Clinical trials: Naltrexone
Pyromania
Naltrexone in the Treatment of Pyromania
The proposed study will consist of 8 weeks of treatment with either naltrexone or placebo in 10 subjects with pyromania.
- Trial name
- NCT00467454
- Testing
- Naltrexone
- Where
- United States
- Sponsor
- University of Minnesota
Opiate Addiction
Comparison of Buprenorphine/Naloxone With Naltrexone in Opioid Dependent Adolescents
This study is designed to determine the relative effectiveness of buprenorphine/naloxone (Suboxone) pharmacotherapy versus naltrexone pharmacotherapy for treatment retention, relapse prevention and opioid craving reduction among…
- Trial name
- NCT01015066
- Testing
- Buprenorphine/naloxone, Naltrexone
- Where
- United States
- Sponsor
- State University of New York at Buffalo
Drug Dependence
Extended Release Naltrexone for Opioid-Dependent Youth
The purpose of this study is to compare 6-month treatment outcomes for 15-21 year old opioid-dependent youth receiving extended release naltrexone (XR-NTX) v. Treatment as Usual (TAU).
- Trial name
- NCT01843023
- Testing
- Extended Release Naltrexone, Psychosocial Treatment, Buprenorphine
- Where
- 2 sites in United States
- Volunteers
- 288 people
- Sponsor
- Friends Research Institute, Inc.
Crohn's Disease
The Efficacy of Low Dose Naltrexone Therapy in Children With Crohn's Disease
It is hypothesized that oral naltrexone will improve inflammation of the bowel by increasing endogenous enkephalin levels in subjects with active Crohn's disease.
- Trial name
- LDN-Ped (NCT00715117)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Milton S. Hershey Medical Center
Eating Disorders, Binge Eating
Naltrexone Neuroimaging in Teens With Eating Disorders
Using a randomized, placebo-controlled, crossover study, this study will evaluate functional magnetic resonance imaging (fMRI) as a pharmacodynamic biomarker of opioid antagonism in adolescents with eating disorders.
- Conditions
- Eating Disorders, Binge Eating, Purging (Eating Disorders), Bulimia Nervosa
- Trial name
- NN-RCT (NCT05509257)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Mercy Hospital Kansas City
Opioid Use Disorder
Expanding the Youth Opioid Recovery Support (YORS) Intervention for MOUD Adherence to Adolescents With OUD
Despite rising rates of fatal opioid overdoses in the United States, adolescents with OUD are far less likely than adults to receive and be retained on medication for opioid use disorder (MOUD).
- Trial name
- YORS (NCT06774248)
- Testing
- Youth Opioid Recovery Support (YORS)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Potomac Health Foundations
Self-injurious Behavior, Self Mutilation
Evaluation of Naltrexone as a Treatment for Self-injurious Behavior
The proposed study examines the effect of oral naltrexone on self-injurious behavior (SIB) in adolescents and adults of normal intelligence.
- Trial name
- NTX-SIB (NCT02726035)
- Testing
- Naltrexone
- Where
- United States
- Sponsor
- Western Michigan University School of Medicine
Opioid-use Disorder
PRimary Care Opioid Use Disorders Treatment (PROUD) Trial
Effective treatment for opioid use disorders (OUDs) requires medications. Two medications for treating OUDs-buprenorphine and injectable naltrexone-can be prescribed in primary care (PC).
- Trial name
- PROUD (NCT03407638)
- Testing
- PROUD Intervention
- Where
- 6 sites in United States
- Volunteers
- 377,373 people
- Sponsor
- Kaiser Permanente
Self-Injurious Behavior, Mental Retardation
Self-Injury: Diagnosis and Treatment
Self-injurious behavior is behavior in which a person hurts or harms himself. This behavior sometimes occurs in people with mental retardation or autism.
- Trial name
- NCT00065936
- Testing
- Naltrexone hydrochloride, Transcutaneous sensory nerve stimulation
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Nonsuicidal Self-Injury
Trial to Evaluate the Effects of Naltrexone in Nonsuicidal Self-injury
The goal of this clinical trial is to learn if naltrexone works to treat nonsuicidal self-injurious behavior in adolescents and adults.
