinson's Disease
Tele-diagnostics for Remote Parkinson's Monitoring
The purpose of this research study is to design, implement, and clinically assess a portable, user worn system for monitoring Parkinson's disease (PD) motor symptoms.
- Trial name
- NCT01356056
- Testing
- Kinesia HomeView
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Great Lakes NeuroTechnologies Inc.
REM Sleep Behavior Disorder
Gut Microbiota in the Progression of Alpha-synucleinopathies
The aim of this study is to correlate baseline gut microbiota features and the progression of neurodegeneration in the established cohort of patients with early Parkinson's disease.
- Trial name
- NCT05353868
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 490 people
- Sponsor
- Chinese University of Hong Kong
Parkinson Disease
New Biomarkers in Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disease and its prevalence is expected to double over the next 30 years, making it a leading cause of neurological disability [GBD 2016 Neurology Collaborators…
- Trial name
- NCT05150158
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS