Clinical trials: Movement Abnormalities
Parkinson Disease
Treatment of Parkinson's Disease With a Transdermal Skin Patch
Patients with Parkinson's disease are missing the chemical neurotransmitter dopamine. This occurs as a result of destructive changes in an area of the brain responsible for making dopamine, the basal ganglia.
- Trial name
- NCT00001931
- Testing
- N-0923
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease, Idiopathic
Parkinson Disease: A Model of National Digital Interventions to Prevent or Slow a Rise of Non-Communicable
According to Parkinson's Disease Medical Center of Excellence's project which was registered Parkinson's disease patients in 2008-2011, it was found that there were more than 60,000 people with Parkinson's disease in Thailand…
- Trial name
- PDRegistry (NCT06609681)
- Where
- Thailand
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Roongrooj Bhidayasiri
Parkinson Disease
Effects of Peripheral Electrical Stimulation With Focused Ultrasound on Motor Symptoms in Parkinson's Patients
Transcranial Ultrasound Stimulation (TUS) is an emerging non-invasive brain stimulation(NIBS) technique that can be used on both superficial and deep brain targets with a high spatial resolution as small as a few cubic…
- Trial name
- tbFUS-FES_PD (NCT06090292)
- Testing
- Real TUS, Real FES
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Dysphagia, Stroke
Wearable Biofeedback for Swallowing Disorders Rehabilitation in Stroke and Parkinson Disease
Dysphagia, or difficulty swallowing, is a common symptom of many neurological diseases but its treatment is not well established or easily accessible.
- Conditions
- Dysphagia, Stroke, Parkinson Disease
- Trial name
- NCT06638944
- Testing
- In-person sEMG-biofeedback, Remote sEMG-biofeedback, Standard-of-care treatment
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Illinois at Urbana-Champaign
Mild Cognitive Impairment, Alzheimer Disease
Skeletal Muscle as a Mediator of Exercise Induced Effects on Metabolism & Cognitive Function: Role for Myokines & miRNAs
The purpose of this study is to determine specific changes in muscle secretory profile (myokines, miRNA) in association with neurodegenerative disease progression and metabolic dysfunction.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Parkinson Disease, Healthy Volunteers
- Trial name
- Brain-Muscle (NCT02253732)
- Testing
- 3 months exercise intervention program
- Where
- 2 sites in Slovakia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Parkinson's Disease, Progressive Supranuclear Palsy(PSP)
Study on Artificial Intelligence-Based Facial and Speech-Related Patterns in Parkinson's Disease and Their Digital Biomarkers
This research employs AI to analyze facial expressions and speech patterns, aiming to develop new digital tools for diagnosing and differentiating Parkinson's disease and similar disorders.
- Conditions
- Parkinson's Disease, Progressive Supranuclear Palsy(PSP), Multiple System Atrophy, Healthy Control
- Trial name
- NCT07392411
- Testing
- video recording
- Where
- China
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Parkinson Disease
Feasibility and Effects of a Pickleball Program for People With Parkinson Disease
Pickleball is a fast-growing sport that has been shown to improve social integration, life satisfaction, function, and cognitive function in older adults.
- Trial name
- NCT05994508
- Testing
- Pickleball program
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Midwestern University
Deep Brain Stimulation
Evaluation of Advanced Imaging and Visualization for Clinical Deep Brain Stimulation
The objective of this project is to evaluate next generation visualization tools and surgical targeting models for clinical deep brain stimulation (DBS).
- Trial name
- NCT06191874
- Testing
- Standard-of-care (SOC) surgery plan, HoloDBS hypothetical surgery plan
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Duke University
Parkinson Disease
Cognitive-Motor Training for Gait Adaptability in Parkinson Disease
Cognitive-motor training combines thinking tasks with physical movements, encouraging participants to choose appropriate actions and adjust their movements according to different task demands.
- Trial name
- NCT07907718
- Testing
- Cognitive-motor training, Conventional physiotherapy
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Yang Ming Chiao Tung University
Parkinson's Disease
A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics (PK) of prasinezumab compared with placebo in participants with early-stage Parkinson's disease (PD) on stable symptomatic monotherapy with…
- Trial name
- PARAISO (NCT07174310)
- Testing
- Prasinezumab
- Where
- 192 sites in United States, Australia and 15 more
- Volunteers
- 900 people
- Sponsor
- Hoffmann-La Roche
Parkinson Disease
Changes in Functional Performance in Individuals With Parkinson's Disease Following 2-month Physiotherapy Intervention
Aim of current study was to evaluate the effect of a 2-month comprehensive physiotherapy intervention on different aspects of functional performance.
