Clinical trials: Muscle Disorder
Cerebral Palsy, Spastic
Effect of Vibration on Muscle Properties, Physical Activity and Balance in Children with Cerebral Palsy
The aim of the 6-month randomized controlled trial, with 6-month no treatment follow-up, is to examine the effects of low-magnitude vibration on muscle, physical activity, and balance in children with spastic cerebral palsy.
- Trial name
- NCT03484078
- Testing
- Vibration Platform
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Georgia
Temporomandibular Disorder, Myalgia
Treatment of Temporomandibular Disorders in Children and Adolsecents
Children and adolescents are treated with routine treatment approaches for adults and one of the most commonly used treatments are occlusal appliances.
- Conditions
- Temporomandibular Disorder, Myalgia, Arthralgia of TMJ
- Trial name
- TMD/PED (NCT03849534)
- Testing
- Soft occlusal appliance, Jaw exercises, Counseling
- Where
- Sweden
- Sponsor
- Karolinska Institutet
Facial Paralysis
Free Neurovascularized Muscle Transfer in Facial Reanimation of Long-standing Facial Palsy Patients
The use of free Neurovascularized muscles like free latissimus and gracillis muscles for reanimation of long-standing facial palsy patients using the hypoglossal nerve for innervating these muscles
- Trial name
- NCT05222698
- Testing
- Facial reanimation surgery by free muscle trasfer.
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sohag University
Respiratory Muscles, Respiration, Artificial
Visualization of Inspiratory Effort and Respiratory Mechanics to Promote Lung- and Diaphragm Protective Ventilation
This is a multicentre prospective cohort trial in adult and pediatric ICU patients. The investigators will measure the effect of a patient's inspiratory effort during mechanical ventilation on the lungs and diaphragm.
- Conditions
- Respiratory Muscles, Respiration, Artificial, Respiratory Function Tests
- Trial name
- VIREM (NCT05459116)
- Testing
- Placement of nasogastric balloon
- Where
- 3 sites in Belgium, Canada
- Volunteers
- 150 people
- Sponsor
- University Hospital, Antwerp
Sarcopenia
Respiratory Sarcopenia in Older Adults
The objectives of this study are to describe the prevalence of respiratory sarcopenia, evaluate its pattern of evolution over a one-year follow-up, and determine the response to a therapeutic exercise program in older adults in a…
- Trial name
- NCT06548984
- Testing
- diaphragmatic exercises, Respiratory muscle training
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Felipe León Morillas
Cerebral Palsy, Spasticity
Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Arm(s) or of Arm(s) and Leg(s) in Cerebral Palsy
The purpose of this study is to determine whether injections of Botulinum toxin type A into muscles of one or both arms alone or in combination with injections into one or both legs are effective and safe in treating…
- Trial name
- XARA (NCT02002884)
- Testing
- IncobotulinumtoxinA (8 Units per kg body weight), IncobotulinumtoxinA (6 Units per kg body weight), IncobotulinumtoxinA (2 Units per kg body weight)
- Where
- 32 sites in United States, Argentina and 4 more
- Volunteers
- 351 people
- Sponsor
- Merz Pharmaceuticals GmbH
Myotonic Dystrophy 1
Myotonic Dystrophy Type 1 Congenital and Juvenile Form: From Diagnosis to Rehabilitation [MDCJ-NeuBeRe]
The rationale of the study is to collect structured data in the neuropsychological, clinical neuroradiologic and neurorehabilitation fields in children/young people affected by congenital and juvenile myotonic dystrophy.
- Trial name
- MDCJ-NeuBeRe (NCT06378216)
- Testing
- neurocognitive evaluations
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Eugenio Medea
Breast Cancer
Bone Geometry and Muscle Density Changes in Postmenopausal Women and Breast Cancer Patients Prescribed Anastrozole
The primary objective of this study is to determine if trabecular or cortical volumetric bone mineral density (vBMD) change over time in postmenopausal breast cancer patients who are prescribed Anastrozole, as measured by pQCT at…
- Trial name
- NCT00421447
- Testing
- Anastrozole
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Hamilton Health Sciences Corporation
Obstetrical Brachial Plexus Palsy
Deficits of Strength of the Rotator Muscles of the Shoulder in Children
The purpose of this retrospective work is to study the consequences of obstetrical brachial plexus paralysis on the rotator muscles of the shoulder.
- Trial name
- ROTPOPB (NCT03440658)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Recurrent Crying Spells
Recurrent Crying Spells in Cerebral Palsy
This is a study of recurrent crying spells in Spastic Cerebral Palsy patients and their treatment.
