Clinical trials: Mycobacterium Avium Complex
Hematologic Malignancy, Acute Leukemia
MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies
This is a phase II, open-label, prospective study of T cell receptor alpha/beta depletion (TCR α/β TCD) peripheral blood stem cell (PBSC) transplantation for children and adults with hematological malignancies.
- Conditions
- Hematologic Malignancy, Acute Leukemia, Remission, Acute Myeloid Leukemia
- Trial name
- NCT05735717
- Testing
- Fludarabine, Busulfan, Melphalan
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Autoimmune Liver Diseases, Immunological Mechanisms
The MAI-FOIE Cohort
The MAI-FOIE cohort will be a French multicenter cohort with the development of a biobank including patients with autoimmune, metabolic and medicated liver diseases
- Trial name
- NCT07594990
- Where
- 13 sites in France
- Volunteers
- 800 people
- Sponsor
- Nantes University Hospital
Presbyopia
The C-MAC Video Laryngoscope Helps Presbyopic Anesthetists
Endotracheal intubation is the de facto gold standard for airway management especially in neonatal and pediatric anesthesia . An efficient neonatal airway management is challenging even in the most experienced hands and the…
- Trial name
- NCT06581705
- Testing
- Video Laryngoscope
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Egymedicalpedia
Infection, Mycobacterium Avium-Intracellulare
Clofazamine for the Treatment of Mycobacterium Avium Intracellulare(MAI)
This protocol is an single patient IND to provide clofazamine to treat one patient who has MAI and is resistant to or can not tolerate standard of care. The drug is not otherwise available.
- Trial name
- NCT00652067
- Volunteers
- 1 people
- Sponsor
- Yale University
Diffuse Large B Cell Lymphoma (DLBCL), Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma
Axatilimab + CAR-T for High-Risk Lymphoma
Axatilimab + CAR-T in High-Risk Lymphoma
- Conditions
- Diffuse Large B Cell Lymphoma (DLBCL), Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma, High-grade B-cell Lymphoma (HGBCL), High-Grade B-Cell Lymphoma, Nos
- Trial name
- NCT07638982
- Testing
- Axatilimab
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Northside Hospital, Inc.
Intubation; Difficult or Failed
A.I. Supported Laryngoscopy and Endotracheal Intubation: a Manikin Study
LarynGuide is a newly developed AI-supported software for video laryngoscopy that supports the user through correct placement of endotracheal tube by means of audio-visual signals and warning of incorrect or potentially dangerous…
- Trial name
- aiTN (NCT06657417)
- Testing
- Video laryngoscopy, Video larnygoscopy
- Where
- Switzerland
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Schulthess Klinik
Tuberculosis, Non-tuberculous Mycobacterial Diseases (Including MAC Disease)
Safety And Efficacy Of Rifabutin In Patients For Non-HIV Patients
The objective of this surveillance is to collect information about 1) adverse drug reaction not expected from the LPD (unknown adverse drug reaction), 2) the incidence of adverse drug reactions in this surveillance, and 3)factors…
- Trial name
- NCT00810407
- Testing
- rifabutin
- Volunteers
- 628 people
- Sponsor
- Pfizer
Anesthesia, Endotracheal
A Comparison of McGrath MAC Videolaryngoscopy and Macintosh Laryngoscopy for Orotracheal Intubation in Children With Torticollis
The primary purpose of this study is to investigate the effects of McGrath MAC videolaryngoscopy on the intubation time for orotracheal intubation in children with torticollis.
- Trial name
- NCT03582787
- Testing
- McGrath MAC videolaryngoscopy, Macintosh Laryngoscopy
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Ajou University School of Medicine
Intubation; Difficult, Cervical Spine Injury
Head Motion in Pediatric Patients Endotracheally Intubated With Video Laryngoscopy Versus Direct Laryngoscopy
The purpose of this study is to evaluate if intubation with video laryngoscopy (VL) will result in less head motion and therefore less cervical motion when compared with direct laryngoscopy (DL).
- Trial name
- NCT02405390
- Testing
- Video Laryngoscopy, Direct Laryngoscopy, Storz C-Mac® laryngoscope
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Nicklaus Children's Hospital f/k/a Miami Children's Hospital
Mycobacterium Avium-intracellulare Infection, HIV Infections
A Phase II Safety and Efficacy Study of Clarithromycin in the Treatment of Disseminated M. Avium Complex (MAC) Infections in Patients With AIDS
This study is designed to evaluate the efficacy and safety of clarithromycin given orally at 1 of 3 doses to treat disseminated Mycobacterium avium complex infections (MAC) in patients with AIDS.
- Trial name
- NCT00000644
- Testing
- Clarithromycin
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Mycobacterium Avium-Intracellulare Infection
A Randomized, Double-Blinded, Placebo-Controlled, Phase II Inhaled Interferon Gamma-1b and Antimycobacterials to Treat Pulmonary Mycobacterium Avium Complex Infections
This study will test the safety and effectiveness of inhaled interferon gamma-1b and oral antibiotics for treating mycobacterium avium complex (MAC) infection of the lungs.
- Trial name
- NCT00021567
- Testing
- Interferon Gamma for Aerosol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Mycobacterium Avium-intracellulare Infection, HIV Infections
The Safety and Effectiveness of Clarithromycin and Rifabutin Used Alone or in Combination to Prevent Mycobacterium Avium Complex (MAC) or Disseminated MAC Disease in HIV-Infected Patients
To compare the efficacy and safety of clarithromycin alone versus rifabutin alone versus the two drugs in combination for the prevention or delay of Mycobacterium avium Complex (MAC) bacteremia or disseminated MAC disease.
- Trial name
- NCT00001030
- Testing
- Clarithromycin, Rifabutin
- Where
- 42 sites in United States, Tanzania
- Volunteers
- 1,100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Children
Reduction in MACbar of Sevoflurane by Dexmedetomidine in Children
The study was designed to define the interaction of intravenous infusion of dexmedetomidine, an a2-adrenergic agonist, and sevoflurane in children having surgery by using the minimum alveolar concentration which can block…
- Trial name
- NCT02261675
- Testing
- dexmedetomidine
- Volunteers
- 63 people
- Sponsor
- Cai Li
Pyloric Stenosis, Intubation, Pediatric
Conventional Direct Laryngoscopy Vs. Video Laryngoscopy With The C-MAC For Pyloromyotomy
The purpose of this study is to compare two different ways of placing breathing tubes for surgery. Both ways are used currently to place breathing tubes and are safe and effective.
- Trial name
- NCT02775214
- Testing
- Video Laryngoscopy
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Indiana University
Intubation
C-MAC Video Stylet vs. Video Endoscope
The purpose of the study is to compare first attempt success rates and time until intubation to establish the learning curves of the participating anaesthesiologists with two different intubation strategies: (Karl Storz C-MAC VS…
- Trial name
- NCT03749837
- Testing
- C- MAC VS, Video Endoscope
- Where
- 3 sites in Canada, Spain and 1 more
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Mycobacterium Avium-intracellulare Infection, HIV Infections
Study of Four Different Treatment Approaches for Patients Who Have Mycobacterium Avium Complex Disease (MAC) Plus AIDS
To compare the safety and efficacy of two doses of clarithromycin in combination with ethambutol and either rifabutin or clofazimine for the treatment of disseminated Mycobacterium avium Complex (MAC) disease in AIDS patients.
- Trial name
- NCT00001047
- Testing
- Ethambutol hydrochloride, Clarithromycin, Clofazimine
- Where
- 16 sites in United States
- Volunteers
- 400 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Anti-Bacterial Agents
Carbapenems De-escalation as Antimicrobial Stewardship
Early de-escalation of carbapenems can reduce unnecessary use of carbaepenems compared with late de-escalation without compromised clinical outcomes
- Trial name
- NCT03114358
- Testing
- Early Carbapenem de-escalation
- Volunteers
- 104 people
- Sponsor
- Chiang Mai University
Hypoxemia, Obstructive Sleep Apnea
The Prediction Model of Hypoxemia for Safe Bronchoscopy
The purpose of this study is to develop the hypoxemia prediction model during fiberoptic bronchoscopy under MAC(monitored anesthesia care) anesthesia.
- Trial name
- NCT01370993
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Bundang Hospital
Classical Hodgkin Lymphoma
CD30 CAR T-cells Post AutoHSCT for Poor-risk Hodgkin Lymphoma
Patients with poor risk classical Hodgkin Lymphoma (cHL) will undergo myeloablative chemotherapy (MAC) with autologous stem cell transplantation (AutoHSCT) and subsequently receive autologous CD30+ CAR T-cells.
- Trial name
- NCT06617286
- Testing
- CD30 CAR T-cell
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- New York Medical College
Sickle Cell Disease
Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease
This is a follow-up trial to NYMC 526 (NCT01461837) to assess the safety, efficacy and toxicity of administering Defibrotide prophylaxis for high-risk sickle cell or beta thalassemia patients undergoing a familial haploidentical…
- Trial name
- NYMC-571 (NCT02675959)
- Testing
- Defibrotide
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- New York Medical College