Clinical trials: Movement Disorders
Cerebral Palsy, Infant, Premature, Diseases
Associations Between Early Neonatal Neuroimaging, Hammersmith Infant Neurological Examination and General Movements
High risk infant is defined as infant with a negative history of environmental and biological factors, which can lead to neuromotor development problems.
- Conditions
- Cerebral Palsy, Infant, Premature, Diseases, Infant Development, Neurologic Disorder
- Trial name
- highrisk (NCT05217186)
- Testing
- Measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Parkinson´s Disease
The Effect of High-Volume Walking With Visual Cues (VC) in Parkinson´s Disease (PD)
People with disease (PD) tend to walk with short steps, decreased velocity, and increased stride time variability. Short steps and increased variability are related to greater fall risk.
- Trial name
- NCT01391741
- Testing
- Visual Cues, Walking without visual cues
- Where
- Iceland
- Volunteers
- 26 people
- Sponsor
- University of Iceland
Angelman Syndrome
A Study to Investigate the Pharmacokinetics (PK) and Safety and to Provide Proof of Mechanism of Alogabat in Children and Adolescents Aged 5-17 Years With Angelman Syndrome (AS) With Deletion Genotype.
This is a two-part, Phase IIa, multicenter, 12-week, open-label study. Up to 56 participants with deletion AS aged 5-17 years (inclusive) will be enrolled in the study.
- Trial name
- Aldebaran (NCT05630066)
- Testing
- Alogabat
- Where
- 19 sites in United States, Australia and 4 more
- Volunteers
- 48 people
- Sponsor
- Hoffmann-La Roche
Depression, Anxiety
UCSF TARA Study: Training for Awareness, Resilience and Action
The investigators aim to refine and pilot test an innovative group treatment model for adolescent depression and anxiety, Training for Awareness, Resilience and Action (TARA) in a sample of 14-18 year olds with depressive or…
- Trial name
- NCT02480257
- Testing
- TARA
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of California, San Francisco
Parkinson Disease
Validation of a Non-Motor Fluctuation Assessment Instrument (NoMoFA) for Parkinson's Disease
Investigators have developed a comprehensive questionnaire that assesses the presence of non-motor fluctuations (NMFs) in individuals with Parkinson's disease (PD).
- Trial name
- NCT03845634
- Where
- Canada
- Volunteers
- 202 people
- Sponsor
- Assistive Technology Clinic, Canada
Parkinson's Disease
Effect of Stimulus Rate on Cognitive and Motor Activity in Young Subjects, Elderly Subjects, and Patients With Parkinson's Disease
The purpose of this study is to investigate how changes in the brain associated with Parkinson's disease influence the control of motor and thinking speed.
- Trial name
- NCT00026598
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonia, Dystonic Cerebral Palsy
Enhancing Sensorimotor Processing in Children With Dystonia
Dystonia is a severely disabling movement disorder with no cure, in which people suffer painful muscle spasms causing twisting movements and abnormal postures. There are many causes, including genetic conditions and brain injury.
- Conditions
- Dystonia, Dystonic Cerebral Palsy, Dystonia, Secondary, Dystonia, Primary
- Trial name
- NCT05612464
- Testing
- No intervention
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- King's College London
Laser, Intrusion
Histological Change of The Dentinal-Pulp Complex and Root Resorption
The purpose of the study is evaluate the histological changes of the dentinal-pulp complex and root resorption in maxillary premolars with intrusive orthodontic movement under a low power laser effects.
- Conditions
- Laser, Intrusion, Histology, Resorption
- Trial name
- NCT01642693
- Testing
- Low power laser in teeth after intrusive movement, Simulated laser in teeth with intrusive movements
- Where
- Colombia
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Parkinson's Disease, Depression
Internet-CBT (Cognitive Behavioral Therapy) for Depression and Anxiety in Parkinsons Disease
The purpose of this project is to develop and evaluate Internet-based Cognitive Behavioral Therapy (ICBT) for Parkinson's Disease (PD) patients with concurrent depression or anxiety symptoms.
- Conditions
- Parkinson's Disease, Depression, Anxiety, Insomnia
- Trial name
- NCT01545414
- Testing
- ICBT, ICONTROL
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Karolinska Institutet
Parkinson Disease (PD)
A Multimodal Convergent Cohort of Parkinson's Disease at FJMUUH (FJMUUH-PD): Natural History Study
Parkinson's disease (PD) is a common neurodegenerative disorder in middle-aged and elderly individuals, with a global incidence of 2.0% among adults aged 65 and over.
