Clinical trials: NSAIDs
Pain, Postoperative, Recovery of Function
Intravenous Paracetamol for Postoperative Pain
The purpose of this study is to define if intravenous paracetamol may improve analgesia and outcome in pediatric surgical patients treated with non-steroidal anti-inflammatory drugs (NSAIDs) postoperatively.
- Conditions
- Pain, Postoperative, Recovery of Function, Child
- Trial name
- IVPARACET (NCT02248493)
- Testing
- Paracetamol, Ketoprofen, Tramadol
- Where
- Lithuania
- Volunteers
- 54 people
- Sponsor
- Lithuanian University of Health Sciences
Tonsillitis Chronic, Tonsillitis Recurrent
The Effect of Systemic Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Vs Intraoperative Infiltration of Steroids in Tonsillar Bed Following Tonsillectomy on Post Tonsillectomy Pain.
The aim of this study is to compare the efficacy of adding paracetamol to systemic non-steroidal anti-inflammatory drugs (NSAIDs) versus adding dexamethasone as local infiltration to paracetamol on post tonsillectomy pain control.
- Conditions
- Tonsillitis Chronic, Tonsillitis Recurrent, OSA - Obstructive Sleep Apnea
- Trial name
- NSAIDs (NCT07035314)
- Testing
- Dexamethasone, NSAIDs, Control (Standard treatment)
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Arthritis, Rheumatoid
Safety and Efficacy of Meloxicam Compared to Other Nonsteroidal Antiinflammatory Drugs (NSAIDs) in an Observational Cohort Study of Patients With Rheumatoid Arthritis, Osteoarthritis, Lumbago, Scapulohumeral Periarthritis, Neck, Shoulder and Arm Syndrome
Study to assess the safety profile of meloxicam by comparing incidence of gastrointestinal adverse events of meloxicam with that of NSAID in the routine daily therapeutic situation.
- Trial name
- NCT02180516
- Testing
- Meloxicam, Other Non Steroidal Anti-Inflammatory Drugs (NSAIDs) except etodolac
- Volunteers
- 9,984 people
- Sponsor
- Boehringer Ingelheim
Acute Abdominal Pain, Acupuncture Therapy
Acupuncture Versus Compound Diclofenac Sodium for Pain Relief in Non-Traumatic Acute Abdominal
The investigators designed this clinical study to evaluate the efficacy and safety of semi-standardized acupuncture and moxibustion combined with compound diclofenac sodium injection in the emergency department (ED) compared with…
- Conditions
- Acute Abdominal Pain, Acupuncture Therapy, Acupuncture, Opioids
- Trial name
- ACU-NTAA (NCT06982755)
- Testing
- acupuncture, compound diclofenac sodium, acupuncture combined with compound diclofenac sodium
- Volunteers
- 176 people
- Sponsor
- The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
Dysmenorrhea
Efficacy and Safety Study of Low Dose Oral Contraceptive Pill to Treat Primary Dysmenorrhea
The purpose of this study is to determine whether combination oral contraceptive pill of norethindrone and ethinyl estradiol is effective in the treatment of primary dysmenorrhea.
- Trial name
- NCT00746096
- Testing
- IKH-01
- Volunteers
- 115 people
- Sponsor
- Nobelpharma
Ductus Arteriosis, Patent, Bacterial Infections and Mycoses
Safety of Fluconazole Treatment of Premature and Full-term Newborn Infants
This study will investigate pharmacological interventions between fluconazole and ibuprofen when they are given to premature newborn babys.
- Trial name
- NCT02079298
- Testing
- Treatment with fluconazole., 2. Treatment with both fluconazole and Ibuprofen., 3. Treatment with ibuprofen.
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Anders Rane, MD, PhD, Senior professor
NSAID, Biomarkers
Pediatric Non-Steroidal Anti-Inflammatory Drugs (NSAID) Allergy Study
Non-steroidal anti-inflammatory drugs (NSAIDs) are some of the most commonly used medications to treat pain and inflammation. Many are available over the counter and are frequently used in children to reduce fever and relieve…
- Conditions
- NSAID, Biomarkers, Phenotyping, Children
- Trial name
- NSAID-AS (NCT07034066)
- Where
- Spain
- Volunteers
- 257 people
- Sponsor
- Fundació Sant Joan de Déu
Cesarean Delivery, Postpartum Comfort
Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies
Cesarean delivery is a commonly performed surgical procedure associated with worse postpartum pain when compared to vaginal birth. Uncontrolled postpartum pain is associated with increased neonatal and maternal risks.
- Conditions
- Cesarean Delivery, Postpartum Comfort, Postpartum Pain, Post-operative Pain
- Trial name
- PACESS (NCT07102641)
- Testing
- Acetaminophen, NSAID (Ketorolac/Ibuprofen)
- Where
- United States
- Volunteers
- 825 people
- Sponsor
- Thomas Jefferson University
Supracondylar Humerus Fracture
NSAIDs vs Opioids for Post-op Pain in Supracondylar Humerus Fractures
The purpose of this study is to determine if using the combination of acetaminophen (also known as Tylenol) and ibuprofen (also known as Motrin or Advil) will provide equal or better pain control as compared to…
- Trial name
- NCT04905563
- Testing
- Acetaminophen-Hydrocodone, Acetaminophen and Ibuprofen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Le Bonheur Children's Hospital
Aneurysm Abdominal, Endovacular Repair
Post Implantation Syndrome and Administration on NSAIDs in Patients Undergoing EVAR for AAA
INTRODUCTION Post-implantation syndrome is the clinical and biochemical expression of an inflammatory response following endovascular repair of an aortic aneurysm.
