Clinical trials: Muscle Disorders
Musculoskeletal Pain, Neck Pain
Trends in Prevalence of 11 Site-specific Musculoskeletal Pain Among U.S. Adults, 1999-2018
The goal of this observational study is to explore the prevalence trends of 11 site-specific musculoskeletal pain from 1999 to 2018. The main question it aims to answer is: Does the prevalence of musculoskeletal pain among U.S.
- Conditions
- Musculoskeletal Pain, Neck Pain, Low Back Pain, Joint Pain
- Trial name
- NCT06494670
- Testing
- No intervention
- Volunteers
- 565,219 people
- Sponsor
- Fan luying
Muscular Dystrophy, Duchenne
Validating Cardiac MRI Biomarkers and Genotype-Phenotype Correlations for DMD
This study will collect MRI from healthy volunteer boys and boys with Duchenne Muscular Dystrophy (DMD) to help researchers identify and validate cardiac MRI biomarkers to better understand the health of the heart and changes in…
- Trial name
- NCT02834650
- Testing
- Cardiac MRI with contrast, Cardiac MRI without contrast, Blood Test
- Where
- 3 sites in United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Stanford University
Bladder Cancer, Bladder Cancer Stage I
Loop Resection or Cold-cup Biopsy? A Study Comparing the Accuracy of Muscle Samples During Bladder Tumor Surgery
In this report the investigators compared two deep muscle sampling methods (Loop resection and Cold-Cup Biopsy) during endoscopic resection of bladder tumors for patients with suspected bladder cancer in Tygerberg hospital.
- Conditions
- Bladder Cancer, Bladder Cancer Stage I, TURBT
- Trial name
- NCT06796413
- Testing
- Loop Resection or Cold-cup biopsy
- Where
- South Africa
- Volunteers
- 120 people
- Sponsor
- University of Stellenbosch
Duchenne Muscular Dystrophy
Exploratory Study of NS-065/NCNP-01 in DMD
This study is designed to assess the safety, tolerability, efficacy and pharmacokinetics (PK) of NS-065/NCNP-01 in subjects diagnosed with Duchenne muscular dystrophy (DMD).
- Trial name
- NCT02081625
- Testing
- NS-065/NCNP-01
- Where
- Japan
- Volunteers
- 10 people
- Sponsor
- National Center of Neurology and Psychiatry, Japan
Cerebral Palsy (CP)
Effects of Barefoot vs. Shod Whole Body Vibration Training in Children With Cerebral Palsy
Cerebral palsy (CP) refers to a group of lifelong conditions that affect the development of movement and coordination that lead to activity limitations due to damage to the developing fetal or neonatal brain tissue.
- Trial name
- NCT06596525
- Testing
- Conventional physical therapy, Barefoot Whole Body Vibration Training (WBVTb), Shod Whole Body Vibration Training (WBVTs)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Trakya University
Developmental Coordination Disorder
Tai Chi-muscle Power Training for Primary School Children With Developmental Coordination Disorder
Objectives: To compare the effectiveness of Tai Chi-muscle power training (TC-MPT), Tai Chi (TC) alone, muscle power training (MPT) alone, and usual care (as a control) for improving the limits of stability (LOS) of balance…
- Trial name
- NCT03598478
- Testing
- TC-MPT, TC, MPT
- Where
- Hong Kong
- Volunteers
- 156 people
- Sponsor
- The University of Hong Kong
Laminopathies, Emerinopathies
Observatoire Des Patients Atteints de Laminopathies et Emerinopathies (Observatory for PAtients With Laminopathies and Emerinopathies)
Laminopathies and emerinopathies are complex group of rare disorders due to mutations in A-type lamins (LMNA) and Emerin (EMD) genes.
- Trial name
- OPALE (NCT03058185)
- Where
- 29 sites in France
- Volunteers
- 800 people
- Sponsor
- Pitié-Salpêtrière Hospital
Duchenne Muscular Dystrophy
Evaluate the Efficacy and Safety of EN001 in Patients With Duchenne Muscular Dystrophy
A Multi-center, Randomized, Double-blind, Placebo-controlled, Phase 1/2 Trial to Evaluate the Efficacy and Safety of EN001 in Patients with Duchenne Muscular Dystrophy
- Trial name
- NCT06328725
- Testing
- EN001
- Where
- 2 sites in South Korea
- Volunteers
- 88 people
- Sponsor
- ENCell
Rare Genetic Muscle Diseases, Muscular Dystrophy, Duchenne
Transcriptomic Analysis to Put an End to Misdiagnosis in Patients With Rare Muscle Diseases
Since 2017, more than 250 analyses performed at the Molecular Genetics Laboratory of the Timone Enfant Hospital have yielded negative results in patients with rare genetic muscle diseases.