- Trial name
- RCSCPSQ (NCT01955655)
- Testing
- Baclofen
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Sathbhavana Brain Clinic
Cardiovascular Disease
STATIN: Web-based Investigation of Side Effects
Statins are known to cause rare but serious side effects such as rhabdomyolysis (breakdown of muscle tissue) but many patients stop taking statins due to less severe symptoms, such as muscle pain or fatigue.
- Trial name
- STATINWISE (NCT02781064)
- Testing
- Atorvastatin 20mg
- Where
- 58 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Shoulder Injuries, Musculoskeletal Injury
Shoulder Instability in Children: Muscle Activity and Movement
The aim of this study is to identify factors responsible for recurrent shoulder instability in children. Shoulder instability, i.e.
- Conditions
- Shoulder Injuries, Musculoskeletal Injury, Pediatric ALL, Dislocation, Shoulder
- Trial name
- NCT04311216
- Testing
- 3D movement analysis with surface electromyography
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Urinary Incontinence, Epispadias, Male
Autologous Muscle Stem Cell Therapy for Treatment of Congenital Urinary Incontinence in Epispadias Patients
The aim of this trial is to evaluate the safety and efficacy of an autologous muscle stem cell therapy in the treatment of congenital urinary incontinence in isolated epispadias.
- Trial name
- MUST (NCT04729582)
- Testing
- Primary human muscle stem cells (Satori-01)
- Where
- 2 sites in Germany
- Volunteers
- 21 people
- Sponsor
- Simone Spuler, MD
Cerebral Palsy
Improvement in Gross Motor Function and Muscle Tone in Children With Cerebral Palsy Related to Neonatal Icterus
The purpose of this study is to evaluate the safety and effectiveness of stem cells for cerebral palsy related to neonatal icterus
- Trial name
- NCT03123562
- Testing
- Stem cell transplantation
- Where
- Vietnam
- Volunteers
- 25 people
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Asthma in Children
Video Game-Based and Conventional Breathing Exercises on Pulmonary and Extrapulmonary Features in Children with Asthma
Conventional breathing exercises are recommended as a support to drug therapy, which is the primary treatment modality for symptom management in asthma patients.
- Trial name
- NCT06546566
- Testing
- Video Game-Based Breathing Exercises, Conventional Breathing Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Atlas University
Skeletal Disorder
Bone and Muscle Health in Kids
Vitamin D deficiency in childhood leads to poor bone growth and muscle weakness, yet it is unknown if the amount of vitamin D a woman consumes during her pregnancy affects her child's bone and muscle development.
- Trial name
- BONUSKids (NCT03537443)
- Testing
- Cholecalciferol (vitamin D3)
- Where
- Bangladesh
- Volunteers
- 642 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Duchenne Muscular Dystrophy, Performance
Lower Limb Flexibility in Duchenne Muscular Dystrophy: Effects on Functional Performance
The investigator investigated the effect of lower limb flexibility on functional performance of children with Duchenne Muscular Dystrophy.
- Conditions
- Duchenne Muscular Dystrophy, Performance, Flexibility
- Trial name
- NCT03534349
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Hernias, Diaphragmatic, Congenital
Resistance Exercise in Children With Post-operative Congenital Diaphragmatic Hernia
Congenital diaphragmatic hernia (CDH) is a life-threatening condition with long-term complications including respiratory tract infections, respiratory muscle weakness, and abnormal lung functions.
- Trial name
- hernia (NCT04900649)
- Testing
- chest resistance exercise, chest expansion exercises
- Where
- Saudi Arabia
- Volunteers
- 32 people
- Sponsor
- Qassim University
Prostatic Neoplasms
Exercise in Men Receiving Radiation Therapy for Prostate Cancer.
Androgen Deprivation Therapy is a commonly used treatment for men with Prostate Cancer. Unfortunately this can lead to functional decline, fatigue, increased body fatness, loss of lean body tissue and impaired QOL.
- Trial name
- NCT00253916
- Testing
- Aerobic cardiovascular exercise program, Resistance Exercise Program
- Where
- Canada
- Volunteers
- 121 people
- Sponsor
- Ottawa Hospital Research Institute
Long-chain Fatty Acid Oxidation Disorders (LC-FAOD)
Long-Chain Fatty Acid Oxidation Disorders Online Disease Monitoring Program
The objectives of this study are to characterize the disease impact, the disease management and resource utilization, and provide benefits to the LC-FAOD community, by use of a convenient online platform for participants (or…
- Trial name
- NCT04812106
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Ultragenyx Pharmaceutical Inc
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