- Trial name
- NiNsSIB (NCT06622239)
- Testing
- Naltrexone
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Hospital
Moderate-severe Pain
Safety and Pharmacokinetic Study of ALO-02 in Children Ages 7-17 With Pain
Safety and pharmacokinetics of an abuse-deterrent, extended-release formulation of oxycodone hydrochloride with a sequestered naltrexone core in children 7-17 with moderate-severe pain.
- Trial name
- NCT02680847
- Testing
- ALO-02
- Where
- 16 sites in United States
- Volunteers
- 32 people
- Sponsor
- Pfizer
Osteoarthritis, Arthritis, Rheumatoid
Low Dose Naltrexone for Chronic Pain From Arthritis
Over 100 million Americans report chronic pain. Veterans are disproportionately affected for multiple reasons, including injuries and post-traumatic stress disorder.
- Conditions
- Osteoarthritis, Arthritis, Rheumatoid, Arthritis, Psoriatic
- Trial name
- LDN-VA (NCT03008590)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- VA Office of Research and Development
Nonsuicidal Self-Injury, Self-Injurious Behavior
Naltrexone for Nonsuicidal Self-Injury
This randomized, double-blinded, placebo-controlled clinical trial aims to evaluate the efficacy and safety of naltrexone in reducing nonsuicidal self-injurious behavior among individuals with nonsuicidal self-injury.
- Trial name
- NCT07641283
- Testing
- Naltrexone 50mg (Whanin Naltrexone Tab. 50mg)
- Where
- 3 sites in South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Hospital
Fibromyalgia
LDN and tDCS in Fibromyalgia
Fibromyalgia is a complex generalized and diffuse musculoskeletal chronic pain; and pharmacological approaches are widely used to relieve pain and increase life quality.
- Trial name
- NCT04502251
- Testing
- Low-Dose Naltrexone, Transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 92 people
- Sponsor
- Centro Universitario La Salle
Erectile Dysfunction
Effects of Yohimbine and Naltrexone on Sexual Function
The purpose of this study is to evaluate the safety and effectiveness of the drugs yohimbine and naltrexone in treating men with erectile dysfunction (ED) (the inability to achieve or maintain penile erection for satisfactory…
- Trial name
- NCT00042536
- Testing
- Naltrexone HCL/ Yohimbine HCL
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Psoriasis
Efficacy of Low Dose Naltrexone in Psoriasis
Objective of the study is to determine the efficacy of low dose naltrexone in the patients of psoriasis, which is a chronic relapsing and remitting disease.
- Trial name
- NCT04250792
- Testing
- Naltrexone Pill
- Where
- Pakistan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
Opioid Use Disorder (OUD), Chronic Pain
Addiction Treatment in Primary Care Expansion
The Veterans Health Administration (VA) is a national leader in addressing the twin epidemics of chronic pain and opioid use, misuse, and opioid use disorder (OUD); but important challenges remain.
- Trial name
- APEX (NCT03547882)
- Where
- 2 sites in United States
- Sponsor
- VA Office of Research and Development
Opioid-use Disorder
Intervention to Expand Opioid Use Disorder Treatment Pharmacotherapy Prescribers
This is a cluster-randomized controlled trial designed to increase the availability of buprenorphine and extended-release naltrexone treatment capacity for opioid use disorder (OUD).
- Trial name
- NCT02926482
- Testing
- Prescriber Recruitment Bundle (PRB)
- Where
- 3 sites in United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Fibromyalgia
Low Dose Naltrexone for the Treatment of Juvenile Primary Fibromyalgia Syndrome
The purpose of this research is to obtain data or information on the safety and effectiveness of low dose naltrexone (LDN) for treating the symptoms of juvenile primary fibromyalgia syndrome.
- Trial name
- NCT00855972
- Testing
- Low Dose Naltrexone
- Sponsor
- Stanford University
Anorexia Nervosa/Bulimia, Anorexia in Adolescence
Oral Naltrexone In Pediatric Eating Disorders
The objective of this study is to evaluate the effectiveness of oral naltrexone tablets in pediatric and adolescent eating disorders, in particular anorexia nervosa and bulimia nervosa, as compared to placebo.
- Conditions
- Anorexia Nervosa/Bulimia, Anorexia in Adolescence, Anorexia Nervosa, Atypical, Anorexia Nervosa, Binge Eating/Purging Type
- Trial name
- ONPED (NCT05073679)
- Testing
- Naltrexone Hydrochloride, Control
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Rosemary Claire Roden