Clinical trials: Movement Disorders
Adolescent Idiopathic Scoliosis (AIS)
Effects of Body Awareness Therapy on Posture, Trunk Movement, Scoliosis & Body Awareness in Adolescents With Scoliosis
Adolescent idiopathic scoliosis (AIS) is a complex deformity of the spine, and its cause remains unknown. AIS can have negative physical, psychological, and social effects on an individual's health.
- Trial name
- NCT06855030
- Testing
- Scoliosis Specific Exercise, Basic Body Awareness Therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gözde Yagci (Gür)
Movement Disorders
Multimodal MR Imaging Study on ET and PD Patients Subjected With MRgFUS Thalamotomy
The technological advance of magnetic resonance-guided focused ultrasound (MRgFUS) has once again brought lesion therapy back to the clinical frontline for the treatment of movement disorder.
- Trial name
- NCT05623644
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Tourette Syndrome, Tic Disorders
A Handwriting Intervention Program for Children With Tic Disorders
The purpose of this study is to evaluate the effectiveness of a computerized handwriting training protocol (MovAlyzeR), through daily practice of handwriting on an electronic device to improve handwriting skills in children with…
- Trial name
- NCT04246112
- Testing
- Handwriting intervention
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Alabama at Birmingham
Parkinson Disease
Digital Dance for People With Parkinson's Disease During the COVID-19 Pandemic
Dance as a treatment to support physical, cognitive and emotional functioning, has gained increased acceptance as a healthcare intervention for people with Parkinson's Disease (PD).
- Trial name
- NCT04942392
- Testing
- Digital dance for PD
- Where
- Sweden
- Volunteers
- 33 people
- Sponsor
- Umeå University
Angelman Syndrome
REVEAL: A Phase 3 Study of Obudanersen (ION582) in Angelman Syndrome
The purpose of this study is to evaluate the efficacy and safety of obudanersen in children and adults with Angelman syndrome caused by a deletion or mutation of the UBE3A gene.
- Trial name
- NCT06914609
- Testing
- obudanersen
- Where
- 41 sites in United States, Australia and 10 more
- Volunteers
- 156 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Parkinson Disease
Chinese PD-GBA Registry
The purpose of the Chinese Parkinson's disease with GBA variants Registry (CPD-GBAR) is to develop a database of patients of Parkinson's disease with Glucocerebrosidase (GBA) gene variants in mainland China.
- Trial name
- NCT03523065
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xiangya Hospital of Central South University
Rett Syndrome, Tourette Syndrome
The Role of Probiotics PS128 in Movement Disorders
Pediatric movement disorders comprise of a large number of different neurological diseases including Rett syndrome (RTT) and Tourette syndrome.
- Conditions
- Rett Syndrome, Tourette Syndrome, Tic Disorders
- Trial name
- NCT03259971
- Testing
- Probiotic-Lactobacillus plantarum PS128
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital
Huntington Disease
Far Infrared Irradiation for Managing, Control and Treatment of Huntington's Disease (HD)
Huntington's disease (HD) is a fatal disease with profound neurological and behavioral features. HD is typically characterized by uncontrollable movements and psychological disturbances.
- Trial name
- NCT00675077
- Testing
- Far Infrared Radiation
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- GAAD Medical Research Institute Inc.
Parkinson's Disease With Dementia
The Impact of Pharmacological and Electric Modulation of NMDA Pathway on the Cognitive Flexibility and Volitional Movement Preparation in Patients With Parkinson's Disease
The project will investigate the effect of pharmacological and electric modulation of N-methyl-D-aspartate (NMDA) pathway on the cognitive flexibility and volitional movement preparation in patients with Parkinson's disease (PD).
- Trial name
- NCT01785628
- Testing
- Sarcosine Capsule
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- China Medical University Hospital
Atypical Parkinsonism, Dementia With Lewy Bodies
Focused Ultrasound Thalamotomy for Tremor Relief in Atypical Parkinsonism
The goal of this retrospective observational study is to describe the efficacy of focused ultrasound ventral-intermediate nucleus thalamotomy in patients with atypical parkinsonism.
- Conditions
- Atypical Parkinsonism, Dementia With Lewy Bodies, Multiple System Atrophy, MSA
- Trial name
- FUSAP (NCT06204575)
- Testing
- Data collection
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Rambam Health Care Campus
Ankylosed Teeth
Ankylosed Teeth Treatment by Bone Orthodontic Treatment
Codify the treatment of teeth by stiff Corticotomy technique. Evaluate the duration of treatment and tooth movement.