- Trial name
- NCT03568903
- Testing
- Comprehensive physical therapy
- Volunteers
- 44 people
- Sponsor
- University of Tartu
Parkinson Disease
Virtual Exercises in Patients With Parkinson's Disease.
Introduction: Although the motor changes are well determined in Parkinson's disease (PD), few studies describe the effects the virtual exercises on the clinical and functional outcomes in this disease.
- Trial name
- NCT02023034
- Testing
- Virtual exercises
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Faculdade Evangelica do Parana
Early-stage Parkinson's Disease
Evaluation of the Tolerance and Acceptability of Rasagiline in the Treatment of Early-stage Parkinson's Disease
Title: Evaluation of the tolerance and acceptability of Rasagiline in the treatment of early-stage Parkinson's disease. Type of study: Phase IV Study objectives: Principal objective: To evaluate the tolerance and acceptability of…
- Trial name
- ACTOR (NCT01048229)
- Testing
- Rasagiline, Pramipexole
- Volunteers
- 112 people
- Sponsor
- Qualissima
Huntington Disease
Time-Restricted Eating in Huntington's Disease: A Clinical Pilot Study
This trial examines whether 12 weeks of time-restricted eating (TRE), otherwise known as intermittent fasting, appears safe and feasible in persons with early-stage Huntington's disease (HD).
- Trial name
- TREHD (NCT06490367)
- Testing
- Time-Restricted Eating Diet
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Oregon Health and Science University
Resistance Training, Yoga
Mindfulness and Yoga or Resistance Exercise Training Fpr Parkinson's Patients
The investigators propose to compare the effects of a 16-week specially designed yoga program to a power-based resistance training program on affect trait mindfulness, anxiety, depression, functionality, and quality of life.
- Trial name
- NCT05513534
- Testing
- Yoga, High-speed Resistance Training
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Miami
Parkinson's Disease, Levodopa Induced Dyskinesia (LID)
Efficacy and Safety of Amantadine Hydrogen Chloride (HCl) ER Tablets in Parkinson's Disease Subjects With LID
The purpose of this multi-center, randomized, double-blind, parallel-group, 26 week study is to compare the efficacy and safety of two different dose levels of Amantadine Extended Release Tablets to placebo for the treatment of…
- Trial name
- ALLAY-LID-II (NCT02153632)
- Testing
- amantadine HCl ER
- Where
- 56 sites in United States, Canada and 3 more
- Volunteers
- 135 people
- Sponsor
- Adamas Pharmaceuticals, Inc.
Blepharospasm of Both Eyelids, Blepharospasm of Left Eyelid
DaxibotulinumtoxinA for Blepharospasm
This study aims to provide real-world information about the duration, safety, and overall benefit of DaxibotulinumtoxinA (also called DAXI) treatment for adults living with blepharospasm (BSP), a condition that causes…
- Conditions
- Blepharospasm of Both Eyelids, Blepharospasm of Left Eyelid, Blepharospasm of Right Eyelid, Blepharospasm, Benign Essential
- Trial name
- BLEXI (NCT07489430)
- Testing
- Botulinum Neurotoxin Type A
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Parkinson's Disease
Italian Validation of the Revised MDS-Unified Parkinson's Disease Rating Scale
The present study is part of an international program and deals with the translation and validation program for the Italian version of the MDS-UPDRS.
- Trial name
- IRIS (NCT01092936)
- Testing
- Rating Scale administration
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Fondazione Neureca
Parkinson Disease
LRRK2 Mutation and Parkinson's Disease
The Leucine-Rich Repeat Kinase 2 (LRRK2) is implicated in autosomal dominant Parkinson's disease (PKD). An inhibitor for the leucine-rich repeat kinase 2 (LRRK2) is in pre-clinical development for potential use in treating…
- Trial name
- NCT01424475
- Testing
- Healthy, PKD Patients
- Where
- United Kingdom
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Mindfulness, Caregivers
Dyadic Mindfulness for People With Parkinson's Disease and Their Caregivers
The proposed two-arm randomized waitlist-controlled trial will use a mixed-methods design to investigate the effects of dyadic mindfulness on physio-psycho-spiritual outcomes in people with Parkinson's Disease (PwPD) and their…
- Conditions
- Mindfulness, Caregivers, Movement Disorders, Neurodegenerative Disease
- Trial name
- NCT06821230
- Testing
- Dyadic mindfulness
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.