Clinical trials: Multicenter Prospective Study
Method of Differentiating Benignancy and Malignancy, Grading and Staging for GIST
Study to Compare Pathologic Type, NIH and WHO Criteria,and Mechanism of GIST Malignant Transformation
Evaluate the reliability of morphology standards for GIST pathologic type, staging and grading by retrospective analyzing clinical data; on this basis, establish a GIST standardized and individualized treatment mode to maximum…
- Trial name
- NCT03381053
- Testing
- Imatinib 400mg
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Head Injury
Broad Validation Study of a Management Algorithm Mild Head Injury in Children
Head injury is a frequent reason for consultation with pediatric emergencies, over 95% are mild head injury defined by a Glasgow score greater than or equal to 13.
- Trial name
- EVEACE (NCT02357186)
- Where
- 9 sites in France
- Volunteers
- 7,871 people
- Sponsor
- Nantes University Hospital
Distal Radius Fracture, Radiological Outcome
Cortical Comminution and Intra-articular Involvement in Distal Radius Fractures Can Predict Radiological Outcome. A Prospective Multicenter Study
Background: Although fractures of the distal radius are the most common skeletal injury, the utility of the available classification systems to predict fracture stability is limited.
- Trial name
- NCT01778673
- Testing
- Cast immobilization
- Where
- Sweden
- Sponsor
- Sundsvall Hospital
Neuroblastoma
Prospective Multicenter Study of the Genomic, Transcriptomic, and Biological Profile of Patients With Neuroblastoma
This is an investigator-initiated, multicenter, prospective, non-profit study. Patients who provide informed consent to participate will be asked to provide a peripheral blood sample, a fresh tumor tissue sample (obtained by…
- Trial name
- PREME (NCT07881172)
- Where
- 35 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Giannina Gaslini
Breast Neoplasms
A Multicenter Prospective Observational Cohort Based on a Breast Cancer Medical Record Database in China
1. To construct a prospective, multi-center breast cancer treatment cohort in China, and analyze the factors affecting breast cancer diagnosis and treatment. 2.
- Trial name
- NCT06591039
- Testing
- The study did not involve intervention in the patient's treatment regimen
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Fudan University
Ventricular Arrythmia
China Inherited Ventricular Arrhythmias Registry
This is an observational, prospective, multi-center registry, aiming at building a risk stratification for malignant inherited ventricular arrhythmias, including Brugada syndrome(Brs)、Long QT syndrome(LQTS)、Short QT…
- Trial name
- NCT03880708
- Where
- China
- Volunteers
- 500 people
- Sponsor
- China National Center for Cardiovascular Diseases
CEBPA Double Mutation, Acute Myeloid Leukemia
Efficacy of HAD Induction With Intensified Cytarabine in Newly-diagnosed CEBPA Double Mutated Acute Myeloid Leukemia
Acute myeloid leukemia is a heterogenous hematological malignancy, characterized by different cytogenetic or molecular features.
- Trial name
- NCT04415008
- Testing
- HAD induction with intermediate dose cytarabine
- Where
- China
- Volunteers
- 61 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Dry Eye Syndrome
Assessment of the Mu-Drop System for Serum Eye Drops
Rationale: Serum eye drops (SEDs) are used to treat patients with severe signs and symptoms of dry eyes and other corneal defects.
- Trial name
- AmuSED (NCT03539159)
- Testing
- Allogeneic conventional sized serum eye drops, Allogeneic micro sized serum eye drops
- Where
- 6 sites in Netherlands
- Volunteers
- 54 people
- Sponsor
- Sanquin Research & Blood Bank Divisions
LUMBAR Syndrome
Screening LUMBAR Syndrome in Infants With Infantile Hemangiomas
The objective of this study is to determine the maximal diameter threshold at which infants with lumbosacral, sacrococcygeal, perineal, gluteal, or lower-limb extending infantile hemangiomas should undergo screening for LUMBAR…
- Trial name
- NCT07616323
- Testing
- MRI
- Where
- China
- Volunteers
- 70 people
- Sponsor
- West China Hospital
Pulmonary Arterial Hypertension
A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension
The purpose of this study to confirm the selexipag starting dose(s), selected based on pharmacokinetic (PK) extrapolation from adults, that leads to similar exposure as adults doses in children from greater than or equal to (>=)…
- Trial name
- NCT03492177
- Testing
- selexipag (Uptravi)
- Where
- 34 sites in United States, Belarus and 14 more
- Volunteers
- 63 people
- Sponsor
- Actelion
Constipation
Efficacy of Dicopeg Junior in Comparison With Lactulose for the Treatment of Functional Constipation in Children Aged 6 Months to 6 Years.
Assessment of efficacy of Dicopeg Junior, compared to lactulose, in the treatment of functional constipation in children aged 6 months to 6 years.
- Trial name
- NCT03177434
- Testing
- polyethylene glycols (PEG) 3350, Lactulose Oral Product
- Where
- 3 sites in Poland
- Volunteers
- 102 people
- Sponsor
- Children's Memorial Health Institute, Poland
Locally Advanced Non-small Cell Lung Cancer
Pembrolizumab + Platinum Doublets Without Radiation for Programmed Death-ligand 1 (PD-L1) ≥50% Locally Advanced NSCLC
This is a phase II, multicenter, single-arm, non-blind study. To 21 patients with PD-L1 ≥50% locally advanced non-small cell lung cancer, the combination of Pembrolizumab and platinum-doublets will be intravenously administered…
- Trial name
- Evolution (NCT04153734)
- Testing
- Pembrolizumab, Cis Platinum, Carboplatin
- Volunteers
- 21 people
- Sponsor
- Kobe Minimally Invasive Cancer Center
Hemophilia B
BAX 326 Pediatric Study
The purpose of this study is to assess BAX 326 pharmacokinetic parameters, to evaluate its hemostatic efficacy, safety, immunogenicity, and changes in health-related quality of life in pediatric patients.
- Trial name
- NCT01488994
- Testing
- BAX326
- Where
- 11 sites in India, Poland and 4 more
- Volunteers
- 23 people
- Sponsor
- Baxalta now part of Shire
Pain Management
Evaluation of Paro, a Therapeutic Assistance Robot in Analgesic Management During the Placement of a Peripheral Intravenous Line in Infants and Children.
Peripheral intravenous catheterization is one of the most frequently performed procedures in pediatric emergency departments and hospital units.
- Trial name
- PARO (NCT07299006)
- Testing
- Experimental group: Standard multimodal pain management strategy supplemented with the PARO therapeutic robot., Non-pharmacological and standard pharmacological interventions.
- Where
- 5 sites in France
- Volunteers
- 120 people
- Sponsor
- Fondation Lenval
Pneumonia, Bacterial, Community-Acquired Infections
A Safety and Tolerability Study of Doripenem Compared With Cefepime in Hospitalized Children With Bacterial Pneumonia
The purpose of this study is to evaluate the safety and tolerability of doripenem compared to cefepime in children hospitalized with pneumonia.
- Conditions
- Pneumonia, Bacterial, Community-Acquired Infections, Nosocomial Infection, Pneumonia, Ventilator-Associated
- Trial name
- NCT01110421
- Testing
- Cefepime, Doripenem, Amoxicillin/clavulanate potassium
- Where
- 25 sites in United States, Argentina and 8 more
- Volunteers
- 7 people
- Sponsor
- Janssen Research & Development, LLC
Atopic Dermatitis
AD Treatment Optimization With Ebglyss in Real-World Practice: A Multicenter Study of Patient-Centered Outcomes
The goal of this Phase 4 clinical study is to learn how Ebglyss (lebrikizumab) works and how it is dosed in everyday dermatology care for adults and adolescents (age 12 and older) with moderate-to-severe atopic dermatitis…
- Trial name
- AD-TEMPO (NCT07856134)
- Testing
- Lebrikizumab-lbkz
- Where
- 10 sites in United States
- Volunteers
- 250 people
- Sponsor
- Forefront Dermatology S.C
Limbal Stem Cell Deficiency Due to Ocular Burn
Follow-up Study After ACLSCT for Restoration of Corneal Epithelium in Patients With LSCD Due to Ocular Burns
This is a multinational, multicentre, prospective, non-pharmacological follow-up study of the clinical trial HOLOCORE. All patients transplanted with Holoclar in the HOLOCORE clinical trial who consent to participate will be…
- Trial name
- HOLOCORE-FU (NCT03288844)
- Testing
- Ophthalmologic examinations, Digital pictures, QoL Questionnaires
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- Holostem s.r.l.
Congestive Heart Failure
Study to Evaluate the Safety of Twice Daily Oral Carvedilol
The objective of this study is to evaluate the long-term safety of carvedilol in pediatric patients with chronic heart failure, who completed the Pediatric Carvedilol Study 321.
- Trial name
- NCT00129363
- Testing
- Carvedilol
- Where
- 17 sites in United States
- Volunteers
- 75 people
- Sponsor
- Shaddy, Robert, M.D.
Beta Thalassemia Transfusion Dependent
Effect of Deferasirox on Patients With Cardiac MRI T2* < 20 Msec
This study will assess the safety and efficacy of deferasirox in patients with cardiac MRI T2* < 20 msec.
- Trial name
- NCT00879242
- Testing
- Deferasirox
- Where
- 2 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Novartis Pharmaceuticals
Endometrial Polyp, Endometrial Diseases
The Use of Drospirenone/Estetrol, Nomegestrol Acetate/Estradiol and Ethinylestradiol/Dienogest in Random Start Rapid Endometrial Preparation
The presence of a thin endometrium plays an important role in enabling the best conditions for hysteroscopic surgery. Recently, for this purpose, many studies have evaluated the effect of preoperative administration of a variety…
- Trial name
- NCT06324851
- Testing
- Drospirenone / Estetrol, Nomegestrol Acetate / Estradiol, Ethinylestradiol / Dienogest
- Where
- 2 sites in Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Palermo