- Trial name
- OBS (NCT02337153)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Parkinson Disease, Dyskinesia, Drug-Induced
Open Label, Safety, Tolerability and Efficacy of AFQ056 in Parkinson's Patients With L-dopa Induced Dyskinesias
The purpose of this study is to generate long-term safety, tolerability and efficacy data for AFQ056 in patients who have participated in and completed any AFQ056 phase II study in PD-LID (Parkinson's disease, L-dopa induced…
- Conditions
- Parkinson Disease, Dyskinesia, Drug-Induced, Levodopa
- Trial name
- NCT01173731
- Testing
- AFQ056
- Where
- 22 sites in United States, Australia and 4 more
- Volunteers
- 66 people
- Sponsor
- Novartis Pharmaceuticals
Tourette's Syndrome
A Study of the Effectiveness and Safety of Tetrabenazine MR in Pediatric Subjects With Tourette's Syndrome
The purpose of this clinical trial is to study the therapeutic effect of tetrabenazine MR in children with Tourette's Syndrome, as measured by the improvement in total tic score of the Yale Global Tic Severity Scale (YGTSS).
- Trial name
- TBZ-MR (NCT01133353)
- Testing
- Tetrabenazine MR
- Sponsor
- Bausch Health Americas, Inc.
Ocular Motility Disorders
Oculomotor Training Improves Reading Eye Movement
Children with reading eye movement problems were recruited for this study. The treatment group was provided with oculomotor training for 8 weeks, the control group was given placebo exercises.
- Trial name
- NCT02981875
- Testing
- oculomotor training
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Epilepsy-Dyskinesia, Epilepsy
Registry and Natural History of Epilepsy-Dyskinesia Syndromes
The Registry and Natural History of Epilepsy-Dyskinesia Syndromes is focused on gathering longitudinal clinical data as well as biological samples (blood, urine, and/or skin/tissue) from male and female patients, of all ages, who…
- Conditions
- Epilepsy-Dyskinesia, Epilepsy, Dyskinesia, EDS
- Trial name
- NCT06967727
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Boston Children's Hospital
Parkinson Disease, Gait Disorders, Neurologic
Investigating Therapies for Freezing of Gait
Freezing of gait (FOG) is arguably one of the most debilitating motor symptoms experienced by individuals with Parkinson's disease (PD).
- Trial name
- NCT03065127
- Testing
- Cognitive Training, Cognitive Behavioural Therapy, Proprioceptive Training
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- Sun Life Financial Movement Disorders Research and Rehabilitation Centre
Dementia, Dementia, Vascular
Exploring Biomarkers in Age Stratified PUMCH Dementia Cohort
Biomarkers are important for early and precise diagnosis of dementia. However, the causes of dementia in different age are different.
- Conditions
- Dementia, Dementia, Vascular, Dementia Frontal, Dementia, Mixed
- Trial name
- NCT04924361
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Infantile Hemiplegia
Intensive Therapies in Children With Hemiplegia
This is a comparative study where two protocols of intensive therapies will be applied to study the improvements in the functional performance of the affected upper limb of children with hemiparesis and check whether to increase…
- Trial name
- CIMT/BIT (NCT03465046)
- Testing
- intensive therapies(CIMT/BIT): protocol 1 or protocol 2
- Where
- Spain
- Volunteers
- 41 people
- Sponsor
- University of Salamanca
Angelman Syndrome, Smith-Magenis Syndrome
Ghrelin in Patients With a Rare Disease Associated With Intellectual Disability, and Hyperphagia, and/or Overweight, and/or Obesity
A significantly higher proportion of patients with rare diseases (RD) with intellectual disability (ID), present hyperphagia, overweight or obesity, compared to the general population.
- Conditions
- Angelman Syndrome, Smith-Magenis Syndrome, X Fragile Syndrome, Epilepsy
- Trial name
- HOGRID (NCT04768803)
- Testing
- acylated and unacylated ghrelin dosages
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Toulouse
Malocclusion, Angle Class II, Tooth Movement Techniques
Palatal Guide Wire for Canine Control During Miniscrew-Supported Distalization
When crowded or protruded teeth are treated by removing an upper premolar on each side, the canine (eye tooth) is first moved backward into the space.
- Trial name
- PGWCanine (NCT07845227)
- Testing
- Palatal guide wire, Miniscrew-supported canine distalization
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Atlas University
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