Clinical trials: Muscle
Mitochondrial Disorders, Mitochondrial Disease
Tissue Sample Study for Mitochondrial Disorders
The investigators are studying patients with undefined mitochondrial diseases to identify genetic mutations in nuclear or mitochondrial Deoxyribonucleic Acid (DNA).
- Conditions
- Mitochondrial Disorders, Mitochondrial Disease, Melas, Kearns Sayer
- Trial name
- NCT01803906
- Where
- United States
- Volunteers
- 6,900 people, healthy volunteers welcome
- Sponsor
- Columbia University
Migraine
Effects Of Dry Needling On Sternocleidomastoid Muscle For Pain And Disability In Migraine
To determine the effects, sequel of dry needling in migraine by resolving MTrPs in sternocleidomastoid muscle. To determine the possession of dry needling technique to mitigate the frequency, intensity and duration of headache.
- Trial name
- NCT05285852
- Testing
- Dry Needling
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Spasticity
Optical Stimulation in Peripheral Nerves for Select Rhizotomy Procedures
The purpose of this study is to determine the safe and effective levels of optical stimulation in peripheral nerves of humans otherwise undergoing nerve lesioning in surgery.
- Trial name
- Rhizotomy (NCT00575536)
- Testing
- Rhizotomy for children with spasticity
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Vanderbilt University
Recurrent Childhood Soft Tissue Sarcoma, Recurrent Ewing Sarcoma
Trabectedin and Irinotecan for Refractory Pediatric Sarcomas
The purpose of the study is to evaluate patients with refractory childhood sarcomas, who have been treated with a combination therapy of trabectedin and irinotecan (within compassionate use), to determine, if this is a promising…
- Conditions
- Recurrent Childhood Soft Tissue Sarcoma, Recurrent Ewing Sarcoma, Recurrent Rhabdomyosarcoma
- Trial name
- TrIPReSarc (NCT02509234)
- Testing
- Combined chemotherapy with trabectedin followed by irinotecan
- Volunteers
- 30 people
- Sponsor
- Technical University of Munich
Low Back Pain, Athletic Injuries
Hamstring Viscoelasticity and Low Back Pain
Low back pain (LBP) is a prevalent issue among adolescent rowers, particularly males aged 14 to 16 years, with a high lifetime prevalence (94%) and point prevalence (65%).
- Trial name
- NCT05939609
- Testing
- Ballistic Stretching Exercise, Extender Exercise, Kinesiotaping
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Nisantasi University
Duchenne Muscular Dystrophy
A 48-Week, Open Label, Study to Evaluate the Efficacy and Safety of AMONDYS 45, EXONDYS 51, VYONDYS 53 in Subjects With DuchenneMuscular Dystrophy Carrying Eligible DMD Duplications.
This is an 48-week open-label study to determine the efficacy and safety of AMONDYS 45, EXONDYS 51, VYONDYS 53 for the treatment of boys with duchenne muscular dystrophy who have a single exon duplication of either exon 45, 51 or…
- Trial name
- NCT04179409
- Testing
- Amondys 45, Exondys 51, Vyondys 53
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Kevin Flanigan
Neuromuscular Diseases (NMD), ALS (Amyotrophic Lateral Sclerosis)
Invasive Home Ventilation in Denmark
The aim of this study is to describe national trends over the past 10 years in patients receiving invasive home mechanical ventilation (HMV) in Denmark.
- Conditions
- Neuromuscular Diseases (NMD), ALS (Amyotrophic Lateral Sclerosis), Spinal Cord Injuries (SCI), Duchenne Muscular Dystrophy (DMD)
- Trial name
- HOMEVENT DK (NCT07467187)
- Where
- Denmark
- Volunteers
- 450 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Muscle Strength, Ultrasonography
Minimalist Shoes Walking for Children
This is a single-blind randomized control study that will investigate the effects of a 12-week in-school walking training with minimalist shoes for local preschool children on intrinsic foot muscle size, muscle strength, and foot…
- Conditions
- Muscle Strength, Ultrasonography, Child, Preschool
- Trial name
- NCT03853863
- Testing
- in-school walking training with minimalist shoes, in-school walking training with protective shoes
- Where
- China
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Immune Checkpoint Inhibitor-associated Myocarditis
ATROPOS: Survival Analysis of ICI-associated Myocarditis
ATROPOS is an international, registry-based observational study of cancer patients with immune checkpoint inhibitor-associated myocarditis (ICI-M).
- Trial name
- ATROPOS (NCT07633587)
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Cerebral Palsy
Ankle-foot Orthoses for Night Splinting in Children With CP: Impact on Passive Stiffness in Plantarflexors Muscles
Children with cerebral palsy present early in the childhood altered muscular properties, characterized by short muscle belly length and increased stiffness which contribute to contracture and limiting joint range of motion.
- Trial name
- NIGHTSTRETCH (NCT03686644)
- Testing
- Wearing of night splint ankle foot orthoses (phase A), No wearing of night splint ankle foot orthoses (phase B)
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Sensory Recovery
Muscle-in-vein Conduits for Digital Nerve Reconstruction
The actual study should provide a first direct comparison between results after reconstruction of sensory nerves of the hand using muscle-in-vein conduits to the standard methods of nerve transplantation and direct nerve suture.
