Clinical trials: Moyamoya
Moyamoya Disease, Gut Microbiota
Gut Microbiota in Patients With Moyamoya Disease
This study is to find out the association between gut microbiota and moyamoya disease.
- Trial name
- NCT04890782
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Moya Moya Disease
Managing Transient Neurologic Episodes in Surgery for Moyamoya Disease
The goal of this study is to study the incidence of post-operative Transient Neurologic Events (TNEs) within 30 days postoperatively, as assessed by clinical neurological scales, binned by week.
- Trial name
- MagNETs (NCT06880341)
- Testing
- Standard of Care
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Stanford University
Moyamoya Disease, Magnetic Resonance Imaging
Predicative Value of Multimodal MRI in Moyamoya Disease
Moyamoya disease (MMD) is a nonatherosclerotic cerebrovascular abnormality, characterized by a progressive stenosis or occlusion of the intracranial internal carotid arteries (ICAs) and their proximal branches, with subsequent…
- Trial name
- NCT03785171
- Testing
- surgical revascularization
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Moyamoya Disease
Family-Based Moyamoya Susceptibility and Early Detection
This single-center, prospective, family-based observational cohort study aims to investigate susceptibility to moyamoya disease (MMD) and to develop strategies for early screening in individuals at increased familial risk.
- Trial name
- FAMES (NCT07517354)
- Testing
- 5T High-Resolution MRI
- Where
- China
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Moyamoya Disease
The Role of m6A RNA Modification in Moyamoya Disease
The purpose of this study is to detect the change of m6A RNA modification from peripheral blood of patients with moyamoya disease, and to assess the relationship between clinical characteristics.
- Trial name
- NCT04696094
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Moyamoya Disease, Moyamoya Syndrome
Development and Validation of Risk Prediction Models for Stroke and Cognitive Impairment in Moyamoya Disease and Moyamoya Syndrome
This multicenter prospective observational cohort study aims to develop and validate individualized risk prediction models for stroke and cognitive decline in patients with moyamoya disease or moyamoya syndrome by integrating…
- Trial name
- NCT07894107
- Where
- 13 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Tiantan Hospital
Moyamoya Disease, Intracranial Hemorrhages
5T MRI and Metabolomics-Based Hemorrhage Risk Prediction in Moyamoya Disease
Intracranial hemorrhage is a leading cause of death and disability in patients with moyamoya disease (MMD), yet clinically available tools for predicting long-term hemorrhage risk are lacking.
- Conditions
- Moyamoya Disease, Intracranial Hemorrhages, Stroke
- Trial name
- NCT07781579
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Beijing Hospital
Moyamoya Disease
RNF213 Variants and Collateral Vessels in Moyamoya Disease
The purpose of this study is to detect the association between RNF213 variants and collateral vessels in patients with moyamoya disease.
- Trial name
- NCT04906564
- Testing
- Identification of genetic variants
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Tiantan Hospital
Moyamoya
NIRS to Evaluate Haemodynamic Reserve in Paediatric Moyamoya
Near infrared spectroscpy is a validated method of evaluating cerebral blood flow. The aim in this pilot study to explore its use in children with moyamoya disease.
- Trial name
- NIRS moyamoya (NCT05160454)
- Testing
- near infrared spectroscopy
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Moyamoya Disease
Long-term Outcomes of Conservative Management in Patients with Moyamoya Disease and Their First-degree Relatives (LAMORA)
The purpose of this study is to investigate the long-term outcomes of conservative management in patients with moyamoya disease and their first-degree relatives, and provide potential pathogenesis of moyamoya disease.
- Trial name
- NCT05332756
- Testing
- Conservative management
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Tiantan Hospital
Moyamoya Disease
Cardiac Index-Guided Intraoperative Hemodynamic Management in Pediatric Moyamoya Surgery
This prospective randomized controlled trial evaluates whether individualized cardiac index-guided intraoperative hemodynamic management reduces postoperative transient ischemic episodes in pediatric patients undergoing…
- Trial name
- NCT07304947
- Testing
- Cardiac Index-Guided Hemodynamic Management, Blood Pressure-Guided Standard Hemodynamic Management
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Seoul National University Hospital
Moyamoya Disease
Functional Disorders Moya Moya Young Patients
Moya Moya disease is a rare condition of the vessels that supply blood to the brain. It normally occurs without apparent cause. In both children and adults, the disease is mainly manifested by strokes.
- Trial name
- TFMoya : ADAR (NCT05772572)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Moyamoya Disease, Revascularization
The Evolution and Prognosis of Moyamoya Disease
To investigate the evolution of imaging appearances and cognitive function of Moyamoya disease (MMD) and to establish a prognosis evaluation system based on imaging biomarkers in MMD.
- Conditions
- Moyamoya Disease, Revascularization, Cognitive Impairment, Functional Impairment
- Trial name
- NCT05619068
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese PLA General Hospital
Moyamoya Disease, TIA
The Effect of RIC on TIA/Stroke in Children With Moyamoya Disease
Moyamoya disease is a common reason of transient ischemic attack (TIA) and stroke in children. Remote ischemic conditioning (RIC) has been shown to prevent recurrent stroke in intracranial arterial stenosis, but it is unclear…
- Conditions
- Moyamoya Disease, TIA, Children, Stroke
- Trial name
- RIC-PMD-1 (NCT03821181)
- Testing
- RIC group
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Capital Medical University
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Carotid Artery, Internal
Internal Carotid Artery Blood Flow in Pediatric Moyamoya Patients
Little is known about how general anesthesia-induced decrease in cerebral blood flow in pediatric moyamoya pateints. We investigated this question in patients undergoing moyamoya surgery, hypothesizing that cardiorespiratory…
- Trial name
- NCT04134221
- Testing
- Ultrasound assessment
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Moya Moya Disease
Moya Moya Syndrome With or Withtout Sickle Cell Disease
Moya Moya disease or syndrome ar characterized by a progressive or occlusion of the intracranial carotid arteries and their mainproximal branches, followed by the development of fragile neovessels at the base of the skull, leding…
- Trial name
- BMM-ScD (NCT05050344)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Cerebrovascular Accident, Moyamoya Disease
Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya Disease and Stroke Patients
Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya disease and stroke patients
- Trial name
- NCT01419275
- Testing
- Xenon contrast agent, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Stanford University
Pain
Goal-directed Analgesia Using ANI During General Anesthesia in Children With Moyamoya Disease
Analgesia Nociception Index (ANI) has been proposed for the evaluation of the nociception-antinociception balance in the perioperative period.
- Trial name
- NCT05672212
- Testing
- ANI (Analgesia/Nociception Index) monitoring, standard monitoring, Sufentanil
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Moyamoya Disease, Pediatrics
Effect of Recombinant Human EPO on the Postoperative Neurologic Outcome in Pediatric Moyamoya Patients
This study evaluates the effect of recombinant human erythropoietin (rHuEPO) on the neovascularization of pediatric moyamoya disease patients.
- Conditions
- Moyamoya Disease, Pediatrics, Cerebrovascular Disorders
- Trial name
- NCT03882060
- Testing
- erythropoietin, Normal saline
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital