Clinical trials: Multiple Trauma/Injuries
Trauma, Burns
Inflammation and the Host Response to Injury (Burns)
The purpose of this study is to help improve our understanding of the biology involved in the body's response to serious trauma or burn injury.
- Conditions
- Trauma, Burns, Multiple Organ Failure
- Trial name
- NCT00257244
- Where
- 4 sites in United States
- Volunteers
- 280 people
- Sponsor
- Massachusetts General Hospital
Multiple Trauma, Traumatic Brain Injury
Spinal Clearance Study: Expediting the Spinal Clearance Process in the Major Trauma Patient
The Alfred Hospital receives approximately 40% of the major trauma patients in Victoria, all of whom are at risk for spinal injuries.
- Conditions
- Multiple Trauma, Traumatic Brain Injury, Spinal Injuries
- Trial name
- NCT00163826
- Where
- Australia
- Volunteers
- 299 people
- Sponsor
- Bayside Health
Femoral Neck Fracture
The Effect of Periarticular Multi-Drug Regimen on Pain After Partial Hip Replacement
This prospective randomized study aims to evaluate the effectiveness of periarticular multi-drug regimen injection on the relief of pain in patients undergoing partial hip replacement.
- Trial name
- NCT01112436
- Testing
- periarticular injection of multidrug regimen, none of medication preoperatively and intraoperatively
- Where
- South Korea
- Volunteers
- 258 people
- Sponsor
- Chung-Ang University Hospital
Femur Fracture
Pediatric Locking Nail for the Treatment of Femoral Fractures in Children
The purpose of this multi-center prospective clinical outcomes study is to determine validity and safety of the pediatric locking nail for femoral fracture management in children with open physes.
- Trial name
- PLN (NCT00725894)
- Testing
- Pediatric Locking Nail
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Zimmer Biomet
Traumatic Hemorrhage, Coagulopathy
Factor In the Initial Resuscitation of Severe Trauma 2 Patients
Injury is the leading cause of death for people between the ages of 1-44. This is especially true in trauma patients who have bleeding complications.
- Conditions
- Traumatic Hemorrhage, Coagulopathy, Massive Hemorrhage
- Trial name
- FiiRST-2 (NCT04534751)
- Testing
- Fibrinogen + PCC, Frozen Plasma
- Where
- 6 sites in Canada
- Volunteers
- 142 people
- Sponsor
- University Health Network, Toronto
Wound Heal
The Efficacy of Hyaluronic Acid and Honey in Healing of Multiple Extraction Sockets of Primary Teeth Compared to Saline
This study aims to evaluate the effect of hyaluronic acid and honey compared to saline in healing of multiple extraction sockets of primary teeth in a group of children aging from Two to Seven years old.
- Trial name
- NCT05161403
- Testing
- Hyaluronic acid, honey
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries, Pulp Exposure, Dental
Clinical Study Evaluating Solventum™ Vitrebond™ Pulp Protect Liner/Base for Direct Capping of Pulpal Exposure
This research study is looking at the safety and effectiveness of Solventum™ Vitrebond™ Pulp Protect Liner/Base for direct pulp capping (DPC) on permanent teeth that have pulp exposure due either to deep cavities, trauma, or…
- Conditions
- Dental Caries, Pulp Exposure, Dental, Tooth Decay, Dental Decay
- Trial name
- NCT07231237
- Testing
- Vitrebond™ Pulp Protect Liner/Base
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Solventum US LLC
Stress, Emotional, Stress-related Mental Disorders
Effects of Parent-Adolescent Joint Interventions for Adolescents With Adverse Childhood Experiences
The study aims to examine the effectiveness of joint parent-adolescent intervention in improving the mental health outcomes of participants, specifically by reducing symptoms of depression, anxiety, and PTSD, as measured by the…
- Conditions
- Stress, Emotional, Stress-related Mental Disorders, Adverse Childhood Experiences
- Trial name
- EASY-PEP (NCT06619821)
- Testing
- Emotiaonl skill enhancement, PCE promotion, Psychoeducation
- Where
- 2 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Peking University
Traumatic Injuries, Traumatic Injury of Spine
Human Impact Exposure Onboard High-Speed Boats
Operating high-speed boats is dangerous. The purpose of this study is to establish what levels and what characteristics of impact exposure cause injuries.
- Conditions
- Traumatic Injuries, Traumatic Injury of Spine, Traumatic Head Injury
- Trial name
- MASHIEN (NCT05299736)
- Where
- Sweden
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Multiple Trauma
Thoracic Injuries in Pediatric Polytraumatized Patients: Epidemiology, Treatment and Outcome
The present study predicts that concomitant chest injuries in polytraumatized pediatric patients are a potential source of substantial morbidity and mortality.
- Trial name
- NCT02398175
- Testing
- reanimation/intubation
- Volunteers
- 71 people
- Sponsor
- Medical University of Vienna
Tuberous Sclerosis Complex, Self-injury
Rapalogues for Autism Phenotype in TSC: A Feasibility Study
The purpose of this study is to assess the feasibility and safety of administering rapalogues, sirolimus or everolimus, in participants with Tuberous Sclerosis Complex (TSC) and self-injury and to measure cognitive and behavioral…
- Conditions
- Tuberous Sclerosis Complex, Self-injury, Autism
- Trial name
- RAPT (NCT01929642)
- Testing
- Sirolimus, Everolimus
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Acute Drug-induced Liver Injury, Chronic Liver Disease
A Diagnostic Study on Patients With Drug-induced Liver Injury
This study is a multi-center, prospective, non-interventional cohort study with an estimated enrollment of 600 patients with acute DILI.
- Trial name
- NCT04526548
- Volunteers
- 600 people
- Sponsor
- Drug Induced Liver Disease Study Group
Post-traumatic Stress Disorder, Suicide
Effectiveness of PTSD Treatment For Suicidal and Multi-Diagnostic Clients
The present project has two primary aims: (1) to examine the effectiveness of a multi-component implementation strategy in improving adoption and adherence to the Dialectical Behavior Therapy Prolonged Exposure (DBT PE) protocol…
- Conditions
- Post-traumatic Stress Disorder, Suicide, Self-injurious Behavior
- Trial name
- NCT02615197
- Testing
- Dialectical Behavior Therapy, Dialectical Behavior Therapy Prolonged Exposure protocol
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Washington
Brain Injuries
Implementation Study on Hospital-to-home Advanced Rehabilitation Technologies (ART)
To study the feasibility of the various model of ART rental service for home use, prescribed and supervised by experienced rehabilitation professionals and supported by tech partners, and its efficacy in improving function in…
- Trial name
- R@H (NCT07904624)
- Testing
- ART
- Where
- 3 sites in Singapore
- Volunteers
- 1,000 people
- Sponsor
- National University Hospital, Singapore
Acute Subdural Hematoma
Scandinavian Multicentre Acute Subdural Hematoma (SMASH) Study
In a multi-national population-based cohort, the investigators want to compare the clinical course and clinical outcome of elderly patients (≥70 y/o) compared with younger patients (< 70 y/o) with acute subdural hematoma treated…
- Trial name
- SMASH (NCT03284190)
- Testing
- Surgery
- Volunteers
- 1,600 people
- Sponsor
- Karolinska University Hospital
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Bronchopulmonary Dysplasia
Efficacy and Safety Evaluation of Pneumostem® Versus a Control Group for Treatment of BPD in Premature Infants
The objective of this study is to evaluate the efficacy and safety of a single intratracheal administration of Pneumostem® for treatment of Bronchopulmonary Dysplasia (BPD) in high-risk premature infants by comparing…
- Trial name
- NCT01828957
- Testing
- Pneumostem®, Normal Saline
- Where
- 2 sites in South Korea
- Volunteers
- 69 people
- Sponsor
- Medipost Co Ltd.
Family Relations, Psychological Trauma
Multifamily Healing Spaces for Family Resilience in Rwanda
This cluster-randomized waitlist-control trial evaluated Multifamily Healing Spaces (MFHS), a culturally adapted behavioral family intervention for genocide-affected communities in Rwanda.
- Conditions
- Family Relations, Psychological Trauma, Stress Disorders, Post-Traumatic, Parent-Child Relation
- Trial name
- MFHS-CRT (NCT07621705)
- Testing
- Multifamily Healing Spaces
- Where
- 5 sites in Rwanda
- Volunteers
- 319 people
- Sponsor
- Alexandros Lordos, PhD
Disaster, PTSD
Feasibility and Efficacy of a Digital Mental Health Intervention for Teen Wildfire Survivors
In October, 2017, Northern California experienced devastating and historic wildfires. Sonoma Rises is an app designed for anyone who was impacted by this event and is intended to help survivors of disaster find their new normal.
- Conditions
- Disaster, PTSD, Adolescent Behavior, Trauma
- Trial name
- NCT03868761
- Testing
- Sonoma Rises
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Stanford University
Congenital Heart Disease, Postoperative Pulmonary Complications
Perioperative Lidocaine for Lung Protection in Infants Undergoing Cardiac Surgery
Cardiopulmonary bypass-associated pulmonary injury is a common complication after infant cardiac surgery and may contribute to impaired oxygenation, prolonged mechanical ventilation, and longer intensive care stay.
- Conditions
- Congenital Heart Disease, Postoperative Pulmonary Complications, Acute Lung Injury
- Trial name
- PLICS (NCT07499154)
- Testing
- Lidocaine %2 ampoule, Normal Saline (0.9% NaCl)
- Where
- China
- Volunteers
- 320 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine