Clinical trials: Muscle Spasticity
Leukodystrophy, White Matter Disease
LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies
Leukodystrophies, and other heritable disorders of the white matter of the brain, were previously resistant to genetic characterization, largely due to the extreme genetic heterogeneity of molecular causes.
- Conditions
- Leukodystrophy, White Matter Disease, 4H Syndrome, Adrenoleukodystrophy
- Trial name
- NCT02699190
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Children's Hospital of Philadelphia
Activities of Daily Living, Postural Control
Effect of Callisthenic Training on Mobility and ADL Performance in Spastic Diplegic Cerebral Palsy Patients
Almost 2 to 3 out of every 1000 children have Cerebral palsy in Pakistan.Spastic type of CP is dominant about 75%, diplegia (40%) and hemiplegic are (35.5%).Spastic diplegics have tightness of lower limb more than upper…
- Conditions
- Activities of Daily Living, Postural Control, Spasticity, Mobility
- Trial name
- NCT06966076
- Testing
- calisthenic training, Conventional physical therapy group
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Foundation University Islamabad
Spasticity, Muscle
Efficiency of the Super Inductive System in Spasticity Treatment
The aim of the study is to see whether a physical therapy program can relieve pain, decrease spasticity and increase muscle contraction force by using the super inductive system (high frequency electromagnetic field).
- Trial name
- NCT04190238
- Testing
- Super inductive system (high frequency electromagnetic field), Physical therapy
- Where
- Romania
- Volunteers
- 60 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Spasticity, Dystonia
The Effects of Cannabis on Dystonia and Spasticity on Pediatric Patients
A clinical trial is planned to study the effects of cannabis on dystonia and spasticity in children with neurological diseases. The clinical trial will include 40 children divided into two groups: children with spasticity and…
- Trial name
- NCT02470325
- Testing
- Avidekel oil, Enriched Avidekel oil
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Wolfson Medical Center
Sjogren-Larsson Syndrome
ADX-629 Therapy for Sjogren-Larsson Syndrome
This research study will determine whether orally administered ADX-629 is safe and has biochemical efficacy in participants with Sjögren-Larsson syndrome (SLS), a rare inherited disorder of fatty aldehyde metabolism The disease…
- Trial name
- NCT05443685
- Testing
- ADX-629
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Nebraska
Encephalopathy, Psychosis
Neuroimmunology Registry and Biobank
A variety of antineuronal antibodies have been detected in the cerebrospinal fluid (CSF) of patients with neurological diseases.
- Conditions
- Encephalopathy, Psychosis, Impaired Consciousness, Epilepsy
- Trial name
- NCT06958341
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
C10.228.140.140.254
The Socioeconomic Status and Child Characteristics on the Physical Therapy Outcome in Children With Spastic Cerebral Palsy
The main outcome of physical therapy interventions is the progress of gross motor functions which result from the interactions between many factors not limited to physical, medical or surgical interventions but also including…
- Trial name
- NCT04160403
- Testing
- physical therapy intervention
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Zeinab Hussein
Idiopathic Toe Walking, Cerebral Palsy
The Effect of Targeting the Plantaris Muscle-tendon in Surgical Correction of Ankle Equinus in Children
Tight ankle muscles can produce ankle equinus (limited ability to pull the foot upward) and occur often in children, significantly impacting their ability to walk.
- Conditions
- Idiopathic Toe Walking, Cerebral Palsy, Hereditary Spastic Paraparesis, Traumatic Brain Injury
- Trial name
- Plantaris Sx (NCT07090057)
- Testing
- Tendoachilles (TA) lengthening or gastrocnemius (GN) recession, then Plantaris tenotomy, Plantaris tenotomy, then Tendoachilles (TA) lengthening or gastrocnemius (GN) recession
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- University of Alberta
Cerebral Palsy, Genetic Disease
Genetic Etiology in Patients With Cerebral Palsy
Cerebral palsy (CP) is a permanent disorder of movement or posture due to non-progressive impairments of the developing brain. Current estimates indicate that as many as 30% of CP cases may be genetic in nature.
- Conditions
- Cerebral Palsy, Genetic Disease, Developmental Delay, Metabolism, Inborn Errors
- Trial name
- GenCP (NCT05123768)
- Testing
- NGS
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Cerebral Palsy Spastic Diplegia
Ankle Foot Orthosis on Muscle Activity in Cerebral Palsy
To compare the effect of solid ankle foot orthosis and ground reaction foot orthosis on the muscle activity in children with spastic diplegic cerebral palsy (Gross Motor Functional Classification Scale III).
- Trial name
- NCT06291974
- Testing
- electromyography
- Volunteers
- 30 people
- Sponsor
- Delta University for Science and Technology
Cerebral Palsy, Cerebral Palsy, Spastic
Physiotherapy After Botulinum Toxin Injection and Serial Casting
The effects of different physiotherapy programs on children with cerebral palsy who have been received botulinum toxin injection and serial casting application will be determined.
- Trial name
- NCT05312125
- Testing
- backward downhill walking, routine physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 19 people
- Sponsor
- Gazi University
Cerebral Palsy
EXOPULSE Mollii Suit & Cerebral Palsy
Spasticity is a frequent and debilitating symptom in patients with cerebral palsy. It can alter the patients' balance, mobility, as well as their quality of life (QoL).
- Trial name
- EXOCEP (NCT06266286)
- Testing
- EXOPULSE MOLLII SUIT (active)
- Where
- 4 sites in France
- Volunteers
- 32 people
- Sponsor
- Institut De La Colonne Vertebrale Et Des Neurosciences
Cerebrovascular Accident
Botulinim Toxin Type A Injections by Different Guidance in Stroke Patients With Spasticity on Upper Extremities
The aims of this study were to compare the injection locations of key spastic muscles on upper extremity by three different guidance localization methods ( surface anatomy landmark, ultrasonography, electric stimulation) and the…
- Trial name
- NCT02557737
- Testing
- Botulinum Toxin Type A
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Cerebral Palsy
Validity and Reliability The Foot-taping Test in Children With Cerebral Palsy
In spastic cerebral palsy, there are interrelated neuromuscular deficits that can affect ankle joint control, including impaired selective voluntary motor control, muscle weakness, spasticity, and shortened muscle-tendon units.
- Trial name
- NCT07091201
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Afyonkarahisar Health Sciences University
Spastic Diplegic Cerebral Palsy
Efficacy and Functional Outcomes of Botulinum Toxin A Injections to Hamstrings in Flexed Knee Gait in Cerebral Palsy
The study proposes to determine if injections of BTX-A to the hamstring muscles result in measurable physiologic changes not observed with normal saline injections in children with spastic diplegic cerebral palsy who walk with a…
- Trial name
- NCT00261131
- Testing
- Botulinum Toxin A
- Volunteers
- 250 people
- Sponsor
- Shriners Hospitals for Children
Cerebral Palsy, Spastic Hemiplegic Cerebral Palsy
Mechanical Vibration on Children With Cerebral Palsy
The purpose of this study was to assess the effect of mechanical vibration on spasticity and balance in children with cerebral palsy.
- Trial name
- NCT05593406
- Testing
- Vibration Group, Control Group
- Where
- Greece
- Volunteers
- 13 people
- Sponsor
- University of Thessaly
CP (Cerebral Palsy)
rTMS Treatment of Spasticity in Children With Cerebral Palsy/ Hemiplegia Due to ABI - a RCT
This RCT aims to investigate the effect of repetitive transcranial magnatic stimulation (rTMS) in treating children with hemiplegoc cerebral palsy.
- Trial name
- NCT06128746
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- The University of Hong Kong
Cervical Dystonia, Blepharospasm
Efficacy and Safety of 10-Week or Shorter vs 12-Week or Longer Injection Intervals of Botulinum Toxin
Our hypothesis is that botulinum toxin injections (with onabotulinum toxin, incobotulinum toxin, and abobotulinum toxin) given at 10-week or shorter intervals for the indication of treatment of muscle spasms associated with…
- Conditions
- Cervical Dystonia, Blepharospasm, Limb Dystonia, Hemifacial Spasm
- Trial name
- NCT05103202
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Texas Southwestern Medical Center
Spastic Diplegic Cerebral Palsy
Repetitive Transcranial Magnetic Stimulation Versus Botulinum Injection on Spasticity on Children With Diplegic Cerebral Palsy
This trial will enroll 75 children with spastic diplegic cerebral palsy both matched in age, sex, degree of disability and cognitive functions with the same exclusion criteria undergoing the same physical therapy.
- Trial name
- NCT06218316
- Testing
- botulinum toxin A, Transcranial Magnetic Stimulation, Rehabilitation Training Protocol
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- MTI University
Cerebral Palsy, Spastic
Functional Electrical Stimulation During Walking in Cerebral Palsy
Children with spastic cerebral palsy (CP) often walk with insufficient ankle dorsiflexion in the swing phase. A pathological gait, known as drop-foot gait, can be the result and this has 2 major complications: foot-slap during…
- Conditions
- Cerebral Palsy, Spastic, Foot Drop
- Trial name
- NCT03440632
- Testing
- FES
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Maastricht University Medical Center