Clinical trials: Muscle Contracture
Dupuytren Contracture
BOND Study: the Benefit Of Night Splinting in Dupuytrens'
The BOND study is a prospective, randomised single blinded controlled trial to assess the effect of night splinting in patients who have had collagenase injection and manipulation therapy for Dupuytren's Contracture.
- Trial name
- BOND (NCT03031080)
- Testing
- Thermoplastic Hand Splint
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Bladder Cancer, Triple Negative Breast Cancer
A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours
This clinical trial is evaluating a drug called HMBD-001 (an anti-HER3 monoclonal antibody) in participants with advanced HER3 positive solid tumours.
- Conditions
- Bladder Cancer, Triple Negative Breast Cancer, Castration-resistant Prostate Cancer, Cervical Cancer
- Trial name
- NCT05057013
- Testing
- HMBD-001, HMBD-001 and enzalutamide
- Where
- 4 sites in United Kingdom
- Volunteers
- 81 people
- Sponsor
- Cancer Research UK
Arthroscopy
Arthroscopic Release Of Shoulder Internal Rotation Contracture In Brachial Plexus Palsy
The purpose of this study is to evaluate the efficacy periarticular capsuloligamentous arthroscopic release of shoulder internal rotation contracture in brachial plexus palsy without any further intervention as tendon transfer.
- Trial name
- NCT05995795
- Testing
- ARTHROSCOY
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assiut University
Burn Contracture of Skin
Serial Casting for Upper Extremity Burn Contractures
The use of a splint, serial casting and passive stretching have been described in the literature as conservative interventions to manage joint contractures after burn injury.
- Trial name
- NCT05425433
- Testing
- Tailored serial casting intercention
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Breast Implant; Complications, Breast Implant Infection
Comparative Analysis of Two Animal-derived ADMs in Irradiated Implant-based Reconstruction
The goal of this retrospective observational trial is to compare two different devices, used in implant-based breast reconstruction, called acellular dermal matrices, which are a sort of collagen patch that integrates with the…
- Conditions
- Breast Implant; Complications, Breast Implant Infection, Implant Capsular Contracture, Breast Seroma
- Trial name
- RTADM (NCT06139588)
- Testing
- acellular dermal matrix implant for breast reconstruction
- Where
- Italy
- Volunteers
- 146 people
- Sponsor
- European Institute of Oncology
Internal Rotation Contracture-shoulder, Articulation Disorders
Internal Rotation Deficit of the Glenohumeral Joint in Advanced-level Handball Players
The main objective of this study is to estimate the incidence and prevalence of Internal Rotation Deficit (IRD) defined by a measure of IRD 2 (Internal Rotation Deficit in position 2) strictly greater than 20 ° in a population of…
- Conditions
- Internal Rotation Contracture-shoulder, Articulation Disorders, Athletic Injuries
- Trial name
- GIRDH (NCT02011243)
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Osteotomy of Lower Extremity
PediLoc® Blade Plate in Distal Femoral Osteotomies
Background: The PediLoc® Locking Cannulated Blade Plate System, originally designed for proximal femoral osteotomies, has also been used for multidimensional deformity correction of the distal femur.
- Trial name
- NCT06950047
- Testing
- distal femoral osteotomies using the PediLoc® Locking Cannulated Blade Plate System, distal femoral osteotomies using the 90°LCP-PCP
- Where
- Switzerland
- Volunteers
- 111 people
- Sponsor
- University Children's Hospital, Zurich
Cerebral Palsy
Early Intervention in Infants With Cerebral Palsy
Contractures are a frequent cause of reduced mobility in children with Cerebral palsy (CP) already at the age of 2-3 years. Reduced muscle use and muscle growth have been suggested as key factors in the development of…
- Trial name
- CONTRACT (NCT04250454)
- Testing
- CONTRACT
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- University of Copenhagen
Cerebral Palsy, Spastic, Achilles Tendon Contracture
Myofascial Release Plus Physiotherapy for Children With Cerebral Palsy Post Achilles Tendon Surgery in Gaza (MFR-CP25)
"This study aims to evaluate the effectiveness of adding Myofascial Release (MFR) technique to a conventional physiotherapy program for children with cerebral palsy after Achilles tendon surgery.
- Trial name
- MFR-CP25 (NCT07148856)
- Testing
- Conventional Physiotherapy, Myofascial Release Technique
- Where
- Palestinian Territories
- Volunteers
- 40 people
- Sponsor
- Ismail K. Al-Qudra
Cerebral Palsy, Muscle
How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery.