- Trial name
- NCT03727412
- Testing
- Drugs, Generic (Naprosyn)
- Where
- Greece
- Volunteers
- 186 people
- Sponsor
- University of Thessaly
Alzheimer Disease
The Effect of Short-Term Statins and NSAIDs on Levels of Beta-Amyloid, a Protein Associated With Alzheimer's Disease
The purpose of this study is to determine whether short-term use of the drugs ibuprofen and lovastatin affects levels of a protein called beta-amyloid in people who are at risk for developing Alzheimer's Disease (AD).
- Trial name
- NCT00046358
- Testing
- Lovostatin, Ibuprofen
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Surgery, Pain, Post Operative
Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial
This trial is being completed to compare two commonly used options to treat pain after discharge from surgery. Participants that undergo tonsil removal, gallbladder removal, and knee scope will be eligible to enroll.
- Trial name
- CARES for Kids (NCT06671002)
- Testing
- NSAID, Opioid, Acetaminophen
- Where
- 9 sites in United States
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Obsessive-Compulsive Disorder, Pediatric Psychiatric Disorder
Adjunctive Celecoxib in Childhood-onset OCD Study
This is a randomized, controlled, single-centre phase II superiority trial to determine the efficacy of 12 weeks of celecoxib (50 mg or 100 mg orally twice daily, dosed based on weight) compared to placebo as an adjunct to…
- Trial name
- ACE-OCD (NCT04673578)
- Testing
- Celecoxib
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of British Columbia
Dysmenorrhea
Efficacy and Safety Study of NPC-01 to Treat Dysmenorrhea
The purpose of this study is to determine whether NPC-01 is effective in the treatment of dysmenorrhea.
- Trial name
- NCT01129102
- Testing
- NPC-01, IKH-01
- Volunteers
- 215 people
- Sponsor
- Nobelpharma
Tuberculosis
Potential Efficacy and Safety of Using Adjunctive Ibuprofen for XDR-TB Tuberculosis
Novel approaches to improve TB treatment outcomes (to reduce morbidity, mortality, and the duration of TB treatment) and to treat XDR-TB cases are urgently required.
- Trial name
- NSAIDS-XDRTB (NCT02781909)
- Testing
- Ibuprofen, Standard of Care TB treatment
- Where
- 2 sites in Georgia, South Africa
- Volunteers
- 24 people
- Sponsor
- Fundació Institut Germans Trias i Pujol
Chronic Kidney Disease, Pediatric Urology
Safety of Short-course of NSAIDs in Pediatric Patients With CKD
The purpose of this study is to determine if non-steroidal anti-inflammatory (NSAID) use in the postoperative setting increases the risk of acute kidney injury (AKI) in pediatric patients with mild-to-moderate chronic kidney…
- Trial name
- NCT06860711
- Testing
- NSAIDs
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- University of Colorado, Denver
Preeclampsia Severe, Preeclampsia Postpartum
Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial
A randomized non-inferiority trial of women with preeclampsia with severe features to determine if the addition of nonsteroidal anti-inflammatory drugs is inferior or non-inferior to standard analgesic bundles in their impact on…
- Trial name
- PANDA (NCT03978767)
- Testing
- Ibuprofen 600 mg, Ketorolac, Acetaminophen
- Where
- United States
- Volunteers
- 287 people
- Sponsor
- Washington University School of Medicine
Pain
Pharmacokinetics & Safety of Diclofenac Potassium Oral Solution in Ped. Subjects (2-12 Yrs) With Mild-Mod. Acute Pain
As part of the Pediatric Research Equity Act (PREA) commitment, the objectives of the study are to characterize the pharmacokinetic (PK) profile and to determine the safety and tolerability of diclofenac potassium oral solution…
- Trial name
- NCT02287350
- Testing
- diclofenac potassium oral solution
- Where
- 5 sites in United States
- Volunteers
- 51 people
- Sponsor
- Depomed
Gastric Ulcer, Duodenal Ulcer
Nexium Capsules Non-steroidal Anti-inflammatory Drug (NSAID) Specific Clinical Experience Investigation
The purpose of this investigation is to collect following data in patients given Nexium capsule (Nexium) for long term in usual-post-marketing therapy to prevention of recurrence of gastric ulcer or duodenal ulcer with…
- Trial name
- NCT01562600
- Where
- 46 sites in Japan
- Volunteers
- 1,634 people
- Sponsor
- AstraZeneca
Orthodontic Appliance Complication
Control of Pain From Braces With Patient Advice Sheets
To compare the analgesic property of acupressure with NSAIDs (Ibuprofen) in controlling pain following orthodontic treatment. This will be achieved by assessing the effectiveness of acupressure in controlling pain and discomfort…
- Trial name
- COPPAS (NCT03159520)
- Testing
- Advice sheet
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Dundee