Clinical trials: Movement Abnormalities
Tourette's Syndrome
Ecopipam Treatment of Tourette's Syndrome in Subjects 7-17 Years
Tourette's Syndrome is a neurological disease characterized by motor and vocal tics. It has been hypothesized that abnormal interactions of dopamine with its receptors may cause the tics.
- Trial name
- NCT02102698
- Testing
- Ecopipam
- Where
- 11 sites in United States
- Volunteers
- 40 people
- Sponsor
- Emalex Biosciences Inc.
Parkinson Disease
Chinese PD-SNCA Registry
The purpose of the Chinese PD-SNCA Registry(CPD-SNCAR) is to develop a database of patients of Parkinson's disease with a-synuclein (SNCA) gene variants in mainland China.
- Trial name
- NCT03523052
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Xiangya Hospital of Central South University
Lysosomal Storage Disorders, Gaucher Disease
Genetic Studies of Lysosomal Storage Disorders
The purpose of this study is to identify genetic, biochemical, and clinical factors that are associated with disease severity in people with Gaucher disease and other lysosomal storage disorders.
- Conditions
- Lysosomal Storage Disorders, Gaucher Disease, Parkinson Disease
- Trial name
- NCT00001215
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Parkinson Disease
Effectiveness of Intensive Rehabilitation in Advanced Stages of Parkinson's Disease.
this study is aimed to evaluate the effectiveness of an Multidisciplinary Intensive Rehabilitation Treatment in Advanced Stages of Parkinson's Disease.
- Trial name
- NCT02731170
- Testing
- MIRT
- Where
- Italy
- Volunteers
- 439 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Tourette Syndrome, Obsessive Compulsive Disorder
Developmental Phenomenology of Obsessive Compulsive Disorder and Tourette Syndrome in Children and Adolescents
OBJECTIVES: I. Characterize the natural history, associated features, and severity of symptoms of obsessive compulsive disorder and Tourette syndrome in children and adolescents. II.
- Trial name
- NCT00004324
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Center for Research Resources (NCRR)
Parkinson's Disease, Multiple System Atrophy, Parkinson Variant
AB-1005 Long-Term Follow-up Study
This is an observational, long term, follow-up study for participants with Parkinson's disease (PD) or Multiple System Atrophy-Parkinsonian subtype (MSA-P) who participated in prior interventional studies with AB-1005.
- Trial name
- NCT07081841
- Testing
- Observation
- Where
- 2 sites in United States
- Volunteers
- 132 people
- Sponsor
- AskBio Inc
Angelman Syndrome
A Trial of Levodopa in Angelman Syndrome
This study is designed to determine whether levodopa will lead to an improvement in the development and tremor in children with Angelman syndrome (AS).
- Trial name
- NCT01281475
- Testing
- Levodopa
- Where
- 7 sites in United States
- Volunteers
- 67 people
- Sponsor
- Wen-Hann Tan
ADCY5-related Dyskinesia
Caffeine Efficacy in ADCY5-related Dyskinesia
Heterozygous mutations in ADCY5 induce hyperactivity of striatal adenylate cyclase type 5 (AC5), manifesting as early-onset hyperkinetic movement disorders. Numerous treatments have been tried without much efficacy thus far.
- Trial name
- ADCY5-CAF (NCT04469283)
- Testing
- caffeine and movement disorders
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson Disease, Gait, Unsteady
Effect of Haptic Cueing on Long-Range Autocorrelations in Parkinson's Disease Gait Variability
Parkinson's Disease (PD) patients suffer from gait impairments responsible for falls and bad quality of life: reduced speed and stride length, randomness in the temporal organization of stride duration variability (reduced…
- Trial name
- NCT05790759
- Testing
- No cueing versus Haptic cueing versus Auditory cueing during parkinson's disease gait
- Where
- 2 sites in Belgium
- Volunteers
- 10 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Parkinson Disease
Donepezil to Treat Dementia in Parkinson's Disease
This study will evaluate the safety and effectiveness of donepezil (Aricept) for treating mild dementia in patients with Parkinson's disease.