- Conditions
- Rare Genetic Muscle Diseases, Muscular Dystrophy, Duchenne, Muscular Dystrophy, Becker, Congenital Myopathy
- Trial name
- ARNseq-Musc (NCT06833489)
- Testing
- ARN extraction from muscle biopsies
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Child Development, Sarcopenia
Abdominal Skeletal Muscle Compartments in Turkish Children
The aim of this study was to establish reference values for three compartments of the abdominal skeletal muscle area (psoas muscle area, paraspinal muscle area, and total skeletal muscle area) obtained from cross-sectional…
- Trial name
- NCT06121791
- Testing
- Normal values of abdominal level muscle areas of Turkish children
- Where
- Turkey (Türkiye)
- Volunteers
- 2,168 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Duchenne Muscular Dystrophy, Muscle Strength
Effect of Muscle Strength on Hamstring Flexibility in Children With Duchenne Muscular Dystrophy
Investigator researched that the effect of trunk and lower extremity muscle strength on hamstring flexibility in children with Duchenne Muscular Dystrophy.
- Conditions
- Duchenne Muscular Dystrophy, Muscle Strength, Lower Extremity, Hamstring Contractures
- Trial name
- NCT03589573
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Molar Incisor Hypomineralization
The Effect of Molar Incisor Hypomineralisation on the Stomatognathic System
This study aims to examine whether children with Molar Incisor Hypomineralization (MIH) are more likely to have problems with the jaw joint and chewing muscles.
- Trial name
- NCT06951139
- Testing
- Ultrasound and Shear Wave Elastography
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ozge Gungor
Recurrent or Refractory Solid Tumors, Ewing Sarcoma
Phase 1 Dose-escalating Study of MM-398 (Irinotecan Sucrosofate Liposome Injection) Plus Intravenous Cyclophosphamide in Recurrent or Refractory Pediatric Solid Tumors
This is a Phase 1 study of the combination of two drugs: MM-398 and Cyclophosphamide. The goal is to find the highest dose of MM-398 that can be given safely when it is used together with the chemotherapy drug Cyclophosphamide.
- Conditions
- Recurrent or Refractory Solid Tumors, Ewing Sarcoma, Rhabdomyosarcoma, Neuroblastoma
- Trial name
- NCT02013336
- Testing
- MM-398 (Irinotecan Sucrosofate Liposome Injection) plus cyclophosphamide
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- South Plains Oncology Consortium
TMJ Disorder
Condylar Position Changes in Anterior Disc Displacement with Reduction
the goal of this clinical trial is to know if TMJ lavage does change the condyle position in patients diagnosed with unilateral anterior disc displacement with reduction.
- Trial name
- NCT06856811
- Testing
- tmj lavage with ringer lactate solution
- Where
- Yemen
- Volunteers
- 14 people
- Sponsor
- Sana'a University
Duchene Muscular Dystrophy, Becker Muscular Dystrophy
Multiparametric Ultrafast Ultrasound Biomarkers for Duchenne and Becker Muscular Dystrophies
The purpose of this research study is to determine the potential of a multiparametric ultrasound approach to non-invasively monitor disease progression and to serve as an objective outcome measure for future clinical trials in…
- Trial name
- INNOVAN (NCT07378553)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Cerebral Palsy (CP), Physical Functional Performance
Action Observation Training for Functional Performance in Children with Cerebral Palsy
This study is a randomized control trial and aims to determine the effects of Action Observation on balance and mobility in patients with cerebral palsy compared to training without action observation.
- Trial name
- NCT06672328
- Testing
- Training with Action Observation Therapy, Training without Action Observation Therapy
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Foundation University Islamabad
Myotonic Dystrophy
An Open-Label Extension Study to Evaluate the Long-Term Safety and Efficacy of Once Daily Mexiletine PR in Patients With Myotonic Dystrophy Type 1 and Type 2 Who Have Completed MEX-DM-302 Study.
This is an open-label extension study intended to evaluate the long-term safety and efficacy of mexiletine PR in patients with myotonic dystrophy type 1 and type 2 (DM1 and DM2) who have completed the parent study MEX-DM-302.
- Trial name
- NCT06549400
- Testing
- Mexiletine granules for prolonged-release oral suspension
- Where
- 6 sites in Belgium, Denmark and 4 more
- Volunteers
- 176 people
- Sponsor
- Lupin Ltd.
Duchenne Muscular Dystrophy
PDE Inhibitors in DMD Study (Acute Dosing Study)
PDE5A inhibition, which boosts NO-cGMP signaling, will relieve functional muscle ischemia and restore normal blood flow regulation (i.e., functional sympatholysis) during exercise in boys with DMD.
- Trial name
- NCT01580501
- Testing
- Tadalafil and Sildenafil
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Back Pain, Low Back Pain
Neck and Low Back Pain in Physical Therapy Students at The University of the West Indies, Mona, Jamaica
The purpose of this study is to determine the prevalence of neck and low back pain among physical therapy students enrolled at The University of the West Indies, Mona.
- Conditions
- Back Pain, Low Back Pain, Musculoskeletal Pain, Spine Health
- Trial name
- NCT07177001
- Testing
- Clinical Control Group (Group A), Spine Exercise Program (Group B)
- Where
- Jamaica
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Muscular Dystrophies
Self-management Training for Parents With Chronic Muscular Dystrophia
The relentless progressive process of muscular dystrophy requires extraordinary medical, physical, and emotional care with severe consequences for caring parents (increased stress and diminished social, psychological and physical…
- Trial name
- ZRM-CMD-P (NCT02641275)
- Testing
- Structured self-management-training
- Sponsor
- University Children's Hospital, Zurich
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