Cerebral palsy (CP) is a motor disorder caused by an injury to the immature brain. Even though the brain damage does not change, children with CP will have progressively weaker, shorter and stiffer muscles that will lead to…
- Conditions
- Cerebral Palsy, Muscle, Muscle Contracture, Muscle Spasticity
- Trial name
- CPTDBiopsy (NCT05506228)
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Eva Ponten
Shoulder Injuries, Patient Satisfaction
Conjoint Tendon Resection During Reverse Total Shoulder Arthroplasty
Reverse total shoulder arthroplasty (RTSA) can reliably restore active forward elevation, abduction, and external rotation, which are often lost in patients with massive rotator cuff tears.
- Conditions
- Shoulder Injuries, Patient Satisfaction, Internal Rotation Contracture-shoulder
- Trial name
- NCT05753904
- Testing
- Conjoint Tendon Resection
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Capsular Contracture Associated With Implant
Prevention of Capsular Contracture in Postmastectomy Patients Undergoing Implant-based Reconstructions
The study plans to evaluate capsular contracture at 1-year follow-up in postmastectomy patients receiving immediate implant-based reconstruction and Capsulase® supplementation in the postoperative period.
- Trial name
- NCT06785610
- Testing
- Capsulase®
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- European Institute of Oncology
Management of Postburn Neck Contracture
Pre-expanded Flap Versus Free Flap for Postburn Neck Contracture
This prospective, randomized, parallel-group trial was conducted at two tertiary care centers in Egypt between April 2022 and October 2024.
- Trial name
- SCAIP (NCT07865689)
- Testing
- surgery (any volume) and / or pharmaceuticals treatment initiated or planned or only dynamic observation, in accordance with current clinical guidelines
- Where
- Egypt
- Volunteers
- 2 people
- Sponsor
- South Valley University
Shoulder Posterior Capsular Contracture
Youth Throwers Respond to Stretching
The purpose of this study is to document the rates of youth baseball player demographics, incidence of arm pain, usage of different pitch types, and degree of internal rotation contracture in the throwing versus the non-throwing…
- Trial name
- Safethrow (NCT01065181)
- Volunteers
- 1,261 people, healthy volunteers welcome
- Sponsor
- Metzger, Charles, M.D.
Epidermolysis Bullosa Dystrophica
Proof of Concept Study for a Dressing Glove
Epidermolysis Bullosa (EB) is a group of genetic conditions causing extensive, painful skin blisters and wounds. Four main types of EB are recognised, which all affect the hands but those patients usually requiring hand therapy…
- Trial name
- NCT03241628
- Testing
- Dressing Glove
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Joint Contracture, Contracture
Recurrence of Extremity Joint Contracture After Z-Plasty Versus Full-Thickness Skin Graft
The purpose of this study is to compare how often joint contractures in the arms and legs come back after two common types of reconstructive surgery: Z-plasty and full-thickness skin graft (FTSG).
- Conditions
- Joint Contracture, Contracture, Cicatrix, Burn Scar Contractures
- Trial name
- NCT07885046
- Testing
- Z-Plasty, Full-Thickness Skin Graft
- Volunteers
- 300 people
- Sponsor
- Universitas Sebelas Maret
Proximal Interphalangeal Finger Joint Contractures
High Doses of Total End Range Time Offer Better Results Than Low Doses Treating Proximal Interphalangeal Joint Stiffness
Elastic Tension Digital Neoprene Orthosis is a new device that can increase the dose of treatment of the proximal interphalangeal flexion contractures.
- Trial name
- NCT05625451
- Testing
- Elastic Tension Digital Neoprene Orthosis
- Where
- Spain
- Volunteers
- 91 people
- Sponsor
- Vicenç Punsola Izard
Burn Joints, Joint Contractures
Effect of Paraffin Wax on Joint Contractures
Limited studies have objectively evaluated the benefit on skin pliability, and relieving itch and pain of paraffin wax, nor has paraffin wax treatment been compared to mineral oil, which is an ingredient in therapeutic paraffin…
- Trial name
- NCT07837687
- Testing
- Paraffin wax, Mineral oil
- Volunteers
- 12 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Internal Rotation Contracture-shoulder
Glenohumeral Rotation After Throwing: RCT Comparing the Sleeper Stretch to the 90/90 Hip Lift With Balloon Blow Exercise
The primary purpose of this study is to determine if the loss of internal rotation following a throwing session is best restored through soft tissue stretching with the sleeper stretch or with scapular repositioning with the…
- Trial name
- NCT03091530
- Testing
- Sleeper Stretch, 90/90 Hip Lift with Balloon Blow Exercise
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Duke University
Flexion Contracture of Proximal Interphalangeal Joint, Joint Deformities, Acquired
Rationale and Analysis of the Use of ETDNO in the Treatment of PIPJ Flexion Contracture:
Introduction: Flexion contracture is one of the most frequent complications in finger trauma. The use of orthoses to obtain the best total end range time (TERT) is the most popular method to treat this pathology .
- Trial name
- NCT05465603
- Testing
- ETDNO (Elastic Tension digital neoprene orthosis)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Vicenç Punsola Izard