- Trial name
- NCT00030979
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Primary Dystonia
Comparison of the Efficacy of Double Monopolar Versus Interleaving Stimulation Modes for Pallidal Deep Brain Stimulation
The aim of the study is to compare the efficacy and the safety profile of the newly introduced interleaving stimulation mode to those of the standard double monopolar stimulation mode during pallidal deep brain stimulation of…
- Trial name
- NCT01497639
- Testing
- Interleaving stimulation mode (Medtronic), Double monopolar stimulation mode (Medtronic)
- Where
- Hungary
- Volunteers
- 34 people
- Sponsor
- University of Pecs
Tourette's Disorder
Efficacy & Safety Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder
The goal of the current study is to determine efficacy and safety of once-weekly aripiprazole in reducing Total Tic Severity (TTS) score in children and adolescents with Tourette's Disorder.
- Trial name
- NCT01418339
- Testing
- Aripiprazole
- Where
- 39 sites in United States, Canada and 4 more
- Volunteers
- 135 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Tourette Syndrome, Tics
Cognitive-psychophysiological Treatment for Tics in Young People With Tourette's Syndrome With or Without Biofeedback
The goal of this clinical trial is to compare the effectiveness of CoPs therapy with or without the therapeutic component of biofeedback in treating tics in Tourette Syndrome with emerging young adults. Hypotheses: 1.
- Conditions
- Tourette Syndrome, Tics, Tourette Syndrome in Adolescence
- Trial name
- CoBRa (NCT06873841)
- Testing
- Cognitive psychophysiological, Cognitive psychophysiological and Biofeedback
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Université du Québec a Montréal
Parkinson's Disease (PD), Spinal Cord Stimulation (SCS)
Trial of Four Spinal Cord Stimulation Paradigms for Gait Impairment in Parkinson's Disease
Patients with PD and SCS treatment for gait impairment entered a cross-over trial of four stimulation paradigms; high frequency/low pulse width, low frequency/high pulse width, Fast-Acting Sub-perception Therapy, and MicroBurst.
- Trial name
- NCT07659405
- Testing
- Stimulation paradigm: High frequency / low pulse width, Stimulation paradigm: Low frequency / high pulse width, MicroBurst
- Where
- Denmark
- Volunteers
- 11 people
- Sponsor
- University of Aarhus
Tourette Syndrome
Safety and Efficacy Study of NBI-98854 in Children and Adolescents With Tourette Syndrome
Phase 2, double-blind, placebo-controlled study to assess the safety and efficacy of NBI-98854 administered once daily (qd) for a total of 6 weeks of treatment.
- Trial name
- NCT02679079
- Testing
- NBI-98854
- Where
- 44 sites in United States
- Volunteers
- 98 people
- Sponsor
- Neurocrine Biosciences
Gaucher Disease, Parkinson Disease
World Data on Ambroxol for Patients With GD and GBA Related PD
Ambroxol hydrochloride is an oral mucolytic drug available over-the-counter for many years as cough medicine. In 2009 it was found to also act as a pharmacological chaperone (PC) for mutant glucocerebrosidase, albeit in a…
- Conditions
- Gaucher Disease, Parkinson Disease, GBA Gene Mutation
- Trial name
- NCT04388969
- Where
- 3 sites in Israel
- Volunteers
- 300 people
- Sponsor
- Shaare Zedek Medical Center
Tourette Syndrome
Developing New Treatments for Tourette Syndrome: Therapeutic Trials With Modulators of Glutamatergic Neurotransmission
A joint NIH -Tourette Syndrome Association Conference has emphasized the critical need for the testing and development of new pharmacotherapy for tic suppression in Tourette syndrome (TS).
- Trial name
- NCT01018056
- Testing
- D-serine, Riluzole
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Johns Hopkins University
Parkinson Disease (PD)
The Effect of Beechband on Parkinson's Symptoms
Parkinson's disease can affect movement, balance, and everyday activities. The Beechband is a wrist-worn device that provides intermittent vibrations.
- Trial name
- NCT07821151
- Testing
- Beechband
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Exeter
Dementia With Lewy Bodies
The PACE-DLB Study
The PACE-DLB Study is for people with at least moderate dementia with Lewy bodies (DLB) and their primary caregiver. The study's goals are to learn more about the experiences of people with DLB and their caregivers as DLB…
- Trial name
- NCT04829656
- Where
- 5 sites in United States
- Volunteers
- 378 people
- Sponsor
- University of Florida
Nystagmus
Eye Muscle Surgery to Treat Congenital Nystagmus
This study will examine the safety and effectiveness of a new surgical procedure to correct congenital nystagmus-a disorder of eye muscle-vision-brain coordination characterized by rapid to and fro eye movements (oscillation).
- Trial name
- NCT00001866
- Testing
- horizontal muscles of the eye will be cut and then reattached in the same position
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Eye Institute (NEI)