- Trial name
- NCT07588763
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Fujian Medical University Union Hospital
Malocclusion
The Use of Clear Aligners With Movement Enhancement Techniques
The purpose of this study is to use clear aligners to measure tooth movement and length of treatment.
- Trial name
- NCT02087163
- Testing
- Movement Enhancement Technique, Clear Aligner
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Align Technology, Inc.
Parkinson's Disease
Long-Term Safety, Tolerability and Efficacy in Perampanel Treated Parkinson's Disease Patients With Motor Fluctuations
A 48-month open label multi-centered extension study to evaluate the long-term safety, tolerability and efficacy of E2007 in patients with Parkinson's Disease with "wearing off" motor fluctuations and "on" period Dyskinesias.
- Trial name
- NCT01634360
- Testing
- Perampanel
- Volunteers
- 185 people
- Sponsor
- Eisai Inc.
Angelman Syndrome
Expanded Access/Compassionate Use of Rugonersen in Patients With Angelman Syndrome
For a patient to be considered for this EAP, they must have consented to participate in the TANGELO Optional Open-label Extension (OOE), and continue to meet the inclusion/ exclusion criteria and have not received any other…
- Trial name
- NCT07136454
- Testing
- Rugonersen
- Sponsor
- Oak Hill Bio Ltd
Pediatric Disorder, Genetic Predisposition
Pharmacogenomic Contributions to Trihexyphenidyl Biotransformation and Response in Children With Dystonic Cerebral Palsy
This study looks at how a medicine called trihexyphenidyl works in children with dystonic cerebral palsy. The study aims to understand how trihexyphenidyl is broken down and used in the body of pediatric patients and whether this…
- Conditions
- Pediatric Disorder, Genetic Predisposition, Dystonia, Secondary, Dystonia
- Trial name
- TRIKE2 (NCT06554288)
- Testing
- Trihexyphenidyl
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Mercy Hospital Kansas City
Major Neurocognitive Disorder, Alzheimer Disease
Exergaming Revolution in Dementia
This pilot randomized controlled trial evaluates the effect of a 12 weeks exergaming training in people with major neurocognitive disorders (MNCD) living in long-term care facilities.
- Conditions
- Major Neurocognitive Disorder, Alzheimer Disease, Parkinson Disease, Lewy Body Dementia
- Trial name
- GameDementia (NCT06631742)
- Testing
- Exergaming on Dividat Senso, Usual Care
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Eastern Switzerland University of Applied Sciences
Malocclusion, Angle Class II, Tooth Movement Techniques
Palatal Guide Wire for Canine Control During Miniscrew-Supported Distalization
When crowded or protruded teeth are treated by removing an upper premolar on each side, the canine (eye tooth) is first moved backward into the space.
- Trial name
- PGWCanine (NCT07845227)
- Testing
- Palatal guide wire, Miniscrew-supported canine distalization
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Atlas University
Angelman Syndrome
Angelman Syndrome Video Assessment (ASVA) Source Material Study
This is a longitudinal, observational, nonrandomized, fully remote study enrolling approximately 55 participant-caregiver dyads.
- Trial name
- ASVA SMS (NCT05637697)
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- The Emmes Company, LLC
Tic Disorder
Neurocognitive Correlates of Behavioral Treatment for Childhood Tic Disorders
The study aims to clarify the functional anatomy of key brain circuits associated with cognitive control in children and adolescents with chronic tic disorders (CTD) and to compare and contrast hypothesized mechanisms related to…
- Trial name
- NCT00675675
- Testing
- Comprehensive Behavioral Intervention for Tics (CBIT), Minimal Contact Waitlist
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- John Piacentini
Parkinson Disease
Molecular Epidemiology of Parkinson's Disease
The aim of this research is to discover genes which modify risk for Parkinson's disease. The study includes 800 patients with Parkinson's disease, and their estimated 1,222 available siblings.
- Trial name
- NCT00042107
- Where
- United States
- Volunteers
- 2,022 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Neurologic Disorders
Evaluation and Treatment of Neurosurgical Disorders
Objective: This protocol is designed to allow the Surgical Neurology Branch to evaluate and treat the neurosurgical disorders of protocol participants.
- Trial name
- NCT00060541
- Testing
- Laboratory tests, Radiological exams
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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