- Trial name
- NCT01958632
- Testing
- Nerve reconstruction
- Where
- Germany
- Volunteers
- 77 people
- Sponsor
- BG Trauma Center Tuebingen
Pain, Acute
Bilateral Ultrasound-Guided Intra Muscular Quadratus Lumborum Block Versus Trans Muscular Quadratus Lumborum Block for Peri-Operative Analgesia in Abdominal Surgeries in Pediatric Patients. A Comparative Controlled Randomized Study.
To compare between the intra muscular quadratous lamborum and the Trans muscular quadratous lamborum in pediatric population under going abdominal surgeries regards to first request of rescue analgesia, degree of pain relief…
- Trial name
- NCT04029987
- Testing
- Bilateral Ultrasound-Guided Transmuscular Quadratus Lumborum Block., Bilateral Ultrasound-Guided intra smuscular Quadratus Lumborum Block., Control
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Duchenne Muscular Dystrophy (DMD)
DMD and Gamified Physiotherapy
Duchenne Muscular Dystrophy (DMD) is a progressive neuromuscular disease that limits children's physical function, mobility, and participation in daily life.
- Trial name
- Gamified DMD (NCT07368400)
- Testing
- Gamified Mobile Physiotherapy Exercise Application, Standard Home Exercise Instructions
- Volunteers
- 46 people
- Sponsor
- Başak Çağla Arslan
Duchenne Muscular Dystrophy
A Gene Delivery Study to Evaluate the Safety and Expression of Delandistrogene Moxeparvovec in Participants Under the Age of Four With Duchenne Muscular Dystrophy (DMD)
This open-label, single-arm study will evaluate the safety and expression of delandistrogene moxeparvovec in participants with DMD. Participants will be in the study for approximately 264 weeks.
- Trial name
- ENVOL (NCT06128564)
- Testing
- delandistrogene moxeparvovec
- Where
- 7 sites in Belgium, France and 4 more
- Volunteers
- 13 people
- Sponsor
- Hoffmann-La Roche
Muscle Architecture
Motor Imagery and Muscle Architecture
The aim of this study is to examine the effects of plyometric training on biceps femoris longus (BFl) and vastus lateralis (VL) muscle architecture in healthy football players.
- Trial name
- NCT05558033
- Testing
- Plyometric Exercise, Football Training
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Chronic Fatigue Syndrome
Pilot Study for the NorCAPITAL Trial
The aim of this pilot study for the NorCAPITAL trial is to investigate the feasibility and safety of the drug clonidine in adolescent chronic fatigue syndrome (CFS).
- Trial name
- NCT01507701
- Testing
- Clonidine
- Where
- Norway
- Volunteers
- 5 people
- Sponsor
- Oslo University Hospital
Hodgkin Disease, Non-Hodgkin Lymphoma
Most Closely Matched 3rd Party Rapidly Generated LMP, BARF1 And EBNA1 Specific CTL, EBV-Positive Lymphoma (MABEL)
The subject has a type of cancer or lymph gland disease associated with a virus called Epstein Barr Virus (EBV), which has come back, is at risk of coming back, or has not gone away after standard treatments.
- Conditions
- Hodgkin Disease, Non-Hodgkin Lymphoma, Severe Chronic Active Epstein Barr Virus, T/NK-lymphoproliferative Disease
- Trial name
- MABEL (NCT02287311)
- Testing
- MABEL CTLs, Cyclophosphamide, Fludarabine
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Baylor College of Medicine
Diplegic Spastic Cerebral Palsy
Comparing the Instrument-Assisted Soft Tissue Mobilization and Neurodevelopmental Therapy for Gross Motor Functions, Muscle Tone and Spasticity in Children with Spastic Diplegic Cerebral Palsy (GMFCS Levels I and II)
Cerebral palsy is a neurological condition that affects individuals worldwide, with a global burden of 0.9%. However, prevalence rates show regional variation, with high-income countries reporting rates of 0.2% and low-income…
- Trial name
- IASTM;NDT;CP (NCT06702709)
- Testing
- Instrument Assisted Soft Tissue Mobilization, Neurodevelopmental Therapy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Ziauddin University
Transfer Dysphagia, Oropharyngeal Dysphagia
Onabotulinum Toxin A (Botox) in the Treatment of Pharyngo-esophageal Dysphagia
Dysphagia in patients with stroke, multiple sclerosis, parkinsonism or dystonia can occur due to relative hypertonia of the cricopharyngeus muscle. In the resting state, muscle is contracted and relaxes only during deglutition.
- Conditions
- Transfer Dysphagia, Oropharyngeal Dysphagia, Cricopharyngeus Muscle Dysfunction
- Trial name
- NCT04695600
- Testing
- Botulinum Toxin Type A Injection [Botox]
- Where
- India
- Volunteers
- 100 people
- Sponsor
- All India Institute of Medical Sciences
Pulmonary Arterial Hypertension
Peripheral Muscle Microcirculation and Exercise-induced Blood Flow Distribution in Pulmonary Arterial Hypertension
Pulmonary artery hypertension (PAH) is a rare, severe disease, characterized by a progressive increase in pulmonary vascular resistance ultimately leading to right ventricular (RV) failure and premature death.
- Trial name
- NCT01520493
- Testing
- Submaximal exercises
- Where
- 2 sites in Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laval University